Homo sapiens

351 known processes

INSR

insulin receptor

(Aliases: CD220,HHF5)

INSR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular polysaccharide biosynthetic process GO:0033692 21 1.000
regulation of glycogen metabolic process GO:0070873 15 1.000
cellular carbohydrate biosynthetic process GO:0034637 21 1.000
regulation of glucan biosynthetic process GO:0010962 14 1.000
glycogen biosynthetic process GO:0005978 16 1.000
glycogen metabolic process GO:0005977 22 1.000
regulation of polysaccharide biosynthetic process GO:0032885 20 1.000
regulation of glucose import GO:0046324 21 1.000
energy reserve metabolic process GO:0006112 22 1.000
cellular glucan metabolic process GO:0006073 22 1.000
stem cell division GO:0017145 2 1.000
Fly
positive regulation of glycogen metabolic process GO:0070875 10 1.000
glucan biosynthetic process GO:0009250 16 1.000
positive regulation of cellular response to insulin stimulus GO:1900078 6 1.000
asymmetric stem cell division GO:0098722 1 1.000
Fly
regulation of glycogen biosynthetic process GO:0005979 14 1.000
regulation of carbohydrate metabolic process GO:0006109 54 1.000
hexose transport GO:0008645 30 1.000
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.999
regulation of glucose transport GO:0010827 23 0.999
regulation of activin receptor signaling pathway GO:0032925 14 0.999
regulation of glucose metabolic process GO:0010906 28 0.999
positive regulation of cellular component movement GO:0051272 181 0.999
cellular response to nitrogen compound GO:1901699 144 0.999
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.999
glucan metabolic process GO:0044042 22 0.999
sulfur compound metabolic process GO:0006790 101 0.999
hexose metabolic process GO:0019318 55 0.998
positive regulation of glucose metabolic process GO:0010907 12 0.998
single organism carbohydrate metabolic process GO:0044723 193 0.998
branched chain amino acid metabolic process GO:0009081 4 0.998
positive regulation of glucose import in response to insulin stimulus GO:2001275 3 0.998
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.998
carbohydrate transport GO:0008643 37 0.998
cellular response to endogenous stimulus GO:0071495 336 0.998
lipid metabolic process GO:0006629 381 0.998
Fly
cellular lipid metabolic process GO:0044255 303 0.998
positive regulation of fatty acid beta oxidation GO:0032000 5 0.997
positive regulation of lipid metabolic process GO:0045834 50 0.997
cellular response to hormone stimulus GO:0032870 125 0.997
response to peptide GO:1901652 65 0.997
oxidation reduction process GO:0055114 396 0.997
monocarboxylic acid metabolic process GO:0032787 185 0.997
insulin like growth factor receptor signaling pathway GO:0048009 13 0.996
Human
response to oxygen containing compound GO:1901700 369 0.996
fatty acid metabolic process GO:0006631 115 0.996
anion transmembrane transport GO:0098656 76 0.996
mating GO:0007618 1 0.996
Fly
cellular response to ph GO:0071467 9 0.996
Human
cellular response to insulin stimulus GO:0032869 41 0.995
regulation of insulin receptor signaling pathway GO:0046626 13 0.995
monosaccharide metabolic process GO:0005996 74 0.995
cellular response to oxygen containing compound GO:1901701 276 0.995
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.995
regulation of cellular ketone metabolic process GO:0010565 50 0.995
regulation of generation of precursor metabolites and energy GO:0043467 27 0.994
positive regulation of cell motility GO:2000147 177 0.993
positive regulation of glycogen biosynthetic process GO:0045725 10 0.993
regulation of lipid catabolic process GO:0050994 23 0.992
glucose transport GO:0015758 30 0.992
glucose metabolic process GO:0006006 45 0.992
chemical homeostasis GO:0048878 306 0.992
energy derivation by oxidation of organic compounds GO:0015980 43 0.991
cellular carbohydrate metabolic process GO:0044262 84 0.991
carbohydrate metabolic process GO:0005975 207 0.991
polysaccharide metabolic process GO:0005976 33 0.990
generation of precursor metabolites and energy GO:0006091 68 0.990
regulation of lipid metabolic process GO:0019216 96 0.989
carbohydrate biosynthetic process GO:0016051 42 0.989
polysaccharide biosynthetic process GO:0000271 27 0.989
lipid localization GO:0010876 106 0.988
Worm
insulin receptor signaling pathway GO:0008286 23 0.988
cellular polysaccharide metabolic process GO:0044264 27 0.988
monosaccharide transport GO:0015749 32 0.988
enzyme linked receptor protein signaling pathway GO:0007167 303 0.987
regulation of fatty acid beta oxidation GO:0031998 8 0.986
associative learning GO:0008306 1 0.985
regulation of cellular response to insulin stimulus GO:1900076 17 0.985
response to organonitrogen compound GO:0010243 156 0.985
circadian sleep wake cycle GO:0042745 2 0.982
Fly
transformation of host cell by virus GO:0019087 2 0.982
response to interleukin 15 GO:0070672 6 0.982
response to nitrogen compound GO:1901698 184 0.979
steroid metabolic process GO:0008202 94 0.978
positive regulation of locomotion GO:0040017 186 0.978
ion transmembrane transport GO:0034220 338 0.978
cellular response to peptide hormone stimulus GO:0071375 56 0.976
positive regulation of insulin receptor signaling pathway GO:0046628 3 0.975
response to hormone GO:0009725 175 0.975
positive regulation of transport GO:0051050 336 0.974
positive regulation of leukocyte activation GO:0002696 80 0.973
behavior GO:0007610 112 0.973
Fly
regulation of natural killer cell differentiation GO:0032823 2 0.973
activation of mapk activity GO:0000187 45 0.973
cellular amine metabolic process GO:0044106 41 0.971
positive regulation of glucose transport GO:0010828 17 0.967
negative regulation of plasma membrane long chain fatty acid transport GO:0010748 4 0.961
regulation of cellular component movement GO:0051270 334 0.961
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.961
positive regulation of fatty acid metabolic process GO:0045923 11 0.960
cellular response to peptide GO:1901653 59 0.959
regulation of carbohydrate biosynthetic process GO:0043255 27 0.959
organic anion transport GO:0015711 103 0.958
female gamete generation GO:0007292 2 0.957
Fly
positive regulation of mitotic cell cycle GO:0045931 60 0.954
positive regulation of cell migration GO:0030335 172 0.953
positive regulation of carbohydrate metabolic process GO:0045913 21 0.949
somatic stem cell maintenance GO:0035019 4 0.947
amine metabolic process GO:0009308 44 0.947
regulation of cell motility GO:2000145 299 0.946
regulation of fatty acid transport GO:2000191 8 0.946
inactivation of mapkk activity GO:0051389 1 0.945
Human
female gonad development GO:0008585 10 0.941
Fly
axon regeneration GO:0031103 1 0.940
regulation of locomotion GO:0040012 329 0.937
regulation of cell migration GO:0030334 289 0.936
cellular ketone metabolic process GO:0042180 80 0.936
regulation of glucose import in response to insulin stimulus GO:2001273 4 0.935
sex determination GO:0007530 3 0.934
Mouse
neurological system process GO:0050877 163 0.931
positive regulation of secretion by cell GO:1903532 108 0.931
negative regulation of programmed cell death GO:0043069 321 0.930
Human
determination of adult lifespan GO:0008340 2 0.928
Worm Fly
negative regulation of ion transmembrane transport GO:0034766 26 0.928
fatty acid catabolic process GO:0009062 29 0.927
regulation of polysaccharide metabolic process GO:0032881 21 0.926
response to organic cyclic compound GO:0014070 204 0.922
Rat Fly
positive regulation of lipid catabolic process GO:0050996 13 0.920
regulation of response to wounding GO:1903034 101 0.917
regulation of secretion by cell GO:1903530 177 0.917
positive regulation of cellular carbohydrate metabolic process GO:0010676 16 0.917
cellular lipid catabolic process GO:0044242 65 0.917
negative regulation of protein phosphorylation GO:0001933 140 0.915
Human Rat
somatic muscle development GO:0007525 1 0.912
Fly
taurine metabolic process GO:0019530 1 0.910
secretion GO:0046903 254 0.909
small molecule catabolic process GO:0044282 92 0.908
negative regulation of ion transport GO:0043271 39 0.906
positive regulation of cardiac muscle cell apoptotic process GO:0010666 1 0.904
Human
glucose import in response to insulin stimulus GO:0044381 4 0.904
dna replication GO:0006260 116 0.901
cellular lactam metabolic process GO:0072338 1 0.896
anion transport GO:0006820 161 0.890
cell growth GO:0016049 160 0.889
Human Fly
glucose import GO:0046323 24 0.884
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.881
Human
regulation of ion transmembrane transport GO:0034765 132 0.879
circadian sleep wake cycle sleep GO:0050802 2 0.879
Fly
lipid modification GO:0030258 84 0.876
regulation of mesenchymal cell proliferation GO:0010464 5 0.876
monocarboxylic acid catabolic process GO:0072329 37 0.874
cellular response to starvation GO:0009267 58 0.865
Worm
hormone transport GO:0009914 68 0.863
protein autophosphorylation GO:0046777 123 0.861
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 12 0.856
regulation of growth GO:0040008 165 0.853
lipid oxidation GO:0034440 33 0.850
cellular response to organonitrogen compound GO:0071417 124 0.848
natural killer cell differentiation GO:0001779 2 0.847
regulation of anion transport GO:0044070 25 0.844
neuron projection regeneration GO:0031102 1 0.843
negative regulation of cell death GO:0060548 345 0.838
Human
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.831
positive regulation of cell activation GO:0050867 81 0.831
positive regulation of cell cycle GO:0045787 140 0.828
positive regulation of map kinase activity GO:0043406 80 0.826
positive regulation of developmental process GO:0051094 314 0.825
response to peptide hormone GO:0043434 61 0.818
regulation of hormone levels GO:0010817 125 0.817
anatomical structure homeostasis GO:0060249 100 0.814
Fly
negative regulation of secretion GO:0051048 58 0.808
regulation of peptide hormone secretion GO:0090276 41 0.804
tricarboxylic acid metabolic process GO:0072350 4 0.802
hormone mediated signaling pathway GO:0009755 22 0.801
response to insulin GO:0032868 45 0.800
negative regulation of secretion by cell GO:1903531 52 0.799
negative regulation of cell proliferation GO:0008285 228 0.785
negative regulation of insulin receptor signaling pathway GO:0046627 8 0.784
mammary gland development GO:0030879 17 0.783
negative regulation of transport GO:0051051 176 0.782
Rat Worm
dicarboxylic acid metabolic process GO:0043648 29 0.781
peptidyl tyrosine modification GO:0018212 170 0.780
negative regulation of leukocyte apoptotic process GO:2000107 16 0.779
response to alkaline ph GO:0010446 2 0.779
Human
regulation of cytokine production GO:0001817 232 0.768
regulation of hormone secretion GO:0046883 57 0.767
organic acid catabolic process GO:0016054 71 0.766
lipid biosynthetic process GO:0008610 177 0.765
response to oxygen levels GO:0070482 100 0.764
Fly
reactive nitrogen species metabolic process GO:2001057 3 0.756
cell activation GO:0001775 213 0.756
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.754
positive regulation of natural killer cell activation GO:0032816 8 0.754
positive regulation of cell proliferation GO:0008284 301 0.752
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.750
secretion by cell GO:0032940 226 0.749
regulation of ion transport GO:0043269 189 0.749
gland development GO:0048732 48 0.745
biological adhesion GO:0022610 331 0.742
blastoderm segmentation GO:0007350 2 0.736
nerve development GO:0021675 4 0.732
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.732
ventral spinal cord development GO:0021517 1 0.728
response to decreased oxygen levels GO:0036293 96 0.723
Fly
regulation of organ growth GO:0046620 7 0.721
Fly
cellular response to external stimulus GO:0071496 111 0.719
Worm
circadian sleep wake cycle process GO:0022410 2 0.714
Fly
positive regulation of transferase activity GO:0051347 227 0.711
growth GO:0040007 202 0.707
b cell activation GO:0042113 33 0.707
negative regulation of cellular response to insulin stimulus GO:1900077 8 0.697
regulation of response to external stimulus GO:0032101 222 0.697
Worm
cranial nerve development GO:0021545 4 0.696
negative regulation of feeding behavior GO:2000252 1 0.696
Fly
regulation of transferase activity GO:0051338 355 0.689
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.688
leukocyte activation GO:0045321 164 0.687
regulation of insulin secretion GO:0050796 33 0.686
ethanolamine containing compound metabolic process GO:0042439 26 0.681
choline metabolic process GO:0019695 1 0.679
lipid storage GO:0019915 28 0.672
Worm
positive regulation of glycolytic process GO:0045821 4 0.670
phospholipid metabolic process GO:0006644 99 0.665
negative regulation of fatty acid transport GO:2000192 6 0.664
regulation of fatty acid oxidation GO:0046320 9 0.663
tube development GO:0035295 125 0.662
lipid catabolic process GO:0016042 84 0.661
glycosyl compound catabolic process GO:1901658 413 0.657
regulation of transmembrane transport GO:0034762 139 0.654
response to oxidative stress GO:0006979 121 0.652
Worm Fly
organ growth GO:0035265 12 0.649
Fly
fatty acid transport GO:0015908 25 0.647
response to starvation GO:0042594 59 0.643
Worm
modulation by virus of host morphology or physiology GO:0019048 10 0.639
negative regulation of apoptotic process GO:0043066 316 0.638
Human
inner ear morphogenesis GO:0042472 4 0.632
prostate gland morphogenesis GO:0060512 1 0.622
post embryonic organ development GO:0048569 1 0.621
negative regulation of insulin secretion GO:0046676 9 0.620
negative regulation of lipid transport GO:0032369 18 0.620
peptide secretion GO:0002790 51 0.616
regulation of jak stat cascade GO:0046425 44 0.614
leukocyte proliferation GO:0070661 74 0.613
protein heterooligomerization GO:0051291 16 0.611
negative regulation of wnt signaling pathway GO:0030178 69 0.606
lymphocyte activation GO:0046649 133 0.604
erythrocyte differentiation GO:0030218 28 0.603
response to estradiol GO:0032355 23 0.599
Rat
negative regulation of transmembrane transport GO:0034763 29 0.594
cellular response to lipid GO:0071396 127 0.593
Human
positive regulation of protein phosphorylation GO:0001934 313 0.585
negative regulation of glycogen biosynthetic process GO:0045719 3 0.579
positive regulation of hormone secretion GO:0046887 25 0.575
regeneration GO:0031099 4 0.570
regulation of leukocyte proliferation GO:0070663 67 0.557
positive regulation of mapk cascade GO:0043410 190 0.556
circadian behavior GO:0048512 2 0.554
Fly
regulation of organic acid transport GO:0032890 8 0.552
renal tubule development GO:0061326 19 0.552
response to nutrient levels GO:0031667 81 0.551
Rat Worm
regulation of immune response GO:0050776 201 0.543
creatinine metabolic process GO:0046449 1 0.541
inositol lipid mediated signaling GO:0048017 55 0.540
Human
long term memory GO:0007616 2 0.536
activin receptor signaling pathway GO:0032924 24 0.534
positive regulation of glucose import GO:0046326 16 0.533
female sex differentiation GO:0046660 12 0.530
Fly
cellular amide metabolic process GO:0043603 69 0.528
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.527
nitric oxide metabolic process GO:0046209 22 0.523
viral process GO:0016032 146 0.522
response to wounding GO:0009611 168 0.521
antimicrobial humoral response GO:0019730 26 0.520
response to abiotic stimulus GO:0009628 336 0.520
Human Worm Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.519
embryonic camera type eye development GO:0031076 2 0.514
regulation of cellular amino acid metabolic process GO:0006521 6 0.512
positive regulation of immune response GO:0050778 159 0.512
negative regulation of cell differentiation GO:0045596 171 0.509
cellular amino acid metabolic process GO:0006520 116 0.508
response to extracellular stimulus GO:0009991 85 0.505
Rat Worm
myeloid cell differentiation GO:0030099 117 0.505
homeostasis of number of cells GO:0048872 40 0.504
peptide transport GO:0015833 74 0.504
semicircular canal morphogenesis GO:0048752 1 0.502
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.501
alcohol metabolic process GO:0006066 114 0.501
mitotic cell cycle GO:0000278 326 0.500
response to tumor necrosis factor GO:0034612 76 0.498
Rat
digestive system development GO:0055123 75 0.496
Mouse
protein heterotetramerization GO:0051290 3 0.495
negative regulation of cellular protein metabolic process GO:0032269 353 0.495
Human Rat
gamma delta t cell activation GO:0046629 3 0.494
stem cell differentiation GO:0048863 93 0.491
vacuole organization GO:0007033 44 0.490
Worm
cellular response to nutrient levels GO:0031669 69 0.489
Worm
positive regulation of secretion GO:0051047 116 0.487
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.486
interleukin 6 mediated signaling pathway GO:0070102 7 0.483
carboxylic acid catabolic process GO:0046395 71 0.483
negative regulation of phosphorus metabolic process GO:0010563 267 0.481
Human Rat
response to axon injury GO:0048678 1 0.477
ribonucleoside bisphosphate metabolic process GO:0033875 7 0.476
regulation of steroid metabolic process GO:0019218 32 0.468
regulation of intracellular protein transport GO:0033157 123 0.466
Worm
regulation of fatty acid metabolic process GO:0019217 24 0.466
cellular response to interferon gamma GO:0071346 24 0.460
cell division GO:0051301 168 0.457
positive regulation of immune system process GO:0002684 283 0.452
jak stat cascade GO:0007259 46 0.450
erythrocyte homeostasis GO:0034101 31 0.450
positive regulation of response to wounding GO:1903036 28 0.449
cellular biogenic amine metabolic process GO:0006576 34 0.445
organic acid transport GO:0015849 65 0.442
positive regulation of multicellular organism growth GO:0040018 6 0.441
Worm Fly
positive regulation of natural killer cell proliferation GO:0032819 3 0.440
negative regulation of erythrocyte differentiation GO:0045647 3 0.440
positive regulation of kinase activity GO:0033674 204 0.439
succinate metabolic process GO:0006105 1 0.436
dna biosynthetic process GO:0071897 40 0.435
long chain fatty acid transport GO:0015909 18 0.429
system process GO:0003008 349 0.428
nitrogen compound transport GO:0071705 191 0.427
peptide hormone secretion GO:0030072 50 0.425
spinal cord development GO:0021510 4 0.424
oxaloacetate metabolic process GO:0006107 1 0.422
response to ph GO:0009268 12 0.421
Human
cell development GO:0048468 328 0.415
Human Fly
single organism nuclear import GO:1902593 104 0.415
Worm
fatty acid beta oxidation GO:0006635 22 0.414
positive regulation of peptide secretion GO:0002793 15 0.414
regulation of insulin like growth factor receptor signaling pathway GO:0043567 8 0.413
reactive oxygen species metabolic process GO:0072593 75 0.412
Rat Fly
regulation of reactive oxygen species metabolic process GO:2000377 41 0.410
Rat Fly
3 phosphoadenosine 5 phosphosulfate metabolic process GO:0050427 1 0.410
lymphocyte apoptotic process GO:0070227 20 0.408
regulation of peptide transport GO:0090087 62 0.407
oogenesis GO:0048477 2 0.405
Fly
single organism cellular localization GO:1902580 332 0.391
Worm
vascular endothelial growth factor receptor signaling pathway GO:0048010 19 0.390
regulation of autophagic vacuole assembly GO:2000785 6 0.389
Worm
memory GO:0007613 3 0.381
positive regulation of fatty acid oxidation GO:0046321 6 0.377
organelle fission GO:0048285 149 0.377
male sex differentiation GO:0046661 25 0.369
regulation of establishment of protein localization GO:0070201 242 0.367
Worm
multicellular organismal aging GO:0010259 3 0.367
Worm Fly
defense response to virus GO:0051607 71 0.363
cellular modified amino acid metabolic process GO:0006575 64 0.361
cell morphogenesis GO:0000902 296 0.359
Fly
protein oligomerization GO:0051259 173 0.358
lymphocyte proliferation GO:0046651 70 0.356
protein targeting GO:0006605 187 0.355
Worm
purine ribonucleoside bisphosphate metabolic process GO:0034035 1 0.350
inorganic diphosphate transport GO:0030505 2 0.349
negative regulation of response to external stimulus GO:0032102 83 0.344
establishment of protein localization to organelle GO:0072594 172 0.342
Worm
striated muscle cell apoptotic process GO:0010658 3 0.341
Human
respiratory burst GO:0045730 12 0.338
regulation of lipid biosynthetic process GO:0046890 47 0.336
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.336
cellular response to alkaline ph GO:0071469 1 0.334
Human
nucleoside bisphosphate metabolic process GO:0033865 7 0.332
activation of protein kinase b activity GO:0032148 14 0.330
response to biotic stimulus GO:0009607 276 0.330
mesenchymal cell proliferation GO:0010463 7 0.328
cognition GO:0050890 43 0.327
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.326
reproductive process GO:0022414 106 0.325
Mouse Worm Fly
negative regulation of peptide hormone secretion GO:0090278 10 0.324
t cell differentiation in thymus GO:0033077 4 0.322
circulatory system development GO:0072359 262 0.321
regulation of lymphocyte proliferation GO:0050670 64 0.321
cardiac muscle cell apoptotic process GO:0010659 3 0.319
Human
fatty acid oxidation GO:0019395 31 0.317
positive regulation of lymphocyte activation GO:0051251 73 0.315
regulation of plasma membrane long chain fatty acid transport GO:0010746 4 0.315
positive regulation of growth GO:0045927 58 0.315
monocarboxylic acid transport GO:0015718 32 0.315
negative regulation of intracellular signal transduction GO:1902532 183 0.314
Human
reactive oxygen species biosynthetic process GO:1903409 4 0.313
rhythmic behavior GO:0007622 2 0.312
Fly
segmentation GO:0035282 4 0.312
citrate metabolic process GO:0006101 2 0.312
regulation of lipid transport GO:0032368 44 0.310
immune response GO:0006955 307 0.306
Human
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 9 0.304
negative regulation of behavior GO:0048521 15 0.301
Fly
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.298
negative regulation of circadian sleep wake cycle sleep GO:0042321 1 0.295
Fly
rhythmic process GO:0048511 31 0.294
Fly
regulation of smooth muscle cell proliferation GO:0048660 28 0.294
positive regulation of phosphorylation GO:0042327 394 0.293
regulation of secretion GO:0051046 194 0.293
leukocyte differentiation GO:0002521 98 0.291
positive regulation of hormone biosynthetic process GO:0046886 4 0.289
negative regulation of phosphate metabolic process GO:0045936 267 0.286
Human Rat
regulation of peptide secretion GO:0002791 42 0.284
regulation of lymphocyte apoptotic process GO:0070228 15 0.283
regulation of behavior GO:0050795 82 0.282
Fly
negative regulation of peptide secretion GO:0002792 11 0.282
mononuclear cell proliferation GO:0032943 71 0.281
regulation of response to oxidative stress GO:1902882 26 0.281
Worm
cell projection assembly GO:0030031 126 0.278
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.277
regulation of dna metabolic process GO:0051052 153 0.277
peripheral nervous system development GO:0007422 2 0.277
lymphocyte homeostasis GO:0002260 4 0.275
regulation of kinase activity GO:0043549 314 0.273
membrane lipid metabolic process GO:0006643 53 0.270
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.268
regulation of natural killer cell activation GO:0032814 9 0.268
pyruvate metabolic process GO:0006090 26 0.268
positive regulation of developmental growth GO:0048639 16 0.266
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.265
positive regulation of dna replication GO:0045740 35 0.264
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.264
peptidyl tyrosine autophosphorylation GO:0038083 5 0.264
Human Mouse
defense response to other organism GO:0098542 129 0.263
positive regulation of natural killer cell differentiation GO:0032825 2 0.262
positive regulation of catabolic process GO:0009896 310 0.262
regulation of wnt signaling pathway GO:0030111 123 0.252
cardiovascular system development GO:0072358 262 0.250
negative regulation of epithelial cell proliferation GO:0050680 48 0.250
alpha amino acid metabolic process GO:1901605 72 0.250
regulation of response to reactive oxygen species GO:1901031 12 0.250
Worm
regulation of blood coagulation GO:0030193 42 0.249
regulation of respiratory burst GO:0060263 8 0.244
regulation of cell activation GO:0050865 125 0.244
creatine metabolic process GO:0006600 2 0.243
blood vessel development GO:0001568 172 0.242
muscle cell proliferation GO:0033002 35 0.241
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.240
negative regulation of developmental process GO:0051093 247 0.240
mammary gland involution GO:0060056 1 0.238
ribonucleoside triphosphate metabolic process GO:0009199 412 0.235
ameboidal type cell migration GO:0001667 135 0.235
cellular response to tumor necrosis factor GO:0071356 63 0.234
positive regulation of cell differentiation GO:0045597 211 0.233
Human
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.231
response to growth factor GO:0070848 205 0.230
Mouse
cell differentiation in spinal cord GO:0021515 1 0.229
response to external biotic stimulus GO:0043207 261 0.228
regulation of endothelial cell proliferation GO:0001936 56 0.227
digestive tract development GO:0048565 75 0.225
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 12 0.224
response to reactive oxygen species GO:0000302 61 0.224
Worm
inorganic anion transport GO:0015698 60 0.222
response to caffeine GO:0031000 3 0.221
regulation of mononuclear cell proliferation GO:0032944 65 0.220
tube morphogenesis GO:0035239 95 0.219
g protein coupled receptor signaling pathway GO:0007186 207 0.218
lactation GO:0007595 3 0.217
post embryonic development GO:0009791 2 0.214
Worm
response to estrogen GO:0043627 47 0.213
Rat
insulin secretion GO:0030073 39 0.211
hematopoietic or lymphoid organ development GO:0048534 186 0.210
regulation of striated muscle cell apoptotic process GO:0010662 3 0.209
Human
phosphatidylinositol mediated signaling GO:0048015 55 0.209
Human
negative regulation of protein metabolic process GO:0051248 391 0.205
Human Rat
positive regulation of peptide hormone secretion GO:0090277 15 0.205
positive regulation of stem cell proliferation GO:2000648 10 0.204
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.203
negative regulation of multi organism process GO:0043901 92 0.202
negative regulation of ossification GO:0030279 21 0.202
negative regulation of lymphocyte apoptotic process GO:0070229 8 0.202
2 oxoglutarate metabolic process GO:0006103 4 0.202
regulation of cell differentiation GO:0045595 393 0.201
Human
regulation of b cell differentiation GO:0045577 2 0.201
photoreceptor cell differentiation GO:0046530 2 0.197
endothelial cell proliferation GO:0001935 65 0.197
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.197
mitotic cell cycle process GO:1903047 286 0.196
positive regulation of steroid metabolic process GO:0045940 13 0.196
glycerolipid metabolic process GO:0046486 107 0.195
organophosphate biosynthetic process GO:0090407 163 0.195
b cell differentiation GO:0030183 6 0.193
regulation of cell growth GO:0001558 135 0.193
Fly
ovulation cycle GO:0042698 9 0.192
regulation of protein serine threonine kinase activity GO:0071900 179 0.191
positive regulation of leukocyte proliferation GO:0070665 48 0.190
regulation of nitric oxide biosynthetic process GO:0045428 17 0.189
hemopoiesis GO:0030097 180 0.186

INSR disease predictions

Disease DO term ID Size Probability Func Analog Org
diabetes mellitus DOID:9351 31 0.995
type 2 diabetes mellitus DOID:9352 28 0.995
disease of metabolism DOID:0014667 295 0.995
carbohydrate metabolism disease DOID:0050013 32 0.995
glucose metabolism disease DOID:4194 32 0.995
acquired metabolic disease DOID:0060158 58 0.995
inherited metabolic disorder DOID:655 242 0.971
vascular disease DOID:178 25 0.832
cardiovascular system disease DOID:1287 106 0.832
nutrition disease DOID:374 17 0.528
metal metabolism disorder DOID:896 19 0.297
immune system disease DOID:2914 155 0.210