|
|
protein refolding
|
GO:0042026 |
14 |
1.000
|
|
|
|
protein folding
|
GO:0006457 |
38 |
1.000
|
Yeast |
|
|
de novo protein folding
|
GO:0006458 |
2 |
1.000
|
|
|
|
chaperone cofactor dependent protein refolding
|
GO:0070389 |
4 |
1.000
|
|
|
|
de novo posttranslational protein folding
|
GO:0051084 |
2 |
1.000
|
|
|
|
intracellular protein transmembrane transport
|
GO:0065002 |
24 |
1.000
|
|
|
|
protein transmembrane transport
|
GO:0071806 |
25 |
1.000
|
|
|
|
chaperone mediated protein folding
|
GO:0061077 |
13 |
1.000
|
|
|
|
chaperone mediated protein folding requiring cofactor
|
GO:0051085 |
1 |
1.000
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
1.000
|
Yeast Fly |
|
|
circadian sleep wake cycle
|
GO:0042745 |
2 |
1.000
|
Fly |
|
|
establishment of protein localization to mitochondrial membrane
|
GO:0090151 |
7 |
1.000
|
|
|
|
sleep
|
GO:0030431 |
2 |
1.000
|
Fly |
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
1.000
|
|
|
|
response to unfolded protein
|
GO:0006986 |
24 |
1.000
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
1.000
|
|
|
|
intracellular protein transmembrane import
|
GO:0044743 |
23 |
0.999
|
|
|
|
regulation of circadian sleep wake cycle
|
GO:0042749 |
2 |
0.999
|
Fly |
|
|
protein targeting to mitochondrion
|
GO:0006626 |
19 |
0.999
|
|
|
|
protein import into mitochondrial outer membrane
|
GO:0045040 |
4 |
0.998
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.998
|
Worm |
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.998
|
|
|
|
regulation of circadian sleep wake cycle sleep
|
GO:0045187 |
2 |
0.998
|
Fly |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.997
|
Worm |
|
|
cellular heat acclimation
|
GO:0070370 |
3 |
0.997
|
|
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.997
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.996
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.996
|
Fly |
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
9 |
0.994
|
Human |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.994
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.992
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.992
|
Worm |
|
|
circadian sleep wake cycle process
|
GO:0022410 |
2 |
0.990
|
Fly |
|
|
response to temperature stimulus
|
GO:0009266 |
22 |
0.990
|
Yeast Fly |
|
|
response to heat
|
GO:0009408 |
21 |
0.990
|
Yeast Fly |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.989
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.989
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.983
|
Human |
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.983
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.979
|
Worm Fly |
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.979
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.978
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.977
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.975
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.975
|
|
|
|
cotranslational protein targeting to membrane
|
GO:0006613 |
2 |
0.975
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.972
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.972
|
|
|
|
peptidyl proline modification
|
GO:0018208 |
15 |
0.971
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.971
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.970
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.970
|
|
|
|
cellular response to heat
|
GO:0034605 |
14 |
0.964
|
Yeast |
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.963
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.961
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.951
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.943
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.940
|
|
|
|
regulation of transposition
|
GO:0010528 |
7 |
0.938
|
Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.937
|
|
|
|
protein localization to endoplasmic reticulum
|
GO:0070972 |
19 |
0.931
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.931
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.926
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.926
|
Zebrafish Fly |
|
|
response to topologically incorrect protein
|
GO:0035966 |
29 |
0.926
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.926
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.925
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.922
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.921
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.916
|
|
|
|
small nucleolar ribonucleoprotein complex assembly
|
GO:0000491 |
3 |
0.916
|
Yeast |
|
|
outer mitochondrial membrane organization
|
GO:0007008 |
4 |
0.915
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.911
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.910
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.908
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.906
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.906
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.906
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.902
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.901
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.901
|
|
|
|
negative regulation of inclusion body assembly
|
GO:0090084 |
9 |
0.895
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.894
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.891
|
Zebrafish Fly |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.879
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.877
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.876
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.875
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.867
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.864
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.863
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.863
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.861
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.858
|
Human |
|
|
protein peptidyl prolyl isomerization
|
GO:0000413 |
8 |
0.858
|
|
|
|
aging
|
GO:0007568 |
66 |
0.855
|
Worm |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.840
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.836
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.830
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.822
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.818
|
Fly |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.817
|
|
|
|
chaperone mediated protein complex assembly
|
GO:0051131 |
9 |
0.814
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.813
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.805
|
|
|
|
muscle cell development
|
GO:0055001 |
29 |
0.804
|
Zebrafish |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.804
|
|
|
|
centrosome cycle
|
GO:0007098 |
32 |
0.795
|
Fly |
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.790
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.786
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.775
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.774
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.762
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.762
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.739
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.735
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.734
|
|
|
|
srp dependent cotranslational protein targeting to membrane
|
GO:0006614 |
2 |
0.725
|
|
|
|
regulation of atp metabolic process
|
GO:1903578 |
29 |
0.725
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.723
|
Human |
|
|
cytoplasmic translation
|
GO:0002181 |
8 |
0.718
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.701
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.695
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.695
|
Worm Fly |
|
|
response to radiation
|
GO:0009314 |
151 |
0.678
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.665
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.660
|
|
|
|
negative regulation of fibril organization
|
GO:1902904 |
1 |
0.659
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.656
|
Human |
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.647
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.634
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.629
|
Human |
|
|
organelle disassembly
|
GO:1903008 |
9 |
0.625
|
|
|
|
sperm motility
|
GO:0030317 |
6 |
0.624
|
|
|
|
regulation of inclusion body assembly
|
GO:0090083 |
13 |
0.621
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.618
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.607
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.605
|
|
|
|
toxin transport
|
GO:1901998 |
4 |
0.603
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.602
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.598
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.596
|
|
|
|
heat acclimation
|
GO:0010286 |
3 |
0.595
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.595
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.590
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.583
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.580
|
Zebrafish |
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.578
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.575
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.568
|
Human |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.568
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.561
|
Zebrafish |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.553
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.552
|
Worm |
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.549
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.546
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.537
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.532
|
Fly |
|
|
mitochondrial membrane organization
|
GO:0007006 |
40 |
0.516
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.513
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.509
|
Human |
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.509
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.508
|
Human |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.503
|
Human |
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.499
|
Fly |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.478
|
|
|
|
detection of abiotic stimulus
|
GO:0009582 |
15 |
0.477
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.467
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.461
|
|
|
|
glucocorticoid receptor signaling pathway
|
GO:0042921 |
5 |
0.461
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.458
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.446
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.439
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.437
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.427
|
Zebrafish |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.426
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.424
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.421
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.414
|
|
|
|
regulation of microtubule based process
|
GO:0032886 |
74 |
0.413
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.413
|
Fly |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.391
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.391
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.389
|
Fly |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.388
|
|
|
|
regulation of atpase activity
|
GO:0043462 |
25 |
0.387
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.384
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.382
|
|
|
|
myosin filament organization
|
GO:0031033 |
2 |
0.375
|
Zebrafish |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.373
|
|
|
|
centrosome duplication
|
GO:0051298 |
28 |
0.365
|
|
|
|
growth
|
GO:0040007 |
202 |
0.363
|
|
|
|
cell recognition
|
GO:0008037 |
9 |
0.361
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.358
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.351
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.348
|
Fly |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.343
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.341
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.334
|
|
|
|
dna recombination
|
GO:0006310 |
77 |
0.327
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.324
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.323
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.320
|
Fly |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.320
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.315
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.315
|
|
|
|
cellular response to topologically incorrect protein
|
GO:0035967 |
19 |
0.312
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.310
|
Fly |
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.302
|
Zebrafish |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.302
|
Fly |
|
|
inclusion body assembly
|
GO:0070841 |
17 |
0.300
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.298
|
Worm Fly |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.297
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.293
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.291
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.290
|
Human |
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.289
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.285
|
|
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
31 |
0.281
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.280
|
Fly |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.279
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.278
|
Human Worm |
|
|
segmentation
|
GO:0035282 |
4 |
0.278
|
Fly |
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.278
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.273
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.270
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.269
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.264
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.261
|
|
|
|
centrosome organization
|
GO:0051297 |
58 |
0.259
|
Fly |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.252
|
|
|
|
positive regulation of atpase activity
|
GO:0032781 |
19 |
0.250
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.246
|
Zebrafish |
|
|
establishment of protein localization to endoplasmic reticulum
|
GO:0072599 |
11 |
0.246
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.243
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.239
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.236
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.236
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.235
|
Human |
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.229
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.228
|
|
|
|
mitotic spindle organization
|
GO:0007052 |
27 |
0.226
|
Fly |
|
|
detection of chemical stimulus
|
GO:0009593 |
55 |
0.225
|
|
|
|
protein targeting to er
|
GO:0045047 |
7 |
0.225
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.221
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.221
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.219
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.217
|
Human |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.217
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.214
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.214
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.213
|
Human |
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.212
|
Fly |
|
|
endoplasmic reticulum unfolded protein response
|
GO:0030968 |
16 |
0.212
|
|
|
|
myosin filament assembly
|
GO:0031034 |
2 |
0.211
|
Zebrafish |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.208
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.207
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.207
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.206
|
|
|
|
response to calcium ion
|
GO:0051592 |
46 |
0.204
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.197
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.191
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.188
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.187
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.183
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.182
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.182
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.182
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.179
|
Fly |
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.177
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.177
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.176
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.175
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.171
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.168
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.168
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.165
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.162
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.162
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.160
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.160
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.158
|
Fly |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.156
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.154
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.150
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.149
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.148
|
|
|
|
positive regulation of response to tumor cell
|
GO:0002836 |
8 |
0.145
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.143
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.143
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.142
|
Human |
|
|
meiotic cell cycle
|
GO:0051321 |
13 |
0.140
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.138
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.136
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.136
|
|
|
|
system process
|
GO:0003008 |
349 |
0.135
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.133
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.132
|
Human |
|
|
response to drug
|
GO:0042493 |
81 |
0.127
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.127
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.126
|
Human |
|
|
detection of stimulus involved in sensory perception
|
GO:0050906 |
43 |
0.126
|
|
|
|
axon development
|
GO:0061564 |
34 |
0.125
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.125
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.124
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.123
|
|
|
|
negative regulation of peptidyl serine dephosphorylation
|
GO:1902309 |
1 |
0.122
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.122
|
Fly |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.120
|
|
|
|
detection of external stimulus
|
GO:0009581 |
15 |
0.119
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.119
|
|
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.117
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.117
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.115
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.114
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.110
|
|
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.110
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.108
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.108
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.106
|
Yeast |
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.105
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.105
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.105
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.104
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.104
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.103
|
|
|
|
positive regulation of atp catabolic process
|
GO:1903291 |
19 |
0.102
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.101
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.100
|
|
|
|
microtubule polymerization
|
GO:0046785 |
18 |
0.099
|
|
|
|
microtubule polymerization or depolymerization
|
GO:0031109 |
37 |
0.098
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.097
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.097
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.096
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.096
|
|
|
|
immune response to tumor cell
|
GO:0002418 |
9 |
0.095
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.094
|
|
|
|
rhythmic process
|
GO:0048511 |
31 |
0.094
|
Fly |
|
|
neuron projection development
|
GO:0031175 |
106 |
0.093
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.090
|
Human |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.089
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.089
|
Zebrafish Fly |
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.086
|
|
|
|
intracellular mrna localization
|
GO:0008298 |
1 |
0.085
|
Fly |
|
|
cellular response to inorganic substance
|
GO:0071241 |
45 |
0.083
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.083
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.083
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.082
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.080
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.079
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.078
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.077
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.076
|
Fly |
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.076
|
|
|
|
microtubule organizing center organization
|
GO:0031023 |
62 |
0.075
|
Fly |
|
|
spermatid development
|
GO:0007286 |
4 |
0.075
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.075
|
Human |
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.074
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.073
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.073
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.073
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.073
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
11 |
0.072
|
Human |
|
|
immune response
|
GO:0006955 |
307 |
0.072
|
Human |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.072
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.072
|
Human |
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.072
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.071
|
Human |
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.071
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.070
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.068
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.068
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.067
|
|
|
|
regulation of atp catabolic process
|
GO:1903289 |
25 |
0.067
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.066
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.066
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.065
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.065
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
23 |
0.064
|
|
|
|
ribonucleoprotein complex subunit organization
|
GO:0071826 |
81 |
0.064
|
Yeast |
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.062
|
|
|
|
microtubule anchoring
|
GO:0034453 |
24 |
0.062
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.062
|
|
|
|
response to uv a
|
GO:0070141 |
6 |
0.062
|
|
|
|
striated muscle cell development
|
GO:0055002 |
27 |
0.062
|
Zebrafish |
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.061
|
Human |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.060
|
Worm Fly |
|
|
nuclear import
|
GO:0051170 |
106 |
0.057
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.057
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.056
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.056
|
|
|
|
sex differentiation
|
GO:0007548 |
45 |
0.056
|
Worm |
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.054
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.054
|
|
|
|
lung saccule development
|
GO:0060430 |
2 |
0.053
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.053
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.053
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.052
|
|
|
|
body morphogenesis
|
GO:0010171 |
11 |
0.052
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.051
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.050
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.050
|
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.050
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.049
|
|
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.048
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.048
|
Human |
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
38 |
0.048
|
Human |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.047
|
|
|
|
gamete generation
|
GO:0007276 |
25 |
0.047
|
Fly |
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.045
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.045
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.045
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.045
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.044
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.043
|
|
|
|
regulation of interleukin 10 production
|
GO:0032653 |
16 |
0.043
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.043
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.043
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.043
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.042
|
|
|
|
somatic diversification of immune receptors
|
GO:0002200 |
8 |
0.042
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.042
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.041
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.041
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.041
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.039
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.039
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.039
|
Human |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.039
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.038
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.038
|
|
|
|
lung alveolus development
|
GO:0048286 |
4 |
0.038
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.038
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.038
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
34 |
0.038
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.037
|
Human |
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.036
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.036
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.035
|
|
|
|
retrograde transport endosome to golgi
|
GO:0042147 |
45 |
0.035
|
|
|
|
protein polymerization
|
GO:0051258 |
71 |
0.035
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.035
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.034
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.034
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.033
|
|
|
|
regulation of mitochondrial membrane potential
|
GO:0051881 |
23 |
0.033
|
|
|
|
cellular polysaccharide metabolic process
|
GO:0044264 |
27 |
0.032
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.032
|
|
|
|
axon guidance
|
GO:0007411 |
12 |
0.032
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.031
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.031
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.031
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.030
|
|
|
|
unsaturated fatty acid metabolic process
|
GO:0033559 |
37 |
0.030
|
|
|
|
visual perception
|
GO:0007601 |
27 |
0.030
|
|
|
|
cellular component assembly involved in morphogenesis
|
GO:0010927 |
73 |
0.030
|
Zebrafish |
|
|
protein import into nucleus translocation
|
GO:0000060 |
22 |
0.030
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.030
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.030
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.029
|
|
|
|
binding of sperm to zona pellucida
|
GO:0007339 |
3 |
0.029
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.029
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.029
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.029
|
Zebrafish Fly |
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.029
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.029
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.029
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.028
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.028
|
Worm |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.028
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
28 |
0.028
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
22 |
0.028
|
|
|
|
interferon gamma mediated signaling pathway
|
GO:0060333 |
7 |
0.028
|
Human |
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.027
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.027
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.027
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.027
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.027
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.027
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.027
|
Fly |
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.026
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.026
|
|
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.026
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.026
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.025
|
Fly |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.025
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.025
|
|
|
|
embryonic placenta development
|
GO:0001892 |
1 |
0.025
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.024
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.024
|
|
|
|
regulation of erythrocyte differentiation
|
GO:0045646 |
17 |
0.024
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.024
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.024
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.023
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.023
|
|
