Homo sapiens

0 known processes

IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

(Aliases: IMPD2,IMPDH-II)

IMPDH2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
dna dealkylation GO:0035510 13 0.273
cellular macromolecule catabolic process GO:0044265 380 0.250
post embryonic development GO:0009791 2 0.198
determination of adult lifespan GO:0008340 2 0.185
cellular amino acid metabolic process GO:0006520 116 0.183
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.171
rrna modification GO:0000154 2 0.163
tube development GO:0035295 125 0.153
cofactor metabolic process GO:0051186 87 0.142
oxidation reduction process GO:0055114 396 0.138
Human Mouse
regulation of cell cycle process GO:0010564 266 0.136
negative regulation of programmed cell death GO:0043069 321 0.134
female gamete generation GO:0007292 2 0.120
cellular modified amino acid metabolic process GO:0006575 64 0.116
positive regulation of developmental process GO:0051094 314 0.115
regulation of cell cycle GO:0051726 393 0.105
organelle assembly GO:0070925 176 0.105
demethylation GO:0070988 37 0.101
ncrna metabolic process GO:0034660 108 0.100
organonitrogen compound biosynthetic process GO:1901566 200 0.098
Mouse
translational initiation GO:0006413 48 0.098
ribonucleoprotein complex biogenesis GO:0022613 116 0.093
dna demethylation GO:0080111 12 0.092
ribose phosphate biosynthetic process GO:0046390 82 0.091
mitotic cell cycle phase transition GO:0044772 162 0.089
regulation of mitotic cell cycle GO:0007346 189 0.083
negative regulation of multicellular organismal process GO:0051241 317 0.082
purine containing compound biosynthetic process GO:0072522 88 0.081
Mouse
regulation of establishment of protein localization GO:0070201 242 0.080
negative regulation of cell cycle GO:0045786 193 0.079
translation GO:0006412 132 0.076
nucleotide biosynthetic process GO:0009165 109 0.074
Mouse
mitotic cell cycle process GO:1903047 286 0.072
regulation of intracellular transport GO:0032386 195 0.070
cytoplasmic transport GO:0016482 379 0.069
vesicle mediated transport GO:0016192 371 0.068
cellular response to oxidative stress GO:0034599 85 0.065
positive regulation of cell proliferation GO:0008284 301 0.064
immune response GO:0006955 307 0.064
negative regulation of developmental process GO:0051093 247 0.062
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.061
positive regulation of apoptotic process GO:0043065 246 0.060
cell development GO:0048468 328 0.059
regulation of cellular response to stress GO:0080135 244 0.059
regulation of cellular amino acid metabolic process GO:0006521 6 0.059
protein processing GO:0016485 226 0.058
amine metabolic process GO:0009308 44 0.057
protein oligomerization GO:0051259 173 0.057
morphogenesis of an epithelium GO:0002009 60 0.056
positive regulation of immune system process GO:0002684 283 0.056
regulation of protein transport GO:0051223 213 0.056
negative regulation of cell death GO:0060548 345 0.054
purine ribonucleotide biosynthetic process GO:0009152 79 0.053
response to organic cyclic compound GO:0014070 204 0.053
cellular ketone metabolic process GO:0042180 80 0.051
rrna metabolic process GO:0016072 40 0.050
chemical homeostasis GO:0048878 306 0.050
cellular macromolecular complex assembly GO:0034622 324 0.049
cellular response to dna damage stimulus GO:0006974 379 0.049
secretion by cell GO:0032940 226 0.048
ribonucleoside triphosphate metabolic process GO:0009199 412 0.047
response to endoplasmic reticulum stress GO:0034976 49 0.047
nucleotide catabolic process GO:0009166 408 0.046
negative regulation of apoptotic process GO:0043066 316 0.044
microtubule cytoskeleton organization GO:0000226 176 0.044
system process GO:0003008 349 0.044
protein localization to organelle GO:0033365 280 0.044
cellular amine metabolic process GO:0044106 41 0.043
single organism membrane organization GO:0044802 268 0.042
apoptotic signaling pathway GO:0097190 268 0.042
negative regulation of protein metabolic process GO:0051248 391 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.041
endocytosis GO:0006897 159 0.041
growth GO:0040007 202 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.041
cell cycle phase transition GO:0044770 173 0.041
negative regulation of cell cycle process GO:0010948 121 0.040
protein maturation GO:0051604 233 0.040
epithelium development GO:0060429 227 0.040
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.039
endoplasmic reticulum unfolded protein response GO:0030968 16 0.039
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.039
regulation of cell cycle phase transition GO:1901987 126 0.039
carbohydrate derivative biosynthetic process GO:1901137 207 0.038
tube morphogenesis GO:0035239 95 0.038
chromatin organization GO:0006325 351 0.038
response to oxygen containing compound GO:1901700 369 0.038
regulation of protein localization GO:0032880 296 0.037
positive regulation of cellular component organization GO:0051130 376 0.036
negative regulation of cell cycle phase transition GO:1901988 89 0.036
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.036
regulation of reactive oxygen species metabolic process GO:2000377 41 0.036
leukocyte activation GO:0045321 164 0.036
Mouse
regulation of anatomical structure morphogenesis GO:0022603 286 0.036
mitotic cell cycle GO:0000278 326 0.035
rna modification GO:0009451 27 0.035
embryo development GO:0009790 123 0.034
regulation of cell differentiation GO:0045595 393 0.034
sulfur compound metabolic process GO:0006790 101 0.034
regulation of mapk cascade GO:0043408 262 0.034
positive regulation of transport GO:0051050 336 0.034
oogenesis GO:0048477 2 0.033
organophosphate catabolic process GO:0046434 430 0.033
regulation of dna metabolic process GO:0051052 153 0.033
response to abiotic stimulus GO:0009628 336 0.033
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.032
positive regulation of programmed cell death GO:0043068 249 0.032
negative regulation of cellular protein metabolic process GO:0032269 353 0.032
regulation of mitochondrion organization GO:0010821 54 0.031
mammary gland morphogenesis GO:0060443 2 0.031
ion homeostasis GO:0050801 230 0.031
cell type specific apoptotic process GO:0097285 125 0.031
rna methylation GO:0001510 18 0.031
establishment of protein localization to organelle GO:0072594 172 0.031
transmembrane transport GO:0055085 399 0.030
regulation of nucleotide metabolic process GO:0006140 269 0.030
negative regulation of cellular component organization GO:0051129 235 0.030
cellular lipid metabolic process GO:0044255 303 0.029
cell morphogenesis GO:0000902 296 0.029
regulation of cell migration GO:0030334 289 0.029
intracellular protein transport GO:0006886 270 0.029
receptor mediated endocytosis GO:0006898 84 0.029
immune response regulating signaling pathway GO:0002764 97 0.029
negative regulation of mitotic cell cycle GO:0045930 102 0.029
regulation of response to dna damage stimulus GO:2001020 94 0.029
positive regulation of dna repair GO:0045739 25 0.028
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.028
Human
regulation of cellular amine metabolic process GO:0033238 11 0.028
regulation of mitotic cell cycle phase transition GO:1901990 118 0.028
purine nucleotide catabolic process GO:0006195 405 0.028
membrane organization GO:0061024 292 0.027
nucleoside phosphate biosynthetic process GO:1901293 109 0.027
Mouse
modification dependent macromolecule catabolic process GO:0043632 212 0.027
tissue morphogenesis GO:0048729 96 0.027
regulation of kinase activity GO:0043549 314 0.027
negative regulation of catabolic process GO:0009895 104 0.027
nucleoside triphosphate metabolic process GO:0009141 422 0.027
immune effector process GO:0002252 159 0.026
response to external biotic stimulus GO:0043207 261 0.026
regulation of intracellular protein transport GO:0033157 123 0.026
nucleoside triphosphate catabolic process GO:0009143 394 0.026
cellular response to abiotic stimulus GO:0071214 117 0.026
microtubule based process GO:0007017 210 0.026
innate immune response GO:0045087 178 0.026
atp metabolic process GO:0046034 176 0.026
regulation of proteasomal protein catabolic process GO:0061136 87 0.026
regulation of growth GO:0040008 165 0.026
protein targeting GO:0006605 187 0.026
multicellular organismal aging GO:0010259 3 0.026
organelle fission GO:0048285 149 0.025
regulation of cytokine production GO:0001817 232 0.025
nucleocytoplasmic transport GO:0006913 176 0.025
protein modification by small protein conjugation GO:0032446 342 0.025
epithelial cell proliferation GO:0050673 128 0.025
defense response GO:0006952 315 0.024
negative regulation of phosphate metabolic process GO:0045936 267 0.024
cell division GO:0051301 168 0.024
positive regulation of intracellular transport GO:0032388 104 0.024
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.024
nuclear transport GO:0051169 179 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
cell activation GO:0001775 213 0.023
Mouse
cellular homeostasis GO:0019725 196 0.023
mitotic nuclear division GO:0007067 119 0.023
negative regulation of cellular catabolic process GO:0031330 83 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
glycosyl compound catabolic process GO:1901658 413 0.023
rna phosphodiester bond hydrolysis GO:0090501 35 0.023
negative regulation of organelle organization GO:0010639 126 0.023
heme metabolic process GO:0042168 8 0.023
covalent chromatin modification GO:0016569 254 0.022
developmental growth GO:0048589 48 0.022
positive regulation of organelle organization GO:0010638 195 0.022
response to hormone GO:0009725 175 0.022
monocarboxylic acid metabolic process GO:0032787 185 0.022
regulation of translation GO:0006417 89 0.022
macromolecule methylation GO:0043414 97 0.022
positive regulation of cellular component biogenesis GO:0044089 158 0.021
regulation of oxidative phosphorylation GO:0002082 3 0.021
embryonic morphogenesis GO:0048598 85 0.021
cell cycle checkpoint GO:0000075 117 0.021
digestive tract development GO:0048565 75 0.021
positive regulation of protein transport GO:0051222 135 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.021
nuclear division GO:0000280 128 0.021
lipid metabolic process GO:0006629 381 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
chromatin modification GO:0016568 298 0.020
mrna metabolic process GO:0016071 175 0.020
purine ribonucleoside metabolic process GO:0046128 437 0.020
Human
purine nucleoside monophosphate metabolic process GO:0009126 186 0.020
Human
response to nitrogen compound GO:1901698 184 0.020
single organism cellular localization GO:1902580 332 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
peptidyl tyrosine phosphorylation GO:0018108 170 0.020
positive regulation of response to dna damage stimulus GO:2001022 43 0.020
ribonucleoside monophosphate metabolic process GO:0009161 187 0.020
Human
regulation of camp metabolic process GO:0030814 52 0.020
cellular component morphogenesis GO:0032989 314 0.020
toxin transport GO:1901998 4 0.019
purine ribonucleoside catabolic process GO:0046130 398 0.019
regulation of transcription from rna polymerase ii promoter mitotic GO:0046021 1 0.019
response to other organism GO:0051707 261 0.019
negative regulation of cell differentiation GO:0045596 171 0.019
reproductive system development GO:0061458 56 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
response to cytokine GO:0034097 232 0.019
Mouse
regulation of behavior GO:0050795 82 0.019
purine containing compound catabolic process GO:0072523 411 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
coenzyme metabolic process GO:0006732 65 0.019
myeloid cell differentiation GO:0030099 117 0.019
t cell differentiation in thymus GO:0033077 4 0.019
positive regulation of cell death GO:0010942 263 0.019
response to oxidative stress GO:0006979 121 0.019
dna repair GO:0006281 198 0.019
cellular chemical homeostasis GO:0055082 180 0.019
positive regulation of protein phosphorylation GO:0001934 313 0.018
organ morphogenesis GO:0009887 147 0.018
positive regulation of intracellular protein transport GO:0090316 76 0.018
positive regulation of cytokine production GO:0001819 167 0.018
glucose homeostasis GO:0042593 31 0.018
regulation of proteolysis GO:0030162 293 0.018
ossification GO:0001503 121 0.018
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.018
single organism reproductive process GO:0044702 98 0.017
small molecule catabolic process GO:0044282 92 0.017
negative regulation of protein modification process GO:0031400 200 0.017
er nucleus signaling pathway GO:0006984 23 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
methylation GO:0032259 106 0.017
positive regulation of phosphorylation GO:0042327 394 0.017
segmentation GO:0035282 4 0.017
positive regulation of cell motility GO:2000147 177 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
secretion GO:0046903 254 0.016
lymphocyte activation GO:0046649 133 0.016
Mouse
cellular response to cytokine stimulus GO:0071345 181 0.016
Mouse
regulation of locomotion GO:0040012 329 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
nitrogen compound transport GO:0071705 191 0.016
osteoblast differentiation GO:0001649 92 0.016
protein homooligomerization GO:0051260 100 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
mitochondrion organization GO:0007005 156 0.016
regulation of cellular component biogenesis GO:0044087 281 0.016
response to inorganic substance GO:0010035 127 0.016
nucleosome organization GO:0034728 66 0.016
regulation of protein catabolic process GO:0042176 155 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.016
negative regulation of immune system process GO:0002683 136 0.016
cellular protein complex assembly GO:0043623 188 0.016
positive regulation of innate immune response GO:0045089 79 0.016
gtp catabolic process GO:0006184 237 0.016
regulation of protein kinase activity GO:0045859 289 0.015
regulation of cellular component movement GO:0051270 334 0.015
spindle organization GO:0007051 53 0.015
muscle cell cellular homeostasis GO:0046716 3 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
epithelial tube morphogenesis GO:0060562 38 0.015
cell adhesion GO:0007155 325 0.015
ribonucleoprotein complex assembly GO:0022618 78 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
response to organonitrogen compound GO:0010243 156 0.015
guanosine containing compound metabolic process GO:1901068 244 0.015
Human
regulation of feeding behavior GO:0060259 3 0.015
dna catabolic process endonucleolytic GO:0000737 37 0.015
protein catabolic process GO:0030163 325 0.015
nuclear import GO:0051170 106 0.015
regulation of multi organism process GO:0043900 157 0.015
regulation of cell development GO:0060284 161 0.015
i kappab kinase nf kappab signaling GO:0007249 166 0.014
regulation of protein complex assembly GO:0043254 147 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
neurogenesis GO:0022008 169 0.014
protein dna complex subunit organization GO:0071824 80 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
mitotic cell cycle checkpoint GO:0007093 68 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
protein autophosphorylation GO:0046777 123 0.014
neurological system process GO:0050877 163 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
locomotory behavior GO:0007626 1 0.014
cell projection organization GO:0030030 252 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
anterior posterior axis specification GO:0009948 2 0.014
reproductive process GO:0022414 106 0.014
cellular protein catabolic process GO:0044257 261 0.014
regulation of nucleocytoplasmic transport GO:0046822 98 0.014
positive regulation of dna metabolic process GO:0051054 73 0.014
positive regulation of immune response GO:0050778 159 0.014
regulation of protein localization to nucleus GO:1900180 85 0.014
cellular response to lipid GO:0071396 127 0.014
digestive system development GO:0055123 75 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
Mouse
activation of immune response GO:0002253 114 0.013
dna conformation change GO:0071103 113 0.013
positive regulation of translation GO:0045727 35 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.013
immune response activating signal transduction GO:0002757 90 0.013
positive regulation of growth GO:0045927 58 0.013
ribonucleotide biosynthetic process GO:0009260 81 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
atp transport GO:0015867 4 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
positive regulation of catabolic process GO:0009896 310 0.013
regeneration GO:0031099 4 0.013
defense response to other organism GO:0098542 129 0.013
regulation of nucleotide biosynthetic process GO:0030808 50 0.013
negative regulation of transport GO:0051051 176 0.013
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.013
hemopoiesis GO:0030097 180 0.013
adult locomotory behavior GO:0008344 1 0.013
multi organism cellular process GO:0044764 156 0.013
histone modification GO:0016570 251 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
Human
single organism nuclear import GO:1902593 104 0.013
rna processing GO:0006396 255 0.013
metal ion homeostasis GO:0055065 169 0.013
regulation of protein targeting GO:1903533 91 0.012
regulation of cell adhesion GO:0030155 166 0.012
convergent extension GO:0060026 1 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
protein tetramerization GO:0051262 47 0.012
response to lipid GO:0033993 206 0.012
immune system development GO:0002520 195 0.012
neuron projection development GO:0031175 106 0.012
microtubule organizing center organization GO:0031023 62 0.012
generation of precursor metabolites and energy GO:0006091 68 0.012
generation of neurons GO:0048699 152 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
mapk cascade GO:0000165 288 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
brain development GO:0007420 97 0.012
negative regulation of intracellular transport GO:0032387 60 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.012
lymphocyte proliferation GO:0046651 70 0.012
Mouse
circulatory system process GO:0003013 113 0.012
camp metabolic process GO:0046058 61 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
positive regulation of proteolysis GO:0045862 142 0.012
blastoderm segmentation GO:0007350 2 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
positive regulation of developmental growth GO:0048639 16 0.012
multicellular organism reproduction GO:0032504 42 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.011
ribosomal subunit export from nucleus GO:0000054 4 0.011
response to biotic stimulus GO:0009607 276 0.011
negative regulation of kinase activity GO:0033673 106 0.011
dna packaging GO:0006323 77 0.011
ubiquitin dependent protein catabolic process GO:0006511 206 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
regulation of membrane potential GO:0042391 95 0.011
rrna processing GO:0006364 35 0.011
cation homeostasis GO:0055080 189 0.011
glycerolipid metabolic process GO:0046486 107 0.011
histone exchange GO:0043486 3 0.011
protein localization to nucleus GO:0034504 136 0.011
single organism cell adhesion GO:0098602 179 0.011
aging GO:0007568 66 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
one carbon metabolic process GO:0006730 1 0.011
calcium ion homeostasis GO:0055074 122 0.011
response to bacterium GO:0009617 144 0.011
metal ion transport GO:0030001 272 0.011
lymphocyte homeostasis GO:0002260 4 0.011
circulatory system development GO:0072359 262 0.011
regulation of transferase activity GO:0051338 355 0.011
regulation of protein processing GO:0070613 150 0.011
carbohydrate homeostasis GO:0033500 31 0.011
cardiovascular system development GO:0072358 262 0.011
nucleoside diphosphate metabolic process GO:0009132 16 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
actin filament based process GO:0030029 224 0.010
positive regulation of cellular component movement GO:0051272 181 0.010
leukocyte proliferation GO:0070661 74 0.010
Mouse
cytokine production GO:0001816 247 0.010
purine nucleotide biosynthetic process GO:0006164 84 0.010
Mouse
cell aging GO:0007569 52 0.010
regulation of cell division GO:0051302 116 0.010
embryo development ending in birth or egg hatching GO:0009792 34 0.010
central nervous system development GO:0007417 123 0.010
protein localization to membrane GO:0072657 160 0.010
positive regulation of secretion by cell GO:1903532 108 0.010
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.010
regulation of response to biotic stimulus GO:0002831 55 0.010
cation transmembrane transport GO:0098655 238 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.010
protein targeting to nucleus GO:0044744 104 0.010
necrotic cell death GO:0070265 21 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
chemotaxis GO:0006935 157 0.010
protein import GO:0017038 130 0.010
ribonucleoside catabolic process GO:0042454 406 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010

IMPDH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.333
amino acid metabolic disorder DOID:9252 50 0.333
inherited metabolic disorder DOID:655 242 0.333
central nervous system disease DOID:331 186 0.015
nervous system disease DOID:863 431 0.015
retinal disease DOID:5679 118 0.012
sensory system disease DOID:0050155 203 0.012
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012