|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
1.000
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
1.000
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
1.000
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
1.000
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
1.000
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
1.000
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
1.000
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
1.000
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
1.000
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
1.000
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
1.000
|
Mouse |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
1.000
|
Mouse |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
1.000
|
|
|
|
immune response
|
GO:0006955 |
307 |
1.000
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
1.000
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
1.000
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
1.000
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
1.000
|
Mouse |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
1.000
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
1.000
|
|
|
|
serine phosphorylation of stat protein
|
GO:0042501 |
4 |
1.000
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.999
|
|
|
|
regulation of cd40 signaling pathway
|
GO:2000348 |
3 |
0.999
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
7 |
0.999
|
Zebrafish |
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.999
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.999
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.999
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.999
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.999
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.998
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.998
|
Mouse |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.998
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.997
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.997
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.996
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.995
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.995
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.994
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.994
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.994
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.992
|
Mouse |
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.992
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.992
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.992
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.992
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.991
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
2 |
0.991
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.991
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.991
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.990
|
Mouse |
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.990
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.989
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.989
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.988
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.988
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.988
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.987
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.985
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.984
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.984
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.983
|
Mouse |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.979
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.978
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
39 |
0.974
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.973
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.973
|
Mouse |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.969
|
|
|
|
b cell homeostasis
|
GO:0001782 |
1 |
0.968
|
Mouse |
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
12 |
0.966
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.966
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.963
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.963
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.963
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.962
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.962
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.961
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.961
|
Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.958
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.956
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.948
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.947
|
Mouse |
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
1 |
0.937
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.929
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.928
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.928
|
Mouse |
|
|
regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031664 |
13 |
0.922
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.917
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.917
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.913
|
Mouse |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.912
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.910
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.907
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.904
|
|
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.904
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.902
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
25 |
0.902
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.897
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.891
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.887
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.885
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.883
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.882
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.882
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.875
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.875
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.873
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.868
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.867
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.867
|
Mouse |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.864
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.860
|
Mouse |
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.860
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.857
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.850
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.849
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.845
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.842
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.838
|
Mouse |
|
|
immune effector process
|
GO:0002252 |
159 |
0.838
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.837
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.837
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.836
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.834
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.832
|
|
|
|
positive regulation of interleukin 8 biosynthetic process
|
GO:0045416 |
8 |
0.828
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.823
|
Mouse |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.822
|
Mouse |
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.814
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.809
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.809
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.808
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.803
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.800
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.799
|
|
|
|
fat soluble vitamin metabolic process
|
GO:0006775 |
19 |
0.799
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.783
|
Mouse |
|
|
protein maturation
|
GO:0051604 |
233 |
0.780
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.780
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.780
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.772
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.771
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.768
|
Mouse |
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.766
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.766
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.763
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.760
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.758
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.753
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.752
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.749
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.747
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.742
|
|
|
|
positive regulation of type i interferon production
|
GO:0032481 |
20 |
0.742
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.735
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.734
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.721
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.716
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.716
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.708
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.707
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.707
|
|
|
|
interleukin 1 beta production
|
GO:0032611 |
22 |
0.703
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.701
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.697
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.690
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.684
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.682
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.678
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.666
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.665
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.662
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.662
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.654
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.653
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.652
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.650
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.650
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.649
|
Mouse |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.644
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.643
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.641
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.640
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.638
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.635
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.632
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.624
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.620
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.618
|
|
|
|
cd40 signaling pathway
|
GO:0023035 |
3 |
0.607
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
22 |
0.601
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
16 |
0.600
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.595
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.586
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.585
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.574
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.574
|
|
|
|
interferon beta production
|
GO:0032608 |
23 |
0.570
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.564
|
|
|
|
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
|
GO:0035872 |
5 |
0.550
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.547
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.536
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.535
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.534
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.532
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.531
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.531
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.526
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.525
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.520
|
|
|
|
ribonucleoprotein complex biogenesis
|
GO:0022613 |
116 |
0.511
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.510
|
Mouse |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.509
|
|
|
|
regulation of interleukin 8 biosynthetic process
|
GO:0045414 |
11 |
0.508
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.497
|
|
|
|
antibacterial humoral response
|
GO:0019731 |
24 |
0.494
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.493
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.490
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.488
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.484
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.483
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.478
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.476
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.472
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.470
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.465
|
Mouse |
|
|
protein targeting
|
GO:0006605 |
187 |
0.461
|
|
|
|
amide biosynthetic process
|
GO:0043604 |
15 |
0.452
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.448
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
11 |
0.445
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.443
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.441
|
|
|
|
gland development
|
GO:0048732 |
48 |
0.437
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.434
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.431
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.430
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.426
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.426
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.425
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.423
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.422
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.421
|
|
|
|
positive regulation of defense response to virus by host
|
GO:0002230 |
14 |
0.420
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.420
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.416
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.416
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.411
|
Mouse |
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.408
|
|
|
|
positive regulation of humoral immune response
|
GO:0002922 |
3 |
0.404
|
|
|
|
regulation of polysaccharide metabolic process
|
GO:0032881 |
21 |
0.404
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.399
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.398
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.394
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.392
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.386
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.385
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.381
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.375
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.370
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.364
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
11 |
0.363
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
40 |
0.361
|
Mouse |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.359
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.358
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.358
|
Mouse |
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.357
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.356
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.348
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.348
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.346
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.337
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.335
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.330
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.329
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.329
|
|
|
|
negative regulation of innate immune response
|
GO:0045824 |
18 |
0.328
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.324
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.323
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.320
|
|
|
|
nitric oxide biosynthetic process
|
GO:0006809 |
20 |
0.319
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.315
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.312
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.311
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.309
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.303
|
|
|
|
regulation of cyclin dependent protein serine threonine kinase activity
|
GO:0000079 |
36 |
0.301
|
|
|
|
nitric oxide metabolic process
|
GO:0046209 |
22 |
0.301
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.299
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.293
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
22 |
0.293
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.292
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.292
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.290
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.287
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.285
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.284
|
|
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
9 |
0.283
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.276
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.269
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.266
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.265
|
|
|
|
response to nicotine
|
GO:0035094 |
12 |
0.265
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.263
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.262
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.261
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.258
|
|
|
|
positive regulation of interleukin 8 production
|
GO:0032757 |
36 |
0.258
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.256
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.251
|
|
|
|
negative regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031665 |
7 |
0.247
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.247
|
|
|
|
positive regulation of defense response to bacterium
|
GO:1900426 |
1 |
0.245
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.245
|
Mouse |
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.245
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.241
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.241
|
|
|
|
negative regulation of interleukin 1 beta production
|
GO:0032691 |
6 |
0.240
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.239
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.236
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.233
|
|
|
|
nf kappab import into nucleus
|
GO:0042348 |
22 |
0.231
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.230
|
|
|
|
toll like receptor 3 signaling pathway
|
GO:0034138 |
4 |
0.230
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.227
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.224
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.223
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.222
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.221
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.221
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.220
|
|
|
|
negative regulation of protein secretion
|
GO:0050709 |
29 |
0.218
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.218
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.216
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.216
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.216
|
|
|
|
steroid biosynthetic process
|
GO:0006694 |
46 |
0.213
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.212
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.211
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.209
|
|
|
|
negative regulation of interleukin 1 production
|
GO:0032692 |
8 |
0.209
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.206
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.204
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.204
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.203
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.202
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.200
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.199
|
|
|
|
regulation of nitric oxide biosynthetic process
|
GO:0045428 |
17 |
0.199
|
|
|
|
peptide metabolic process
|
GO:0006518 |
51 |
0.198
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.197
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.196
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.194
|
|
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.191
|
|
|
|
interleukin 12 biosynthetic process
|
GO:0042090 |
1 |
0.191
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.190
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.190
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.190
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.188
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.183
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.183
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.181
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.180
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.180
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.179
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.177
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.175
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.174
|
|
|
|
necroptotic process
|
GO:0070266 |
16 |
0.171
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.170
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.169
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.169
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.165
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.164
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.164
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.162
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
6 |
0.160
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.159
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.158
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.157
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.155
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.154
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.154
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.152
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.151
|
|
|
|
regulation of cellular amide metabolic process
|
GO:0034248 |
9 |
0.150
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.150
|
|
|
|
regulation of interferon beta biosynthetic process
|
GO:0045357 |
4 |
0.148
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.146
|
|
|
|
carbohydrate biosynthetic process
|
GO:0016051 |
42 |
0.146
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.145
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.145
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.143
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.143
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.142
|
|
|
|
protein linear polyubiquitination
|
GO:0097039 |
5 |
0.142
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.137
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.135
|
|
|
|
regulation of interferon alpha production
|
GO:0032647 |
11 |
0.133
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.131
|
|
|
|
negative regulation of protein localization to nucleus
|
GO:1900181 |
34 |
0.129
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.127
|
|
|
|
negative regulation of response to biotic stimulus
|
GO:0002832 |
18 |
0.127
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
35 |
0.127
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.126
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.125
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.124
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.123
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.121
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.121
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.121
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.118
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.116
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.115
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.115
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.115
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.114
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.113
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.113
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.113
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.112
|
|
|
|
regulation of interleukin 1 production
|
GO:0032652 |
21 |
0.112
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.112
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.110
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.110
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.109
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.108
|
Mouse |
|
|
response to fatty acid
|
GO:0070542 |
13 |
0.108
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.107
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.107
|
|
|
|
negative regulation of vitamin metabolic process
|
GO:0046137 |
6 |
0.106
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.106
|
|
|
|
regulation of monooxygenase activity
|
GO:0032768 |
22 |
0.106
|
|
|
|
positive regulation of response to biotic stimulus
|
GO:0002833 |
18 |
0.104
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.104
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.103
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.103
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.100
|
|
|
|
response to muramyl dipeptide
|
GO:0032495 |
4 |
0.099
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.098
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.098
|
|
|
|
response to dsrna
|
GO:0043331 |
25 |
0.097
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.097
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.096
|
|
|
|
response to exogenous dsrna
|
GO:0043330 |
10 |
0.095
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.094
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.093
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.093
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.091
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.091
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.090
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.090
|
|
|
|
protein complex localization
|
GO:0031503 |
31 |
0.089
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.087
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.087
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
24 |
0.087
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.086
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.086
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.085
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.084
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.084
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.084
|
|
|
|
negative regulation of tumor necrosis factor production
|
GO:0032720 |
20 |
0.084
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.083
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.083
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.083
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.082
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.081
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.081
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.080
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.079
|
|
|
|
negative regulation of lipid catabolic process
|
GO:0050995 |
9 |
0.079
|
|
|
|
cellular response to alkaloid
|
GO:0071312 |
11 |
0.078
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.078
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.078
|
|
|
|
regulation of tumor necrosis factor mediated signaling pathway
|
GO:0010803 |
12 |
0.076
|
|
|
|
negative regulation of protein import into nucleus
|
GO:0042308 |
30 |
0.076
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.075
|
|
|
|
interleukin 1 production
|
GO:0032612 |
26 |
0.075
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.074
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.072
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.072
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.072
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.070
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.068
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.068
|
|
|
|
keratinization
|
GO:0031424 |
2 |
0.067
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.067
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.067
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.067
|
|
