Homo sapiens

142 known processes

LEO1

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

(Aliases: RDL)

LEO1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 1.000
positive regulation of dna templated transcription elongation GO:0032786 18 1.000
mrna 3 end processing GO:0031124 24 1.000
histone h2b ubiquitination GO:0033523 8 1.000
regulation of dna templated transcription elongation GO:0032784 23 0.996
negative regulation of myeloid cell differentiation GO:0045638 42 0.994
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.992
rna 3 end processing GO:0031123 35 0.990
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.990
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.983
positive regulation of mrna metabolic process GO:1903313 19 0.981
regulation of myeloid cell differentiation GO:0045637 81 0.973
rna processing GO:0006396 255 0.962
mrna processing GO:0006397 133 0.956
post embryonic development GO:0009791 2 0.954
Worm
endodermal cell fate commitment GO:0001711 4 0.941
regulation of mrna 3 end processing GO:0031440 12 0.929
mrna metabolic process GO:0016071 175 0.916
cellular amino acid metabolic process GO:0006520 116 0.907
chromatin organization GO:0006325 351 0.901
peptidyl lysine methylation GO:0018022 37 0.889
myeloid cell differentiation GO:0030099 117 0.885
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.882
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.870
positive regulation of mrna 3 end processing GO:0031442 12 0.868
protein monoubiquitination GO:0006513 39 0.839
negative regulation of cell differentiation GO:0045596 171 0.818
negative regulation of multicellular organismal process GO:0051241 317 0.813
hematopoietic or lymphoid organ development GO:0048534 186 0.800
endodermal cell differentiation GO:0035987 31 0.798
protein ubiquitination GO:0016567 314 0.786
histone h3 k4 methylation GO:0051568 27 0.761
histone monoubiquitination GO:0010390 20 0.757
chromatin modification GO:0016568 298 0.725
dna templated transcription elongation GO:0006354 25 0.696
negative regulation of immune system process GO:0002683 136 0.672
histone lysine methylation GO:0034968 50 0.669
histone h3 k79 methylation GO:0034729 2 0.644
regulation of protein complex assembly GO:0043254 147 0.643
digestive tract morphogenesis GO:0048546 56 0.619
regulation of cellular amine metabolic process GO:0033238 11 0.594
histone ubiquitination GO:0016574 31 0.593
covalent chromatin modification GO:0016569 254 0.583
dna templated transcription termination GO:0006353 3 0.582
growth GO:0040007 202 0.565
Worm
ncrna processing GO:0034470 83 0.558
blastocyst development GO:0001824 3 0.538
protein modification by small protein conjugation GO:0032446 342 0.533
hemopoiesis GO:0030097 180 0.522
positive regulation of chromatin modification GO:1903310 30 0.512
negative regulation of developmental process GO:0051093 247 0.506
response to bacterium GO:0009617 144 0.497
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.496
regulation of chromatin organization GO:1902275 56 0.496
formation of primary germ layer GO:0001704 42 0.493
muscle system process GO:0003012 81 0.492
positive regulation of cellular component organization GO:0051130 376 0.490
histone modification GO:0016570 251 0.482
regulation of cellular component biogenesis GO:0044087 281 0.429
histone methylation GO:0016571 60 0.419
regulation of cell differentiation GO:0045595 393 0.417
cellular response to molecule of bacterial origin GO:0071219 62 0.413
peptidyl lysine trimethylation GO:0018023 10 0.409
regulation of dna templated transcription initiation GO:2000142 9 0.400
response to lipopolysaccharide GO:0032496 70 0.390
transcription from rna polymerase iii promoter GO:0006383 19 0.389
cytokine mediated signaling pathway GO:0019221 109 0.379
endocytosis GO:0006897 159 0.326
Worm
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.322
protein complex disassembly GO:0043241 52 0.316
vesicle mediated transport GO:0016192 371 0.312
Worm
gene silencing GO:0016458 49 0.308
response to external biotic stimulus GO:0043207 261 0.288
protein alkylation GO:0008213 74 0.281
response to other organism GO:0051707 261 0.279
cellular response to cytokine stimulus GO:0071345 181 0.269
embryonic morphogenesis GO:0048598 85 0.260
dna templated transcription initiation GO:0006352 35 0.256
stem cell differentiation GO:0048863 93 0.233
ncrna metabolic process GO:0034660 108 0.229
trophectodermal cell differentiation GO:0001829 3 0.226
peptidyl lysine modification GO:0018205 144 0.222
positive regulation of chromosome organization GO:2001252 41 0.222
cellular amine metabolic process GO:0044106 41 0.215
cellular response to oxygen containing compound GO:1901701 276 0.211
positive regulation of organelle organization GO:0010638 195 0.209
stem cell development GO:0048864 69 0.207
tube development GO:0035295 125 0.206
cellular response to lipopolysaccharide GO:0071222 57 0.205
rna polyadenylation GO:0043631 14 0.200
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.197
stem cell maintenance GO:0019827 19 0.189
regulation of dna metabolic process GO:0051052 153 0.188
positive regulation of histone modification GO:0031058 29 0.188
immune system development GO:0002520 195 0.186
histone h3 k4 trimethylation GO:0080182 7 0.177
receptor mediated endocytosis GO:0006898 84 0.174
Worm
erythrocyte differentiation GO:0030218 28 0.171
cellular response to dna damage stimulus GO:0006974 379 0.171
regulation of cellular amino acid metabolic process GO:0006521 6 0.170
anatomical structure formation involved in morphogenesis GO:0048646 284 0.168
cellular response to interleukin 6 GO:0071354 14 0.168
response to biotic stimulus GO:0009607 276 0.164
regulation of cell cycle process GO:0010564 266 0.161
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.160
endoderm development GO:0007492 33 0.160
regulation of cellular ketone metabolic process GO:0010565 50 0.151
digestive tract development GO:0048565 75 0.151
response to oxygen containing compound GO:1901700 369 0.146
amine metabolic process GO:0009308 44 0.140
protein methylation GO:0006479 74 0.138
cell cycle phase transition GO:0044770 173 0.138
regulation of protein ubiquitination GO:0031396 95 0.136
mrna polyadenylation GO:0006378 12 0.135
positive regulation of protein complex assembly GO:0031334 86 0.131
cell fate commitment GO:0045165 27 0.130
cell fate commitment involved in formation of primary germ layer GO:0060795 6 0.122
cellular macromolecular complex assembly GO:0034622 324 0.121
mitotic cell cycle phase transition GO:0044772 162 0.116
negative regulation of cell cycle phase transition GO:1901988 89 0.109
ncrna 3 end processing GO:0043628 4 0.103
regulation of histone modification GO:0031056 47 0.096
muscle contraction GO:0006936 73 0.095
digestive system development GO:0055123 75 0.092
gastrulation GO:0007369 51 0.089
cellular response to biotic stimulus GO:0071216 71 0.089
regulation of cellular response to stress GO:0080135 244 0.088
macromolecular complex disassembly GO:0032984 60 0.087
positive regulation of histone h3 k4 methylation GO:0051571 8 0.085
regulation of transcription by chromatin organization GO:0034401 1 0.083
embryo development GO:0009790 123 0.083
Worm
mitotic cell cycle process GO:1903047 286 0.082
macromolecule methylation GO:0043414 97 0.077
response to molecule of bacterial origin GO:0002237 82 0.076
regulation of chromosome organization GO:0033044 103 0.071
regulation of mrna processing GO:0050684 48 0.070
genetic imprinting GO:0071514 1 0.067
cell development GO:0048468 328 0.067
methylation GO:0032259 106 0.066
protein dna complex assembly GO:0065004 64 0.066
endoderm formation GO:0001706 33 0.062
embryo development ending in birth or egg hatching GO:0009792 34 0.062
Worm
negative regulation of cell cycle GO:0045786 193 0.061
oogenesis GO:0048477 2 0.061
response to lipid GO:0033993 206 0.060
ribonucleoside catabolic process GO:0042454 406 0.059
regulation of chromatin silencing GO:0031935 8 0.056
nucleoside catabolic process GO:0009164 408 0.053
female gamete generation GO:0007292 2 0.052
cell cycle g1 s phase transition GO:0044843 80 0.052
regulation of histone methylation GO:0031060 16 0.051
g1 s transition of mitotic cell cycle GO:0000082 78 0.050
nucleotide catabolic process GO:0009166 408 0.050
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.049
snorna metabolic process GO:0016074 1 0.048
blastocyst formation GO:0001825 3 0.047
negative regulation of cell cycle process GO:0010948 121 0.043
cellular ketone metabolic process GO:0042180 80 0.043
response to cytokine GO:0034097 232 0.042
regulation of response to dna damage stimulus GO:2001020 94 0.039
positive regulation of cellular amine metabolic process GO:0033240 7 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.035
dephosphorylation GO:0016311 209 0.034
negative regulation of gene expression epigenetic GO:0045814 19 0.034
positive regulation of developmental process GO:0051094 314 0.034
Worm
negative regulation of catalytic activity GO:0043086 335 0.033
purine containing compound catabolic process GO:0072523 411 0.033
reproduction GO:0000003 63 0.033
Worm
jak stat cascade GO:0007259 46 0.031
positive regulation of cellular component biogenesis GO:0044089 158 0.031
positive regulation of smoothened signaling pathway GO:0045880 4 0.031
nervous system development GO:0007399 293 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
positive regulation of transcription from rna polymerase i promoter GO:0045943 6 0.031
guanosine containing compound catabolic process GO:1901069 239 0.030
purine ribonucleoside catabolic process GO:0046130 398 0.030
regulation of mitotic cell cycle phase transition GO:1901990 118 0.030
ribonucleoside triphosphate catabolic process GO:0009203 391 0.029
development of primary sexual characteristics GO:0045137 35 0.028
Worm
erythrocyte homeostasis GO:0034101 31 0.027
regulation of cell cycle g1 s phase transition GO:1902806 42 0.027
protein dna complex subunit organization GO:0071824 80 0.027
regulation of protein kinase activity GO:0045859 289 0.027
transcription from rna polymerase i promoter GO:0006360 11 0.027
positive regulation of cell proliferation GO:0008284 301 0.026
multicellular organismal aging GO:0010259 3 0.025
regulation of mitotic cell cycle GO:0007346 189 0.025
regulation of proteolysis GO:0030162 293 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
regulation of wnt signaling pathway GO:0030111 123 0.025
chordate embryonic development GO:0043009 34 0.024
internal protein amino acid acetylation GO:0006475 101 0.024
positive regulation of histone methylation GO:0031062 12 0.023
rna interference GO:0016246 4 0.022
cytoplasmic transport GO:0016482 379 0.022
organophosphate catabolic process GO:0046434 430 0.022
cellular response to lipid GO:0071396 127 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
gtp catabolic process GO:0006184 237 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
regulation of protein stability GO:0031647 87 0.022
regulation of protein processing GO:0070613 150 0.022
segmentation GO:0035282 4 0.021
regulation of gene silencing GO:0060968 24 0.021
negative regulation of proteolysis GO:0045861 132 0.021
protein processing GO:0016485 226 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.020
system process GO:0003008 349 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
regulation of meiosis GO:0040020 3 0.020
response to interleukin 6 GO:0070741 15 0.019
microtubule based process GO:0007017 210 0.019
determination of adult lifespan GO:0008340 2 0.019
dna repair GO:0006281 198 0.019
cell growth GO:0016049 160 0.019
oocyte development GO:0048599 1 0.018
cellular component disassembly GO:0022411 92 0.018
homeostasis of number of cells GO:0048872 40 0.018
purine nucleotide catabolic process GO:0006195 405 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
ribonucleoside triphosphate metabolic process GO:0009199 412 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.018
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
gtp metabolic process GO:0046039 239 0.017
ribonucleoprotein complex biogenesis GO:0022613 116 0.017
regulation of protein complex disassembly GO:0043244 28 0.017
oocyte differentiation GO:0009994 2 0.017
rna phosphodiester bond hydrolysis GO:0090501 35 0.017
trna metabolic process GO:0006399 35 0.017
reproductive process GO:0022414 106 0.016
Worm
positive regulation of protein phosphorylation GO:0001934 313 0.016
sex differentiation GO:0007548 45 0.016
Worm
regeneration GO:0031099 4 0.016
tissue regeneration GO:0042246 3 0.015
protein catabolic process GO:0030163 325 0.015
dna templated transcriptional preinitiation complex assembly GO:0070897 5 0.015
posttranscriptional gene silencing GO:0016441 25 0.015
regulation of epithelial cell proliferation GO:0050678 113 0.015
reproductive system development GO:0061458 56 0.015
Worm
wnt signaling pathway GO:0016055 156 0.015
viral process GO:0016032 146 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
interleukin 6 mediated signaling pathway GO:0070102 7 0.015
regulation of mrna metabolic process GO:1903311 53 0.015
positive regulation of hydrolase activity GO:0051345 331 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
negative regulation of protein processing GO:0010955 142 0.015
positive regulation of wnt signaling pathway GO:0030177 54 0.014
actin filament based process GO:0030029 224 0.014
negative regulation of phosphate metabolic process GO:0045936 267 0.014
regulation of dephosphorylation GO:0035303 96 0.014
brain morphogenesis GO:0048854 1 0.014
regulation of meiotic cell cycle GO:0051445 4 0.014
cellular protein complex assembly GO:0043623 188 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
purine ribonucleotide catabolic process GO:0009154 404 0.014
neuroendocrine cell differentiation GO:0061101 2 0.013
negative regulation of dephosphorylation GO:0035305 63 0.013
organelle assembly GO:0070925 176 0.013
positive regulation of mrna processing GO:0050685 17 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
anterior posterior axis specification GO:0009948 2 0.013
response to hypoxia GO:0001666 96 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.013
neuromuscular junction development GO:0007528 3 0.013
peripheral nervous system development GO:0007422 2 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
guanosine containing compound metabolic process GO:1901068 244 0.012
response to wounding GO:0009611 168 0.012
negative regulation of protein modification process GO:0031400 200 0.012
negative regulation of mitotic cell cycle GO:0045930 102 0.012
protein destabilization GO:0031648 12 0.012
spindle organization GO:0007051 53 0.012
regulation of purine nucleotide metabolic process GO:1900542 264 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
blood vessel morphogenesis GO:0048514 162 0.012
cell activation GO:0001775 213 0.012
rrna metabolic process GO:0016072 40 0.012
regulation of protein transport GO:0051223 213 0.012
protein maturation GO:0051604 233 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
regulation of neurogenesis GO:0050767 82 0.012
regulation of dna repair GO:0006282 47 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
purine ribonucleoside metabolic process GO:0046128 437 0.011
regulation of cell cycle GO:0051726 393 0.011
regulation of growth GO:0040008 165 0.011
Worm
cardiovascular system development GO:0072358 262 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
regulation of membrane potential GO:0042391 95 0.011
rna splicing GO:0008380 131 0.011
myosin filament organization GO:0031033 2 0.011
regulation of transferase activity GO:0051338 355 0.010
viral life cycle GO:0019058 132 0.010
regulation of cellular protein catabolic process GO:1903362 96 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
protein targeting GO:0006605 187 0.010
dna conformation change GO:0071103 113 0.010

LEO1 disease predictions

Disease DO term ID Size Probability Func Analog Org
endocrine gland cancer DOID:170 26 0.655
cancer DOID:162 167 0.655
disease of cellular proliferation DOID:14566 174 0.655
organ system cancer DOID:0050686 164 0.655
endocrine system disease DOID:28 26 0.016