Homo sapiens

226 known processes

HSPD1

heat shock 60kDa protein 1 (chaperonin)

(Aliases: HuCHA60,GROEL,HSP-60,HLD4,SPG13,HSP60,CPN60,HSP65)

HSPD1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein refolding GO:0042026 14 0.998
nucleoside monophosphate metabolic process GO:0009123 191 0.984
protein folding GO:0006457 38 0.978
determination of adult lifespan GO:0008340 2 0.951
post embryonic development GO:0009791 2 0.941
Worm
de novo protein folding GO:0006458 2 0.912
Rat
mitochondrion organization GO:0007005 156 0.903
Worm Fly
de novo posttranslational protein folding GO:0051084 2 0.876
Rat
negative regulation of cell death GO:0060548 345 0.852
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.816
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.752
oxidation reduction process GO:0055114 396 0.743
negative regulation of programmed cell death GO:0043069 321 0.720
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.700
Rat
ribonucleoprotein complex localization GO:0071166 4 0.641
chaperone cofactor dependent protein refolding GO:0070389 4 0.616
growth GO:0040007 202 0.598
Zebrafish
positive regulation of programmed cell death GO:0043068 249 0.596
intracellular protein transmembrane import GO:0044743 23 0.591
positive regulation of apoptotic process GO:0043065 246 0.588
regeneration GO:0031099 4 0.585
Zebrafish
ribonucleoside monophosphate catabolic process GO:0009158 158 0.565
multicellular organismal aging GO:0010259 3 0.536
transmembrane transport GO:0055085 399 0.493
embryo development GO:0009790 123 0.490
Worm
ribonucleoside triphosphate metabolic process GO:0009199 412 0.458
ribonucleotide catabolic process GO:0009261 405 0.455
endoplasmic reticulum unfolded protein response GO:0030968 16 0.443
Worm
negative regulation of apoptotic process GO:0043066 316 0.440
purine nucleoside monophosphate metabolic process GO:0009126 186 0.440
mitochondrial membrane organization GO:0007006 40 0.411
intracellular protein transmembrane transport GO:0065002 24 0.379
nucleoside catabolic process GO:0009164 408 0.367
response to nitrogen compound GO:1901698 184 0.364
Rat
positive regulation of hydrolase activity GO:0051345 331 0.357
purine ribonucleoside metabolic process GO:0046128 437 0.351
cytoplasmic transport GO:0016482 379 0.345
cofactor metabolic process GO:0051186 87 0.335
purine nucleotide catabolic process GO:0006195 405 0.334
purine nucleoside triphosphate metabolic process GO:0009144 412 0.332
atp metabolic process GO:0046034 176 0.326
ribonucleoside monophosphate metabolic process GO:0009161 187 0.324
nuclear transport GO:0051169 179 0.323
protein import GO:0017038 130 0.320
reproductive structure development GO:0048608 55 0.281
coenzyme metabolic process GO:0006732 65 0.273
cellular amino acid metabolic process GO:0006520 116 0.265
regulation of atp metabolic process GO:1903578 29 0.261
aging GO:0007568 66 0.257
multi organism cellular process GO:0044764 156 0.253
anterior posterior axis specification GO:0009948 2 0.249
establishment of protein localization to organelle GO:0072594 172 0.246
nucleoside triphosphate catabolic process GO:0009143 394 0.242
vesicle mediated transport GO:0016192 371 0.240
protein import into mitochondrial matrix GO:0030150 1 0.235
receptor mediated endocytosis GO:0006898 84 0.234
system process GO:0003008 349 0.232
nucleocytoplasmic transport GO:0006913 176 0.215
purine ribonucleotide catabolic process GO:0009154 404 0.213
immune system development GO:0002520 195 0.212
regulation of endopeptidase activity GO:0052548 170 0.206
ossification GO:0001503 121 0.202
positive regulation of cell death GO:0010942 263 0.191
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.187
toxin transport GO:1901998 4 0.174
osteoblast differentiation GO:0001649 92 0.167
single organism cellular localization GO:1902580 332 0.159
regulation of protein transport GO:0051223 213 0.158
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.150
regulation of transferase activity GO:0051338 355 0.145
negative regulation of cell proliferation GO:0008285 228 0.144
purine nucleoside monophosphate catabolic process GO:0009128 158 0.142
energy derivation by oxidation of organic compounds GO:0015980 43 0.138
posttranscriptional regulation of gene expression GO:0010608 213 0.136
cell growth GO:0016049 160 0.129
purine ribonucleoside catabolic process GO:0046130 398 0.129
intracellular protein transport GO:0006886 270 0.127
mitochondrial transport GO:0006839 60 0.126
protein oligomerization GO:0051259 173 0.121
nucleoside triphosphate metabolic process GO:0009141 422 0.120
regulation of protein kinase activity GO:0045859 289 0.120
protein targeting GO:0006605 187 0.118
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.113
nuclear export GO:0051168 69 0.113
response to endoplasmic reticulum stress GO:0034976 49 0.112
Worm
negative regulation of neuron apoptotic process GO:0043524 23 0.112
Rat
nucleotide catabolic process GO:0009166 408 0.110
response to wounding GO:0009611 168 0.109
Zebrafish Rat
oogenesis GO:0048477 2 0.109
cellular response to nitrogen compound GO:1901699 144 0.108
cell cell recognition GO:0009988 4 0.107
response to unfolded protein GO:0006986 24 0.106
reproduction GO:0000003 63 0.105
Worm
regulation of cell growth GO:0001558 135 0.098
nucleoside monophosphate catabolic process GO:0009125 159 0.097
protein transmembrane transport GO:0071806 25 0.096
cellular response to unfolded protein GO:0034620 16 0.091
Worm
cellular response to topologically incorrect protein GO:0035967 19 0.088
Worm
positive regulation of developmental process GO:0051094 314 0.087
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.084
nucleoside phosphate catabolic process GO:1901292 412 0.082
female gamete generation GO:0007292 2 0.081
hemopoiesis GO:0030097 180 0.080
purine containing compound catabolic process GO:0072523 411 0.080
purine nucleoside triphosphate catabolic process GO:0009146 392 0.079
response to temperature stimulus GO:0009266 22 0.078
Rat Fly
rrna metabolic process GO:0016072 40 0.078
generation of precursor metabolites and energy GO:0006091 68 0.077
cellular macromolecule catabolic process GO:0044265 380 0.075
glycosyl compound catabolic process GO:1901658 413 0.073
cotranslational protein targeting to membrane GO:0006613 2 0.073
cellular macromolecular complex assembly GO:0034622 324 0.073
chemical homeostasis GO:0048878 306 0.072
response to abiotic stimulus GO:0009628 336 0.071
Rat Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.071
cation homeostasis GO:0055080 189 0.069
hematopoietic or lymphoid organ development GO:0048534 186 0.069
regulation of neuron apoptotic process GO:0043523 35 0.068
Rat
apoptotic signaling pathway GO:0097190 268 0.067
cellular response to oxygen containing compound GO:1901701 276 0.067
regulation of growth GO:0040008 165 0.066
cellular response to organonitrogen compound GO:0071417 124 0.066
nucleotide biosynthetic process GO:0009165 109 0.065
single organism reproductive process GO:0044702 98 0.065
apoptotic mitochondrial changes GO:0008637 57 0.064
reproductive process GO:0022414 106 0.064
amine metabolic process GO:0009308 44 0.062
cellular response to oxidative stress GO:0034599 85 0.061
gland development GO:0048732 48 0.060
regulation of ion transport GO:0043269 189 0.060
cellular response to cytokine stimulus GO:0071345 181 0.059
metal ion homeostasis GO:0055065 169 0.059
response to hormone GO:0009725 175 0.059
Rat
cellular lipid metabolic process GO:0044255 303 0.059
neuron death GO:0070997 65 0.058
Rat
response to oxidative stress GO:0006979 121 0.057
Rat
cellular protein complex assembly GO:0043623 188 0.057
sulfur compound metabolic process GO:0006790 101 0.055
small gtpase mediated signal transduction GO:0007264 78 0.054
cellular amine metabolic process GO:0044106 41 0.054
negative regulation of cell growth GO:0030308 83 0.053
lipid metabolic process GO:0006629 381 0.052
embryo development ending in birth or egg hatching GO:0009792 34 0.052
Worm
regulation of cell cycle GO:0051726 393 0.050
ribonucleoside catabolic process GO:0042454 406 0.050
response to drug GO:0042493 81 0.049
Rat
reactive oxygen species metabolic process GO:0072593 75 0.048
regulation of mitochondrial membrane potential GO:0051881 23 0.047
nervous system development GO:0007399 293 0.046
reproductive system development GO:0061458 56 0.046
response to virus GO:0009615 126 0.046
ras protein signal transduction GO:0007265 73 0.046
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.046
tissue regeneration GO:0042246 3 0.044
Zebrafish
response to cytokine GO:0034097 232 0.044
regulation of membrane potential GO:0042391 95 0.044
spindle assembly involved in mitosis GO:0090307 12 0.043
regulation of kinase activity GO:0043549 314 0.042
organ morphogenesis GO:0009887 147 0.042
rna localization GO:0006403 41 0.041
regulation of apoptotic signaling pathway GO:2001233 175 0.041
purine nucleoside catabolic process GO:0006152 398 0.041
nitrogen compound transport GO:0071705 191 0.041
cellular component morphogenesis GO:0032989 314 0.040
cellular response to peptide hormone stimulus GO:0071375 56 0.040
protein targeting to nucleus GO:0044744 104 0.039
organophosphate catabolic process GO:0046434 430 0.038
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.038
regulation of multi organism process GO:0043900 157 0.038
positive regulation of cell differentiation GO:0045597 211 0.038
divalent inorganic cation homeostasis GO:0072507 136 0.038
regulation of cell adhesion GO:0030155 166 0.037
small nucleolar ribonucleoprotein complex assembly GO:0000491 3 0.037
single organism membrane organization GO:0044802 268 0.037
regulation of protein localization GO:0032880 296 0.037
ncrna processing GO:0034470 83 0.037
protein localization to organelle GO:0033365 280 0.036
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
membrane organization GO:0061024 292 0.035
dna catabolic process GO:0006308 49 0.035
protein homooligomerization GO:0051260 100 0.035
regulation of dna metabolic process GO:0051052 153 0.035
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
cell type specific apoptotic process GO:0097285 125 0.034
Rat
regulation of cytokine production GO:0001817 232 0.034
i kappab kinase nf kappab signaling GO:0007249 166 0.033
establishment of protein localization to mitochondrial membrane GO:0090151 7 0.033
organonitrogen compound biosynthetic process GO:1901566 200 0.033
innate immune response GO:0045087 178 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
carboxylic acid catabolic process GO:0046395 71 0.032
immune response GO:0006955 307 0.032
renal system development GO:0072001 63 0.032
development of primary sexual characteristics GO:0045137 35 0.032
regulation of establishment of protein localization GO:0070201 242 0.031
gonad development GO:0008406 34 0.031
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
alpha amino acid metabolic process GO:1901605 72 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.030
regulation of endodeoxyribonuclease activity GO:0032071 3 0.030
atp catabolic process GO:0006200 157 0.029
binding of sperm to zona pellucida GO:0007339 3 0.029
organelle assembly GO:0070925 176 0.029
negative regulation of protein phosphorylation GO:0001933 140 0.029
negative regulation of binding GO:0051100 57 0.029
er nucleus signaling pathway GO:0006984 23 0.028
Worm
anterior posterior axis specification embryo GO:0008595 2 0.028
establishment of protein localization to membrane GO:0090150 121 0.028
response to heat GO:0009408 21 0.028
Rat Fly
single organism nuclear import GO:1902593 104 0.028
sex differentiation GO:0007548 45 0.028
microtubule cytoskeleton organization GO:0000226 176 0.028
negative regulation of protein modification process GO:0031400 200 0.028
behavior GO:0007610 112 0.027
cellular metal ion homeostasis GO:0006875 146 0.027
response to extracellular stimulus GO:0009991 85 0.027
chaperone mediated protein complex assembly GO:0051131 9 0.027
regulation of peptidase activity GO:0052547 180 0.026
mitotic cell cycle process GO:1903047 286 0.026
protein processing GO:0016485 226 0.026
regulation of translational initiation in response to stress GO:0043558 1 0.026
nls bearing protein import into nucleus GO:0006607 2 0.026
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.025
organic acid biosynthetic process GO:0016053 97 0.025
positive regulation of protein secretion GO:0050714 60 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
negative regulation of multi organism process GO:0043901 92 0.025
rrna processing GO:0006364 35 0.025
response to oxygen containing compound GO:1901700 369 0.025
Rat
positive regulation of growth GO:0045927 58 0.024
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
regulation of translation in response to stress GO:0043555 3 0.024
regulation of cell differentiation GO:0045595 393 0.024
positive regulation of apoptotic signaling pathway GO:2001235 70 0.024
secretion by cell GO:0032940 226 0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.023
cellular cation homeostasis GO:0030003 163 0.023
blastoderm segmentation GO:0007350 2 0.023
endocytosis GO:0006897 159 0.023
pyrimidine ribonucleoside metabolic process GO:0046131 11 0.023
nuclear import GO:0051170 106 0.023
ribosomal large subunit export from nucleus GO:0000055 3 0.022
chordate embryonic development GO:0043009 34 0.022
gtp catabolic process GO:0006184 237 0.022
rna interference GO:0016246 4 0.022
gmp metabolic process GO:0046037 4 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.022
multicellular organismal reproductive process GO:0048609 40 0.021
epithelial cell differentiation GO:0030855 141 0.021
myosin filament organization GO:0031033 2 0.021
peptidyl proline modification GO:0018208 15 0.021
cellular ion homeostasis GO:0006873 168 0.021
positive regulation of cell motility GO:2000147 177 0.021
myeloid cell differentiation GO:0030099 117 0.021
positive regulation of catabolic process GO:0009896 310 0.021
mitotic cell cycle GO:0000278 326 0.020
protein export from nucleus GO:0006611 29 0.020
neurogenesis GO:0022008 169 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
positive regulation of cytokine production GO:0001819 167 0.020
positive regulation of cell proliferation GO:0008284 301 0.019
monocarboxylic acid metabolic process GO:0032787 185 0.019
circulatory system process GO:0003013 113 0.019
embryonic organ development GO:0048568 36 0.019
response to organic cyclic compound GO:0014070 204 0.019
Rat
embryonic morphogenesis GO:0048598 85 0.019
response to peptide GO:1901652 65 0.018
mapk cascade GO:0000165 288 0.018
negative regulation of endopeptidase activity GO:0010951 84 0.018
striated muscle myosin thick filament assembly GO:0071688 2 0.018
neuron apoptotic process GO:0051402 39 0.018
Rat
mitochondrial translation GO:0032543 17 0.018
lipid localization GO:0010876 106 0.018
wound healing GO:0042060 115 0.018
Zebrafish
secretion GO:0046903 254 0.018
response to hypoxia GO:0001666 96 0.018
Rat
rna export from nucleus GO:0006405 33 0.018
interspecies interaction between organisms GO:0044419 156 0.017
multi organism reproductive process GO:0044703 54 0.017
microtubule based process GO:0007017 210 0.017
mrna processing GO:0006397 133 0.017
rna processing GO:0006396 255 0.017
brain development GO:0007420 97 0.017
activation of immune response GO:0002253 114 0.017
gamete generation GO:0007276 25 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
response to decreased oxygen levels GO:0036293 96 0.017
Rat
regulation of locomotion GO:0040012 329 0.017
negative regulation of growth GO:0045926 97 0.017
regulation of cell migration GO:0030334 289 0.016
hindbrain development GO:0030902 3 0.016
cytokine production GO:0001816 247 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
spindle organization GO:0007051 53 0.016
multicellular organism reproduction GO:0032504 42 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
interaction with host GO:0051701 42 0.016
regulation of rna splicing GO:0043484 62 0.016
spermatid differentiation GO:0048515 4 0.016
pigment biosynthetic process GO:0046148 10 0.015
mitochondrial rna metabolic process GO:0000959 15 0.015
purine containing compound biosynthetic process GO:0072522 88 0.015
hydrogen peroxide metabolic process GO:0042743 20 0.015
regulation of transmembrane transport GO:0034762 139 0.015
protein import into mitochondrial outer membrane GO:0045040 4 0.015
sexual reproduction GO:0019953 37 0.015
regulation of binding GO:0051098 111 0.015
protein localization to membrane GO:0072657 160 0.014
cell adhesion GO:0007155 325 0.014
muscle structure development GO:0061061 98 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
positive regulation of cellular response to oxidative stress GO:1900409 7 0.014
erythrocyte differentiation GO:0030218 28 0.014
translation GO:0006412 132 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
cellular ketone metabolic process GO:0042180 80 0.013
regulation of secretion GO:0051046 194 0.013
tissue homeostasis GO:0001894 63 0.013
sperm egg recognition GO:0035036 3 0.013
protein localization to mitochondrion GO:0070585 25 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
positive regulation of transport GO:0051050 336 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
outer mitochondrial membrane organization GO:0007008 4 0.013
cellular modified amino acid metabolic process GO:0006575 64 0.013
regulation of cellular response to stress GO:0080135 244 0.013
regulation of mrna splicing via spliceosome GO:0048024 32 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
positive regulation of secretion GO:0051047 116 0.013
inflammatory cell apoptotic process GO:0006925 3 0.013
locomotory behavior GO:0007626 1 0.012
response to light stimulus GO:0009416 87 0.012
protein autophosphorylation GO:0046777 123 0.012
establishment of ribosome localization GO:0033753 4 0.012
positive regulation of translation GO:0045727 35 0.012
cell morphogenesis GO:0000902 296 0.012
regulation of myeloid cell differentiation GO:0045637 81 0.012
heart process GO:0003015 62 0.012
microtubule organizing center organization GO:0031023 62 0.012
negative regulation of developmental process GO:0051093 247 0.012
developmental process involved in reproduction GO:0003006 66 0.012
positive regulation of cell migration GO:0030335 172 0.012
muscle cell differentiation GO:0042692 63 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
regulation of protein import into nucleus GO:0042306 78 0.012
heart development GO:0007507 95 0.012
negative regulation of transferase activity GO:0051348 124 0.011
spermatid development GO:0007286 4 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
establishment of protein localization to mitochondrion GO:0072655 22 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
ribosome localization GO:0033750 4 0.011
biological adhesion GO:0022610 331 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
protein targeting to mitochondrion GO:0006626 19 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
neural nucleus development GO:0048857 47 0.011
neurological system process GO:0050877 163 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
regulation of cell development GO:0060284 161 0.011
cellular response to insulin stimulus GO:0032869 41 0.011
response to oxygen levels GO:0070482 100 0.011
Rat
eye development GO:0001654 42 0.011
viral life cycle GO:0019058 132 0.011
ion homeostasis GO:0050801 230 0.010
response to transition metal nanoparticle GO:1990267 29 0.010
regulation of ribonuclease activity GO:0060700 3 0.010
regulation of nuclease activity GO:0032069 11 0.010
sensory perception GO:0007600 103 0.010
cellular response to peptide GO:1901653 59 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
oocyte differentiation GO:0009994 2 0.010
response to insulin GO:0032868 45 0.010

HSPD1 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.472
disease of cellular proliferation DOID:14566 174 0.297
cancer DOID:162 167 0.177
organ system cancer DOID:0050686 164 0.072
central nervous system disease DOID:331 186 0.063
nervous system disease DOID:863 431 0.063
blood platelet disease DOID:2218 10 0.016
hemorrhagic disease DOID:2213 10 0.016
blood coagulation disease DOID:1247 21 0.016
hematopoietic system disease DOID:74 100 0.016
disease of metabolism DOID:0014667 295 0.014
amino acid metabolic disorder DOID:9252 50 0.014
inherited metabolic disorder DOID:655 242 0.014
hereditary spastic paraplegia DOID:2476 19 0.001
paraplegia DOID:607 19 0.001