Homo sapiens

192 known processes

IRS2

insulin receptor substrate 2

(Aliases: IRS-2)

IRS2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of glycogen metabolic process GO:0070873 15 0.964
glucan biosynthetic process GO:0009250 16 0.954
positive regulation of cellular response to insulin stimulus GO:1900078 6 0.944
Human
regulation of glycogen biosynthetic process GO:0005979 14 0.936
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.915
Human Mouse Fly
glycogen metabolic process GO:0005977 22 0.898
somatic muscle development GO:0007525 1 0.890
glucan metabolic process GO:0044042 22 0.887
regulation of glucan biosynthetic process GO:0010962 14 0.882
cellular carbohydrate biosynthetic process GO:0034637 21 0.876
cellular glucan metabolic process GO:0006073 22 0.870
enzyme linked receptor protein signaling pathway GO:0007167 303 0.865
Human Mouse Fly
glycogen biosynthetic process GO:0005978 16 0.861
regulation of glucose metabolic process GO:0010906 28 0.859
cellular polysaccharide biosynthetic process GO:0033692 21 0.825
cellular response to peptide GO:1901653 59 0.803
cellular response to endogenous stimulus GO:0071495 336 0.792
lipid metabolic process GO:0006629 381 0.786
asymmetric stem cell division GO:0098722 1 0.782
Fly
cellular response to ph GO:0071467 9 0.758
oxidation reduction process GO:0055114 396 0.757
energy reserve metabolic process GO:0006112 22 0.751
cellular polysaccharide metabolic process GO:0044264 27 0.744
response to organonitrogen compound GO:0010243 156 0.738
regulation of feeding behavior GO:0060259 3 0.728
regulation of activin receptor signaling pathway GO:0032925 14 0.728
Fly
cellular response to insulin stimulus GO:0032869 41 0.727
cellular response to nitrogen compound GO:1901699 144 0.724
regulation of cellular response to insulin stimulus GO:1900076 17 0.700
Human
monosaccharide metabolic process GO:0005996 74 0.679
response to nitrogen compound GO:1901698 184 0.667
response to oxygen containing compound GO:1901700 369 0.664
cellular response to oxygen containing compound GO:1901701 276 0.605
cellular response to organonitrogen compound GO:0071417 124 0.604
cellular response to hormone stimulus GO:0032870 125 0.593
negative regulation of cell differentiation GO:0045596 171 0.577
cellular response to external stimulus GO:0071496 111 0.564
carbohydrate metabolic process GO:0005975 207 0.554
positive regulation of glucose metabolic process GO:0010907 12 0.528
single organism carbohydrate metabolic process GO:0044723 193 0.523
tor signaling GO:0031929 39 0.517
positive regulation of immune response GO:0050778 159 0.511
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.509
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.507
positive regulation of catabolic process GO:0009896 310 0.505
cellular response to peptide hormone stimulus GO:0071375 56 0.500
cellular carbohydrate metabolic process GO:0044262 84 0.480
response to peptide hormone GO:0043434 61 0.477
response to peptide GO:1901652 65 0.476
regulation of circadian sleep wake cycle GO:0042749 2 0.459
regulation of insulin receptor signaling pathway GO:0046626 13 0.442
circadian sleep wake cycle process GO:0022410 2 0.440
fatty acid metabolic process GO:0006631 115 0.430
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.428
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.424
glucose metabolic process GO:0006006 45 0.420
insulin receptor signaling pathway GO:0008286 23 0.406
Human Mouse Fly
purine containing compound catabolic process GO:0072523 411 0.406
glycosyl compound catabolic process GO:1901658 413 0.392
insulin like growth factor receptor signaling pathway GO:0048009 13 0.383
Human
monocarboxylic acid metabolic process GO:0032787 185 0.382
female gamete generation GO:0007292 2 0.374
Fly
purine nucleoside triphosphate metabolic process GO:0009144 412 0.373
carbohydrate derivative biosynthetic process GO:1901137 207 0.372
hexose metabolic process GO:0019318 55 0.368
cellular component morphogenesis GO:0032989 314 0.365
Fly
regulation of tor signaling GO:0032006 30 0.352
circadian sleep wake cycle GO:0042745 2 0.349
cellular response to starvation GO:0009267 58 0.342
response to hormone GO:0009725 175 0.330
locomotory behavior GO:0007626 1 0.324
glucose homeostasis GO:0042593 31 0.321
polysaccharide biosynthetic process GO:0000271 27 0.317
polysaccharide metabolic process GO:0005976 33 0.314
macroautophagy GO:0016236 39 0.311
autophagy GO:0006914 88 0.304
ribonucleoside triphosphate catabolic process GO:0009203 391 0.301
determination of adult lifespan GO:0008340 2 0.295
Fly
mating GO:0007618 1 0.292
purine ribonucleoside metabolic process GO:0046128 437 0.291
regulation of lipid metabolic process GO:0019216 96 0.290
negative regulation of phosphorus metabolic process GO:0010563 267 0.280
Mouse
cellular lipid metabolic process GO:0044255 303 0.280
regulation of carbohydrate metabolic process GO:0006109 54 0.272
regulation of glucose import GO:0046324 21 0.271
response to testosterone GO:0033574 1 0.269
regulation of cellular component movement GO:0051270 334 0.266
Mouse
cellular amine metabolic process GO:0044106 41 0.264
regulation of polysaccharide biosynthetic process GO:0032885 20 0.263
positive regulation of feeding behavior GO:2000253 1 0.262
lipid biosynthetic process GO:0008610 177 0.254
response to extracellular stimulus GO:0009991 85 0.254
Fly
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.253
cell morphogenesis GO:0000902 296 0.252
Fly
positive regulation of insulin receptor signaling pathway GO:0046628 3 0.252
purine nucleoside triphosphate catabolic process GO:0009146 392 0.251
response to organic cyclic compound GO:0014070 204 0.248
regulation of generation of precursor metabolites and energy GO:0043467 27 0.235
response to alkaline ph GO:0010446 2 0.233
response to abiotic stimulus GO:0009628 336 0.232
Fly
positive regulation of cell death GO:0010942 263 0.230
response to manganese ion GO:0010042 2 0.228
negative regulation of cell death GO:0060548 345 0.227
Mouse
regulation of cell cycle GO:0051726 393 0.227
chemical homeostasis GO:0048878 306 0.226
negative regulation of phosphate metabolic process GO:0045936 267 0.226
Mouse
regulation of glucose import in response to insulin stimulus GO:2001273 4 0.222
Human
intracellular protein transport GO:0006886 270 0.215
negative regulation of wnt signaling pathway GO:0030178 69 0.214
negative regulation of cell proliferation GO:0008285 228 0.210
circadian sleep wake cycle sleep GO:0050802 2 0.209
negative regulation of protein metabolic process GO:0051248 391 0.209
regulation of nucleoside metabolic process GO:0009118 209 0.203
purine nucleotide catabolic process GO:0006195 405 0.203
positive regulation of muscle cell apoptotic process GO:0010661 4 0.199
circadian behavior GO:0048512 2 0.197
g protein coupled receptor signaling pathway GO:0007186 207 0.197
cellular response to nutrient levels GO:0031669 69 0.197
multicellular organismal aging GO:0010259 3 0.196
Fly
response to insulin GO:0032868 45 0.195
carbohydrate biosynthetic process GO:0016051 42 0.191
ribonucleoside catabolic process GO:0042454 406 0.189
negative regulation of apoptotic process GO:0043066 316 0.188
Mouse
ribonucleotide catabolic process GO:0009261 405 0.187
regulation of gtp catabolic process GO:0033124 180 0.187
negative regulation of secretion by cell GO:1903531 52 0.185
Human
negative regulation of glycogen metabolic process GO:0070874 4 0.181
gtp catabolic process GO:0006184 237 0.174
negative regulation of multicellular organismal process GO:0051241 317 0.173
cardiovascular system development GO:0072358 262 0.173
glucose import GO:0046323 24 0.173
response to cytokine GO:0034097 232 0.173
negative regulation of phosphorylation GO:0042326 174 0.171
Mouse
nucleoside catabolic process GO:0009164 408 0.170
positive regulation of apoptotic process GO:0043065 246 0.168
neuron differentiation GO:0030182 138 0.167
protein targeting GO:0006605 187 0.166
protein localization to organelle GO:0033365 280 0.166
response to decreased oxygen levels GO:0036293 96 0.164
Fly
regulation of wnt signaling pathway GO:0030111 123 0.163
behavior GO:0007610 112 0.160
Fly
positive regulation of respiratory burst GO:0060267 5 0.159
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.159
negative regulation of secretion GO:0051048 58 0.158
Human
energy derivation by oxidation of organic compounds GO:0015980 43 0.157
protein heterotetramerization GO:0051290 3 0.157
nucleotide catabolic process GO:0009166 408 0.155
negative regulation of protein phosphorylation GO:0001933 140 0.154
positive regulation of phosphorylation GO:0042327 394 0.153
response to oxidative stress GO:0006979 121 0.153
carbohydrate transport GO:0008643 37 0.153
negative regulation of transport GO:0051051 176 0.152
positive regulation of cell cycle GO:0045787 140 0.151
guanosine containing compound metabolic process GO:1901068 244 0.150
gtp metabolic process GO:0046039 239 0.149
regulation of circadian sleep wake cycle sleep GO:0045187 2 0.148
growth GO:0040007 202 0.146
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.145
Fly
ion transmembrane transport GO:0034220 338 0.143
regulation of establishment of protein localization GO:0070201 242 0.142
regulation of growth GO:0040008 165 0.141
Fly
rhythmic behavior GO:0007622 2 0.141
negative regulation of cellular protein metabolic process GO:0032269 353 0.140
positive regulation of glycogen biosynthetic process GO:0045725 10 0.140
regulation of purine nucleotide metabolic process GO:1900542 264 0.139
positive regulation of nucleotide catabolic process GO:0030813 185 0.139
positive regulation of cellular component organization GO:0051130 376 0.139
response to activity GO:0014823 0 0.138
generation of precursor metabolites and energy GO:0006091 68 0.137
positive regulation of glucose import in response to insulin stimulus GO:2001275 3 0.136
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.136
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.135
Human
regulation of cell cycle process GO:0010564 266 0.135
sulfur compound metabolic process GO:0006790 101 0.134
regulation of angiogenesis GO:0045765 92 0.133
cell morphogenesis involved in differentiation GO:0000904 144 0.133
ribonucleoside triphosphate metabolic process GO:0009199 412 0.133
regulation of intracellular protein transport GO:0033157 123 0.132
sex determination GO:0007530 3 0.132
oogenesis GO:0048477 2 0.131
Fly
response to oxygen levels GO:0070482 100 0.131
Fly
post embryonic development GO:0009791 2 0.128
myoblast fusion GO:0007520 1 0.128
cytoplasmic transport GO:0016482 379 0.126
cell projection organization GO:0030030 252 0.125
regulation of cellular component biogenesis GO:0044087 281 0.124
biological adhesion GO:0022610 331 0.124
cell projection morphogenesis GO:0048858 129 0.123
signal transduction by phosphorylation GO:0023014 297 0.122
regulation of polysaccharide metabolic process GO:0032881 21 0.121
regulation of locomotion GO:0040012 329 0.121
Mouse
response to growth factor GO:0070848 205 0.116
negative regulation of programmed cell death GO:0043069 321 0.116
Mouse
regulation of kinase activity GO:0043549 314 0.114
Mouse
sleep GO:0030431 2 0.112
positive regulation of nucleoside metabolic process GO:0045979 186 0.112
positive regulation of glycoprotein metabolic process GO:1903020 8 0.111
cellular response to growth factor stimulus GO:0071363 197 0.111
neuron projection development GO:0031175 106 0.111
glycoprotein metabolic process GO:0009100 110 0.110
regulation of protein localization GO:0032880 296 0.110
phospholipid metabolic process GO:0006644 99 0.109
regulation of response to external stimulus GO:0032101 222 0.108
negative regulation of intracellular signal transduction GO:1902532 183 0.108
negative regulation of mapk cascade GO:0043409 56 0.108
regulation of transferase activity GO:0051338 355 0.108
Mouse
regulation of carbohydrate biosynthetic process GO:0043255 27 0.108
mitotic cell cycle GO:0000278 326 0.107
response to nutrient levels GO:0031667 81 0.107
Fly
cellular lipid catabolic process GO:0044242 65 0.105
regulation of cell growth GO:0001558 135 0.104
intracellular receptor signaling pathway GO:0030522 104 0.104
nucleoside triphosphate catabolic process GO:0009143 394 0.103
positive regulation of cell proliferation GO:0008284 301 0.103
Mouse
posttranscriptional regulation of gene expression GO:0010608 213 0.102
response to starvation GO:0042594 59 0.102
Fly
cell division GO:0051301 168 0.101
Fly
regeneration GO:0031099 4 0.100
regulation of autophagy GO:0010506 52 0.100
negative regulation of angiogenesis GO:0016525 39 0.099
organophosphate catabolic process GO:0046434 430 0.099
stem cell division GO:0017145 2 0.099
Fly
neurogenesis GO:0022008 169 0.098
regulation of gtpase activity GO:0043087 180 0.097
maintenance of location GO:0051235 112 0.096
establishment of protein localization to organelle GO:0072594 172 0.096
regulation of cellular amino acid metabolic process GO:0006521 6 0.095
negative regulation of cell growth GO:0030308 83 0.095
response to cocaine GO:0042220 1 0.094
syncytium formation by plasma membrane fusion GO:0000768 2 0.094
nucleoside triphosphate metabolic process GO:0009141 422 0.093
regulation of protein transport GO:0051223 213 0.093
nervous system development GO:0007399 293 0.093
Mouse
anion transport GO:0006820 161 0.092
regulation of nervous system development GO:0051960 88 0.092
purine ribonucleoside catabolic process GO:0046130 398 0.092
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.092
regulation of cell migration GO:0030334 289 0.092
Mouse
positive regulation of organelle organization GO:0010638 195 0.091
blood vessel development GO:0001568 172 0.091
protein localization to nucleus GO:0034504 136 0.090
negative regulation of developmental process GO:0051093 247 0.090
regulation of cellular response to stress GO:0080135 244 0.088
protein targeting to nucleus GO:0044744 104 0.088
negative regulation of catalytic activity GO:0043086 335 0.088
Mouse
regulation of nucleocytoplasmic transport GO:0046822 98 0.087
guanosine containing compound catabolic process GO:1901069 239 0.086
rho protein signal transduction GO:0007266 26 0.086
nucleoside phosphate catabolic process GO:1901292 412 0.086
negative regulation of insulin receptor signaling pathway GO:0046627 8 0.085
regulation of transcription factor import into nucleus GO:0042990 39 0.085
circulatory system development GO:0072359 262 0.084
purine ribonucleotide catabolic process GO:0009154 404 0.083
regulation of secretion by cell GO:1903530 177 0.083
Human Mouse
positive regulation of glycogen metabolic process GO:0070875 10 0.082
regulation of cell differentiation GO:0045595 393 0.080
positive regulation of programmed cell death GO:0043068 249 0.080
cellular response to extracellular stimulus GO:0031668 72 0.078
negative regulation of cellular response to insulin stimulus GO:1900077 8 0.078
protein import into nucleus GO:0006606 104 0.077
regulation of purine nucleotide catabolic process GO:0033121 205 0.077
inactivation of mapkk activity GO:0051389 1 0.077
steroid metabolic process GO:0008202 94 0.077
associative learning GO:0008306 1 0.076
Fly
positive regulation of organ growth GO:0046622 2 0.076
regulation of hormone levels GO:0010817 125 0.075
Human Mouse
regulation of nucleotide metabolic process GO:0006140 269 0.074
single organism cellular localization GO:1902580 332 0.074
response to ph GO:0009268 12 0.074
regulation of intracellular transport GO:0032386 195 0.074
nuclear transport GO:0051169 179 0.073
regulation of cellular amine metabolic process GO:0033238 11 0.073
regulation of macroautophagy GO:0016241 19 0.072
positive regulation of cellular carbohydrate metabolic process GO:0010676 16 0.072
glucose transport GO:0015758 30 0.072
positive regulation of gtp catabolic process GO:0033126 166 0.072
negative regulation of protein modification process GO:0031400 200 0.071
negative regulation of feeding behavior GO:2000252 1 0.071
female gonad development GO:0008585 10 0.071
transformation of host cell by virus GO:0019087 2 0.071
anatomical structure homeostasis GO:0060249 100 0.070
Fly
mhc class ii biosynthetic process GO:0045342 4 0.068
positive regulation of transport GO:0051050 336 0.067
positive regulation of camp dependent protein kinase activity GO:2000481 4 0.067
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.067
negative regulation of protein transport GO:0051224 75 0.066
organic anion transport GO:0015711 103 0.066
cell development GO:0048468 328 0.066
Fly
positive regulation of cell motility GO:2000147 177 0.066
Mouse
striated muscle cell apoptotic process GO:0010658 3 0.066
regulation of nucleotide catabolic process GO:0030811 205 0.066
cell fate determination GO:0001709 3 0.065
regulation of cytoplasmic transport GO:1903649 149 0.065
regulation of response to oxidative stress GO:1902882 26 0.065
cell growth GO:0016049 160 0.065
Fly
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.065
cell differentiation in spinal cord GO:0021515 1 0.065
positive regulation of gtpase activity GO:0043547 166 0.065
positive regulation of glycolytic process GO:0045821 4 0.064
glycoprotein biosynthetic process GO:0009101 91 0.064
muscle structure development GO:0061061 98 0.064
actin filament based process GO:0030029 224 0.063
negative regulation of intracellular transport GO:0032387 60 0.063
regulation of mapk cascade GO:0043408 262 0.063
nucleocytoplasmic transport GO:0006913 176 0.063
negative regulation of kinase activity GO:0033673 106 0.063
Mouse
monosaccharide transport GO:0015749 32 0.063
regulation of anatomical structure morphogenesis GO:0022603 286 0.062
positive regulation of protein phosphorylation GO:0001934 313 0.061
wnt signaling pathway GO:0016055 156 0.061
regulation of cellular ketone metabolic process GO:0010565 50 0.061
regulation of protein catabolic process GO:0042176 155 0.061
regulation of cytokine production GO:0001817 232 0.061
atp catabolic process GO:0006200 157 0.061
negative regulation of catabolic process GO:0009895 104 0.060
regulation of mitosis GO:0007088 63 0.060
regulation of response to reactive oxygen species GO:1901031 12 0.060
regulation of protein kinase activity GO:0045859 289 0.059
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.059
long term memory GO:0007616 2 0.059
regulation of neural precursor cell proliferation GO:2000177 4 0.059
actin cytoskeleton organization GO:0030036 207 0.058
regulation of cellular carbohydrate catabolic process GO:0043471 11 0.057
regulation of fatty acid transport GO:2000191 8 0.056
lipid localization GO:0010876 106 0.056
axon regeneration GO:0031103 1 0.056
regulation of hydrogen peroxide metabolic process GO:0010310 6 0.056
negative regulation of transferase activity GO:0051348 124 0.056
Mouse
positive regulation of protein kinase b signaling GO:0051897 42 0.056
positive regulation of carbohydrate metabolic process GO:0045913 21 0.055
regulation of protein serine threonine kinase activity GO:0071900 179 0.055
single organism membrane organization GO:0044802 268 0.055
protein import GO:0017038 130 0.055
protein catabolic process GO:0030163 325 0.055
positive regulation of locomotion GO:0040017 186 0.055
Mouse
regulation of glucose transport GO:0010827 23 0.054
positive regulation of transferase activity GO:0051347 227 0.054
pyruvate metabolic process GO:0006090 26 0.053
purine nucleoside catabolic process GO:0006152 398 0.053
regulation of cell motility GO:2000145 299 0.052
Mouse
mitotic cell cycle process GO:1903047 286 0.052
organelle fission GO:0048285 149 0.052
negative regulation of cellular catabolic process GO:0031330 83 0.052
blood vessel morphogenesis GO:0048514 162 0.052
viral process GO:0016032 146 0.052
regulation of autophagic vacuole assembly GO:2000785 6 0.052
positive regulation of cellular component movement GO:0051272 181 0.051
Mouse
positive regulation of dna metabolic process GO:0051054 73 0.051
oocyte development GO:0048599 1 0.051
regulation of small gtpase mediated signal transduction GO:0051056 156 0.050
peptidyl lysine modification GO:0018205 144 0.050
stress activated mapk cascade GO:0051403 93 0.050
regulation of cellular component size GO:0032535 82 0.050
positive regulation of myeloid cell apoptotic process GO:0033034 2 0.050
cellular response to dna damage stimulus GO:0006974 379 0.049
inner ear morphogenesis GO:0042472 4 0.049
positive regulation of ras gtpase activity GO:0032320 117 0.049
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.049
positive regulation of mitotic cell cycle GO:0045931 60 0.048
striated muscle cell differentiation GO:0051146 43 0.048
cell cell signaling GO:0007267 155 0.048
Human Mouse
small gtpase mediated signal transduction GO:0007264 78 0.048
positive regulation of cell cycle process GO:0090068 106 0.048
positive regulation of nucleotide metabolic process GO:0045981 230 0.048
regulation of ras gtpase activity GO:0032318 128 0.048
epithelium development GO:0060429 227 0.048
myeloid cell differentiation GO:0030099 117 0.048
activation of protein kinase b activity GO:0032148 14 0.047
interspecies interaction between organisms GO:0044419 156 0.047
nuclear division GO:0000280 128 0.047
mapk cascade GO:0000165 288 0.047
regulation of cell division GO:0051302 116 0.046
regulation of neurogenesis GO:0050767 82 0.046
neuron projection regeneration GO:0031102 1 0.046
protein oligomerization GO:0051259 173 0.045
neuron projection morphogenesis GO:0048812 50 0.045
negative regulation of protein kinase activity GO:0006469 98 0.045
cardiac muscle cell apoptotic process GO:0010659 3 0.045
response to purine containing compound GO:0014074 40 0.044
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.044
response to axon injury GO:0048678 1 0.044
regulation of glycoprotein metabolic process GO:1903018 19 0.044
response to transition metal nanoparticle GO:1990267 29 0.044
rna processing GO:0006396 255 0.044
negative regulation of immune system process GO:0002683 136 0.044
carbohydrate catabolic process GO:0016052 36 0.043
immune response GO:0006955 307 0.043
Fly
amine metabolic process GO:0009308 44 0.043
regulation of peptide hormone secretion GO:0090276 41 0.043
Human Mouse
ventral spinal cord development GO:0021517 1 0.043
regulation of protein localization to nucleus GO:1900180 85 0.043
cytokinesis GO:0000910 96 0.042
photoreceptor cell differentiation GO:0046530 2 0.042
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.042
phosphatidylinositol mediated signaling GO:0048015 55 0.042
Human
neuron remodeling GO:0016322 2 0.042
positive regulation of kinase activity GO:0033674 204 0.042
post embryonic organ development GO:0048569 1 0.042
reactive oxygen species metabolic process GO:0072593 75 0.042
anatomical structure formation involved in morphogenesis GO:0048646 284 0.042
positive regulation of striated muscle cell apoptotic process GO:0010663 1 0.042
reproductive process GO:0022414 106 0.041
Fly
microtubule cytoskeleton organization GO:0000226 176 0.041
vascular endothelial growth factor receptor signaling pathway GO:0048010 19 0.041
regulation of behavior GO:0050795 82 0.041
vasculature development GO:0001944 181 0.040
camp biosynthetic process GO:0006171 47 0.040
negative regulation of growth GO:0045926 97 0.040
response to reactive oxygen species GO:0000302 61 0.040
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.040
negative regulation of cellular component organization GO:0051129 235 0.040
negative regulation of protein processing GO:0010955 142 0.040
negative regulation of blood vessel morphogenesis GO:2000181 41 0.040
lymphocyte activation GO:0046649 133 0.039
Mouse
autophagic vacuole assembly GO:0000045 19 0.039
negative regulation of locomotion GO:0040013 118 0.039
cell part morphogenesis GO:0032990 137 0.039
regulation of striated muscle cell apoptotic process GO:0010662 3 0.039
small molecule catabolic process GO:0044282 92 0.039
cellular chemical homeostasis GO:0055082 180 0.039
positive regulation of lipid metabolic process GO:0045834 50 0.039
stress activated protein kinase signaling cascade GO:0031098 94 0.038
b cell activation GO:0042113 33 0.038
Mouse
muscle cell differentiation GO:0042692 63 0.038
multi organism reproductive process GO:0044703 54 0.038
Fly
regulation of nuclear division GO:0051783 65 0.038
regulation of cellular response to growth factor stimulus GO:0090287 76 0.038
cellular amino acid metabolic process GO:0006520 116 0.038
regulation of cardiac muscle cell apoptotic process GO:0010665 3 0.038
endothelial cell migration GO:0043542 86 0.038
apoptotic signaling pathway GO:0097190 268 0.037
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.037
response to biotic stimulus GO:0009607 276 0.037
regulation of protein import into nucleus GO:0042306 78 0.037
regulation of translation GO:0006417 89 0.037
negative regulation of cellular amine metabolic process GO:0033239 3 0.037
glycerolipid biosynthetic process GO:0045017 51 0.037
microtubule based process GO:0007017 210 0.037
response to tumor necrosis factor GO:0034612 76 0.036
response to inorganic substance GO:0010035 127 0.036
glucose import in response to insulin stimulus GO:0044381 4 0.036
Human
embryonic camera type eye development GO:0031076 2 0.036
negative regulation of hydrolase activity GO:0051346 182 0.036
nucleoside monophosphate metabolic process GO:0009123 191 0.036
response to nutrient GO:0007584 20 0.036
regulation of cell development GO:0060284 161 0.035
positive regulation of protein kinase activity GO:0045860 190 0.035
regulation of respiratory burst GO:0060263 8 0.035
modification dependent protein catabolic process GO:0019941 209 0.035
multi organism cellular process GO:0044764 156 0.035
vesicle mediated transport GO:0016192 371 0.035
response to interleukin 15 GO:0070672 6 0.035
hemopoiesis GO:0030097 180 0.035
erythrocyte homeostasis GO:0034101 31 0.035
neuron development GO:0048666 113 0.035
negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 3 0.035
respiratory burst GO:0045730 12 0.035
negative regulation of cytoplasmic transport GO:1903650 46 0.035
positive regulation of immune system process GO:0002684 283 0.034
Mouse Fly
response to lipid GO:0033993 206 0.034
protein processing GO:0016485 226 0.034
nucleotide biosynthetic process GO:0009165 109 0.034
single organism nuclear import GO:1902593 104 0.034
reactive oxygen species biosynthetic process GO:1903409 4 0.034
tissue regeneration GO:0042246 3 0.034
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.034
glycerolipid metabolic process GO:0046486 107 0.034
embryonic viscerocranium morphogenesis GO:0048703 1 0.033
negative regulation of insulin secretion GO:0046676 9 0.033
Human
regulation of erythrocyte differentiation GO:0045646 17 0.033
regulation of mitotic cell cycle GO:0007346 189 0.033
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.033
regulation of lipid catabolic process GO:0050994 23 0.032
cell adhesion GO:0007155 325 0.032
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.032
chemotaxis GO:0006935 157 0.032
organelle assembly GO:0070925 176 0.032
taxis GO:0042330 157 0.032
cellular response to abiotic stimulus GO:0071214 117 0.032
semicircular canal morphogenesis GO:0048752 1 0.032
hexose transport GO:0008645 30 0.032
neuronal stem cell division GO:0036445 1 0.032

IRS2 disease predictions

Disease DO term ID Size Probability Func Analog Org
hyperinsulinemic hypoglycemia DOID:13317 7 0.993
disease of metabolism DOID:0014667 295 0.993
carbohydrate metabolic disorder DOID:2978 55 0.993
inherited metabolic disorder DOID:655 242 0.993
diabetes mellitus DOID:9351 31 0.668
carbohydrate metabolism disease DOID:0050013 32 0.668
glucose metabolism disease DOID:4194 32 0.668
acquired metabolic disease DOID:0060158 58 0.668
type 2 diabetes mellitus DOID:9352 28 0.432
cancer DOID:162 167 0.078
disease of cellular proliferation DOID:14566 174 0.078
organ system cancer DOID:0050686 164 0.078
nutrition disease DOID:374 17 0.039