Homo sapiens

53 known processes

ITM2B

integral membrane protein 2B

(Aliases: E25B,BRICD2B,BRI2,BRI,FBD,E3-16,ABRI)

ITM2B biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.495
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.457
positive regulation of exocytosis GO:0045921 35 0.410
negative regulation of multicellular organismal process GO:0051241 317 0.370
Human
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.279
regulation of innate immune response GO:0045088 97 0.275
positive regulation of innate immune response GO:0045089 79 0.255
positive regulation of natural killer cell activation GO:0032816 8 0.221
regulation of leukocyte mediated immunity GO:0002703 38 0.217
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.199
leukocyte activation GO:0045321 164 0.175
defense response GO:0006952 315 0.169
innate immune response GO:0045087 178 0.166
positive regulation of leukocyte degranulation GO:0043302 3 0.162
signal transduction by phosphorylation GO:0023014 297 0.161
positive regulation of immune system process GO:0002684 283 0.148
regulation of hormone levels GO:0010817 125 0.145
leukocyte mediated immunity GO:0002443 59 0.131
protein localization to organelle GO:0033365 280 0.128
cell killing GO:0001906 34 0.128
antigen processing and presentation via mhc class ib GO:0002475 3 0.128
regulation of cytokine production GO:0001817 232 0.126
apoptotic signaling pathway GO:0097190 268 0.125
Mouse
cytokine production GO:0001816 247 0.118
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.113
natural killer cell mediated immunity GO:0002228 23 0.111
positive regulation of secretion by cell GO:1903532 108 0.109
positive regulation of immune response GO:0050778 159 0.107
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.104
regulation of defense response GO:0031347 154 0.102
regulation of leukocyte activation GO:0002694 115 0.100
immune response GO:0006955 307 0.096
mapk cascade GO:0000165 288 0.096
positive regulation of immune effector process GO:0002699 40 0.096
protein processing GO:0016485 226 0.089
cellular amide metabolic process GO:0043603 69 0.085
regulation of protein localization GO:0032880 296 0.085
natural killer cell mediated cytotoxicity GO:0042267 23 0.082
regulation of mapk cascade GO:0043408 262 0.080
protein modification by small protein conjugation GO:0032446 342 0.075
regulation of cell differentiation GO:0045595 393 0.075
Human
post embryonic development GO:0009791 2 0.073
cell activation GO:0001775 213 0.073
positive regulation of leukocyte mediated immunity GO:0002705 24 0.073
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.072
regulation of cell killing GO:0031341 22 0.071
regulation of lymphocyte mediated immunity GO:0002706 33 0.070
cellular protein catabolic process GO:0044257 261 0.069
regulation of exocytosis GO:0017157 46 0.068
cellular homeostasis GO:0019725 196 0.066
regulation of leukocyte mediated cytotoxicity GO:0001910 19 0.065
negative regulation of glycoprotein metabolic process GO:1903019 8 0.062
regulation of intracellular transport GO:0032386 195 0.061
post golgi vesicle mediated transport GO:0006892 36 0.061
positive regulation of cellular catabolic process GO:0031331 284 0.058
determination of adult lifespan GO:0008340 2 0.057
negative regulation of developmental process GO:0051093 247 0.057
Human
immune effector process GO:0002252 159 0.057
lymphocyte activation GO:0046649 133 0.056
actin polymerization or depolymerization GO:0008154 56 0.056
lymphocyte mediated immunity GO:0002449 48 0.055
cellular component disassembly GO:0022411 92 0.055
circulatory system development GO:0072359 262 0.054
regulation of secretion GO:0051046 194 0.053
hormone metabolic process GO:0042445 61 0.053
regulation of cell activation GO:0050865 125 0.051
system process GO:0003008 349 0.049
blood vessel morphogenesis GO:0048514 162 0.048
regulation of purine nucleotide metabolic process GO:1900542 264 0.048
natural killer cell degranulation GO:0043320 2 0.048
negative regulation of protein metabolic process GO:0051248 391 0.047
negative regulation of cellular protein metabolic process GO:0032269 353 0.047
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.047
regulation of immune response GO:0050776 201 0.047
regulation of protein maturation GO:1903317 150 0.046
positive regulation of transport GO:0051050 336 0.046
purine nucleoside triphosphate metabolic process GO:0009144 412 0.046
regulation of cellular component movement GO:0051270 334 0.045
regulation of lymphocyte activation GO:0051249 103 0.045
regulation of glycoprotein metabolic process GO:1903018 19 0.044
phospholipid translocation GO:0045332 2 0.044
positive regulation of catabolic process GO:0009896 310 0.043
chemical homeostasis GO:0048878 306 0.043
metal ion transport GO:0030001 272 0.043
regulation of natural killer cell mediated immunity GO:0002715 16 0.042
peptide metabolic process GO:0006518 51 0.042
protein ubiquitination GO:0016567 314 0.041
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.041
intracellular protein transport GO:0006886 270 0.041
actin filament based process GO:0030029 224 0.040
cytoplasmic transport GO:0016482 379 0.039
positive regulation of cell proliferation GO:0008284 301 0.039
long term memory GO:0007616 2 0.039
positive regulation of cell killing GO:0031343 19 0.038
positive regulation of leukocyte activation GO:0002696 80 0.037
regulation of cytoskeleton organization GO:0051493 177 0.037
posttranscriptional regulation of gene expression GO:0010608 213 0.037
cellular amino acid metabolic process GO:0006520 116 0.036
regulation of peptidase activity GO:0052547 180 0.036
wnt signaling pathway GO:0016055 156 0.036
sensory perception of taste GO:0050909 36 0.036
protein catabolic process GO:0030163 325 0.036
negative regulation of cell proliferation GO:0008285 228 0.035
regulation of immune effector process GO:0002697 91 0.035
negative regulation of protein processing GO:0010955 142 0.034
regulation of protein catabolic process GO:0042176 155 0.034
regulation of protein stability GO:0031647 87 0.034
rho protein signal transduction GO:0007266 26 0.034
positive regulation of t cell tolerance induction GO:0002666 2 0.033
exocytosis GO:0006887 71 0.033
detection of chemical stimulus GO:0009593 55 0.033
microtubule based process GO:0007017 210 0.033
protein complex disassembly GO:0043241 52 0.032
regulation of leukocyte differentiation GO:1902105 61 0.032
regulation of cell migration GO:0030334 289 0.032
nucleoside triphosphate catabolic process GO:0009143 394 0.032
negative regulation of intracellular signal transduction GO:1902532 183 0.031
endocrine process GO:0050886 25 0.031
cell adhesion GO:0007155 325 0.031
protein refolding GO:0042026 14 0.030
negative regulation of cell death GO:0060548 345 0.030
actin cytoskeleton organization GO:0030036 207 0.030
organelle fusion GO:0048284 36 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
positive regulation of nucleotide catabolic process GO:0030813 185 0.029
positive regulation of gtpase activity GO:0043547 166 0.029
cellular protein complex disassembly GO:0043624 36 0.029
golgi to vacuole transport GO:0006896 3 0.029
positive regulation of lymphocyte activation GO:0051251 73 0.028
response to bacterium GO:0009617 144 0.028
small gtpase mediated signal transduction GO:0007264 78 0.028
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
cation transport GO:0006812 331 0.028
response to external biotic stimulus GO:0043207 261 0.028
metal ion homeostasis GO:0055065 169 0.027
regulation of cell cycle GO:0051726 393 0.027
leukocyte mediated cytotoxicity GO:0001909 27 0.027
adaptive immune response GO:0002250 49 0.027
protein stabilization GO:0050821 64 0.027
transforming growth factor beta production GO:0071604 14 0.027
epithelium migration GO:0090132 119 0.027
cation homeostasis GO:0055080 189 0.026
single organism membrane organization GO:0044802 268 0.026
transforming growth factor beta1 production GO:0032905 3 0.026
non canonical wnt signaling pathway GO:0035567 14 0.026
positive regulation of cytokine production GO:0001819 167 0.026
positive regulation of cell differentiation GO:0045597 211 0.026
protein maturation GO:0051604 233 0.026
leukocyte activation involved in immune response GO:0002366 30 0.026
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.026
positive regulation of phosphorylation GO:0042327 394 0.026
anatomical structure homeostasis GO:0060249 100 0.026
enzyme linked receptor protein signaling pathway GO:0007167 303 0.026
positive regulation of hydrolase activity GO:0051345 331 0.026
positive regulation of cellular component organization GO:0051130 376 0.026
negative regulation of locomotion GO:0040013 118 0.025
immune system development GO:0002520 195 0.025
locomotory behavior GO:0007626 1 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
memory GO:0007613 3 0.025
angiogenesis GO:0001525 147 0.025
positive regulation of cell activation GO:0050867 81 0.024
cellular macromolecule catabolic process GO:0044265 380 0.024
ribonucleotide catabolic process GO:0009261 405 0.024
regulation of actin cytoskeleton organization GO:0032956 116 0.024
regulated secretory pathway GO:0045055 20 0.024
lysosomal transport GO:0007041 33 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
negative regulation of transport GO:0051051 176 0.023
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.023
hemopoiesis GO:0030097 180 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
negative regulation of cell cycle GO:0045786 193 0.022
positive regulation of secretion GO:0051047 116 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.022
establishment of planar polarity GO:0001736 3 0.022
cellular ketone metabolic process GO:0042180 80 0.022
response to inorganic substance GO:0010035 127 0.022
organophosphate catabolic process GO:0046434 430 0.022
negative regulation of immune system process GO:0002683 136 0.022
positive regulation of regulatory t cell differentiation GO:0045591 3 0.022
regulation of establishment of protein localization GO:0070201 242 0.022
cellular response to growth factor stimulus GO:0071363 197 0.022
negative regulation of catabolic process GO:0009895 104 0.022
regulation of natural killer cell activation GO:0032814 9 0.022
eye pigmentation GO:0048069 1 0.021
positive regulation of nucleoside metabolic process GO:0045979 186 0.021
macromolecular complex disassembly GO:0032984 60 0.021
response to hormone GO:0009725 175 0.021
regulation of proteolysis GO:0030162 293 0.021
biological adhesion GO:0022610 331 0.021
endosomal transport GO:0016197 129 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
secretion by cell GO:0032940 226 0.021
cardiovascular system development GO:0072358 262 0.021
regulation of cellular response to stress GO:0080135 244 0.021
cellular metal ion homeostasis GO:0006875 146 0.020
regulation of actin filament based process GO:0032970 141 0.020
regulation of gtp catabolic process GO:0033124 180 0.020
positive regulation of mapk cascade GO:0043410 190 0.020
sensory perception of chemical stimulus GO:0007606 38 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
response to other organism GO:0051707 261 0.020
regulation of ion transport GO:0043269 189 0.020
blood vessel endothelial cell migration GO:0043534 42 0.020
positive regulation of wnt signaling pathway GO:0030177 54 0.020
regulation of regulated secretory pathway GO:1903305 10 0.020
regulation of endopeptidase activity GO:0052548 170 0.020
cellular hormone metabolic process GO:0034754 41 0.019
negative regulation of vasculature development GO:1901343 43 0.019
regulation of ras gtpase activity GO:0032318 128 0.019
negative regulation of b cell mediated immunity GO:0002713 3 0.019
prostate gland development GO:0030850 3 0.019
regulation of secretion by cell GO:1903530 177 0.019
regulation of anatomical structure size GO:0090066 101 0.019
t cell differentiation in thymus GO:0033077 4 0.019
protein depolymerization GO:0051261 30 0.019
regulation of multi organism process GO:0043900 157 0.019
negative regulation of programmed cell death GO:0043069 321 0.018
positive regulation of rho gtpase activity GO:0032321 56 0.018
response to biotic stimulus GO:0009607 276 0.018
detection of stimulus GO:0051606 85 0.018
response to wounding GO:0009611 168 0.018
regulation of transforming growth factor beta1 production GO:0032908 3 0.018
hematopoietic or lymphoid organ development GO:0048534 186 0.018
ras protein signal transduction GO:0007265 73 0.018
intrinsic apoptotic signaling pathway GO:0097193 127 0.018
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.017
regulation of transferase activity GO:0051338 355 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
negative regulation of protein maturation GO:1903318 142 0.017
regulation of organelle transport along microtubule GO:1902513 2 0.017
transition metal ion transport GO:0000041 23 0.017
oogenesis GO:0048477 2 0.017
regulation of angiotensin levels in blood GO:0002002 3 0.017
regulation of angiotensin metabolic process GO:0060177 3 0.017
cell growth GO:0016049 160 0.017
regulation of actin polymerization or depolymerization GO:0008064 56 0.017
cholesterol transport GO:0030301 39 0.017
regulation of wnt signaling pathway GO:0030111 123 0.017
regulation of myeloid cell differentiation GO:0045637 81 0.016
peripheral nervous system development GO:0007422 2 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
circulatory system process GO:0003013 113 0.016
regulation of microtubule based process GO:0032886 74 0.016
calcium ion homeostasis GO:0055074 122 0.016
regulation of leukocyte proliferation GO:0070663 67 0.016
blood circulation GO:0008015 113 0.016
tissue regeneration GO:0042246 3 0.016
leukocyte differentiation GO:0002521 98 0.016
protein localization to membrane GO:0072657 160 0.016
establishment of protein localization to organelle GO:0072594 172 0.016
regulation of rho gtpase activity GO:0032319 66 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
membrane organization GO:0061024 292 0.016
regulation of microtubule based movement GO:0060632 6 0.016
regulation of t cell activation GO:0050863 77 0.015
regulation of apoptotic signaling pathway GO:2001233 175 0.015
nerve development GO:0021675 4 0.015
lipid translocation GO:0034204 2 0.015
activation of immune response GO:0002253 114 0.015
negative regulation of jak stat cascade GO:0046426 4 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
organic hydroxy compound metabolic process GO:1901615 147 0.015
purine containing compound catabolic process GO:0072523 411 0.015
regulation of binding GO:0051098 111 0.015
negative regulation of protein transport GO:0051224 75 0.015
divalent inorganic cation homeostasis GO:0072507 136 0.015
multicellular organismal aging GO:0010259 3 0.015
meiosis i GO:0007127 4 0.015
epithelial cell proliferation GO:0050673 128 0.015
glycoprotein metabolic process GO:0009100 110 0.015
regulation of neuronal synaptic plasticity GO:0048168 1 0.015
regulation of gtpase activity GO:0043087 180 0.015
negative regulation of peptidase activity GO:0010466 91 0.014
nucleoside catabolic process GO:0009164 408 0.014
cellular chemical homeostasis GO:0055082 180 0.014
regeneration GO:0031099 4 0.014
dendritic cell differentiation GO:0097028 13 0.014
carbohydrate metabolic process GO:0005975 207 0.014
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.014
cellular amine metabolic process GO:0044106 41 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
endomembrane system organization GO:0010256 196 0.014
myeloid cell differentiation GO:0030099 117 0.014
negative regulation of protein modification process GO:0031400 200 0.013
epithelium development GO:0060429 227 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
female gamete generation GO:0007292 2 0.013
regulation of t cell proliferation GO:0042129 42 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
Human
positive regulation of ras gtpase activity GO:0032320 117 0.013
blood vessel development GO:0001568 172 0.013
peptide hormone processing GO:0016486 9 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
Human
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.013
natural killer cell activation GO:0030101 12 0.013
cellular response to oxidative stress GO:0034599 85 0.013
transition metal ion homeostasis GO:0055076 31 0.012
engulfment of apoptotic cell GO:0043652 2 0.012
regulation of locomotion GO:0040012 329 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.012
positive regulation of defense response GO:0031349 87 0.012
cell projection organization GO:0030030 252 0.012
Human
neurological system process GO:0050877 163 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
response to oxidative stress GO:0006979 121 0.012
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.012
blastoderm segmentation GO:0007350 2 0.012
regulation of protein processing GO:0070613 150 0.012
negative regulation of cell motility GO:2000146 104 0.012
amine metabolic process GO:0009308 44 0.012
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.012
positive regulation of leukocyte differentiation GO:1902107 37 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
secretion GO:0046903 254 0.011
positive regulation of autophagy GO:0010508 24 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
cellular response to hormone stimulus GO:0032870 125 0.011
regulation of nucleotide catabolic process GO:0030811 205 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
divalent inorganic cation transport GO:0072511 158 0.011
regulation of cell cycle process GO:0010564 266 0.011
astrocyte differentiation GO:0048708 4 0.011
regulation of myeloid leukocyte differentiation GO:0002761 39 0.011
nuclear transport GO:0051169 179 0.011
positive regulation of protein transport GO:0051222 135 0.011
interspecies interaction between organisms GO:0044419 156 0.011
cellular protein complex assembly GO:0043623 188 0.011
positive regulation of developmental process GO:0051094 314 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
single organism cell adhesion GO:0098602 179 0.011
regulation of cellular amine metabolic process GO:0033238 11 0.011
response to virus GO:0009615 126 0.011
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
positive regulation of cell death GO:0010942 263 0.011
cellular response to glucocorticoid stimulus GO:0071385 4 0.011
neuron development GO:0048666 113 0.011
Human
positive regulation of cell cycle GO:0045787 140 0.011
negative regulation of proteolysis GO:0045861 132 0.011
epithelial cell differentiation GO:0030855 141 0.011
regulation of autophagy GO:0010506 52 0.011
interferon gamma production GO:0032609 39 0.011
protein localization to synapse GO:0035418 2 0.011
import into cell GO:0098657 2 0.011
inflammatory response GO:0006954 79 0.010
interaction with host GO:0051701 42 0.010
negative regulation of leukocyte mediated immunity GO:0002704 14 0.010
cell activation involved in immune response GO:0002263 30 0.010
canonical wnt signaling pathway GO:0060070 116 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
vesicle mediated transport GO:0016192 371 0.010
regulation of protein kinase activity GO:0045859 289 0.010
patterning of blood vessels GO:0001569 2 0.010
iron ion homeostasis GO:0055072 15 0.010
actin filament organization GO:0007015 128 0.010
immune response regulating signaling pathway GO:0002764 97 0.010
growth GO:0040007 202 0.010
negative regulation of defense response GO:0031348 47 0.010
thyroid hormone generation GO:0006590 2 0.010
cytoskeleton dependent intracellular transport GO:0030705 21 0.010

ITM2B disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.524
lysosomal storage disease DOID:3211 47 0.524
inherited metabolic disorder DOID:655 242 0.524
epilepsy syndrome DOID:1826 41 0.016
central nervous system disease DOID:331 186 0.016
brain disease DOID:936 73 0.016
variable age at onset electroclinical syndrome DOID:0050706 8 0.016
electroclinical syndrome DOID:0050701 32 0.016
nervous system disease DOID:863 431 0.016
cerebral degeneration DOID:1443 16 0.013
cancer DOID:162 167 0.012
disease of cellular proliferation DOID:14566 174 0.012
retinal disease DOID:5679 118 0.011
sensory system disease DOID:0050155 203 0.011
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
mucopolysaccharidosis DOID:12798 11 0.011
acquired metabolic disease DOID:0060158 58 0.002
amyloidosis DOID:9120 10 0.002
cerebral amyloid angiopathy DOID:9246 3 0.000