Homo sapiens

174 known processes

IL6R

interleukin 6 receptor

(Aliases: IL-6R-alpha,IL-6R-1,MGC104991,CD126,IL6RA)

IL6R biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of collagen metabolic process GO:0010713 3 0.988
ciliary neurotrophic factor mediated signaling pathway GO:0070120 5 0.985
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.984
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.899
cellular ketone metabolic process GO:0042180 80 0.859
positive regulation of cellular amine metabolic process GO:0033240 7 0.824
regulation of cellular ketone metabolic process GO:0010565 50 0.693
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.678
leukemia inhibitory factor signaling pathway GO:0048861 3 0.632
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.615
regulation of cellular amine metabolic process GO:0033238 11 0.551
peptidyl tyrosine modification GO:0018212 170 0.504
negative regulation of collagen biosynthetic process GO:0032966 2 0.476
regulation of cellular amino acid metabolic process GO:0006521 6 0.454
cellular amine metabolic process GO:0044106 41 0.389
interleukin 27 mediated signaling pathway GO:0070106 1 0.381
interleukin 6 mediated signaling pathway GO:0070102 7 0.370
cellular divalent inorganic cation homeostasis GO:0072503 128 0.357
response to cytokine GO:0034097 232 0.353
t cell activation GO:0042110 99 0.340
cellular amino acid metabolic process GO:0006520 116 0.333
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.321
ion homeostasis GO:0050801 230 0.313
leukocyte activation GO:0045321 164 0.306
positive regulation of acute inflammatory response GO:0002675 2 0.299
amine metabolic process GO:0009308 44 0.294
positive regulation of t helper cell differentiation GO:0045624 2 0.289
regulation of mapk cascade GO:0043408 262 0.279
metal ion homeostasis GO:0055065 169 0.278
peptidyl tyrosine phosphorylation GO:0018108 170 0.272
regulation of cell differentiation GO:0045595 393 0.256
branching involved in salivary gland morphogenesis GO:0060445 1 0.255
cellular response to interleukin 6 GO:0071354 14 0.250
oncostatin m mediated signaling pathway GO:0038165 3 0.249
regulation of cytokine production GO:0001817 232 0.249
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.246
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.244
t cell selection GO:0045058 4 0.238
hormone secretion GO:0046879 65 0.237
positive regulation of t cell activation GO:0050870 54 0.236
interleukin 6 production GO:0032635 37 0.236
immune response GO:0006955 307 0.234
chemical homeostasis GO:0048878 306 0.230
positive regulation of protein phosphorylation GO:0001934 313 0.227
signal transduction by phosphorylation GO:0023014 297 0.225
cytokine production GO:0001816 247 0.224
lipid metabolic process GO:0006629 381 0.220
cell activation GO:0001775 213 0.219
neutrophil apoptotic process GO:0001781 2 0.218
regulation of hormone levels GO:0010817 125 0.217
positive regulation of lymphocyte activation GO:0051251 73 0.210
positive regulation of cytokine production GO:0001819 167 0.209
positive regulation of jak stat cascade GO:0046427 35 0.207
positive regulation of cell activation GO:0050867 81 0.205
positive regulation of mapk cascade GO:0043410 190 0.201
regulation of response to external stimulus GO:0032101 222 0.194
cellular lipid metabolic process GO:0044255 303 0.194
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.190
multicellular organismal metabolic process GO:0044236 34 0.182
lymphocyte activation GO:0046649 133 0.179
anatomical structure homeostasis GO:0060249 100 0.177
cytosolic calcium ion homeostasis GO:0051480 89 0.173
salivary gland morphogenesis GO:0007435 4 0.171
positive regulation of locomotion GO:0040017 186 0.168
regulation of defense response GO:0031347 154 0.162
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.154
response to oxygen containing compound GO:1901700 369 0.151
Rat
inflammatory response GO:0006954 79 0.150
response to abiotic stimulus GO:0009628 336 0.149
Rat
chemokine production GO:0032602 32 0.145
negative regulation of transport GO:0051051 176 0.143
regulation of response to wounding GO:1903034 101 0.142
cellular response to cytokine stimulus GO:0071345 181 0.142
chemokine biosynthetic process GO:0042033 4 0.141
peptide secretion GO:0002790 51 0.141
positive regulation of response to wounding GO:1903036 28 0.139
epithelial cell proliferation GO:0050673 128 0.138
inflammatory cell apoptotic process GO:0006925 3 0.137
oxidation reduction process GO:0055114 396 0.136
chemokine metabolic process GO:0050755 4 0.135
regulation of leukocyte activation GO:0002694 115 0.135
regulation of interleukin 6 mediated signaling pathway GO:0070103 3 0.133
mapk cascade GO:0000165 288 0.132
regulation of cytokine biosynthetic process GO:0042035 35 0.131
immune system development GO:0002520 195 0.129
response to virus GO:0009615 126 0.129
negative regulation of protein metabolic process GO:0051248 391 0.126
leukocyte proliferation GO:0070661 74 0.126
positive regulation of cell differentiation GO:0045597 211 0.125
cellular homeostasis GO:0019725 196 0.125
negative regulation of multicellular organismal process GO:0051241 317 0.123
regulation of secretion by cell GO:1903530 177 0.122
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.121
t helper 2 cell differentiation GO:0045064 1 0.120
cellular calcium ion homeostasis GO:0006874 117 0.120
regulation of leukocyte proliferation GO:0070663 67 0.118
positive regulation of leukocyte proliferation GO:0070665 48 0.117
divalent inorganic cation homeostasis GO:0072507 136 0.117
positive regulation of lymphocyte proliferation GO:0050671 46 0.116
regulation of cellular component movement GO:0051270 334 0.116
regulation of epithelial cell proliferation GO:0050678 113 0.116
positive regulation of t cell proliferation GO:0042102 33 0.115
regulation of cell migration GO:0030334 289 0.113
calcium ion homeostasis GO:0055074 122 0.112
positive regulation of response to external stimulus GO:0032103 88 0.112
neutral lipid metabolic process GO:0006638 27 0.111
smooth muscle cell proliferation GO:0048659 28 0.111
positive regulation of immune system process GO:0002684 283 0.111
positive regulation of phosphorylation GO:0042327 394 0.110
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.109
cytokine mediated signaling pathway GO:0019221 109 0.108
response to peptidoglycan GO:0032494 3 0.107
regulation of lymphocyte activation GO:0051249 103 0.106
regulation of jak stat cascade GO:0046425 44 0.106
regulation of multicellular organismal metabolic process GO:0044246 17 0.105
regulation of t cell activation GO:0050863 77 0.103
regulation of peptidyl serine phosphorylation GO:0033135 50 0.102
positive regulation of cellular component organization GO:0051130 376 0.102
cell development GO:0048468 328 0.100
response to oxidative stress GO:0006979 121 0.099
defense response to virus GO:0051607 71 0.099
t cell proliferation GO:0042098 45 0.096
defense response to other organism GO:0098542 129 0.095
nitrogen compound transport GO:0071705 191 0.093
positive regulation of cellular component movement GO:0051272 181 0.092
neuron projection regeneration GO:0031102 1 0.092
negative regulation of secretion by cell GO:1903531 52 0.092
cellular cation homeostasis GO:0030003 163 0.091
cell projection organization GO:0030030 252 0.090
hemopoiesis GO:0030097 180 0.089
regulation of angiogenesis GO:0045765 92 0.089
regulation of t cell proliferation GO:0042129 42 0.089
response to organonitrogen compound GO:0010243 156 0.089
Rat
peptidyl serine phosphorylation GO:0018105 101 0.088
endocrine pancreas development GO:0031018 11 0.088
positive regulation of gliogenesis GO:0014015 4 0.088
nervous system development GO:0007399 293 0.087
response to bacterium GO:0009617 144 0.086
protein secretion GO:0009306 98 0.086
negative regulation of secretion GO:0051048 58 0.085
cellular response to reactive oxygen species GO:0034614 50 0.085
purine containing compound catabolic process GO:0072523 411 0.085
positive regulation of cell migration GO:0030335 172 0.085
hematopoietic or lymphoid organ development GO:0048534 186 0.084
blood vessel morphogenesis GO:0048514 162 0.084
response to nitrogen compound GO:1901698 184 0.084
Rat
positive regulation of mononuclear cell proliferation GO:0032946 47 0.083
regulation of astrocyte differentiation GO:0048710 3 0.083
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.083
cyclic nucleotide metabolic process GO:0009187 82 0.082
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.082
response to wounding GO:0009611 168 0.082
cell type specific apoptotic process GO:0097285 125 0.081
vascular endothelial growth factor production GO:0010573 15 0.080
signal release GO:0023061 70 0.080
system process GO:0003008 349 0.078
cellular response to hydrogen peroxide GO:0070301 37 0.078
negative regulation of cytokine production GO:0001818 82 0.078
myeloid cell differentiation GO:0030099 117 0.078
positive regulation of apoptotic process GO:0043065 246 0.077
cation transport GO:0006812 331 0.077
regulation of camp metabolic process GO:0030814 52 0.076
regulation of inflammatory response GO:0050727 46 0.076
purine ribonucleoside metabolic process GO:0046128 437 0.076
defense response GO:0006952 315 0.076
cytokine biosynthetic process GO:0042089 37 0.076
axon regeneration GO:0031103 1 0.075
epithelium development GO:0060429 227 0.075
response to biotic stimulus GO:0009607 276 0.075
biological adhesion GO:0022610 331 0.074
cellular response to endogenous stimulus GO:0071495 336 0.074
regulation of cell activation GO:0050865 125 0.072
cellular response to oxidative stress GO:0034599 85 0.072
regeneration GO:0031099 4 0.072
purine ribonucleoside catabolic process GO:0046130 398 0.072
acylglycerol metabolic process GO:0006639 27 0.071
regulation of mononuclear cell proliferation GO:0032944 65 0.071
regulation of locomotion GO:0040012 329 0.071
jak stat cascade GO:0007259 46 0.071
positive regulation of nucleotide metabolic process GO:0045981 230 0.070
cellular response to oxygen containing compound GO:1901701 276 0.070
negative regulation of developmental process GO:0051093 247 0.070
ribonucleotide catabolic process GO:0009261 405 0.070
muscle cell cellular homeostasis GO:0046716 3 0.069
amide transport GO:0042886 76 0.068
secretion by cell GO:0032940 226 0.068
positive regulation of programmed cell death GO:0043068 249 0.068
organ morphogenesis GO:0009887 147 0.068
glycosyl compound catabolic process GO:1901658 413 0.067
leukocyte differentiation GO:0002521 98 0.067
positive regulation of immunoglobulin production GO:0002639 4 0.067
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.067
positive regulation of cell proliferation GO:0008284 301 0.067
nucleoside catabolic process GO:0009164 408 0.067
single organism carbohydrate metabolic process GO:0044723 193 0.067
mononuclear cell proliferation GO:0032943 71 0.067
positive regulation of developmental process GO:0051094 314 0.066
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.066
regulation of chemokine biosynthetic process GO:0045073 4 0.066
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.066
organophosphate catabolic process GO:0046434 430 0.066
positive regulation of lymphocyte differentiation GO:0045621 13 0.066
positive regulation of transport GO:0051050 336 0.065
nucleotide catabolic process GO:0009166 408 0.065
glucose homeostasis GO:0042593 31 0.065
hormone transport GO:0009914 68 0.065
peptide transport GO:0015833 74 0.065
ossification GO:0001503 121 0.064
regulation of cell motility GO:2000145 299 0.064
regulation of axon regeneration GO:0048679 1 0.063
regulation of establishment of protein localization GO:0070201 242 0.063
response to organic cyclic compound GO:0014070 204 0.063
Rat
response to lipopolysaccharide GO:0032496 70 0.062
Rat
response to external biotic stimulus GO:0043207 261 0.062
positive regulation of protein kinase activity GO:0045860 190 0.062
regulation of nucleotide metabolic process GO:0006140 269 0.062
posttranscriptional regulation of gene expression GO:0010608 213 0.060
response to axon injury GO:0048678 1 0.060
negative regulation of hormone secretion GO:0046888 15 0.060
defense response to gram positive bacterium GO:0050830 29 0.060
regulation of lymphocyte proliferation GO:0050670 64 0.060
regulation of t helper 2 cell differentiation GO:0045628 1 0.059
purine nucleotide catabolic process GO:0006195 405 0.059
endocrine system development GO:0035270 26 0.059
lymphocyte proliferation GO:0046651 70 0.059
ribonucleoside triphosphate metabolic process GO:0009199 412 0.058
i kappab kinase nf kappab signaling GO:0007249 166 0.058
negative regulation of cell death GO:0060548 345 0.058
positive regulation of interleukin 6 production GO:0032755 21 0.057
regulation of secretion GO:0051046 194 0.057
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.057
regulation of collagen metabolic process GO:0010712 15 0.057
purine nucleoside triphosphate catabolic process GO:0009146 392 0.056
positive regulation of secretion by cell GO:1903532 108 0.056
negative regulation of cell proliferation GO:0008285 228 0.056
cytokine metabolic process GO:0042107 38 0.055
camp metabolic process GO:0046058 61 0.055
t helper cell differentiation GO:0042093 4 0.055
pancreas development GO:0031016 19 0.054
regulation of protein localization GO:0032880 296 0.054
negative regulation of apoptotic process GO:0043066 316 0.054
tissue morphogenesis GO:0048729 96 0.054
regulation of immunoglobulin production GO:0002637 4 0.054
positive regulation of catabolic process GO:0009896 310 0.054
sequestering of calcium ion GO:0051208 17 0.053
regulation of immune effector process GO:0002697 91 0.052
regulation of hormone secretion GO:0046883 57 0.052
response to hormone GO:0009725 175 0.051
Rat
translation GO:0006412 132 0.051
cellular glucan metabolic process GO:0006073 22 0.051
erk1 and erk2 cascade GO:0070371 104 0.050
carbohydrate metabolic process GO:0005975 207 0.050
cation homeostasis GO:0055080 189 0.050
positive regulation of leukocyte differentiation GO:1902107 37 0.049
regulation of transferase activity GO:0051338 355 0.049
leukocyte apoptotic process GO:0071887 31 0.048
neurogenesis GO:0022008 169 0.048
purine nucleoside catabolic process GO:0006152 398 0.048
nucleoside triphosphate metabolic process GO:0009141 422 0.047
positive regulation of transferase activity GO:0051347 227 0.047
regulation of cell cycle GO:0051726 393 0.046
neuron differentiation GO:0030182 138 0.046
triglyceride metabolic process GO:0006641 23 0.046
positive regulation of defense response GO:0031349 87 0.046
vasculature development GO:0001944 181 0.046
response to inorganic substance GO:0010035 127 0.045
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.045
nucleoside phosphate catabolic process GO:1901292 412 0.045
response to molecule of bacterial origin GO:0002237 82 0.045
Rat
maintenance of location GO:0051235 112 0.045
muscle cell proliferation GO:0033002 35 0.045
post embryonic development GO:0009791 2 0.045
positive regulation of epithelial cell proliferation GO:0050679 65 0.045
regulation of cellular response to stress GO:0080135 244 0.044
enzyme linked receptor protein signaling pathway GO:0007167 303 0.044
regulation of protein transport GO:0051223 213 0.043
anatomical structure formation involved in morphogenesis GO:0048646 284 0.043
morphogenesis of a branching structure GO:0001763 21 0.043
negative regulation of angiogenesis GO:0016525 39 0.043
apoptotic signaling pathway GO:0097190 268 0.042
ribonucleoside triphosphate catabolic process GO:0009203 391 0.042
multicellular organismal aging GO:0010259 3 0.042
cellular metal ion homeostasis GO:0006875 146 0.042
regulation of chemokine production GO:0032642 31 0.041
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.041
regulation of erk1 and erk2 cascade GO:0070372 99 0.041
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 3 0.041
immune effector process GO:0002252 159 0.041
response to oxygen levels GO:0070482 100 0.041
multicellular organismal macromolecule metabolic process GO:0044259 29 0.040
adaptive immune response GO:0002250 49 0.040
positive regulation of nucleoside metabolic process GO:0045979 186 0.040
regulation of glial cell differentiation GO:0045685 3 0.040
regulation of alpha beta t cell differentiation GO:0046637 5 0.040
positive regulation of protein secretion GO:0050714 60 0.040
type 2 immune response GO:0042092 6 0.040
response to decreased oxygen levels GO:0036293 96 0.040
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.040
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.040
cellular response to organonitrogen compound GO:0071417 124 0.039
determination of adult lifespan GO:0008340 2 0.039
cell migration involved in gastrulation GO:0042074 1 0.039
generation of neurons GO:0048699 152 0.039
positive regulation of cell death GO:0010942 263 0.039
cellular response to molecule of bacterial origin GO:0071219 62 0.039
chromatin modification GO:0016568 298 0.038
protein catabolic process GO:0030163 325 0.038
regulation of cell adhesion GO:0030155 166 0.038
myeloid dendritic cell chemotaxis GO:0002408 3 0.038
positive regulation of alpha beta t cell activation GO:0046635 10 0.038
negative regulation of phosphorus metabolic process GO:0010563 267 0.038
regulation of intracellular transport GO:0032386 195 0.038
regulation of smooth muscle cell proliferation GO:0048660 28 0.038
calcium ion transport GO:0006816 147 0.038
negative regulation of programmed cell death GO:0043069 321 0.038
alpha beta t cell differentiation GO:0046632 7 0.037
positive regulation of camp metabolic process GO:0030816 41 0.037
regulation of endothelial cell proliferation GO:0001936 56 0.037
cellular response to nitrogen compound GO:1901699 144 0.037
neuron projection development GO:0031175 106 0.037
organophosphate biosynthetic process GO:0090407 163 0.037
response to hypoxia GO:0001666 96 0.036
response to lipid GO:0033993 206 0.036
Rat
positive regulation of b cell activation GO:0050871 17 0.036
positive regulation of t cell differentiation GO:0045582 11 0.036
cellular carbohydrate metabolic process GO:0044262 84 0.036
actin mediated cell contraction GO:0070252 12 0.036
regulation of b cell activation GO:0050864 24 0.035
cellular response to lipopolysaccharide GO:0071222 57 0.035
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.035
response to other organism GO:0051707 261 0.035
morphogenesis of an epithelium GO:0002009 60 0.035
regulation of acute inflammatory response GO:0002673 13 0.035
rhythmic behavior GO:0007622 2 0.035
purine nucleoside triphosphate metabolic process GO:0009144 412 0.035
neutrophil homeostasis GO:0001780 3 0.035
single organism cellular localization GO:1902580 332 0.035
locomotory behavior GO:0007626 1 0.035
regulation of vasculature development GO:1901342 97 0.035
t cell differentiation in thymus GO:0033077 4 0.035
atp metabolic process GO:0046034 176 0.035
ribonucleoside catabolic process GO:0042454 406 0.034
regulation of myeloid cell differentiation GO:0045637 81 0.034
regulation of translation GO:0006417 89 0.034
positive regulation of neurogenesis GO:0050769 49 0.034
purine ribonucleotide catabolic process GO:0009154 404 0.034
oogenesis GO:0048477 2 0.034
response to hydrogen peroxide GO:0042542 40 0.034
ribonucleoside monophosphate metabolic process GO:0009161 187 0.034
response to extracellular stimulus GO:0009991 85 0.034
regulation of t cell differentiation GO:0045580 19 0.034
t cell lineage commitment GO:0002360 1 0.034
purine nucleoside monophosphate metabolic process GO:0009126 186 0.034
positive regulation of kinase activity GO:0033674 204 0.034
negative regulation of cellular amine metabolic process GO:0033239 3 0.034
secretion GO:0046903 254 0.034
cellular component morphogenesis GO:0032989 314 0.034
cellular response to lipid GO:0071396 127 0.033
nucleoside monophosphate metabolic process GO:0009123 191 0.033
negative regulation of response to cytokine stimulus GO:0060761 25 0.033
t cell differentiation GO:0030217 29 0.033
positive regulation of cellular catabolic process GO:0031331 284 0.033
positive regulation of nucleotide catabolic process GO:0030813 185 0.033
regulation of nucleotide catabolic process GO:0030811 205 0.032
organ or tissue specific immune response GO:0002251 22 0.032
regulation of lipid metabolic process GO:0019216 96 0.032
cell activation involved in immune response GO:0002263 30 0.032
defense response to gram negative bacterium GO:0050829 14 0.032
positive t cell selection GO:0043368 2 0.032
lymphocyte differentiation GO:0030098 35 0.032
regulation of kinase activity GO:0043549 314 0.032
carbohydrate homeostasis GO:0033500 31 0.032
regulation of protein serine threonine kinase activity GO:0071900 179 0.032
female gamete generation GO:0007292 2 0.032
sex determination GO:0007530 3 0.032
regulation of nucleoside metabolic process GO:0009118 209 0.031
cellular response to biotic stimulus GO:0071216 71 0.031
negative regulation of cellular protein metabolic process GO:0032269 353 0.031
b cell activation GO:0042113 33 0.031
cell adhesion GO:0007155 325 0.031
positive regulation of calcium ion transport GO:0051928 51 0.031
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.030
regulation of ion homeostasis GO:2000021 73 0.030
regulation of bone mineralization GO:0030500 29 0.030
sulfur compound metabolic process GO:0006790 101 0.030
positive regulation of hydrolase activity GO:0051345 331 0.030
positive regulation of secretion GO:0051047 116 0.030
long term memory GO:0007616 2 0.030
sodium ion transport GO:0006814 61 0.030
phospholipid metabolic process GO:0006644 99 0.029
positive regulation of intracellular transport GO:0032388 104 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
regulation of ion transport GO:0043269 189 0.029
protein localization to organelle GO:0033365 280 0.029
taxis GO:0042330 157 0.029
single organism membrane organization GO:0044802 268 0.029
peripheral nervous system development GO:0007422 2 0.028
cellular chemical homeostasis GO:0055082 180 0.028
regulation of vascular endothelial growth factor production GO:0010574 13 0.028
positive regulation of cell development GO:0010720 92 0.028
neuron development GO:0048666 113 0.028
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.028
negative regulation of blood vessel morphogenesis GO:2000181 41 0.028
ion transmembrane transport GO:0034220 338 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
cell cell signaling GO:0007267 155 0.028
protein ubiquitination GO:0016567 314 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
response to nutrient levels GO:0031667 81 0.027
gland development GO:0048732 48 0.027
transmembrane transport GO:0055085 399 0.027
regulation of purine nucleotide catabolic process GO:0033121 205 0.027
response to steroid hormone GO:0048545 80 0.027
Rat
associative learning GO:0008306 1 0.027
regulation of biomineral tissue development GO:0070167 31 0.027
regulation of nucleotide biosynthetic process GO:0030808 50 0.027
nucleoside monophosphate catabolic process GO:0009125 159 0.027
polysaccharide metabolic process GO:0005976 33 0.026
actin filament based movement GO:0030048 17 0.026
cellular macromolecule catabolic process GO:0044265 380 0.026
atp catabolic process GO:0006200 157 0.026
growth GO:0040007 202 0.026
Rat
regulation of homeostatic process GO:0032844 121 0.026
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.026
positive regulation of ossification GO:0045778 32 0.026
positive regulation of type 2 immune response GO:0002830 2 0.026
positive regulation of ion transport GO:0043270 87 0.025
g protein coupled receptor signaling pathway GO:0007186 207 0.025
myeloid cell homeostasis GO:0002262 34 0.025
ribonucleoside monophosphate catabolic process GO:0009158 158 0.025
carbohydrate derivative biosynthetic process GO:1901137 207 0.025
positive regulation of protein transport GO:0051222 135 0.025
bone mineralization GO:0030282 34 0.025
actin filament based process GO:0030029 224 0.025
glycogen metabolic process GO:0005977 22 0.025
interleukin 8 mediated signaling pathway GO:0038112 2 0.025
ribose phosphate biosynthetic process GO:0046390 82 0.025
regulation of proteolysis GO:0030162 293 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
negative regulation of chemokine production GO:0032682 9 0.025
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 2 0.024
regulation of reactive oxygen species metabolic process GO:2000377 41 0.024
regulation of cytokine mediated signaling pathway GO:0001959 41 0.024
tyrosine phosphorylation of stat protein GO:0007260 33 0.024
regulation of growth GO:0040008 165 0.024
purine nucleoside monophosphate catabolic process GO:0009128 158 0.024
positive regulation of leukocyte activation GO:0002696 80 0.024
membrane organization GO:0061024 292 0.024
regulation of cell cycle process GO:0010564 266 0.024
negative regulation of response to external stimulus GO:0032102 83 0.024
cytoplasmic transport GO:0016482 379 0.024
regulation of metal ion transport GO:0010959 120 0.024
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 1 0.024
single organism cell adhesion GO:0098602 179 0.024
positive regulation of camp mediated signaling GO:0043950 10 0.024
activation of protein kinase activity GO:0032147 90 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
negative regulation of intracellular signal transduction GO:1902532 183 0.023
regulation of anatomical structure morphogenesis GO:0022603 286 0.023
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.023
regulation of sequestering of calcium ion GO:0051282 41 0.023
regulation of type 2 immune response GO:0002828 5 0.023
glucan metabolic process GO:0044042 22 0.023
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.023
negative regulation of immune system process GO:0002683 136 0.023
protein maturation GO:0051604 233 0.023
chemokine c c motif ligand 21 signaling pathway GO:0038116 1 0.023
monovalent inorganic cation transport GO:0015672 128 0.023
leukocyte activation involved in immune response GO:0002366 30 0.023
homeostasis of number of cells GO:0048872 40 0.023
cellular response to tumor necrosis factor GO:0071356 63 0.023
segmentation GO:0035282 4 0.023
positive regulation of homeostatic process GO:0032846 47 0.022
monocarboxylic acid metabolic process GO:0032787 185 0.022
regulation of neuron differentiation GO:0045664 70 0.022
chemokine c c motif ligand 11 production GO:0071954 1 0.022
morphogenesis of a branching epithelium GO:0061138 20 0.022
regulation of sensory perception of pain GO:0051930 3 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
immunoglobulin secretion GO:0048305 1 0.022
receptor internalization GO:0031623 43 0.022

IL6R disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.570
acquired metabolic disease DOID:0060158 58 0.294
gastrointestinal system disease DOID:77 36 0.192
diabetes mellitus DOID:9351 31 0.149
type 2 diabetes mellitus DOID:9352 28 0.149
carbohydrate metabolism disease DOID:0050013 32 0.149
glucose metabolism disease DOID:4194 32 0.149
cancer DOID:162 167 0.093
disease of cellular proliferation DOID:14566 174 0.093
organ system cancer DOID:0050686 164 0.084
inflammatory bowel disease DOID:0050589 9 0.030
intestinal disease DOID:5295 14 0.030
inherited metabolic disorder DOID:655 242 0.025