Homo sapiens

67 known processes

LMNA

lamin A/C

(Aliases: HGPS,LDP1,FPL,LMN1,CDCD1,LMNL1,CDDC,PRO1,EMD2,CMT2B1,LFP,LMNC,LGMD1B,IDC,FPLD,CMD1A)

LMNA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin filament based process GO:0030029 224 0.987
Worm Fly
actin cytoskeleton organization GO:0030036 207 0.957
Worm Fly
actin filament organization GO:0007015 128 0.955
Fly
cell projection organization GO:0030030 252 0.844
circulatory system development GO:0072359 262 0.830
Mouse
regulation of actin cytoskeleton organization GO:0032956 116 0.810
Fly
biological adhesion GO:0022610 331 0.801
cell adhesion GO:0007155 325 0.793
positive regulation of cellular component organization GO:0051130 376 0.789
post embryonic development GO:0009791 2 0.787
Worm
cell matrix adhesion GO:0007160 85 0.765
regulation of cytoskeleton organization GO:0051493 177 0.751
Fly
regulation of protein localization GO:0032880 296 0.723
Mouse
nucleoside catabolic process GO:0009164 408 0.698
endothelial cell migration GO:0043542 86 0.676
regulation of cellular ketone metabolic process GO:0010565 50 0.654
nucleoside phosphate catabolic process GO:1901292 412 0.640
purine nucleotide catabolic process GO:0006195 405 0.613
single organism cellular localization GO:1902580 332 0.611
Mouse Worm Fly
regulation of cell differentiation GO:0045595 393 0.590
purine nucleoside catabolic process GO:0006152 398 0.588
glycosyl compound catabolic process GO:1901658 413 0.569
cell substrate adhesion GO:0031589 132 0.568
regulation of rho protein signal transduction GO:0035023 79 0.568
single organismal cell cell adhesion GO:0016337 148 0.566
regulation of anatomical structure morphogenesis GO:0022603 286 0.565
organophosphate catabolic process GO:0046434 430 0.545
purine nucleoside triphosphate metabolic process GO:0009144 412 0.539
positive regulation of gtpase activity GO:0043547 166 0.534
guanosine containing compound metabolic process GO:1901068 244 0.503
cell activation GO:0001775 213 0.500
cell development GO:0048468 328 0.498
Mouse Worm
regulation of protein localization to nucleus GO:1900180 85 0.492
Mouse
regulation of actin filament based process GO:0032970 141 0.491
Fly
nucleoside triphosphate catabolic process GO:0009143 394 0.491
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.490
regulation of nucleoside metabolic process GO:0009118 209 0.484
single organism membrane organization GO:0044802 268 0.483
Mouse Fly
regulation of gtpase activity GO:0043087 180 0.478
establishment of protein localization to membrane GO:0090150 121 0.477
purine containing compound catabolic process GO:0072523 411 0.469
cellular response to growth factor stimulus GO:0071363 197 0.465
single organism cell adhesion GO:0098602 179 0.464
regulation of cellular amine metabolic process GO:0033238 11 0.464
chemotaxis GO:0006935 157 0.456
cellular amine metabolic process GO:0044106 41 0.450
positive regulation of gtp catabolic process GO:0033126 166 0.447
nucleoside triphosphate metabolic process GO:0009141 422 0.439
cell morphogenesis GO:0000902 296 0.432
regulation of purine nucleotide metabolic process GO:1900542 264 0.431
actin filament bundle organization GO:0061572 54 0.415
positive regulation of cell adhesion GO:0045785 84 0.410
purine nucleoside triphosphate catabolic process GO:0009146 392 0.405
ameboidal type cell migration GO:0001667 135 0.405
blood circulation GO:0008015 113 0.403
Zebrafish
regulation of cell morphogenesis GO:0022604 153 0.397
cellular component morphogenesis GO:0032989 314 0.389
Worm
cell chemotaxis GO:0060326 112 0.388
regulation of cell migration GO:0030334 289 0.386
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 412 0.386
negative regulation of organelle organization GO:0010639 126 0.379
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.377
ribonucleotide catabolic process GO:0009261 405 0.371
leukocyte migration GO:0050900 107 0.364
protein catabolic process GO:0030163 325 0.360
Worm
nucleotide catabolic process GO:0009166 408 0.357
rho protein signal transduction GO:0007266 26 0.357
nervous system development GO:0007399 293 0.347
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.344
regulation of cellular component biogenesis GO:0044087 281 0.334
Fly
i kappab kinase nf kappab signaling GO:0007249 166 0.332
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.330
regulation of actin filament bundle assembly GO:0032231 36 0.330
establishment of protein localization to plasma membrane GO:0090002 68 0.329
regulation of gtp catabolic process GO:0033124 180 0.324
guanosine containing compound catabolic process GO:1901069 239 0.322
regulation of nucleotide catabolic process GO:0030811 205 0.315
protein localization to membrane GO:0072657 160 0.309
cellular macromolecular complex assembly GO:0034622 324 0.307
Worm Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.301
regulation of establishment of protein localization GO:0070201 242 0.300
purine ribonucleoside metabolic process GO:0046128 437 0.299
positive regulation of nucleotide catabolic process GO:0030813 185 0.298
ribonucleoside triphosphate catabolic process GO:0009203 391 0.292
regulation of cellular amino acid metabolic process GO:0006521 6 0.292
positive regulation of programmed cell death GO:0043068 249 0.288
plasma membrane organization GO:0007009 115 0.285
wound healing GO:0042060 115 0.283
positive regulation of intracellular protein transport GO:0090316 76 0.281
positive regulation of transport GO:0051050 336 0.278
positive regulation of hydrolase activity GO:0051345 331 0.275
epithelial cell differentiation GO:0030855 141 0.269
response to growth factor GO:0070848 205 0.261
positive regulation of nucleoside metabolic process GO:0045979 186 0.257
enzyme linked receptor protein signaling pathway GO:0007167 303 0.254
positive regulation of cell proliferation GO:0008284 301 0.253
Worm
cellular response to endogenous stimulus GO:0071495 336 0.249
positive regulation of cytoplasmic transport GO:1903651 82 0.246
regulation of stress fiber assembly GO:0051492 32 0.245
regulation of cell substrate adhesion GO:0010810 68 0.244
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.242
small gtpase mediated signal transduction GO:0007264 78 0.242
regulation of nucleotide metabolic process GO:0006140 269 0.241
ribonucleoside catabolic process GO:0042454 406 0.238
gtp catabolic process GO:0006184 237 0.236
protein oligomerization GO:0051259 173 0.233
secretion GO:0046903 254 0.233
anatomical structure formation involved in morphogenesis GO:0048646 284 0.232
Worm
secretion by cell GO:0032940 226 0.231
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.230
positive regulation of cell death GO:0010942 263 0.229
epithelial cell migration GO:0010631 119 0.229
purine ribonucleoside catabolic process GO:0046130 398 0.229
regulation of rho gtpase activity GO:0032319 66 0.223
endomembrane system organization GO:0010256 196 0.222
Mouse Fly
protein targeting GO:0006605 187 0.220
Mouse
cell junction organization GO:0034330 79 0.219
protein localization to plasma membrane GO:0072659 93 0.218
growth GO:0040007 202 0.218
Worm
neuron differentiation GO:0030182 138 0.216
protein import GO:0017038 130 0.212
Mouse
response to inorganic substance GO:0010035 127 0.212
amine metabolic process GO:0009308 44 0.210
regulation of locomotion GO:0040012 329 0.208
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.208
positive regulation of protein transport GO:0051222 135 0.207
purine ribonucleotide catabolic process GO:0009154 404 0.206
intracellular protein transport GO:0006886 270 0.204
Mouse
actin filament bundle assembly GO:0051017 54 0.201
inorganic cation transmembrane transport GO:0098662 194 0.200
cytoplasmic transport GO:0016482 379 0.194
Mouse
regulation of intracellular transport GO:0032386 195 0.193
protein localization to nucleus GO:0034504 136 0.192
Mouse Fly
response to wounding GO:0009611 168 0.190
mitotic nuclear division GO:0007067 119 0.189
Worm
stress fiber assembly GO:0043149 40 0.188
positive regulation of apoptotic process GO:0043065 246 0.175
positive regulation of ras gtpase activity GO:0032320 117 0.170
blood vessel endothelial cell migration GO:0043534 42 0.169
ras protein signal transduction GO:0007265 73 0.168
cell part morphogenesis GO:0032990 137 0.167
vasculature development GO:0001944 181 0.164
regulation of cell motility GO:2000145 299 0.161
Mouse
leukotriene a4 metabolic process GO:1901751 1 0.161
response to abiotic stimulus GO:0009628 336 0.160
response to lipid GO:0033993 206 0.160
organelle assembly GO:0070925 176 0.157
Worm
circulatory system process GO:0003013 113 0.154
Zebrafish
regulation of ras gtpase activity GO:0032318 128 0.151
gtp metabolic process GO:0046039 239 0.150
myeloid cell differentiation GO:0030099 117 0.150
homotypic cell cell adhesion GO:0034109 47 0.149
taxis GO:0042330 157 0.149
cellular ketone metabolic process GO:0042180 80 0.148
cell junction assembly GO:0034329 67 0.148
negative regulation of cellular component movement GO:0051271 106 0.148
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.144
locomotory behavior GO:0007626 1 0.143
Fly
regulation of protein import into nucleus GO:0042306 78 0.143
cellular component assembly involved in morphogenesis GO:0010927 73 0.142
Worm
system process GO:0003008 349 0.142
Zebrafish
negative regulation of multicellular organismal process GO:0051241 317 0.142
regulation of peptidase activity GO:0052547 180 0.140
positive regulation of cell substrate adhesion GO:0010811 37 0.140
positive regulation of protein localization to nucleus GO:1900182 48 0.139
positive regulation of cell migration GO:0030335 172 0.139
mitotic cell cycle process GO:1903047 286 0.139
Worm Fly
positive regulation of intracellular transport GO:0032388 104 0.138
cardiovascular system development GO:0072358 262 0.138
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.138
muscle structure development GO:0061061 98 0.137
platelet aggregation GO:0070527 32 0.135
regulation of protein transport GO:0051223 213 0.134
regulation of microtubule cytoskeleton organization GO:0070507 61 0.133
response to oxygen containing compound GO:1901700 369 0.133
nucleocytoplasmic transport GO:0006913 176 0.133
Mouse
regulation of proteolysis GO:0030162 293 0.133
positive regulation of catabolic process GO:0009896 310 0.131
vesicle mediated transport GO:0016192 371 0.131
Worm
nuclear division GO:0000280 128 0.130
Worm
positive regulation of cellular component movement GO:0051272 181 0.125
negative regulation of apoptotic process GO:0043066 316 0.125
Mouse
substrate adhesion dependent cell spreading GO:0034446 41 0.125
cellular response to abiotic stimulus GO:0071214 117 0.124
cellular amino acid metabolic process GO:0006520 116 0.123
regulation of cardiac muscle cell membrane potential GO:0086036 1 0.122
positive regulation of cell differentiation GO:0045597 211 0.119
regulation of small gtpase mediated signal transduction GO:0051056 156 0.118
multicellular organismal aging GO:0010259 3 0.117
Worm
regulation of endopeptidase activity GO:0052548 170 0.116
positive regulation of nucleotide metabolic process GO:0045981 230 0.116
peptidyl tyrosine phosphorylation GO:0018108 170 0.116
membrane organization GO:0061024 292 0.115
Mouse Fly
positive regulation of axon extension GO:0045773 4 0.114
positive regulation of cellular amine metabolic process GO:0033240 7 0.114
positive regulation of cell development GO:0010720 92 0.114
negative regulation of cellular protein metabolic process GO:0032269 353 0.113
autophagy GO:0006914 88 0.113
organ morphogenesis GO:0009887 147 0.112
Fly
positive regulation of cell motility GO:2000147 177 0.111
negative regulation of transport GO:0051051 176 0.110
negative regulation of protein catabolic process GO:0042177 59 0.110
protein processing GO:0016485 226 0.110
generation of neurons GO:0048699 152 0.108
cellular response to external stimulus GO:0071496 111 0.106
motor neuron axon guidance GO:0008045 2 0.105
regulation of purine nucleotide catabolic process GO:0033121 205 0.105
cation transmembrane transport GO:0098655 238 0.104
metal ion transport GO:0030001 272 0.101
female gamete generation GO:0007292 2 0.101
regulation of anatomical structure size GO:0090066 101 0.100
Fly
regulation of cell adhesion GO:0030155 166 0.100
leukocyte chemotaxis GO:0030595 76 0.099
response to biotic stimulus GO:0009607 276 0.099
positive regulation of defense response GO:0031349 87 0.099
positive regulation of rho gtpase activity GO:0032321 56 0.098
muscle contraction GO:0006936 73 0.098
negative regulation of cell migration GO:0030336 102 0.097
muscle organ development GO:0007517 56 0.096
cell substrate adherens junction assembly GO:0007045 30 0.095
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.095
microtubule based process GO:0007017 210 0.095
Mouse Fly
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.094
regulation of cellular component movement GO:0051270 334 0.094
Mouse
positive regulation of actin filament bundle assembly GO:0032233 25 0.094
regulation of protein targeting GO:1903533 91 0.093
positive regulation of rac gtpase activity GO:0032855 31 0.093
determination of adult lifespan GO:0008340 2 0.092
Worm
embryo development GO:0009790 123 0.091
Worm
negative regulation of protein metabolic process GO:0051248 391 0.091
protein localization to cell surface GO:0034394 28 0.091
organic hydroxy compound metabolic process GO:1901615 147 0.090
innate immune response GO:0045087 178 0.090
hepoxilin metabolic process GO:0051121 1 0.090
regulation of membrane potential GO:0042391 95 0.090
regulation of neurogenesis GO:0050767 82 0.089
angiogenesis GO:0001525 147 0.088
regulation of cell growth GO:0001558 135 0.087
regulation of mitotic cell cycle GO:0007346 189 0.087
Worm
cell projection morphogenesis GO:0048858 129 0.086
neuron projection development GO:0031175 106 0.084
coagulation GO:0050817 78 0.083
myeloid leukocyte migration GO:0097529 62 0.081
positive regulation of phosphorylation GO:0042327 394 0.081
blood vessel morphogenesis GO:0048514 162 0.080
neuron projection regeneration GO:0031102 1 0.079
response to other organism GO:0051707 261 0.079
regulation of protein complex assembly GO:0043254 147 0.078
Fly
interleukin 1 production GO:0032612 26 0.078
regulation of epithelial cell migration GO:0010632 93 0.078
nucleoside monophosphate metabolic process GO:0009123 191 0.077
neurological system process GO:0050877 163 0.076
regulation of defense response GO:0031347 154 0.076
negative regulation of catabolic process GO:0009895 104 0.076
muscle cell development GO:0055001 29 0.076
Mouse Worm
cell growth GO:0016049 160 0.075
positive regulation of developmental process GO:0051094 314 0.075
regulation of cell development GO:0060284 161 0.074
endocytosis GO:0006897 159 0.074
Worm
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.073
intrinsic apoptotic signaling pathway GO:0097193 127 0.073
regulation of cell matrix adhesion GO:0001952 42 0.072
positive regulation of cell growth GO:0030307 48 0.072
regulation of metal ion transport GO:0010959 120 0.072
positive regulation of cholesterol storage GO:0010886 4 0.071
tissue migration GO:0090130 119 0.071
response to external biotic stimulus GO:0043207 261 0.071
blood vessel development GO:0001568 172 0.071
regulation of apoptotic signaling pathway GO:2001233 175 0.070
Mouse
organelle fission GO:0048285 149 0.069
Worm
modification dependent protein catabolic process GO:0019941 209 0.068
protein targeting to nucleus GO:0044744 104 0.067
Mouse
nuclear transport GO:0051169 179 0.067
Mouse
dna replication dependent nucleosome assembly GO:0006335 32 0.066
cell projection assembly GO:0030031 126 0.066
protein localization to organelle GO:0033365 280 0.066
Mouse Fly
positive regulation of locomotion GO:0040017 186 0.066
cell aging GO:0007569 52 0.065
regulation of cellular component size GO:0032535 82 0.065
Fly
cellular response to oxygen containing compound GO:1901701 276 0.063
protein maturation GO:0051604 233 0.063
regulation of response to wounding GO:1903034 101 0.062
response to radiation GO:0009314 151 0.062
transmembrane transport GO:0055085 399 0.061
histone modification GO:0016570 251 0.061
negative regulation of programmed cell death GO:0043069 321 0.061
Mouse
negative regulation of cytoskeleton organization GO:0051494 45 0.060
memory GO:0007613 3 0.060
negative regulation of protein maturation GO:1903318 142 0.060
associative learning GO:0008306 1 0.060
positive regulation of cellular component biogenesis GO:0044089 158 0.060
response to light stimulus GO:0009416 87 0.058
renal system development GO:0072001 63 0.058
calcium ion transmembrane transport GO:0070588 76 0.057
regulation of intracellular protein transport GO:0033157 123 0.057
thiamine transport GO:0015888 3 0.056
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.056
inflammatory response GO:0006954 79 0.056
cytokine production GO:0001816 247 0.055
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.054
negative regulation of cellular component organization GO:0051129 235 0.054
Mouse
cell substrate junction assembly GO:0007044 35 0.054
establishment of protein localization to organelle GO:0072594 172 0.054
Mouse
single organism nuclear import GO:1902593 104 0.053
Mouse
neurogenesis GO:0022008 169 0.053
positive regulation of cell matrix adhesion GO:0001954 23 0.053
dna repair GO:0006281 198 0.053
nitrogen compound transport GO:0071705 191 0.052
cellular lipid metabolic process GO:0044255 303 0.052
positive regulation of organelle organization GO:0010638 195 0.052
response to transforming growth factor beta GO:0071559 94 0.052
response to decreased oxygen levels GO:0036293 96 0.052
thiamine transmembrane transport GO:0071934 2 0.052
post embryonic organ development GO:0048569 1 0.051
actomyosin structure organization GO:0031032 59 0.051
Worm
regulation of growth GO:0040008 165 0.051
Worm
cilium morphogenesis GO:0060271 75 0.051
protein depolymerization GO:0051261 30 0.051
regulation of actin polymerization or depolymerization GO:0008064 56 0.050
Fly
negative regulation of response to external stimulus GO:0032102 83 0.050
protein homooligomerization GO:0051260 100 0.050
regulation of response to external stimulus GO:0032101 222 0.049
regulation of vasculature development GO:1901342 97 0.049
regulation of blood vessel size GO:0050880 18 0.048
bleb assembly GO:0032060 6 0.048
cellular response to nutrient levels GO:0031669 69 0.048
covalent chromatin modification GO:0016569 254 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.047
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.047
actin polymerization or depolymerization GO:0008154 56 0.047
Fly
cellular macromolecule catabolic process GO:0044265 380 0.047
hemopoiesis GO:0030097 180 0.047
sensory perception of smell GO:0007608 2 0.047
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.046
hematopoietic or lymphoid organ development GO:0048534 186 0.046
regulation of protein catabolic process GO:0042176 155 0.046
regulation of ras protein signal transduction GO:0046578 155 0.045
chromosome segregation GO:0007059 114 0.045
Worm
regulation of body fluid levels GO:0050878 99 0.045
leukocyte migration involved in inflammatory response GO:0002523 2 0.045
ubiquitin dependent protein catabolic process GO:0006511 206 0.045
regulation of nucleocytoplasmic transport GO:0046822 98 0.045
regulation of ion transport GO:0043269 189 0.045
regulation of microtubule based process GO:0032886 74 0.045
neuron projection morphogenesis GO:0048812 50 0.045
nucleotide excision repair GO:0006289 31 0.045
epithelium migration GO:0090132 119 0.045
negative regulation of protein transport GO:0051224 75 0.045
anterior posterior axis specification GO:0009948 2 0.045
proteasomal protein catabolic process GO:0010498 176 0.044
negative regulation of proteolysis GO:0045861 132 0.043
calcium ion transport GO:0006816 147 0.043
peptidyl lysine acetylation GO:0018394 101 0.043
neuron development GO:0048666 113 0.042
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.042
Mouse
cellular response to mechanical stimulus GO:0071260 39 0.042
cellular response to oxidative stress GO:0034599 85 0.042
response to lipopolysaccharide GO:0032496 70 0.041
regulation of cytoplasmic transport GO:1903649 149 0.041
mitotic cell cycle phase transition GO:0044772 162 0.041
nucleosome assembly GO:0006334 50 0.041
regulation of protein stability GO:0031647 87 0.040
mitotic cell cycle checkpoint GO:0007093 68 0.040
adherens junction assembly GO:0034333 34 0.040
lipoxin b4 metabolic process GO:2001304 1 0.040
central nervous system development GO:0007417 123 0.040
Fly
regulation of transcription factor import into nucleus GO:0042990 39 0.040
regulation of wnt signaling pathway GO:0030111 123 0.040
peripheral nervous system development GO:0007422 2 0.039
response to nutrient levels GO:0031667 81 0.039
divalent inorganic cation transport GO:0072511 158 0.039
cell cycle phase transition GO:0044770 173 0.039
cell division GO:0051301 168 0.039
regulation of angiogenesis GO:0045765 92 0.039
fatty acid metabolic process GO:0006631 115 0.038
cellular protein catabolic process GO:0044257 261 0.038
behavior GO:0007610 112 0.038
Worm Fly
protein tetramerization GO:0051262 47 0.038
platelet activation GO:0030168 44 0.038
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.038
adenylate cyclase inhibiting dopamine receptor signaling pathway GO:0007195 4 0.037
regulation of chromosome segregation GO:0051983 44 0.037
Worm
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.037
regulation of secretion by cell GO:1903530 177 0.037
lipid localization GO:0010876 106 0.036
hemostasis GO:0007599 76 0.036
regulation of proteasomal protein catabolic process GO:0061136 87 0.036
response to hypoxia GO:0001666 96 0.036
adherens junction organization GO:0034332 36 0.036
cellular protein complex assembly GO:0043623 188 0.036
Worm Fly
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.035
positive regulation of response to external stimulus GO:0032103 88 0.035
gastrulation GO:0007369 51 0.035
cell cell junction organization GO:0045216 69 0.035
negative regulation of protein modification process GO:0031400 200 0.035
oogenesis GO:0048477 2 0.035
regulation of calcium ion transport GO:0051924 79 0.035
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.034
regulation of cell projection organization GO:0031344 107 0.034
atp catabolic process GO:0006200 157 0.034
aging GO:0007568 66 0.034
regulation of immune response GO:0050776 201 0.034
dna replication independent nucleosome organization GO:0034724 27 0.034
actin filament based movement GO:0030048 17 0.034
positive regulation of protein import into nucleus GO:0042307 46 0.034
negative regulation of cellular catabolic process GO:0031330 83 0.034
vitamin transmembrane transport GO:0035461 4 0.034
negative regulation of locomotion GO:0040013 118 0.033
chronological cell aging GO:0001300 2 0.033
sprouting angiogenesis GO:0002040 29 0.033
protein acetylation GO:0006473 116 0.033
regulation of system process GO:0044057 101 0.033
negative regulation of hydrolase activity GO:0051346 182 0.033
regulation of gene silencing GO:0060968 24 0.033
reproductive process GO:0022414 106 0.033
Rat Worm Fly
sister chromatid segregation GO:0000819 54 0.033
negative regulation of chromosome organization GO:2001251 48 0.033
cell cycle checkpoint GO:0000075 117 0.033
mapk cascade GO:0000165 288 0.033
cilium assembly GO:0042384 63 0.033
response to oxidative stress GO:0006979 121 0.032
dna replication independent nucleosome assembly GO:0006336 27 0.032
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.032
regulation of chromosome organization GO:0033044 103 0.032
spindle checkpoint GO:0031577 26 0.032
regulation of protein processing GO:0070613 150 0.031
g2 m transition of mitotic cell cycle GO:0000086 41 0.031
regulation of actin filament polymerization GO:0030833 50 0.031
Fly
negative regulation of catalytic activity GO:0043086 335 0.031
peptidyl tyrosine modification GO:0018212 170 0.031
protein secretion GO:0009306 98 0.031
regulation of cell junction assembly GO:1901888 29 0.031
single organism reproductive process GO:0044702 98 0.031
Rat Worm Fly
apoptotic signaling pathway GO:0097190 268 0.031
Mouse
skin development GO:0043588 76 0.031
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.031
maintenance of location GO:0051235 112 0.031
posttranscriptional regulation of gene expression GO:0010608 213 0.031
regulation of endothelial cell migration GO:0010594 67 0.030
negative regulation of cellular protein catabolic process GO:1903363 38 0.030
negative regulation of protein complex disassembly GO:0043242 20 0.030
protein heterotetramerization GO:0051290 3 0.030
modification dependent macromolecule catabolic process GO:0043632 212 0.030
axon development GO:0061564 34 0.030
regulation of transferase activity GO:0051338 355 0.030
morphogenesis of embryonic epithelium GO:0016331 4 0.030
immune response GO:0006955 307 0.030
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.029
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.029
neurotransmitter secretion GO:0007269 4 0.029
establishment of planar polarity GO:0001736 3 0.029
response to extracellular stimulus GO:0009991 85 0.029
regulation of protein kinase activity GO:0045859 289 0.029
negative regulation of cell cycle phase transition GO:1901988 89 0.029
positive regulation of proteolysis GO:0045862 142 0.028
regulation of cytokine production GO:0001817 232 0.028
macromolecular complex disassembly GO:0032984 60 0.028
nuclear import GO:0051170 106 0.028
Mouse
regulation of cell division GO:0051302 116 0.028
spindle organization GO:0007051 53 0.028
positive regulation of cytoskeleton organization GO:0051495 83 0.028
regulation of nervous system development GO:0051960 88 0.028
protein acylation GO:0043543 138 0.028
response to hormone GO:0009725 175 0.028
interleukin 1 secretion GO:0050701 18 0.027
regulation of cell cell adhesion GO:0022407 57 0.027
cell adhesion mediated by integrin GO:0033627 27 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.027
positive regulation of endopeptidase activity GO:0010950 84 0.027
positive regulation of peptidase activity GO:0010952 88 0.026
mitotic cell cycle GO:0000278 326 0.026
Worm Fly
dna replication dependent nucleosome organization GO:0034723 32 0.026
regulation of cellular protein catabolic process GO:1903362 96 0.026
neutrophil chemotaxis GO:0030593 24 0.026
positive regulation of nervous system development GO:0051962 54 0.026
regulation of protein localization to plasma membrane GO:1903076 40 0.026
regulation of ion homeostasis GO:2000021 73 0.026
regulation of protein localization to cell surface GO:2000008 15 0.025
brain development GO:0007420 97 0.025
adult locomotory behavior GO:0008344 1 0.025
Fly
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.025
viral life cycle GO:0019058 132 0.025
cell fate determination GO:0001709 3 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025

LMNA disease predictions

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 114 0.448
musculoskeletal system disease DOID:17 223 0.448
myopathy DOID:423 104 0.313
muscular dystrophy DOID:9884 51 0.313
muscle tissue disease DOID:66 113 0.313
kidney disease DOID:557 36 0.302
urinary system disease DOID:18 40 0.302
bone disease DOID:0080001 88 0.033
connective tissue disease DOID:65 109 0.033
central nervous system disease DOID:331 186 0.031
neurodegenerative disease DOID:1289 102 0.031
nervous system disease DOID:863 431 0.031
bone development disease DOID:0080006 55 0.026