Homo sapiens

137 known processes

INSIG1

insulin induced gene 1

(Aliases: CL6,CL-6,MGC1405)

INSIG1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
steroid metabolic process GO:0008202 94 0.991
Mouse
lipid metabolic process GO:0006629 381 0.980
Mouse
alcohol metabolic process GO:0006066 114 0.953
Mouse
sterol metabolic process GO:0016125 28 0.941
Mouse
lipid biosynthetic process GO:0008610 177 0.909
Mouse
cholesterol metabolic process GO:0008203 28 0.904
Mouse
sterol biosynthetic process GO:0016126 10 0.885
Mouse
organic hydroxy compound metabolic process GO:1901615 147 0.851
Mouse
response to phenylpropanoid GO:0080184 1 0.672
cellular lipid metabolic process GO:0044255 303 0.642
Mouse
steroid biosynthetic process GO:0006694 46 0.630
Mouse
small molecule biosynthetic process GO:0044283 157 0.629
Mouse
positive regulation of cholesterol storage GO:0010886 4 0.594
organic hydroxy compound biosynthetic process GO:1901617 71 0.504
Mouse
associative learning GO:0008306 1 0.402
organic hydroxy compound transport GO:0015850 63 0.397
response to lipid GO:0033993 206 0.393
monocarboxylic acid biosynthetic process GO:0072330 67 0.393
Mouse
alcohol biosynthetic process GO:0046165 52 0.368
Mouse
visual behavior GO:0007632 2 0.314
negative regulation of map kinase activity GO:0043407 27 0.308
acylglycerol metabolic process GO:0006639 27 0.307
Mouse
response to abiotic stimulus GO:0009628 336 0.276
cholesterol transport GO:0030301 39 0.236
regulation of cholesterol homeostasis GO:2000188 2 0.228
cholesterol biosynthetic process GO:0006695 10 0.228
Mouse
negative regulation of catalytic activity GO:0043086 335 0.215
organophosphate biosynthetic process GO:0090407 163 0.215
negative regulation of protein metabolic process GO:0051248 391 0.199
terpenoid biosynthetic process GO:0016114 2 0.196
regulation of protein kinase activity GO:0045859 289 0.182
vesicle mediated transport GO:0016192 371 0.176
regulation of transferase activity GO:0051338 355 0.166
cellular response to gonadotropin stimulus GO:0071371 4 0.157
post embryonic development GO:0009791 2 0.142
sterol transport GO:0015918 39 0.135
determination of adult lifespan GO:0008340 2 0.128
response to light stimulus GO:0009416 87 0.113
positive regulation of triglyceride biosynthetic process GO:0010867 4 0.106
growth GO:0040007 202 0.104
regulation of protein serine threonine kinase activity GO:0071900 179 0.103
negative regulation of growth of symbiont in host GO:0044130 1 0.103
phosphatidylcholine catabolic process GO:0034638 3 0.099
growth of symbiont in host GO:0044117 1 0.092
lipid localization GO:0010876 106 0.090
response to inorganic substance GO:0010035 127 0.086
positive regulation of lipid storage GO:0010884 10 0.083
triglyceride metabolic process GO:0006641 23 0.082
Mouse
terpenoid metabolic process GO:0006721 27 0.080
chemical homeostasis GO:0048878 306 0.080
multicellular organismal aging GO:0010259 3 0.078
maintenance of location GO:0051235 112 0.077
phospholipid metabolic process GO:0006644 99 0.072
fatty acid elongation polyunsaturated fatty acid GO:0034626 4 0.069
response to nitrogen compound GO:1901698 184 0.067
neutral lipid metabolic process GO:0006638 27 0.067
Mouse
head development GO:0060322 108 0.067
amine metabolic process GO:0009308 44 0.065
cholesterol homeostasis GO:0042632 28 0.064
skin development GO:0043588 76 0.062
negative regulation of cellular protein metabolic process GO:0032269 353 0.052
regulation of kinase activity GO:0043549 314 0.052
glycerolipid metabolic process GO:0046486 107 0.051
Mouse
innate immune response GO:0045087 178 0.049
immune response GO:0006955 307 0.046
cellular alcohol metabolic process GO:0044107 7 0.046
defense response GO:0006952 315 0.044
cellular protein complex assembly GO:0043623 188 0.044
organophosphate catabolic process GO:0046434 430 0.044
lipid storage GO:0019915 28 0.042
response to hormone GO:0009725 175 0.042
response to radiation GO:0009314 151 0.041
response to low density lipoprotein particle GO:0055098 4 0.041
glycerolipid biosynthetic process GO:0045017 51 0.040
response to organonitrogen compound GO:0010243 156 0.038
cellular response to organic cyclic compound GO:0071407 127 0.038
negative regulation of kinase activity GO:0033673 106 0.038
positive regulation of lipid biosynthetic process GO:0046889 22 0.037
isoprenoid biosynthetic process GO:0008299 9 0.037
lipid transport GO:0006869 90 0.037
regulation of cellular ketone metabolic process GO:0010565 50 0.036
Mouse
sphingolipid metabolic process GO:0006665 38 0.036
protein catabolic process GO:0030163 325 0.036
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
positive regulation of triglyceride metabolic process GO:0090208 9 0.035
response to drug GO:0042493 81 0.034
immune system development GO:0002520 195 0.034
phospholipid biosynthetic process GO:0008654 44 0.034
negative regulation of phosphate metabolic process GO:0045936 267 0.033
cellular macromolecule catabolic process GO:0044265 380 0.033
cholesterol import GO:0070508 4 0.032
cellular amino acid metabolic process GO:0006520 116 0.032
lipid catabolic process GO:0016042 84 0.031
mapk cascade GO:0000165 288 0.031
response to oxygen levels GO:0070482 100 0.031
triglyceride biosynthetic process GO:0019432 10 0.031
response to organic cyclic compound GO:0014070 204 0.030
response to lipoprotein particle GO:0055094 5 0.030
cellular lipid catabolic process GO:0044242 65 0.030
cellular amine metabolic process GO:0044106 41 0.030
mitotic cell cycle process GO:1903047 286 0.029
protein oligomerization GO:0051259 173 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
phospholipid catabolic process GO:0009395 12 0.029
isoprenoid metabolic process GO:0006720 39 0.029
neutral lipid biosynthetic process GO:0046460 11 0.028
regulation of lipid metabolic process GO:0019216 96 0.028
Mouse
negative regulation of transferase activity GO:0051348 124 0.028
response to oxygen containing compound GO:1901700 369 0.027
long chain fatty acid biosynthetic process GO:0042759 4 0.027
male sex differentiation GO:0046661 25 0.027
negative regulation of protein processing GO:0010955 142 0.027
cytoplasmic transport GO:0016482 379 0.027
regulation of growth GO:0040008 165 0.027
regulation of mapk cascade GO:0043408 262 0.027
small molecule catabolic process GO:0044282 92 0.027
mitotic cell cycle GO:0000278 326 0.026
embryo development GO:0009790 123 0.026
Mouse
reproductive system development GO:0061458 56 0.025
fatty acid metabolic process GO:0006631 115 0.025
Mouse
cellular biogenic amine metabolic process GO:0006576 34 0.024
positive regulation of catabolic process GO:0009896 310 0.024
cellular alcohol biosynthetic process GO:0044108 7 0.024
anion transport GO:0006820 161 0.024
signal transduction by phosphorylation GO:0023014 297 0.023
endocytosis GO:0006897 159 0.023
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.023
regulation of purine nucleotide metabolic process GO:1900542 264 0.023
regulation of vesicle mediated transport GO:0060627 130 0.023
negative regulation of transport GO:0051051 176 0.023
cellular response to hormone stimulus GO:0032870 125 0.023
neurotransmitter secretion GO:0007269 4 0.023
response to decreased oxygen levels GO:0036293 96 0.022
negative regulation of intracellular signal transduction GO:1902532 183 0.022
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.022
regulation of protein localization GO:0032880 296 0.022
cytoskeleton dependent cytokinesis GO:0061640 22 0.022
purine containing compound catabolic process GO:0072523 411 0.022
regulation of lipid transport by regulation of transcription from rna polymerase ii promoter GO:0072367 4 0.022
regulation of purine nucleotide catabolic process GO:0033121 205 0.022
system process GO:0003008 349 0.022
response to alcohol GO:0097305 64 0.022
nervous system development GO:0007399 293 0.022
negative regulation of phosphorylation GO:0042326 174 0.021
cellular response to lipid GO:0071396 127 0.021
glycoprotein metabolic process GO:0009100 110 0.021
regulation of homeostatic process GO:0032844 121 0.021
lipoprotein metabolic process GO:0042157 42 0.021
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.020
negative regulation of protein phosphorylation GO:0001933 140 0.020
neuromuscular junction development GO:0007528 3 0.020
negative regulation of protein modification process GO:0031400 200 0.020
mating GO:0007618 1 0.020
negative regulation of cellular amine metabolic process GO:0033239 3 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
acylglycerol biosynthetic process GO:0046463 11 0.019
negative regulation of cholesterol efflux GO:0090370 2 0.019
cholesterol efflux GO:0033344 28 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
very long chain fatty acid biosynthetic process GO:0042761 7 0.019
cognition GO:0050890 43 0.019
dephosphorylation GO:0016311 209 0.018
ras protein signal transduction GO:0007265 73 0.018
membrane organization GO:0061024 292 0.018
response to nutrient levels GO:0031667 81 0.018
response to extracellular stimulus GO:0009991 85 0.018
regulation of intracellular transport GO:0032386 195 0.017
reproductive process GO:0022414 106 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
reactive nitrogen species metabolic process GO:2001057 3 0.017
oogenesis GO:0048477 2 0.017
growth involved in symbiotic interaction GO:0044110 2 0.017
regulation of cell motility GO:2000145 299 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.017
regulation of cytoplasmic transport GO:1903649 149 0.017
proteasomal protein catabolic process GO:0010498 176 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
visual learning GO:0008542 1 0.016
response to external biotic stimulus GO:0043207 261 0.016
glycoprotein transport GO:0034436 2 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
protein processing GO:0016485 226 0.016
organic anion transport GO:0015711 103 0.016
regulation of map kinase activity GO:0043405 108 0.016
protein tetramerization GO:0051262 47 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
response to sterol GO:0036314 14 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
actin filament based process GO:0030029 224 0.016
rhythmic behavior GO:0007622 2 0.015
myosin filament assembly GO:0031034 2 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
sex differentiation GO:0007548 45 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
purine ribonucleoside metabolic process GO:0046128 437 0.015
regulation of triglyceride metabolic process GO:0090207 11 0.015
nucleocytoplasmic transport GO:0006913 176 0.015
regulation of cell migration GO:0030334 289 0.015
regulation of protein maturation GO:1903317 150 0.015
cellular protein catabolic process GO:0044257 261 0.015
positive regulation of secretion GO:0051047 116 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
alcohol catabolic process GO:0046164 20 0.015
regulation of lipid transport GO:0032368 44 0.015
protein targeting GO:0006605 187 0.015
cardiovascular system development GO:0072358 262 0.015
positive regulation of intracellular transport GO:0032388 104 0.014
lipoprotein catabolic process GO:0042159 1 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
response to steroid hormone GO:0048545 80 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
response to other organism GO:0051707 261 0.014
apoptotic signaling pathway GO:0097190 268 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
blastoderm segmentation GO:0007350 2 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
hindbrain development GO:0030902 3 0.014
regulation of response to external stimulus GO:0032101 222 0.014
ion homeostasis GO:0050801 230 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
regulation of proteolysis GO:0030162 293 0.014
transmembrane transport GO:0055085 399 0.014
positive regulation of golgi to plasma membrane protein transport GO:0042998 2 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.014
adult locomotory behavior GO:0008344 1 0.014
anterior posterior axis specification GO:0009948 2 0.014
single organism cellular localization GO:1902580 332 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
intracellular protein transport GO:0006886 270 0.014
regulation of protein localization to plasma membrane GO:1903076 40 0.014
nucleoside phosphate catabolic process GO:1901292 412 0.013
nuclear transport GO:0051169 179 0.013
positive regulation of developmental process GO:0051094 314 0.013
cellular homeostasis GO:0019725 196 0.013
nucleoside catabolic process GO:0009164 408 0.013
regulation of cell cycle GO:0051726 393 0.013
nerve development GO:0021675 4 0.013
receptor mediated endocytosis GO:0006898 84 0.013
endomembrane system organization GO:0010256 196 0.013
poly n acetyllactosamine metabolic process GO:0030309 2 0.013
rho protein signal transduction GO:0007266 26 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
central nervous system development GO:0007417 123 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
carbohydrate metabolic process GO:0005975 207 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
multicellular organismal response to stress GO:0033555 1 0.013
photoreceptor cell differentiation GO:0046530 2 0.013
regulation of immune response GO:0050776 201 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
cation transmembrane transport GO:0098655 238 0.013
peripheral nervous system development GO:0007422 2 0.013
sensory perception of smell GO:0007608 2 0.013
establishment of tissue polarity GO:0007164 3 0.013
sequestering of calcium ion GO:0051208 17 0.013
regulation of triglyceride biosynthetic process GO:0010866 5 0.013
purine nucleoside catabolic process GO:0006152 398 0.013
cellular response to oxygen containing compound GO:1901701 276 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
fat cell differentiation GO:0045444 32 0.012
Mouse
spermatid differentiation GO:0048515 4 0.012
glycosylation GO:0070085 71 0.012
response to metal ion GO:0010038 84 0.012
regulation of cell differentiation GO:0045595 393 0.012
Mouse
protein homooligomerization GO:0051260 100 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
rab protein signal transduction GO:0032482 4 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
aging GO:0007568 66 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
nuclear import GO:0051170 106 0.012
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.012
negative regulation of proteolysis GO:0045861 132 0.012
nucleotide catabolic process GO:0009166 408 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
response to sucrose GO:0009744 1 0.012
oocyte development GO:0048599 1 0.012
response to fungus GO:0009620 4 0.012
phospholipid transport GO:0015914 23 0.012
microtubule based process GO:0007017 210 0.012
response to purine containing compound GO:0014074 40 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
negative regulation of endopeptidase activity GO:0010951 84 0.012
cell morphogenesis GO:0000902 296 0.012
motor neuron axon guidance GO:0008045 2 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
response to nutrient GO:0007584 20 0.012
regulation of cholesterol storage GO:0010885 8 0.012
intestinal cholesterol absorption GO:0030299 4 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
protein localization to plasma membrane GO:0072659 93 0.012
regulation of defense response GO:0031347 154 0.012
behavior GO:0007610 112 0.011
spinal cord development GO:0021510 4 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
cell development GO:0048468 328 0.011
protein localization to organelle GO:0033365 280 0.011
response to peptide hormone GO:0043434 61 0.011
sulfur compound biosynthetic process GO:0044272 38 0.011
segmentation GO:0035282 4 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
carboxylic acid biosynthetic process GO:0046394 97 0.011
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
regulation of multi organism process GO:0043900 157 0.011
regulation of growth of symbiont in host GO:0044126 1 0.011
positive regulation of lipid metabolic process GO:0045834 50 0.011
nucleoside triphosphate metabolic process GO:0009141 422 0.011
regeneration GO:0031099 4 0.011
fatty acid elongation saturated fatty acid GO:0019367 5 0.011
metal ion transport GO:0030001 272 0.011
regulation of cytokine production GO:0001817 232 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
neurological system process GO:0050877 163 0.011
morphogenesis of a polarized epithelium GO:0001738 3 0.011
protein import GO:0017038 130 0.011
inner ear morphogenesis GO:0042472 4 0.011
Mouse
striated muscle myosin thick filament assembly GO:0071688 2 0.011
neuroblast proliferation GO:0007405 4 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
regulation of protein transport GO:0051223 213 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
cellular response to sterol GO:0036315 7 0.011
memory GO:0007613 3 0.011
interspecies interaction between organisms GO:0044419 156 0.011
single organism behavior GO:0044708 28 0.011
cell fate determination GO:0001709 3 0.011
purine nucleoside triphosphate metabolic process GO:0009144 412 0.011
negative regulation of catabolic process GO:0009895 104 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
spermatid development GO:0007286 4 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
sex determination GO:0007530 3 0.011
purine ribonucleoside catabolic process GO:0046130 398 0.011
peptide transport GO:0015833 74 0.010
taxis GO:0042330 157 0.010
atp metabolic process GO:0046034 176 0.010
behavioral response to ethanol GO:0048149 2 0.010
cerebellum development GO:0021549 2 0.010
response to axon injury GO:0048678 1 0.010
cation homeostasis GO:0055080 189 0.010
forebrain generation of neurons GO:0021872 3 0.010

INSIG1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.124
lipid metabolism disorder DOID:3146 26 0.124
inherited metabolic disorder DOID:655 242 0.124
disease of cellular proliferation DOID:14566 174 0.024
familial hyperlipidemia DOID:1168 9 0.015
sensory system disease DOID:0050155 203 0.015
nervous system disease DOID:863 431 0.015
cancer DOID:162 167 0.015
retinal disease DOID:5679 118 0.012
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012
immune system disease DOID:2914 155 0.012
myopathy DOID:423 104 0.010
muscular disease DOID:0080000 114 0.010
musculoskeletal system disease DOID:17 223 0.010
muscle tissue disease DOID:66 113 0.010