Homo sapiens

0 known processes

HSPA9

heat shock 70kDa protein 9 (mortalin)

(Aliases: GRP-75,MTHSP75,HSPA9B,CSA,MOT,MOT2,MGC4500,GRP75,PBP74)

HSPA9 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein refolding GO:0042026 14 0.998
Yeast
determination of adult lifespan GO:0008340 2 0.997
Worm
mitochondrion organization GO:0007005 156 0.980
Yeast
post embryonic development GO:0009791 2 0.977
Worm
vesicle mediated transport GO:0016192 371 0.951
cellular amino acid metabolic process GO:0006520 116 0.921
embryo development GO:0009790 123 0.873
Worm
protein folding GO:0006457 38 0.815
Yeast
multicellular organismal aging GO:0010259 3 0.813
Worm
receptor mediated endocytosis GO:0006898 84 0.803
negative regulation of apoptotic process GO:0043066 316 0.752
ribonucleoside monophosphate metabolic process GO:0009161 187 0.716
Yeast
purine nucleoside monophosphate metabolic process GO:0009126 186 0.691
Yeast
nucleoside catabolic process GO:0009164 408 0.647
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.627
Yeast
atp catabolic process GO:0006200 157 0.610
Yeast
transmembrane transport GO:0055085 399 0.602
Yeast
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.601
Yeast
translation GO:0006412 132 0.584
apoptotic signaling pathway GO:0097190 268 0.581
ribonucleoside monophosphate catabolic process GO:0009158 158 0.578
Yeast
protein transmembrane transport GO:0071806 25 0.553
Yeast
ribonucleotide catabolic process GO:0009261 405 0.544
Yeast
embryo development ending in birth or egg hatching GO:0009792 34 0.531
Worm
positive regulation of programmed cell death GO:0043068 249 0.531
innate immune response GO:0045087 178 0.525
positive regulation of peptidase activity GO:0010952 88 0.495
positive regulation of apoptotic process GO:0043065 246 0.474
response to unfolded protein GO:0006986 24 0.469
Worm
rna processing GO:0006396 255 0.465
protein import into mitochondrial matrix GO:0030150 1 0.447
Yeast
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.443
cytoplasmic transport GO:0016482 379 0.442
Yeast Mouse
protein processing GO:0016485 226 0.437
cellular macromolecule catabolic process GO:0044265 380 0.395
Yeast
reproduction GO:0000003 63 0.394
Worm
regulation of cell growth GO:0001558 135 0.382
regulation of apoptotic signaling pathway GO:2001233 175 0.367
regulation of cell migration GO:0030334 289 0.341
establishment of protein localization to membrane GO:0090150 121 0.335
purine ribonucleoside metabolic process GO:0046128 437 0.319
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.316
Yeast
de novo protein folding GO:0006458 2 0.304
regulation of endopeptidase activity GO:0052548 170 0.298
secretion GO:0046903 254 0.291
positive regulation of cytokine production GO:0001819 167 0.291
response to abiotic stimulus GO:0009628 336 0.288
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.284
Yeast
negative regulation of protein modification process GO:0031400 200 0.283
regulation of ion transport GO:0043269 189 0.280
negative regulation of cell death GO:0060548 345 0.280
posttranscriptional regulation of gene expression GO:0010608 213 0.279
nucleoside monophosphate metabolic process GO:0009123 191 0.278
Yeast
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.272
atp metabolic process GO:0046034 176 0.272
Yeast
purine nucleoside catabolic process GO:0006152 398 0.251
Yeast
nucleoside triphosphate catabolic process GO:0009143 394 0.250
Yeast
purine nucleoside triphosphate catabolic process GO:0009146 392 0.250
Yeast
response to nitrogen compound GO:1901698 184 0.248
cellular response to nitrogen compound GO:1901699 144 0.247
negative regulation of cellular protein metabolic process GO:0032269 353 0.235
negative regulation of protein metabolic process GO:0051248 391 0.227
defense response GO:0006952 315 0.223
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.223
Yeast
regulation of translation GO:0006417 89 0.220
negative regulation of catalytic activity GO:0043086 335 0.218
ribonucleoside triphosphate metabolic process GO:0009199 412 0.218
Yeast
protein import GO:0017038 130 0.216
Yeast
endocytosis GO:0006897 159 0.216
negative regulation of cellular component organization GO:0051129 235 0.211
nucleoside triphosphate metabolic process GO:0009141 422 0.209
Yeast
intracellular protein transport GO:0006886 270 0.204
Yeast Mouse
negative regulation of programmed cell death GO:0043069 321 0.204
protein maturation GO:0051604 233 0.201
positive regulation of proteolysis GO:0045862 142 0.194
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.191
regulation of kinase activity GO:0043549 314 0.187
response to external biotic stimulus GO:0043207 261 0.183
aging GO:0007568 66 0.170
Worm
purine nucleoside triphosphate metabolic process GO:0009144 412 0.168
Yeast
single organism membrane organization GO:0044802 268 0.166
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.164
regulation of protein kinase activity GO:0045859 289 0.162
regulation of cytokine production GO:0001817 232 0.158
regulation of peptidase activity GO:0052547 180 0.157
osteoblast differentiation GO:0001649 92 0.156
cellular response to endogenous stimulus GO:0071495 336 0.152
regulation of transferase activity GO:0051338 355 0.150
cytokine production GO:0001816 247 0.149
glycosyl compound catabolic process GO:1901658 413 0.144
Yeast
ossification GO:0001503 121 0.144
response to oxygen containing compound GO:1901700 369 0.144
response to hormone GO:0009725 175 0.143
microtubule based process GO:0007017 210 0.140
regulation of proteolysis GO:0030162 293 0.140
negative regulation of protein phosphorylation GO:0001933 140 0.140
purine ribonucleotide catabolic process GO:0009154 404 0.139
Yeast
purine nucleotide catabolic process GO:0006195 405 0.124
Yeast
response to endoplasmic reticulum stress GO:0034976 49 0.121
Worm
establishment of protein localization to organelle GO:0072594 172 0.119
Yeast
protein targeting GO:0006605 187 0.118
Yeast
regulation of protein ubiquitination GO:0031396 95 0.117
rna interference GO:0016246 4 0.116
negative regulation of phosphorus metabolic process GO:0010563 267 0.109
developmental process involved in reproduction GO:0003006 66 0.107
regulation of cellular response to stress GO:0080135 244 0.104
regulation of response to external stimulus GO:0032101 222 0.103
response to organonitrogen compound GO:0010243 156 0.101
positive regulation of developmental process GO:0051094 314 0.100
mrna metabolic process GO:0016071 175 0.099
negative regulation of cell proliferation GO:0008285 228 0.098
purine ribonucleoside catabolic process GO:0046130 398 0.098
Yeast
nucleoside phosphate catabolic process GO:1901292 412 0.098
Yeast
oxidation reduction process GO:0055114 396 0.098
response to topologically incorrect protein GO:0035966 29 0.097
Worm
ribonucleoside triphosphate catabolic process GO:0009203 391 0.097
Yeast
response to cytokine GO:0034097 232 0.094
Rat
positive regulation of apoptotic signaling pathway GO:2001235 70 0.094
organophosphate catabolic process GO:0046434 430 0.090
Yeast
response to oxidative stress GO:0006979 121 0.090
cellular chemical homeostasis GO:0055082 180 0.089
cellular response to oxygen containing compound GO:1901701 276 0.089
cellular component morphogenesis GO:0032989 314 0.087
reproductive structure development GO:0048608 55 0.087
cellular response to organonitrogen compound GO:0071417 124 0.086
cellular protein catabolic process GO:0044257 261 0.086
microtubule cytoskeleton organization GO:0000226 176 0.085
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.083
positive regulation of cell death GO:0010942 263 0.083
er nucleus signaling pathway GO:0006984 23 0.081
Worm
anatomical structure homeostasis GO:0060249 100 0.080
organelle localization GO:0051640 84 0.079
cellular amine metabolic process GO:0044106 41 0.078
establishment of protein localization to mitochondrion GO:0072655 22 0.075
Yeast
cellular response to cytokine stimulus GO:0071345 181 0.074
Rat
regulation of cellular component movement GO:0051270 334 0.072
cell growth GO:0016049 160 0.071
oogenesis GO:0048477 2 0.071
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.071
activation of innate immune response GO:0002218 55 0.070
reproductive process GO:0022414 106 0.069
positive regulation of hydrolase activity GO:0051345 331 0.066
Yeast
immune response GO:0006955 307 0.066
negative regulation of hydrolase activity GO:0051346 182 0.065
guanosine containing compound catabolic process GO:1901069 239 0.065
purine containing compound catabolic process GO:0072523 411 0.064
Yeast
positive regulation of endopeptidase activity GO:0010950 84 0.064
ribonucleoprotein complex biogenesis GO:0022613 116 0.063
regulation of locomotion GO:0040012 329 0.062
cellular response to hormone stimulus GO:0032870 125 0.062
regulation of cell cycle GO:0051726 393 0.062
regulation of growth GO:0040008 165 0.061
single organism cellular localization GO:1902580 332 0.061
Yeast
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.061
response to virus GO:0009615 126 0.060
regulation of defense response GO:0031347 154 0.058
cell cell signaling GO:0007267 155 0.057
establishment of organelle localization GO:0051656 59 0.056
regulation of protein processing GO:0070613 150 0.055
gonad development GO:0008406 34 0.055
positive regulation of response to external stimulus GO:0032103 88 0.055
regulation of cysteine type endopeptidase activity GO:2000116 127 0.055
peptidyl serine phosphorylation GO:0018105 101 0.054
response to other organism GO:0051707 261 0.053
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.052
response to bacterium GO:0009617 144 0.052
response to peptide GO:1901652 65 0.051
apoptotic mitochondrial changes GO:0008637 57 0.049
cytokine mediated signaling pathway GO:0019221 109 0.048
response to cocaine GO:0042220 1 0.047
negative regulation of cell growth GO:0030308 83 0.046
regulation of developmental growth GO:0048638 30 0.045
positive regulation of interleukin 6 production GO:0032755 21 0.043
response to drug GO:0042493 81 0.042
single organism reproductive process GO:0044702 98 0.042
amine metabolic process GO:0009308 44 0.042
negative regulation of phosphorylation GO:0042326 174 0.042
regulation of immune response GO:0050776 201 0.042
protein localization to membrane GO:0072657 160 0.041
reproductive system development GO:0061458 56 0.040
nucleotide catabolic process GO:0009166 408 0.040
Yeast
regulation of innate immune response GO:0045088 97 0.039
growth GO:0040007 202 0.039
Zebrafish
intrinsic apoptotic signaling pathway GO:0097193 127 0.039
response to biotic stimulus GO:0009607 276 0.039
response to organic cyclic compound GO:0014070 204 0.038
regulation of cell motility GO:2000145 299 0.038
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.038
regulation of protein maturation GO:1903317 150 0.037
mesenchyme development GO:0060485 59 0.036
mitochondrial transport GO:0006839 60 0.036
Yeast
positive regulation of defense response GO:0031349 87 0.035
ribonucleoside catabolic process GO:0042454 406 0.035
Yeast
regulation of homeostatic process GO:0032844 121 0.035
protein ubiquitination GO:0016567 314 0.035
neuron differentiation GO:0030182 138 0.035
spermatid differentiation GO:0048515 4 0.034
regulation of cell development GO:0060284 161 0.034
cellular response to peptide hormone stimulus GO:0071375 56 0.033
response to lipid GO:0033993 206 0.033
negative regulation of transferase activity GO:0051348 124 0.033
positive regulation of response to dna damage stimulus GO:2001022 43 0.032
nucleoside monophosphate catabolic process GO:0009125 159 0.032
Yeast
protein targeting to membrane GO:0006612 42 0.031
negative regulation of growth GO:0045926 97 0.031
multicellular organismal reproductive process GO:0048609 40 0.031
negative regulation of intracellular signal transduction GO:1902532 183 0.030
zymogen activation GO:0031638 70 0.030
positive regulation of growth GO:0045927 58 0.029
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.029
negative regulation of kinase activity GO:0033673 106 0.028
cellular response to insulin stimulus GO:0032869 41 0.028
intracellular protein transmembrane transport GO:0065002 24 0.028
Yeast
protein localization to mitochondrion GO:0070585 25 0.028
Yeast
protein modification by small protein conjugation GO:0032446 342 0.028
regulation of calcium ion transport GO:0051924 79 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
response to peptide hormone GO:0043434 61 0.027
development of primary sexual characteristics GO:0045137 35 0.027
extrinsic apoptotic signaling pathway GO:0097191 119 0.027
secretion by cell GO:0032940 226 0.026
regulation of transmembrane transport GO:0034762 139 0.026
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.026
mitochondrial membrane organization GO:0007006 40 0.026
neurotransmitter secretion GO:0007269 4 0.026
positive regulation of catabolic process GO:0009896 310 0.026
Yeast
cellular macromolecular complex assembly GO:0034622 324 0.025
angiogenesis GO:0001525 147 0.025
trna aminoacylation for protein translation GO:0006418 8 0.025
female gamete generation GO:0007292 2 0.025
protein targeting to mitochondrion GO:0006626 19 0.025
Yeast
protein localization to organelle GO:0033365 280 0.025
Yeast
developmental growth GO:0048589 48 0.025
Zebrafish
cell development GO:0048468 328 0.024
single fertilization GO:0007338 11 0.024
negative regulation of protein ubiquitination GO:0031397 35 0.024
enzyme linked receptor protein signaling pathway GO:0007167 303 0.024
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
organelle assembly GO:0070925 176 0.023
positive regulation of innate immune response GO:0045089 79 0.023
tissue homeostasis GO:0001894 63 0.023
chemical homeostasis GO:0048878 306 0.023
nervous system development GO:0007399 293 0.023
anterior posterior axis specification GO:0009948 2 0.023
sexual reproduction GO:0019953 37 0.022
intracellular receptor signaling pathway GO:0030522 104 0.022
cofactor metabolic process GO:0051186 87 0.022
cell division GO:0051301 168 0.022
response to insulin GO:0032868 45 0.021
response to reactive oxygen species GO:0000302 61 0.021
rna splicing via transesterification reactions GO:0000375 90 0.021
response to decreased oxygen levels GO:0036293 96 0.021
membrane organization GO:0061024 292 0.021
morphogenesis of embryonic epithelium GO:0016331 4 0.021
oocyte development GO:0048599 1 0.021
coenzyme metabolic process GO:0006732 65 0.021
ribosome localization GO:0033750 4 0.021
rna catabolic process GO:0006401 71 0.020
cellular response to dna damage stimulus GO:0006974 379 0.020
cellular response to abiotic stimulus GO:0071214 117 0.020
lipid metabolic process GO:0006629 381 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
de novo posttranslational protein folding GO:0051084 2 0.020
regulation of protein binding GO:0043393 66 0.020
sex differentiation GO:0007548 45 0.019
segmentation GO:0035282 4 0.019
regulation of body fluid levels GO:0050878 99 0.019
mitochondrial rna metabolic process GO:0000959 15 0.019
reactive oxygen species metabolic process GO:0072593 75 0.019
ion homeostasis GO:0050801 230 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
cell morphogenesis GO:0000902 296 0.018
positive regulation of type i interferon production GO:0032481 20 0.018
retina homeostasis GO:0001895 42 0.018
immune response regulating signaling pathway GO:0002764 97 0.018
gland development GO:0048732 48 0.018
endoplasmic reticulum unfolded protein response GO:0030968 16 0.018
Worm
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.018
protein import into nucleus GO:0006606 104 0.018
generation of precursor metabolites and energy GO:0006091 68 0.017
response to heat GO:0009408 21 0.017
positive regulation of immune system process GO:0002684 283 0.017
protein catabolic process GO:0030163 325 0.017
ameboidal type cell migration GO:0001667 135 0.017
alpha amino acid metabolic process GO:1901605 72 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
mesenchymal cell development GO:0014031 50 0.017
response to hypoxia GO:0001666 96 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
cell part morphogenesis GO:0032990 137 0.017
nuclear division GO:0000280 128 0.016
activation of immune response GO:0002253 114 0.016
peptidyl serine modification GO:0018209 106 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
positive regulation of translation GO:0045727 35 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 2 0.016
protein stabilization GO:0050821 64 0.016
organic acid catabolic process GO:0016054 71 0.016
leukocyte activation GO:0045321 164 0.016
positive regulation of mitochondrion organization GO:0010822 30 0.016
gtp catabolic process GO:0006184 237 0.016
detection of chemical stimulus GO:0009593 55 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
cellular homeostasis GO:0019725 196 0.015
neuromuscular junction development GO:0007528 3 0.015
negative regulation of jun kinase activity GO:0043508 4 0.015
nuclear transport GO:0051169 179 0.015
Mouse
cation transport GO:0006812 331 0.015
regulation of transporter activity GO:0032409 82 0.014
meiotic chromosome segregation GO:0045132 4 0.014
regulation of binding GO:0051098 111 0.014
regulation of protein transport GO:0051223 213 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
activation of cysteine type endopeptidase activity GO:0097202 57 0.014
alpha amino acid catabolic process GO:1901606 26 0.014
cell morphogenesis involved in differentiation GO:0000904 144 0.014
cellular response to oxidative stress GO:0034599 85 0.014
regulation of cell differentiation GO:0045595 393 0.014
signal transduction in response to dna damage GO:0042770 57 0.013
system process GO:0003008 349 0.013
epithelial to mesenchymal transition GO:0001837 48 0.013
oocyte differentiation GO:0009994 2 0.013
positive regulation of cell migration GO:0030335 172 0.013
response to misfolded protein GO:0051788 5 0.013
cellular response to topologically incorrect protein GO:0035967 19 0.013
Worm
biological adhesion GO:0022610 331 0.013
regulation of mitotic spindle checkpoint GO:1903504 8 0.013
locomotory behavior GO:0007626 1 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
regulation of cell activation GO:0050865 125 0.012
blastoderm segmentation GO:0007350 2 0.012
protein oligomerization GO:0051259 173 0.012
response to molecule of bacterial origin GO:0002237 82 0.012
positive regulation of interferon alpha production GO:0032727 11 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.012
response to purine containing compound GO:0014074 40 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
response to radiation GO:0009314 151 0.012
cellular metal ion homeostasis GO:0006875 146 0.011
intracellular protein transmembrane import GO:0044743 23 0.011
Yeast
organic hydroxy compound metabolic process GO:1901615 147 0.011
regulation of cell division GO:0051302 116 0.011
immune effector process GO:0002252 159 0.011
gtp metabolic process GO:0046039 239 0.011
mitotic cell cycle GO:0000278 326 0.011
metal ion homeostasis GO:0055065 169 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 26 0.011
positive regulation of cell development GO:0010720 92 0.011
ribosome biogenesis GO:0042254 48 0.011
regulation of protein localization GO:0032880 296 0.011
response to temperature stimulus GO:0009266 22 0.011
positive regulation of immune response GO:0050778 159 0.011
vasculature development GO:0001944 181 0.011
positive regulation of cell motility GO:2000147 177 0.011
regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 8 0.011
phosphatidylinositol mediated signaling GO:0048015 55 0.011
regulation of spindle checkpoint GO:0090231 12 0.011
regulation of mitochondrial membrane potential GO:0051881 23 0.011
response to oxygen levels GO:0070482 100 0.011
detection of stimulus GO:0051606 85 0.010
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.010
carboxylic acid catabolic process GO:0046395 71 0.010
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.010
rna splicing GO:0008380 131 0.010
negative regulation of protein processing GO:0010955 142 0.010
response to growth factor GO:0070848 205 0.010
positive regulation of transferase activity GO:0051347 227 0.010
negative regulation of apoptotic signaling pathway GO:2001234 97 0.010
signal transduction by p53 class mediator GO:0072331 72 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
programmed necrotic cell death GO:0097300 18 0.010
regulation of intracellular transport GO:0032386 195 0.010
neurogenesis GO:0022008 169 0.010
cellular amino acid catabolic process GO:0009063 31 0.010
small gtpase mediated signal transduction GO:0007264 78 0.010

HSPA9 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.109
nervous system disease DOID:863 431 0.109
immune system disease DOID:2914 155 0.021
cancer DOID:162 167 0.020
disease of cellular proliferation DOID:14566 174 0.020
organ system cancer DOID:0050686 164 0.020