Homo sapiens

0 known processes

IDH3A

isocitrate dehydrogenase 3 (NAD+) alpha

IDH3A biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.910
Rat
coenzyme metabolic process GO:0006732 65 0.831
Rat
citrate metabolic process GO:0006101 2 0.778
dicarboxylic acid metabolic process GO:0043648 29 0.775
Rat
vesicle mediated transport GO:0016192 371 0.736
Worm
protein import into mitochondrial matrix GO:0030150 1 0.479
tricarboxylic acid metabolic process GO:0072350 4 0.430
Rat
multicellular organismal aging GO:0010259 3 0.375
Worm
mitochondrion organization GO:0007005 156 0.333
intracellular protein transmembrane import GO:0044743 23 0.297
sulfur compound biosynthetic process GO:0044272 38 0.286
energy derivation by oxidation of organic compounds GO:0015980 43 0.279
Rat
transmembrane transport GO:0055085 399 0.265
nucleoside triphosphate metabolic process GO:0009141 422 0.252
oxidoreduction coenzyme metabolic process GO:0006733 19 0.243
Rat
pyridine nucleotide metabolic process GO:0019362 14 0.221
Rat
determination of adult lifespan GO:0008340 2 0.204
Worm
positive regulation of peptidase activity GO:0010952 88 0.186
nucleoside catabolic process GO:0009164 408 0.180
protein processing GO:0016485 226 0.180
mitochondrial transport GO:0006839 60 0.178
purine ribonucleoside metabolic process GO:0046128 437 0.165
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.155
post embryonic development GO:0009791 2 0.154
regulation of peptidase activity GO:0052547 180 0.153
nucleotide catabolic process GO:0009166 408 0.151
protein maturation GO:0051604 233 0.147
coenzyme biosynthetic process GO:0009108 24 0.145
tricarboxylic acid cycle GO:0006099 4 0.144
Rat
organophosphate catabolic process GO:0046434 430 0.143
thioester biosynthetic process GO:0035384 6 0.140
cofactor biosynthetic process GO:0051188 31 0.131
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.130
positive regulation of cell death GO:0010942 263 0.129
nucleoside monophosphate metabolic process GO:0009123 191 0.121
purine nucleotide catabolic process GO:0006195 405 0.118
2 oxoglutarate metabolic process GO:0006103 4 0.115
Rat
ribonucleoside catabolic process GO:0042454 406 0.114
glutamate metabolic process GO:0006536 10 0.112
generation of precursor metabolites and energy GO:0006091 68 0.110
Rat
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.107
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.107
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.105
nicotinamide nucleotide metabolic process GO:0046496 14 0.103
Rat
regeneration GO:0031099 4 0.103
ribonucleoside triphosphate metabolic process GO:0009199 412 0.102
acyl coa biosynthetic process GO:0071616 6 0.097
growth GO:0040007 202 0.095
intracellular protein transmembrane transport GO:0065002 24 0.094
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.091
ribonucleoside triphosphate catabolic process GO:0009203 391 0.090
segmentation GO:0035282 4 0.089
secretion GO:0046903 254 0.088
ribonucleotide catabolic process GO:0009261 405 0.087
purine ribonucleotide catabolic process GO:0009154 404 0.084
regulation of endopeptidase activity GO:0052548 170 0.084
cytoplasmic transport GO:0016482 379 0.084
guanosine containing compound metabolic process GO:1901068 244 0.082
protein localization to mitochondrion GO:0070585 25 0.075
purine nucleoside monophosphate catabolic process GO:0009128 158 0.074
positive regulation of programmed cell death GO:0043068 249 0.073
intracellular protein transport GO:0006886 270 0.073
cellular amino acid biosynthetic process GO:0008652 30 0.072
mitochondrial membrane organization GO:0007006 40 0.071
nucleoside triphosphate catabolic process GO:0009143 394 0.070
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.069
pyridine containing compound metabolic process GO:0072524 18 0.068
Rat
aspartate family amino acid catabolic process GO:0009068 5 0.066
amine metabolic process GO:0009308 44 0.064
epithelium development GO:0060429 227 0.064
purine containing compound catabolic process GO:0072523 411 0.062
glycosyl compound catabolic process GO:1901658 413 0.060
purine nucleoside triphosphate metabolic process GO:0009144 412 0.058
purine ribonucleoside catabolic process GO:0046130 398 0.058
small molecule biosynthetic process GO:0044283 157 0.057
cellular macromolecule catabolic process GO:0044265 380 0.057
establishment of protein localization to mitochondrion GO:0072655 22 0.056
guanosine containing compound catabolic process GO:1901069 239 0.056
spermatid development GO:0007286 4 0.054
regulation of ion transport GO:0043269 189 0.054
purine nucleoside triphosphate catabolic process GO:0009146 392 0.052
receptor mediated endocytosis GO:0006898 84 0.052
Worm
rna interference GO:0016246 4 0.050
Worm
nadh dehydrogenase complex assembly GO:0010257 16 0.050
purine nucleoside monophosphate metabolic process GO:0009126 186 0.048
cellular amino acid metabolic process GO:0006520 116 0.048
cell development GO:0048468 328 0.048
nucleoside phosphate catabolic process GO:1901292 412 0.047
acetyl coa metabolic process GO:0006084 8 0.046
purine nucleoside catabolic process GO:0006152 398 0.046
protein transmembrane transport GO:0071806 25 0.046
negative regulation of catalytic activity GO:0043086 335 0.044
anterior posterior axis specification GO:0009948 2 0.044
cofactor metabolic process GO:0051186 87 0.044
Rat
positive regulation of apoptotic process GO:0043065 246 0.044
positive regulation of proteolysis GO:0045862 142 0.044
single organism cellular localization GO:1902580 332 0.043
protein localization to organelle GO:0033365 280 0.043
regulation of proteolysis GO:0030162 293 0.043
positive regulation of hydrolase activity GO:0051345 331 0.042
single organism membrane organization GO:0044802 268 0.041
system process GO:0003008 349 0.041
establishment of protein localization to organelle GO:0072594 172 0.038
spermatid differentiation GO:0048515 4 0.038
organic anion transport GO:0015711 103 0.037
negative regulation of intracellular signal transduction GO:1902532 183 0.037
regulation of protein maturation GO:1903317 150 0.036
reactive oxygen species metabolic process GO:0072593 75 0.036
dicarboxylic acid catabolic process GO:0043649 9 0.036
nucleoside monophosphate catabolic process GO:0009125 159 0.036
cellular amine metabolic process GO:0044106 41 0.035
pyruvate metabolic process GO:0006090 26 0.035
regulation of cysteine type endopeptidase activity GO:2000116 127 0.035
detection of stimulus GO:0051606 85 0.035
cellular response to oxygen containing compound GO:1901701 276 0.034
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.034
atp metabolic process GO:0046034 176 0.033
single organism carbohydrate metabolic process GO:0044723 193 0.033
activation of cysteine type endopeptidase activity GO:0097202 57 0.033
negative regulation of hydrolase activity GO:0051346 182 0.032
atp catabolic process GO:0006200 157 0.032
protein targeting to mitochondrion GO:0006626 19 0.031
gtp metabolic process GO:0046039 239 0.031
membrane organization GO:0061024 292 0.030
cell morphogenesis GO:0000902 296 0.030
cellular ketone metabolic process GO:0042180 80 0.030
mitochondrial respiratory chain complex assembly GO:0033108 23 0.030
embryo development GO:0009790 123 0.029
Worm
carbohydrate metabolic process GO:0005975 207 0.029
sleep GO:0030431 2 0.029
female gamete generation GO:0007292 2 0.029
regulation of purine nucleotide catabolic process GO:0033121 205 0.029
positive regulation of cell proliferation GO:0008284 301 0.029
zymogen activation GO:0031638 70 0.028
regulation of membrane potential GO:0042391 95 0.028
secretion by cell GO:0032940 226 0.028
response to biotic stimulus GO:0009607 276 0.027
acetyl coa biosynthetic process from pyruvate GO:0006086 4 0.027
apoptotic mitochondrial changes GO:0008637 57 0.027
cellular component disassembly GO:0022411 92 0.026
regulation of purine nucleotide metabolic process GO:1900542 264 0.026
immune system development GO:0002520 195 0.026
negative regulation of protein processing GO:0010955 142 0.026
nucleocytoplasmic transport GO:0006913 176 0.026
dicarboxylic acid biosynthetic process GO:0043650 4 0.025
positive regulation of developmental process GO:0051094 314 0.025
regulation of defense response GO:0031347 154 0.025
defense response GO:0006952 315 0.024
positive regulation of endopeptidase activity GO:0010950 84 0.024
cellular lipid metabolic process GO:0044255 303 0.024
neurological system process GO:0050877 163 0.023
negative regulation of programmed cell death GO:0043069 321 0.023
cation transport GO:0006812 331 0.023
cardiovascular system development GO:0072358 262 0.023
dephosphorylation GO:0016311 209 0.022
hemopoiesis GO:0030097 180 0.022
lipid transport GO:0006869 90 0.022
regulation of transmembrane transport GO:0034762 139 0.022
somitogenesis GO:0001756 2 0.022
regulation of immune response GO:0050776 201 0.022
reproductive process GO:0022414 106 0.022
Worm
organonitrogen compound biosynthetic process GO:1901566 200 0.022
cellular carbohydrate metabolic process GO:0044262 84 0.022
regulation of growth GO:0040008 165 0.022
phototransduction GO:0007602 3 0.022
regulation of innate immune response GO:0045088 97 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
carboxylic acid biosynthetic process GO:0046394 97 0.021
memory GO:0007613 3 0.021
covalent chromatin modification GO:0016569 254 0.020
organic acid catabolic process GO:0016054 71 0.020
translation GO:0006412 132 0.020
response to external biotic stimulus GO:0043207 261 0.020
endocytosis GO:0006897 159 0.020
Worm
negative regulation of phosphate metabolic process GO:0045936 267 0.020
protein targeting GO:0006605 187 0.020
nuclear migration GO:0007097 1 0.020
myeloid cell differentiation GO:0030099 117 0.020
cellular macromolecular complex assembly GO:0034622 324 0.019
multicellular organismal response to stress GO:0033555 1 0.019
acyl coa metabolic process GO:0006637 23 0.019
cation transmembrane transport GO:0098655 238 0.019
aging GO:0007568 66 0.019
Worm
single organism reproductive process GO:0044702 98 0.019
Worm
metal ion transport GO:0030001 272 0.019
small molecule catabolic process GO:0044282 92 0.019
cellular component morphogenesis GO:0032989 314 0.019
cellular respiration GO:0045333 21 0.019
Rat
regulation of protein processing GO:0070613 150 0.019
biological adhesion GO:0022610 331 0.018
calcium ion transport GO:0006816 147 0.018
ion homeostasis GO:0050801 230 0.018
negative regulation of proteolysis GO:0045861 132 0.018
brain morphogenesis GO:0048854 1 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
divalent inorganic cation transport GO:0072511 158 0.018
morphogenesis of embryonic epithelium GO:0016331 4 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
regulation of nucleotide catabolic process GO:0030811 205 0.017
chemical homeostasis GO:0048878 306 0.017
regulation of protein transport GO:0051223 213 0.017
dna catabolic process GO:0006308 49 0.017
negative regulation of cell death GO:0060548 345 0.017
monocarboxylic acid metabolic process GO:0032787 185 0.017
chordate embryonic development GO:0043009 34 0.017
anion transport GO:0006820 161 0.017
regulation of multi organism process GO:0043900 157 0.017
wound healing GO:0042060 115 0.016
alpha amino acid metabolic process GO:1901605 72 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
neuromuscular junction development GO:0007528 3 0.016
histone modification GO:0016570 251 0.016
negative regulation of protein maturation GO:1903318 142 0.016
reproductive structure development GO:0048608 55 0.016
Worm
hormone catabolic process GO:0042447 4 0.016
positive regulation of immune response GO:0050778 159 0.016
lipid biosynthetic process GO:0008610 177 0.016
maintenance of location GO:0051235 112 0.015
organic acid biosynthetic process GO:0016053 97 0.015
regulation of protein localization GO:0032880 296 0.015
locomotory behavior GO:0007626 1 0.015
defense response to bacterium GO:0042742 63 0.015
defense response to other organism GO:0098542 129 0.015
ossification GO:0001503 121 0.015
regulation of transporter activity GO:0032409 82 0.015
blastoderm segmentation GO:0007350 2 0.015
thioester metabolic process GO:0035383 23 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
tissue regeneration GO:0042246 3 0.015
positive regulation of transport GO:0051050 336 0.014
alpha amino acid catabolic process GO:1901606 26 0.014
ribonucleoside monophosphate catabolic process GO:0009158 158 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
sulfur compound metabolic process GO:0006790 101 0.014
positive regulation of cellular component organization GO:0051130 376 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Worm
cellular ion homeostasis GO:0006873 168 0.014
regulation of intracellular transport GO:0032386 195 0.014
anterior posterior axis specification embryo GO:0008595 2 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
behavioral fear response GO:0001662 0 0.014
tissue homeostasis GO:0001894 63 0.014
fear response GO:0042596 0 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regulation of response to external stimulus GO:0032101 222 0.013
immune response GO:0006955 307 0.013
oogenesis GO:0048477 2 0.013
positive regulation of immune system process GO:0002684 283 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
sister chromatid segregation GO:0000819 54 0.013
negative regulation of protein metabolic process GO:0051248 391 0.013
response to organic cyclic compound GO:0014070 204 0.013
glycerol metabolic process GO:0006071 4 0.013
regulation of cellular amine metabolic process GO:0033238 11 0.013
protein modification by small protein removal GO:0070646 92 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
Worm
tripartite regional subdivision GO:0007351 2 0.013
cellular response to oxidative stress GO:0034599 85 0.013
chromatin organization GO:0006325 351 0.013
cellular protein catabolic process GO:0044257 261 0.013
multi organism cellular process GO:0044764 156 0.013
peptide metabolic process GO:0006518 51 0.013
cellular cation homeostasis GO:0030003 163 0.012
embryonic morphogenesis GO:0048598 85 0.012
circulatory system development GO:0072359 262 0.012
receptor metabolic process GO:0043112 81 0.012
cell projection organization GO:0030030 252 0.012
organic acid transport GO:0015849 65 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
ion transmembrane transport GO:0034220 338 0.012
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
nerve development GO:0021675 4 0.012
nitrogen compound transport GO:0071705 191 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
gtp catabolic process GO:0006184 237 0.012
cell growth GO:0016049 160 0.012
cellular protein complex assembly GO:0043623 188 0.012
carboxylic acid transport GO:0046942 63 0.012
nuclear transport GO:0051169 179 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
protein refolding GO:0042026 14 0.012
regulation of cell adhesion GO:0030155 166 0.012
response to oxidative stress GO:0006979 121 0.011
positive regulation of organelle organization GO:0010638 195 0.011
response to wounding GO:0009611 168 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
regulation of locomotion GO:0040012 329 0.011
regulation of ion transmembrane transport GO:0034765 132 0.011
striated muscle cell apoptotic process GO:0010658 3 0.011
protein acylation GO:0043543 138 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
adult locomotory behavior GO:0008344 1 0.011
reproduction GO:0000003 63 0.011
Worm
response to oxygen containing compound GO:1901700 369 0.011
protein import GO:0017038 130 0.011
response to other organism GO:0051707 261 0.011
negative regulation of growth GO:0045926 97 0.011
neuron differentiation GO:0030182 138 0.011
response to lipid GO:0033993 206 0.011
regulation of cellular amino acid metabolic process GO:0006521 6 0.011
cell projection morphogenesis GO:0048858 129 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.011
behavioral defense response GO:0002209 0 0.011
regulation of cell migration GO:0030334 289 0.011
innate immune response GO:0045087 178 0.011
response to radiation GO:0009314 151 0.011
cellular amide metabolic process GO:0043603 69 0.011
positive regulation of catabolic process GO:0009896 310 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.010
reproductive system development GO:0061458 56 0.010
Worm
muscle system process GO:0003012 81 0.010
cell substrate adhesion GO:0031589 132 0.010
regulation of transmembrane transporter activity GO:0022898 74 0.010
cellular chemical homeostasis GO:0055082 180 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.010
response to virus GO:0009615 126 0.010
anatomical structure homeostasis GO:0060249 100 0.010
macromolecular complex disassembly GO:0032984 60 0.010
positive regulation of cellular amine metabolic process GO:0033240 7 0.010

IDH3A disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.607
eye and adnexa disease DOID:1492 150 0.607
nervous system disease DOID:863 431 0.607
eye disease DOID:5614 149 0.588
retinal disease DOID:5679 118 0.127
retinal degeneration DOID:8466 89 0.040
immune system disease DOID:2914 155 0.040
disease of cellular proliferation DOID:14566 174 0.024
retinitis pigmentosa DOID:10584 51 0.023
cancer DOID:162 167 0.023
organ system cancer DOID:0050686 164 0.023
neuropathy DOID:870 52 0.022
neuromuscular disease DOID:440 38 0.020
musculoskeletal system disease DOID:17 223 0.020
microphthalmia DOID:10629 11 0.016
disease of mental health DOID:150 70 0.013
developmental disorder of mental health DOID:0060037 29 0.013