Homo sapiens

27 known processes

KEAP1

kelch-like ECH-associated protein 1

(Aliases: MGC10630,MGC20887,KLHL19,INrf2,MGC9454,MGC4407,KIAA0132,MGC1114)

KEAP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to laminar fluid shear stress GO:0071499 5 0.961
pharynx development GO:0060465 1 0.904
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.875
regulation of oocyte development GO:0060281 1 0.850
regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0000117 1 0.811
cellular response to tumor necrosis factor GO:0071356 63 0.728
protein ubiquitination GO:0016567 314 0.688
regulation of oxidative stress induced cell death GO:1903201 24 0.671
regulation of multi organism process GO:0043900 157 0.664
superoxide metabolic process GO:0006801 20 0.662
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.649
intracellular mrna localization GO:0008298 1 0.631
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.618
oocyte development GO:0048599 1 0.615
cellular response to oxygen containing compound GO:1901701 276 0.601
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.569
oocyte differentiation GO:0009994 2 0.551
anterior posterior axis specification embryo GO:0008595 2 0.541
segmentation GO:0035282 4 0.536
cellular response to cytokine stimulus GO:0071345 181 0.497
blastoderm segmentation GO:0007350 2 0.490
protein modification by small protein conjugation GO:0032446 342 0.485
female gamete generation GO:0007292 2 0.446
regulation of cellular response to oxidative stress GO:1900407 26 0.442
regulation of endothelial cell apoptotic process GO:2000351 24 0.435
anterior posterior axis specification GO:0009948 2 0.433
response to abiotic stimulus GO:0009628 336 0.425
regulation of superoxide metabolic process GO:0090322 6 0.402
response to oxygen containing compound GO:1901700 369 0.390
dorsal ventral axis specification GO:0009950 7 0.386
negative regulation of intracellular signal transduction GO:1902532 183 0.383
cellular response to reactive oxygen species GO:0034614 50 0.379
protein catabolic process GO:0030163 325 0.375
response to cytokine GO:0034097 232 0.361
proteasomal protein catabolic process GO:0010498 176 0.347
tripartite regional subdivision GO:0007351 2 0.335
negative regulation of endothelial cell apoptotic process GO:2000352 16 0.330
regulation of cell maturation GO:1903429 3 0.328
apoptotic signaling pathway GO:0097190 268 0.319
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.307
positive regulation of blood coagulation GO:0030194 11 0.299
cellular response to oxidative stress GO:0034599 85 0.288
regulation of response to external stimulus GO:0032101 222 0.288
blood coagulation GO:0007596 76 0.278
negative regulation of programmed cell death GO:0043069 321 0.268
Human
negative regulation of cellular response to oxidative stress GO:1900408 18 0.260
modification dependent protein catabolic process GO:0019941 209 0.257
Human
response to fluid shear stress GO:0034405 14 0.252
g2 m transition of mitotic cell cycle GO:0000086 41 0.251
determination of adult lifespan GO:0008340 2 0.251
regulation of cellular response to stress GO:0080135 244 0.250
regulation of response to wounding GO:1903034 101 0.250
response to tumor necrosis factor GO:0034612 76 0.248
hematopoietic or lymphoid organ development GO:0048534 186 0.244
cellular response to oxygen radical GO:0071450 6 0.242
cellular response to oxygen levels GO:0071453 55 0.239
reactive oxygen species metabolic process GO:0072593 75 0.239
single organism cellular localization GO:1902580 332 0.238
Human Rat
cellular response to decreased oxygen levels GO:0036294 51 0.235
negative regulation of oxidative stress induced cell death GO:1903202 17 0.234
cytoplasmic transport GO:0016482 379 0.208
Human Rat
regulation of cellular component biogenesis GO:0044087 281 0.206
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.199
Human
endothelial cell apoptotic process GO:0072577 26 0.194
pattern specification process GO:0007389 43 0.194
cellular macromolecule catabolic process GO:0044265 380 0.190
regulation of blood coagulation GO:0030193 42 0.188
protein alkylation GO:0008213 74 0.183
macromolecule methylation GO:0043414 97 0.180
intrinsic apoptotic signaling pathway GO:0097193 127 0.179
methylation GO:0032259 106 0.178
regulation of cell differentiation GO:0045595 393 0.178
regulation of hemostasis GO:1900046 42 0.175
g1 s transition of mitotic cell cycle GO:0000082 78 0.175
rna localization GO:0006403 41 0.175
cell type specific apoptotic process GO:0097285 125 0.173
negative regulation of hydrogen peroxide induced cell death GO:1903206 9 0.170
cell cycle phase transition GO:0044770 173 0.166
embryonic axis specification GO:0000578 5 0.158
negative regulation of multicellular organismal process GO:0051241 317 0.157
regulation of dna templated transcription in response to stress GO:0043620 18 0.155
regulation of reactive oxygen species metabolic process GO:2000377 41 0.155
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.154
atp metabolic process GO:0046034 176 0.152
response to decreased oxygen levels GO:0036293 96 0.135
negative regulation of apoptotic signaling pathway GO:2001234 97 0.134
regulation of ion transmembrane transport GO:0034765 132 0.131
negative regulation of cell death GO:0060548 345 0.125
Human
cell cycle g2 m phase transition GO:0044839 43 0.123
dorsal ventral pattern formation GO:0009953 15 0.122
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.120
modification dependent macromolecule catabolic process GO:0043632 212 0.116
Human
response to reactive oxygen species GO:0000302 61 0.113
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 7 0.112
response to oxygen levels GO:0070482 100 0.112
cellular protein catabolic process GO:0044257 261 0.112
regulation of wound healing GO:0061041 56 0.105
digestive tract development GO:0048565 75 0.104
cellular response to dna damage stimulus GO:0006974 379 0.099
amine metabolic process GO:0009308 44 0.098
cellular response to fluid shear stress GO:0071498 7 0.098
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.097
establishment or maintenance of cell polarity GO:0007163 31 0.095
regulation of response to oxidative stress GO:1902882 26 0.095
autophagy GO:0006914 88 0.095
digestive system development GO:0055123 75 0.094
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.087
oogenesis GO:0048477 2 0.085
regulation of protein catabolic process GO:0042176 155 0.085
regulation of cellular amine metabolic process GO:0033238 11 0.085
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 8 0.079
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.077
response to organonitrogen compound GO:0010243 156 0.076
defense response to other organism GO:0098542 129 0.076
cellular amine metabolic process GO:0044106 41 0.076
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.075
negative regulation of response to oxidative stress GO:1902883 18 0.075
neuron development GO:0048666 113 0.075
single organism membrane organization GO:0044802 268 0.074
Human
regulation of autophagy GO:0010506 52 0.073
cellular amino acid metabolic process GO:0006520 116 0.071
response to endoplasmic reticulum stress GO:0034976 49 0.070
regulation of proteolysis GO:0030162 293 0.069
multicellular organismal aging GO:0010259 3 0.069
positive regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0036091 3 0.068
cellular response to hydrogen peroxide GO:0070301 37 0.067
cell development GO:0048468 328 0.065
cellular response to lipid GO:0071396 127 0.065
response to hypoxia GO:0001666 96 0.065
monocarboxylic acid metabolic process GO:0032787 185 0.064
cell cycle g1 s phase transition GO:0044843 80 0.063
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.062
regulation of peptidase activity GO:0052547 180 0.062
response to hydrogen peroxide GO:0042542 40 0.062
nervous system development GO:0007399 293 0.062
transmembrane transport GO:0055085 399 0.061
positive regulation of programmed cell death GO:0043068 249 0.061
cellular response to superoxide GO:0071451 6 0.061
positive regulation of wound healing GO:0090303 20 0.059
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.059
innate immune response GO:0045087 178 0.058
protein import GO:0017038 130 0.057
Rat
tube development GO:0035295 125 0.057
Human
positive regulation of organelle organization GO:0010638 195 0.057
response to laminar fluid shear stress GO:0034616 8 0.056
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.055
morphogenesis of embryonic epithelium GO:0016331 4 0.053
regulation of translation GO:0006417 89 0.053
Human
negative regulation of apoptotic process GO:0043066 316 0.053
Human
ubiquitin dependent protein catabolic process GO:0006511 206 0.051
Human
wound healing GO:0042060 115 0.051
cellular response to hypoxia GO:0071456 51 0.050
fatty acid metabolic process GO:0006631 115 0.050
single organism reproductive process GO:0044702 98 0.050
regulation of coagulation GO:0050818 44 0.050
defense response to bacterium GO:0042742 63 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.048
positive regulation of coagulation GO:0050820 11 0.048
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
macroautophagy GO:0016236 39 0.047
negative regulation of immune system process GO:0002683 136 0.047
response to wounding GO:0009611 168 0.047
regulation of cell cycle process GO:0010564 266 0.046
Human
mitochondrion organization GO:0007005 156 0.046
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.046
er nucleus signaling pathway GO:0006984 23 0.045
microtubule cytoskeleton organization GO:0000226 176 0.044
removal of superoxide radicals GO:0019430 6 0.044
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 17 0.043
mitotic cell cycle process GO:1903047 286 0.043
myeloid cell homeostasis GO:0002262 34 0.042
regulation of body fluid levels GO:0050878 99 0.042
regulation of cell development GO:0060284 161 0.042
protein methylation GO:0006479 74 0.042
intracellular protein transport GO:0006886 270 0.041
Rat
regulation of protein processing GO:0070613 150 0.041
regulation of embryonic development GO:0045995 20 0.041
positive regulation of apoptotic process GO:0043065 246 0.041
hemostasis GO:0007599 76 0.040
endomembrane system organization GO:0010256 196 0.040
positive regulation of cellular component organization GO:0051130 376 0.040
neuron projection development GO:0031175 106 0.039
positive regulation of cellular amine metabolic process GO:0033240 7 0.038
positive regulation of multi organism process GO:0043902 56 0.038
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 10 0.038
cellular lipid metabolic process GO:0044255 303 0.038
cell death in response to hydrogen peroxide GO:0036474 10 0.037
microtubule based process GO:0007017 210 0.037
rna splicing GO:0008380 131 0.036
mitotic cell cycle GO:0000278 326 0.036
neurogenesis GO:0022008 169 0.036
positive regulation of transport GO:0051050 336 0.036
organic hydroxy compound metabolic process GO:1901615 147 0.034
response to topologically incorrect protein GO:0035966 29 0.034
negative regulation of response to reactive oxygen species GO:1901032 10 0.034
regulation of viral process GO:0050792 103 0.034
negative regulation of transport GO:0051051 176 0.033
Rat
regulation of protein localization GO:0032880 296 0.033
Rat
response to lipid GO:0033993 206 0.033
response to other organism GO:0051707 261 0.032
interspecies interaction between organisms GO:0044419 156 0.032
negative regulation of erythrocyte differentiation GO:0045647 3 0.032
cell morphogenesis involved in differentiation GO:0000904 144 0.032
cell morphogenesis GO:0000902 296 0.031
negative regulation of developmental process GO:0051093 247 0.031
dna repair GO:0006281 198 0.031
regulation of defense response GO:0031347 154 0.031
reproductive process GO:0022414 106 0.031
cytokine production GO:0001816 247 0.031
enzyme linked receptor protein signaling pathway GO:0007167 303 0.031
regulation of protein kinase activity GO:0045859 289 0.030
vesicle mediated transport GO:0016192 371 0.030
Human
erythrocyte homeostasis GO:0034101 31 0.030
regulation of proteasomal protein catabolic process GO:0061136 87 0.030
response to fungus GO:0009620 4 0.030
purine nucleoside monophosphate metabolic process GO:0009126 186 0.030
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.030
regulation of transporter activity GO:0032409 82 0.030
response to unfolded protein GO:0006986 24 0.029
response to bacterium GO:0009617 144 0.029
protein oligomerization GO:0051259 173 0.029
Rat
response to superoxide GO:0000303 6 0.029
regulation of transferase activity GO:0051338 355 0.029
immune response GO:0006955 307 0.029
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.029
response to oxidative stress GO:0006979 121 0.028
regulation of cell cycle GO:0051726 393 0.028
Human
lipid modification GO:0030258 84 0.028
cellular response to biotic stimulus GO:0071216 71 0.027
response to virus GO:0009615 126 0.027
protein localization to organelle GO:0033365 280 0.027
Human Rat
positive regulation of gliogenesis GO:0014015 4 0.027
protein localization to membrane GO:0072657 160 0.027
viral process GO:0016032 146 0.027
defense response to virus GO:0051607 71 0.027
positive regulation of cytokine production GO:0001819 167 0.026
multi organism cellular process GO:0044764 156 0.026
actin polymerization or depolymerization GO:0008154 56 0.026
regulation of cysteine type endopeptidase activity GO:2000116 127 0.025
actin filament polymerization GO:0030041 45 0.025
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.025
defense response GO:0006952 315 0.025
spermatid differentiation GO:0048515 4 0.025
response to hormone GO:0009725 175 0.024
Rat
positive regulation of hydrolase activity GO:0051345 331 0.024
cellular amide metabolic process GO:0043603 69 0.024
negative regulation of protein phosphorylation GO:0001933 140 0.024
regulation of hydrogen peroxide induced cell death GO:1903205 10 0.024
post embryonic development GO:0009791 2 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
protein processing GO:0016485 226 0.023
covalent chromatin modification GO:0016569 254 0.023
negative regulation of protein maturation GO:1903318 142 0.023
regulation of protein complex assembly GO:0043254 147 0.023
negative regulation of catabolic process GO:0009895 104 0.023
lipid catabolic process GO:0016042 84 0.023
ribonucleoside monophosphate metabolic process GO:0009161 187 0.023
protein secretion GO:0009306 98 0.023
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
lymphocyte homeostasis GO:0002260 4 0.022
lipid metabolic process GO:0006629 381 0.022
regulation of dna metabolic process GO:0051052 153 0.022
regulation of ion transport GO:0043269 189 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.022
positive regulation of cell death GO:0010942 263 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
Human
cellular ketone metabolic process GO:0042180 80 0.022
peptidyl serine modification GO:0018209 106 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
cellular component morphogenesis GO:0032989 314 0.022
protein maturation GO:0051604 233 0.022
mitotic cell cycle phase transition GO:0044772 162 0.022
regulation of protein secretion GO:0050708 86 0.022
cellular response to external stimulus GO:0071496 111 0.021
regulation of cytokine production GO:0001817 232 0.021
lipid oxidation GO:0034440 33 0.021
rna processing GO:0006396 255 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
rna catabolic process GO:0006401 71 0.021
response to inorganic substance GO:0010035 127 0.021
Rat
positive regulation of protein transport GO:0051222 135 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.020
cellular lipid catabolic process GO:0044242 65 0.020
protein localization to nucleus GO:0034504 136 0.020
Rat
actin filament organization GO:0007015 128 0.020
negative regulation of proteolysis GO:0045861 132 0.020
translation GO:0006412 132 0.020
Human
cell division GO:0051301 168 0.020
Human
cellular response to hormone stimulus GO:0032870 125 0.020
positive regulation of response to external stimulus GO:0032103 88 0.019
cellular response to nutrient levels GO:0031669 69 0.019
developmental process involved in reproduction GO:0003006 66 0.019
ion transmembrane transport GO:0034220 338 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
positive regulation of cellular component biogenesis GO:0044089 158 0.019
aging GO:0007568 66 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
guanosine containing compound catabolic process GO:1901069 239 0.019
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.019
fatty acid oxidation GO:0019395 31 0.018
nucleoside catabolic process GO:0009164 408 0.018
cell projection organization GO:0030030 252 0.018
regulation of reproductive process GO:2000241 15 0.018
posttranscriptional regulation of gene expression GO:0010608 213 0.018
Human
regulation of protein polymerization GO:0032271 63 0.018
small molecule catabolic process GO:0044282 92 0.018
chromatin organization GO:0006325 351 0.018
cellular response to molecule of bacterial origin GO:0071219 62 0.018
ribonucleoprotein complex biogenesis GO:0022613 116 0.018
positive regulation of ion transport GO:0043270 87 0.018
protein autophosphorylation GO:0046777 123 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
nuclear import GO:0051170 106 0.018
Rat
regulation of response to dna damage stimulus GO:2001020 94 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
regulation of cell activation GO:0050865 125 0.017
neural tube formation GO:0001841 3 0.017
purine ribonucleoside metabolic process GO:0046128 437 0.017
regulation of cellular amino acid metabolic process GO:0006521 6 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.017
regulation of dna repair GO:0006282 47 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
peptidyl serine phosphorylation GO:0018105 101 0.017
zymogen activation GO:0031638 70 0.017
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 5 0.017
protein polymerization GO:0051258 71 0.017
regulation of metal ion transport GO:0010959 120 0.017
eye photoreceptor cell differentiation GO:0001754 2 0.017
regulation of transmembrane transporter activity GO:0022898 74 0.017
response to biotic stimulus GO:0009607 276 0.017
head development GO:0060322 108 0.017
regulation of defense response to bacterium GO:1900424 2 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
regulation of protein stability GO:0031647 87 0.016
spermatid development GO:0007286 4 0.016
negative regulation of kinase activity GO:0033673 106 0.016
mrna processing GO:0006397 133 0.016
reproduction GO:0000003 63 0.016
endoplasmic reticulum unfolded protein response GO:0030968 16 0.016
establishment of protein localization to organelle GO:0072594 172 0.016
Rat
response to oxygen radical GO:0000305 6 0.016
cellular response to nitrogen compound GO:1901699 144 0.016
response to peptide hormone GO:0043434 61 0.016
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.016
regulation of innate immune response GO:0045088 97 0.016
tube closure GO:0060606 3 0.016
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.016
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.016
erythrocyte differentiation GO:0030218 28 0.016
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
positive regulation of peptidase activity GO:0010952 88 0.015
histone modification GO:0016570 251 0.015
coagulation GO:0050817 78 0.015
glucose transport GO:0015758 30 0.015
positive regulation of defense response GO:0031349 87 0.015
carbohydrate transport GO:0008643 37 0.015
peptidyl threonine phosphorylation GO:0018107 41 0.015
immune effector process GO:0002252 159 0.015
organic anion transport GO:0015711 103 0.015
reactive nitrogen species metabolic process GO:2001057 3 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
regulation of response to biotic stimulus GO:0002831 55 0.015
embryonic pattern specification GO:0009880 5 0.014
positive regulation of response to wounding GO:1903036 28 0.014
ribonucleoprotein complex subunit organization GO:0071826 81 0.014
regulation of lipid transport GO:0032368 44 0.014
response to light stimulus GO:0009416 87 0.014
regionalization GO:0003002 29 0.014
cell part morphogenesis GO:0032990 137 0.014
regulation of actin cytoskeleton organization GO:0032956 116 0.014
chromatin modification GO:0016568 298 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
Rat
negative regulation of protein modification process GO:0031400 200 0.014
positive regulation of protein complex assembly GO:0031334 86 0.014
cellular response to unfolded protein GO:0034620 16 0.014
purine containing compound catabolic process GO:0072523 411 0.014
rho protein signal transduction GO:0007266 26 0.014
regulation of transmembrane transport GO:0034762 139 0.014
regulation of cellular protein catabolic process GO:1903362 96 0.014
cellular response to starvation GO:0009267 58 0.014
glucose import GO:0046323 24 0.014
myeloid dendritic cell activation GO:0001773 4 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
viral life cycle GO:0019058 132 0.014
tissue morphogenesis GO:0048729 96 0.014
Human
reactive oxygen species biosynthetic process GO:1903409 4 0.014
positive regulation of endopeptidase activity GO:0010950 84 0.013
regulation of protein transport GO:0051223 213 0.013
Rat
ribonucleotide catabolic process GO:0009261 405 0.013
positive regulation of proteolysis GO:0045862 142 0.013
cellular response to topologically incorrect protein GO:0035967 19 0.013
dendrite development GO:0016358 24 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
Rat
regulation of cell motility GO:2000145 299 0.013
positive regulation of apoptotic signaling pathway GO:2001235 70 0.013
regulation of phospholipid transport GO:2001138 4 0.013
cellular protein complex assembly GO:0043623 188 0.013
immune system development GO:0002520 195 0.013
regulation of oxidoreductase activity GO:0051341 43 0.013
cytokine mediated signaling pathway GO:0019221 109 0.013
regulation of mapk cascade GO:0043408 262 0.013
maintenance of protein location in cell GO:0032507 56 0.013
Rat
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.013
dephosphorylation GO:0016311 209 0.013
glycosyl compound catabolic process GO:1901658 413 0.012
positive regulation of immune response GO:0050778 159 0.012
positive regulation of transporter activity GO:0032411 32 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
multicellular organismal reproductive process GO:0048609 40 0.012
dna replication GO:0006260 116 0.012
ossification GO:0001503 121 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012
growth GO:0040007 202 0.012
positive regulation of intracellular protein transport GO:0090316 76 0.012
positive regulation of transcription during mitosis GO:0045897 2 0.012
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
carboxylic acid catabolic process GO:0046395 71 0.012
positive regulation of autophagy GO:0010508 24 0.012
memory GO:0007613 3 0.012
production of molecular mediator of immune response GO:0002440 37 0.012
regulation of dephosphorylation GO:0035303 96 0.011
positive regulation of cytoskeleton organization GO:0051495 83 0.011
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 9 0.011
response to radiation GO:0009314 151 0.011
ribonucleoside triphosphate metabolic process GO:0009199 412 0.011
secretion by cell GO:0032940 226 0.011
t cell activation GO:0042110 99 0.011
spinal cord development GO:0021510 4 0.011
cell projection morphogenesis GO:0048858 129 0.011
nucleotide catabolic process GO:0009166 408 0.011
gtp catabolic process GO:0006184 237 0.011
striated muscle contraction GO:0006941 52 0.011
regulation of immune effector process GO:0002697 91 0.011
histone methylation GO:0016571 60 0.011
response to monosaccharide GO:0034284 20 0.011
ribonucleoprotein complex assembly GO:0022618 78 0.011
regulation of antimicrobial humoral response GO:0002759 1 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
protein stabilization GO:0050821 64 0.011
peptide metabolic process GO:0006518 51 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
inorganic cation transmembrane transport GO:0098662 194 0.011
regulation of ion transmembrane transporter activity GO:0032412 72 0.011
regulation of lipid metabolic process GO:0019216 96 0.011
autophagic cell death GO:0048102 3 0.011
response to uv GO:0009411 73 0.011
positive regulation of chondrocyte differentiation GO:0032332 4 0.011
ras protein signal transduction GO:0007265 73 0.011
endocytosis GO:0006897 159 0.011
cation transport GO:0006812 331 0.011
Human
generation of neurons GO:0048699 152 0.010
meiotic chromosome segregation GO:0045132 4 0.010
regeneration GO:0031099 4 0.010
regulation of transcription during mitosis GO:0045896 2 0.010
nucleus localization GO:0051647 1 0.010
anatomical structure homeostasis GO:0060249 100 0.010
positive regulation of secretion GO:0051047 116 0.010
cell activation GO:0001775 213 0.010
positive regulation of dna repair GO:0045739 25 0.010
cellular response to extracellular stimulus GO:0031668 72 0.010
response to external biotic stimulus GO:0043207 261 0.010
positive regulation of cell proliferation GO:0008284 301 0.010
positive regulation of lymphocyte activation GO:0051251 73 0.010
regulation of kinase activity GO:0043549 314 0.010
interleukin 8 production GO:0032637 51 0.010
actin filament based process GO:0030029 224 0.010
system process GO:0003008 349 0.010
Human
multicellular organism reproduction GO:0032504 42 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010

KEAP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
eye and adnexa disease DOID:1492 150 0.018
musculoskeletal system disease DOID:17 223 0.017
connective tissue disease DOID:65 109 0.017
eye disease DOID:5614 149 0.016
central nervous system disease DOID:331 186 0.011
retinal disease DOID:5679 118 0.010