|
|
regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002923 |
3 |
0.991
|
|
|
|
positive regulation of immunoglobulin mediated immune response
|
GO:0002891 |
4 |
0.991
|
|
|
|
menstrual cycle phase
|
GO:0022601 |
2 |
0.975
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.912
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.907
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.877
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.811
|
|
|
|
positive regulation of myeloid leukocyte mediated immunity
|
GO:0002888 |
1 |
0.766
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.745
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.674
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.656
|
|
|
|
response to fibroblast growth factor
|
GO:0071774 |
39 |
0.645
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.636
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.613
|
Mouse |
|
|
nerve development
|
GO:0021675 |
4 |
0.599
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
39 |
0.581
|
|
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
26 |
0.571
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.564
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.550
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.540
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.529
|
|
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.517
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.513
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.465
|
Mouse |
|
|
phagocytosis recognition
|
GO:0006910 |
3 |
0.452
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.438
|
Mouse |
|
|
regulation of b cell mediated immunity
|
GO:0002712 |
7 |
0.414
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
4 |
0.394
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.393
|
|
|
|
regulation of immunoglobulin mediated immune response
|
GO:0002889 |
7 |
0.391
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.389
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.387
|
|
|
|
negative regulation of myeloid cell apoptotic process
|
GO:0033033 |
4 |
0.386
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.373
|
|
|
|
positive regulation of t helper cell differentiation
|
GO:0045624 |
2 |
0.362
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.337
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.329
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.319
|
|
|
|
regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043370 |
3 |
0.319
|
|
|
|
negative regulation of humoral immune response
|
GO:0002921 |
7 |
0.314
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.303
|
Mouse |
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.299
|
Mouse |
|
|
response to estradiol
|
GO:0032355 |
23 |
0.295
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.293
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.286
|
|
|
|
negative regulation of acute inflammatory response
|
GO:0002674 |
3 |
0.283
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.271
|
|
|
|
positive regulation of syncytium formation by plasma membrane fusion
|
GO:0060143 |
2 |
0.264
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.261
|
Human |
|
|
positive regulation of immunoglobulin production
|
GO:0002639 |
4 |
0.258
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.257
|
|
|
|
negative regulation of b cell mediated immunity
|
GO:0002713 |
3 |
0.256
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.245
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.243
|
|
|
|
sex determination
|
GO:0007530 |
3 |
0.240
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.231
|
|
|
|
positive regulation of exocytosis
|
GO:0045921 |
35 |
0.230
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.229
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.222
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.208
|
|
|
|
neutrophil apoptotic process
|
GO:0001781 |
2 |
0.208
|
|
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
4 |
0.207
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.205
|
Mouse |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.204
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.204
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.197
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.194
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.194
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.193
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.186
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.186
|
Mouse |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.180
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.180
|
Mouse |
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.170
|
Mouse |
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.170
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.168
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.166
|
Mouse |
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.163
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.162
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.161
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
10 |
0.153
|
Mouse |
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.152
|
|
|
|
immunoglobulin production
|
GO:0002377 |
12 |
0.150
|
|
|
|
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002823 |
8 |
0.149
|
|
|
|
negative regulation of adaptive immune response
|
GO:0002820 |
9 |
0.149
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.147
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.145
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.145
|
|
|
|
cell killing
|
GO:0001906 |
34 |
0.141
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.141
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.140
|
|
|
|
negative regulation of immune effector process
|
GO:0002698 |
38 |
0.139
|
|
|
|
positive regulation of myotube differentiation
|
GO:0010831 |
3 |
0.138
|
|
|
|
fc receptor signaling pathway
|
GO:0038093 |
2 |
0.135
|
|
|
|
membrane fusion
|
GO:0061025 |
43 |
0.133
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.129
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.129
|
Human |
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
16 |
0.128
|
Mouse |
|
|
response to lipid
|
GO:0033993 |
206 |
0.127
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.127
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.120
|
|
|
|
negative regulation of type 2 immune response
|
GO:0002829 |
3 |
0.119
|
|
|
|
regulation of syncytium formation by plasma membrane fusion
|
GO:0060142 |
2 |
0.114
|
|
|
|
synaptic vesicle recycling
|
GO:0036465 |
3 |
0.113
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.110
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.110
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
10 |
0.110
|
Mouse |
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.109
|
|
|
|
positive regulation of mast cell activation
|
GO:0033005 |
2 |
0.108
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.108
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.107
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.105
|
|
|
|
regulation of acute inflammatory response to antigenic stimulus
|
GO:0002864 |
1 |
0.104
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.104
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
4 |
0.103
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.100
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.099
|
|
|
|
positive regulation of acute inflammatory response
|
GO:0002675 |
2 |
0.099
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.099
|
|
|
|
t helper 1 cell differentiation
|
GO:0045063 |
1 |
0.099
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.098
|
|
|
|
b cell proliferation
|
GO:0042100 |
22 |
0.098
|
Mouse |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.097
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.096
|
|
|
|
single organism membrane fusion
|
GO:0044801 |
37 |
0.094
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.092
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.091
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.090
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.088
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.088
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.086
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.086
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.085
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.085
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.083
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.082
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.080
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.079
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.079
|
Mouse |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.078
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.078
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.077
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.076
|
Mouse |
|
|
chromatin modification
|
GO:0016568 |
298 |
0.075
|
|
|
|
dna recombination
|
GO:0006310 |
77 |
0.075
|
|
|
|
positive regulation of myoblast fusion
|
GO:1901741 |
1 |
0.075
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.074
|
|
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.074
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.073
|
|
|
|
t helper 2 cell differentiation
|
GO:0045064 |
1 |
0.073
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.073
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.073
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.073
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.072
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.070
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.070
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.070
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.069
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.068
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.067
|
Human |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.067
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.067
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.066
|
Mouse |
|
|
long term memory
|
GO:0007616 |
2 |
0.066
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.066
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.066
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.065
|
|
|
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.065
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.065
|
Mouse |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.064
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.064
|
|
|
|
positive regulation of muscle cell differentiation
|
GO:0051149 |
15 |
0.064
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.064
|
|
|
|
serotonin transport
|
GO:0006837 |
3 |
0.063
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.062
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.062
|
|
|
|
synaptic vesicle endocytosis
|
GO:0048488 |
2 |
0.062
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.061
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.060
|
|
|
|
platelet morphogenesis
|
GO:0036344 |
4 |
0.059
|
|
|
|
positive regulation of natural killer cell mediated cytotoxicity
|
GO:0045954 |
11 |
0.059
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.059
|
|
|
|
negative regulation of lymphocyte mediated immunity
|
GO:0002707 |
12 |
0.059
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.058
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.057
|
|
|
|
regulation of myoblast fusion
|
GO:1901739 |
1 |
0.056
|
|
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.056
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.056
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
2 |
0.056
|
Mouse |
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.055
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.055
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.054
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.054
|
|
|
|
actomyosin structure organization
|
GO:0031032 |
59 |
0.054
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.054
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.053
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.053
|
|
|
|
endocytic recycling
|
GO:0032456 |
12 |
0.052
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.052
|
|
|
|
negative regulation of cd4 positive alpha beta t cell activation
|
GO:2000515 |
1 |
0.052
|
|
|
|
mucosal immune response
|
GO:0002385 |
21 |
0.051
|
|
|
|
negative regulation of humoral immune response mediated by circulating immunoglobulin
|
GO:0002924 |
3 |
0.051
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.050
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.050
|
|
|
|
inflammatory cell apoptotic process
|
GO:0006925 |
3 |
0.050
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.049
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.049
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.049
|
|
|
|
neutrophil homeostasis
|
GO:0001780 |
3 |
0.049
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
22 |
0.049
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.049
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.049
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.049
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.048
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
4 |
0.047
|
|
|
|
negative regulation of immunoglobulin mediated immune response
|
GO:0002890 |
3 |
0.047
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.047
|
|
|
|
alpha beta t cell activation involved in immune response
|
GO:0002287 |
5 |
0.046
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.046
|
|
|
|
t helper cell differentiation
|
GO:0042093 |
4 |
0.046
|
|
|
|
positive regulation of leukocyte degranulation
|
GO:0043302 |
3 |
0.046
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.046
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.046
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.046
|
|
|
|
regulation of mast cell degranulation
|
GO:0043304 |
3 |
0.045
|
|
|
|
acute inflammatory response to antigenic stimulus
|
GO:0002438 |
1 |
0.045
|
|
|
|
regulation of mast cell activation
|
GO:0033003 |
5 |
0.045
|
|
|
|
positive regulation of isotype switching
|
GO:0045830 |
2 |
0.045
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.045
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.044
|
Mouse |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.044
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.044
|
|
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.043
|
|
|
|
somatic recombination of immunoglobulin gene segments
|
GO:0016447 |
4 |
0.043
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.043
|
|
|
|
alpha beta t cell differentiation involved in immune response
|
GO:0002293 |
5 |
0.043
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.043
|
Mouse |
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.043
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.042
|
Mouse |
|
|
head development
|
GO:0060322 |
108 |
0.042
|
|
|
|
regulation of t helper cell differentiation
|
GO:0045622 |
3 |
0.042
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.042
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.042
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.042
|
|
|
|
regulation of alpha beta t cell differentiation
|
GO:0046637 |
5 |
0.042
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.042
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.041
|
|
|
|
regulation of isotype switching
|
GO:0045191 |
2 |
0.041
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.041
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.041
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.041
|
|
|
|
regulation of myotube differentiation
|
GO:0010830 |
18 |
0.040
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.040
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.040
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.040
|
Mouse |
|
|
placenta development
|
GO:0001890 |
10 |
0.040
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.040
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.040
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.040
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.039
|
|
|
|
t cell lineage commitment
|
GO:0002360 |
1 |
0.039
|
|
|
|
inflammatory response to antigenic stimulus
|
GO:0002437 |
4 |
0.039
|
|
|
|
neutrophil migration
|
GO:1990266 |
25 |
0.039
|
|
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
4 |
0.039
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.039
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.039
|
Mouse |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.039
|
|
|
|
positive regulation of phagocytosis
|
GO:0050766 |
15 |
0.038
|
|
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.038
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.038
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.038
|
|
|
|
somatic diversification of immunoglobulins involved in immune response
|
GO:0002208 |
3 |
0.038
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.038
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.037
|
|
|
|
isotype switching
|
GO:0045190 |
3 |
0.037
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.037
|
Mouse |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.037
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.036
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.036
|
Mouse |
|
|
regulation of neutrophil apoptotic process
|
GO:0033029 |
1 |
0.036
|
|
|
|
chemokine production
|
GO:0032602 |
32 |
0.036
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.036
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.036
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.035
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.035
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.035
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.034
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.034
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.034
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.034
|
|
|
|
negative regulation of interleukin 10 production
|
GO:0032693 |
7 |
0.033
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.033
|
|
|
|
memory
|
GO:0007613 |
3 |
0.033
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.033
|
|
|
|
positive regulation of cd4 positive alpha beta t cell differentiation
|
GO:0043372 |
2 |
0.033
|
|
|
|
organelle fusion
|
GO:0048284 |
36 |
0.032
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.032
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.032
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.032
|
Mouse |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.032
|
|
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.031
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.031
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.031
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.031
|
|
|
|
type 2 immune response
|
GO:0042092 |
6 |
0.031
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.031
|
Mouse |
|
|
natural killer cell mediated immunity
|
GO:0002228 |
23 |
0.031
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.031
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.030
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.030
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.030
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.030
|
Mouse |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.030
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.029
|
|
|
|
negative regulation of cytoskeleton organization
|
GO:0051494 |
45 |
0.029
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.029
|
|
|
|
post embryonic organ development
|
GO:0048569 |
1 |
0.029
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.029
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.029
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.029
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.029
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.028
|
|
|
|
regulation of cdc42 gtpase activity
|
GO:0043088 |
10 |
0.028
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.028
|
|
|
|
biological phase
|
GO:0044848 |
5 |
0.028
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
6 |
0.028
|
Mouse |
|
|
antigen processing and presentation of exogenous antigen
|
GO:0019884 |
4 |
0.028
|
|
|
|
decidualization
|
GO:0046697 |
4 |
0.028
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.028
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.028
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.027
|
Mouse |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.027
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.027
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.027
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.027
|
|
|
|
regulation of mast cell activation involved in immune response
|
GO:0033006 |
3 |
0.027
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.027
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.026
|
|
|
|
regulation of inflammatory response to antigenic stimulus
|
GO:0002861 |
2 |
0.026
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
13 |
0.026
|
Mouse |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.026
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.026
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.026
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.025
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.025
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.025
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.025
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.025
|
Mouse |
|
|
vesicle fusion
|
GO:0006906 |
17 |
0.025
|
|
|
|
mating
|
GO:0007618 |
1 |
0.025
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.025
|
Mouse Rat |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.025
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.024
|
|
|
|
negative regulation of actin filament bundle assembly
|
GO:0032232 |
9 |
0.024
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.024
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.024
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.024
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.024
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.024
|
Mouse |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.023
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.023
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.023
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.023
|
|
|
|
positive regulation of tumor necrosis factor biosynthetic process
|
GO:0042535 |
5 |
0.023
|
|
|
|
negative regulation of cell projection organization
|
GO:0031345 |
22 |
0.023
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.023
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
40 |
0.023
|
Mouse |
|
|
mammary gland morphogenesis
|
GO:0060443 |
2 |
0.023
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.023
|
|
|
|
serotonin secretion
|
GO:0001820 |
1 |
0.023
|
|
|
|
positive regulation of regulated secretory pathway
|
GO:1903307 |
8 |
0.023
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.023
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.022
|
Mouse |
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
24 |
0.022
|
Mouse |
|
|
chromatin assembly or disassembly
|
GO:0006333 |
78 |
0.022
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.022
|
|
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.022
|
|
|
|
viral life cycle
|
GO:0019058 |
132 |
0.022
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.022
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.022
|
Mouse |
|
|
stem cell division
|
GO:0017145 |
2 |
0.022
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.022
|
Mouse |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.021
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.021
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
11 |
0.021
|
|
|
|
negative regulation of t cell receptor signaling pathway
|
GO:0050860 |
4 |
0.021
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.021
|
|
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
25 |
0.021
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
15 |
0.021
|
Mouse |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.021
|
|
|
|
regulation of t helper 1 type immune response
|
GO:0002825 |
5 |
0.021
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.021
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.021
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.021
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.021
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.021
|
|
|
|
regulation of stress fiber assembly
|
GO:0051492 |
32 |
0.021
|
|
|
|
somatic recombination of immunoglobulin genes involved in immune response
|
GO:0002204 |
3 |
0.021
|
|
|
|
positive regulation of type 2 immune response
|
GO:0002830 |
2 |
0.021
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.020
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.020
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.020
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.020
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.020
|
Mouse |
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.020
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.020
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.020
|
|
|
|
negative regulation of nucleotide catabolic process
|
GO:0030812 |
16 |
0.020
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.020
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.020
|
|
|
|
positive regulation of p38mapk cascade
|
GO:1900745 |
8 |
0.020
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.019
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.019
|
Mouse |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.019
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.019
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.019
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.019
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.019
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.019
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.019
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.019
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.019
|
|
|
|
regulation of actin filament bundle assembly
|
GO:0032231 |
36 |
0.019
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.019
|
|
|
|
regulation of b cell activation
|
GO:0050864 |
24 |
0.019
|
Mouse |
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.019
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.019
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.019
|
|
|
|
cellular response to erythropoietin
|
GO:0036018 |
3 |
0.019
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.019
|
Human |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.019
|
|
|
|
branch elongation of an epithelium
|
GO:0060602 |
3 |
0.019
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.019
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.019
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.019
|
|
|
|
antigen processing and presentation
|
GO:0019882 |
33 |
0.019
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.018
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.018
|
|
|
|
cranial nerve development
|
GO:0021545 |
4 |
0.018
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.018
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.018
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.018
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.018
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.018
|
|
|
|
phagocytosis
|
GO:0006909 |
42 |
0.018
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.018
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.018
|
|
|
|
positive regulation of cell size
|
GO:0045793 |
3 |
0.018
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.018
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.018
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.018
|
|
|
|
aging
|
GO:0007568 |
66 |
0.017
|
Mouse |
|
|
neural crest cell development
|
GO:0014032 |
3 |
0.017
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.017
|
|
|
|
growth
|
GO:0040007 |
202 |
0.017
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.017
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.017
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.017
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.017
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.017
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.017
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.017
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.017
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.017
|
|
|
|
positive regulation of steroid hormone biosynthetic process
|
GO:0090031 |
2 |
0.017
|
|
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.017
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.017
|
|
|
|
t cell differentiation involved in immune response
|
GO:0002292 |
7 |
0.017
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.017
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.017
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.017
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.016
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.016
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.016
|
Mouse |
|
|
response to drug
|
GO:0042493 |
81 |
0.016
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.016
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.016
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.016
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.016
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.016
|
|
|
|
regulation of t helper 2 cell differentiation
|
GO:0045628 |
1 |
0.016
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.016
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.016
|
|
