Homo sapiens

491 known processes

LRRK2

leucine-rich repeat kinase 2

(Aliases: ROCO2,DARDARIN,PARK8,RIPK7,AURA17)

LRRK2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of neurotransmitter secretion GO:0046928 3 0.999
neurotransmitter secretion GO:0007269 4 0.999
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.999
regulation of synaptic vesicle exocytosis GO:2000300 2 0.997
positive regulation of protein kinase activity GO:0045860 190 0.995
positive regulation of cellular component organization GO:0051130 376 0.990
neural tube formation GO:0001841 3 0.988
negative regulation of non canonical wnt signaling pathway GO:2000051 1 0.987
positive regulation of mapk cascade GO:0043410 190 0.986
positive regulation of map kinase activity GO:0043406 80 0.982
positive regulation of phosphorylation GO:0042327 394 0.981
regulation of protein serine threonine kinase activity GO:0071900 179 0.981
embryonic epithelial tube formation GO:0001838 4 0.971
cellular component morphogenesis GO:0032989 314 0.969
regulation of mapk cascade GO:0043408 262 0.968
positive regulation of transferase activity GO:0051347 227 0.966
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.958
regulation of intracellular transport GO:0032386 195 0.957
cell development GO:0048468 328 0.957
establishment of vesicle localization GO:0051650 23 0.956
regulation of heart induction GO:0090381 2 0.951
outflow tract septum morphogenesis GO:0003148 4 0.949
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.948
purine ribonucleoside catabolic process GO:0046130 398 0.943
wnt signaling pathway planar cell polarity pathway GO:0060071 5 0.941
purine ribonucleoside metabolic process GO:0046128 437 0.941
cell cell signaling GO:0007267 155 0.940
positive regulation of cytoplasmic transport GO:1903651 82 0.937
microtubule cytoskeleton organization GO:0000226 176 0.931
Fly
positive regulation of transport GO:0051050 336 0.924
regulation of cell projection organization GO:0031344 107 0.923
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.915
positive regulation of catabolic process GO:0009896 310 0.913
blood circulation GO:0008015 113 0.911
positive regulation of apoptotic process GO:0043065 246 0.910
regulation of protein kinase activity GO:0045859 289 0.907
mapk cascade GO:0000165 288 0.904
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.900
establishment or maintenance of monopolar cell polarity GO:0061339 1 0.900
synaptic vesicle endocytosis GO:0048488 2 0.900
Fly
lipid transport GO:0006869 90 0.895
positive regulation of protein phosphorylation GO:0001934 313 0.893
positive regulation of kinase activity GO:0033674 204 0.886
synaptic vesicle exocytosis GO:0016079 3 0.886
purine containing compound catabolic process GO:0072523 411 0.882
nucleoside triphosphate metabolic process GO:0009141 422 0.882
wnt signaling pathway involved in heart development GO:0003306 5 0.877
protein polymerization GO:0051258 71 0.873
single organism membrane organization GO:0044802 268 0.871
synaptic vesicle localization GO:0097479 5 0.871
guanosine containing compound metabolic process GO:1901068 244 0.871
regulation of ion transport GO:0043269 189 0.870
membrane organization GO:0061024 292 0.865
regulation of kinase activity GO:0043549 314 0.863
activation of protein kinase activity GO:0032147 90 0.856
primary neural tube formation GO:0014020 3 0.849
establishment of monopolar cell polarity GO:0061162 1 0.847
regulation of cellular ketone metabolic process GO:0010565 50 0.846
nucleotide catabolic process GO:0009166 408 0.845
regulation of cellular component biogenesis GO:0044087 281 0.843
positive regulation of cell death GO:0010942 263 0.841
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.841
heart induction GO:0003129 4 0.841
striated muscle contraction GO:0006941 52 0.825
regulation of cellular amine metabolic process GO:0033238 11 0.824
positive regulation of cellular amine metabolic process GO:0033240 7 0.821
heart formation GO:0060914 2 0.819
nucleoside phosphate catabolic process GO:1901292 412 0.802
anatomical structure formation involved in morphogenesis GO:0048646 284 0.801
neuron differentiation GO:0030182 138 0.797
tube closure GO:0060606 3 0.796
regulation of neurotransmitter levels GO:0001505 15 0.794
positive regulation of intracellular transport GO:0032388 104 0.788
specification of organ identity GO:0010092 3 0.787
protein localization to organelle GO:0033365 280 0.785
system process GO:0003008 349 0.779
regulation of jnk cascade GO:0046328 73 0.778
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.777
regulation of map kinase activity GO:0043405 108 0.771
regulation of neurotransmitter transport GO:0051588 7 0.768
establishment of organelle localization GO:0051656 59 0.768
developmental cell growth GO:0048588 18 0.768
Worm
purine nucleoside triphosphate catabolic process GO:0009146 392 0.763
nucleoside catabolic process GO:0009164 408 0.760
regulation of heart morphogenesis GO:2000826 4 0.760
regulation of microtubule based process GO:0032886 74 0.759
Fly
establishment of tissue polarity GO:0007164 3 0.751
cellular response to oxygen containing compound GO:1901701 276 0.749
positive regulation of immune response GO:0050778 159 0.748
regulation of transferase activity GO:0051338 355 0.747
regulation of cytoskeleton organization GO:0051493 177 0.745
Fly
sterol transport GO:0015918 39 0.741
actin filament organization GO:0007015 128 0.731
single organism cellular localization GO:1902580 332 0.731
non canonical wnt signaling pathway GO:0035567 14 0.719
positive regulation of developmental process GO:0051094 314 0.718
anion transport GO:0006820 161 0.718
morphogenesis of a polarized epithelium GO:0001738 3 0.716
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 1 0.710
secretion GO:0046903 254 0.707
positive regulation of programmed cell death GO:0043068 249 0.706
vacuole organization GO:0007033 44 0.698
regulation of cellular amino acid metabolic process GO:0006521 6 0.696
ribonucleoside triphosphate metabolic process GO:0009199 412 0.694
circulatory system process GO:0003013 113 0.691
ribonucleoside triphosphate catabolic process GO:0009203 391 0.687
cellular response to abiotic stimulus GO:0071214 117 0.687
negative regulation of apoptotic process GO:0043066 316 0.681
stress activated protein kinase signaling cascade GO:0031098 94 0.677
wnt signaling pathway GO:0016055 156 0.676
response to salt stress GO:0009651 3 0.672
organelle inheritance GO:0048308 2 0.672
purine nucleoside catabolic process GO:0006152 398 0.671
nervous system development GO:0007399 293 0.664
amine metabolic process GO:0009308 44 0.664
positive regulation of jun kinase activity GO:0043507 23 0.660
regulation of protein polymerization GO:0032271 63 0.658
actin filament based process GO:0030029 224 0.651
ribonucleotide catabolic process GO:0009261 405 0.651
establishment of planar polarity GO:0001736 3 0.650
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.648
synaptic transmission GO:0007268 61 0.647
growth GO:0040007 202 0.643
Worm
positive regulation of protein tyrosine kinase activity GO:0061098 24 0.639
peptidyl serine phosphorylation GO:0018105 101 0.635
neuroblast division GO:0055057 1 0.631
carbohydrate metabolic process GO:0005975 207 0.627
canonical wnt signaling pathway GO:0060070 116 0.616
regulation of mitosis GO:0007088 63 0.607
response to reactive oxygen species GO:0000302 61 0.606
negative regulation of catalytic activity GO:0043086 335 0.604
regulation of stress activated mapk cascade GO:0032872 84 0.603
morphogenesis of a branching structure GO:0001763 21 0.595
regulation of cellular response to stress GO:0080135 244 0.593
cardioblast cell fate commitment GO:0042684 1 0.588
cellular protein complex assembly GO:0043623 188 0.586
negative regulation of cardiac muscle tissue development GO:0055026 7 0.586
cellular ketone metabolic process GO:0042180 80 0.577
organophosphate catabolic process GO:0046434 430 0.576
mammary gland formation GO:0060592 1 0.574
activation of innate immune response GO:0002218 55 0.566
synaptic vesicle recycling GO:0036465 3 0.561
Fly
dendrite development GO:0016358 24 0.560
regulation of microtubule cytoskeleton organization GO:0070507 61 0.559
Fly
signal transduction by phosphorylation GO:0023014 297 0.557
regulation of fatty acid transport GO:2000191 8 0.555
negative regulation of phosphate metabolic process GO:0045936 267 0.551
activation of mapk activity GO:0000187 45 0.546
heart field specification GO:0003128 2 0.534
organic hydroxy compound transport GO:0015850 63 0.526
regulation of carbohydrate metabolic process GO:0006109 54 0.524
positive regulation of stress activated mapk cascade GO:0032874 60 0.523
regulation of cellular component size GO:0032535 82 0.518
neural tube closure GO:0001843 3 0.517
endomembrane system organization GO:0010256 196 0.513
regulation of nucleoside metabolic process GO:0009118 209 0.512
ion transmembrane transport GO:0034220 338 0.511
regulation of proteolysis GO:0030162 293 0.508
Mouse
response to abiotic stimulus GO:0009628 336 0.506
positive regulation of cellular catabolic process GO:0031331 284 0.502
regulation of organ formation GO:0003156 4 0.499
organelle fission GO:0048285 149 0.492
negative regulation of protein modification process GO:0031400 200 0.489
Mouse
peptidyl threonine modification GO:0018210 45 0.478
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.477
immune response activating signal transduction GO:0002757 90 0.477
regulation of protein targeting GO:1903533 91 0.477
neurotransmitter transport GO:0006836 10 0.476
regulation of anion transport GO:0044070 25 0.473
activation of immune response GO:0002253 114 0.473
negative regulation of cellular protein metabolic process GO:0032269 353 0.471
Mouse
organelle localization GO:0051640 84 0.470
exocytosis GO:0006887 71 0.467
regulation of protein localization GO:0032880 296 0.466
positive regulation of axon extension GO:0045773 4 0.462
retinal ganglion cell axon guidance GO:0031290 2 0.459
negative regulation of cell fate commitment GO:0010454 3 0.459
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.459
positive regulation of defense response GO:0031349 87 0.456
vesicle localization GO:0051648 26 0.455
developmental growth involved in morphogenesis GO:0060560 23 0.454
Worm
gtp catabolic process GO:0006184 237 0.452
cellular calcium ion homeostasis GO:0006874 117 0.447
apoptotic signaling pathway GO:0097190 268 0.447
establishment of protein localization to organelle GO:0072594 172 0.446
non canonical wnt signaling pathway via jnk cascade GO:0038031 3 0.445
negative regulation of cardioblast differentiation GO:0051892 2 0.438
regulation of establishment of planar polarity GO:0090175 5 0.437
purine ribonucleotide catabolic process GO:0009154 404 0.435
regulation of nucleotide metabolic process GO:0006140 269 0.435
cell morphogenesis GO:0000902 296 0.434
cell projection organization GO:0030030 252 0.434
epidermis morphogenesis GO:0048730 3 0.431
modification dependent protein catabolic process GO:0019941 209 0.430
Mouse
negative chemotaxis GO:0050919 11 0.430
heart process GO:0003015 62 0.429
postsynaptic membrane organization GO:0001941 2 0.428
morphogenesis of embryonic epithelium GO:0016331 4 0.426
cell type specific apoptotic process GO:0097285 125 0.424
response to oxygen containing compound GO:1901700 369 0.423
establishment of apical basal cell polarity GO:0035089 1 0.423
cellular divalent inorganic cation homeostasis GO:0072503 128 0.420
negative regulation of synaptic transmission GO:0050805 2 0.420
receptor internalization GO:0031623 43 0.419
convergent extension GO:0060026 1 0.413
heart contraction GO:0060047 62 0.409
purine nucleoside triphosphate metabolic process GO:0009144 412 0.408
cellular amino acid metabolic process GO:0006520 116 0.408
single organism carbohydrate metabolic process GO:0044723 193 0.406
transmembrane transport GO:0055085 399 0.404
hindlimb morphogenesis GO:0035137 2 0.403
neuromuscular junction development GO:0007528 3 0.403
positive regulation of jnk cascade GO:0046330 52 0.397
regulation of anatomical structure size GO:0090066 101 0.394
Mouse
regulation of secretion by cell GO:1903530 177 0.391
g protein coupled receptor signaling pathway GO:0007186 207 0.388
peptidyl tyrosine modification GO:0018212 170 0.388
regulation of mitotic cell cycle GO:0007346 189 0.383
vesicle mediated transport GO:0016192 371 0.382
epithelium development GO:0060429 227 0.381
cytoplasmic transport GO:0016482 379 0.380
post embryonic development GO:0009791 2 0.376
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 2 0.376
glycosyl compound catabolic process GO:1901658 413 0.375
negative regulation of cardioblast cell fate specification GO:0009997 1 0.375
intracellular protein transport GO:0006886 270 0.373
regulation of cytoplasmic transport GO:1903649 149 0.363
negative regulation of programmed cell death GO:0043069 321 0.363
muscle system process GO:0003012 81 0.354
cell projection morphogenesis GO:0048858 129 0.348
positive regulation of cell differentiation GO:0045597 211 0.348
tube morphogenesis GO:0035239 95 0.347
positive regulation of organelle organization GO:0010638 195 0.347
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.343
regulation of calcium ion transport GO:0051924 79 0.342
locomotory behavior GO:0007626 1 0.337
Mouse
regulation of synaptic vesicle transport GO:1902803 3 0.333
ubiquitin dependent protein catabolic process GO:0006511 206 0.332
Mouse
regulation of cardioblast cell fate specification GO:0042686 1 0.330
lipid localization GO:0010876 106 0.327
jnk cascade GO:0007254 80 0.327
cardiac muscle contraction GO:0060048 34 0.324
regulation of excitatory postsynaptic membrane potential GO:0060079 1 0.321
Mouse
negative regulation of protein kinase activity GO:0006469 98 0.317
positive regulation of gtp catabolic process GO:0033126 166 0.316
embryonic forelimb morphogenesis GO:0035115 4 0.314
small gtpase mediated signal transduction GO:0007264 78 0.313
peptidyl tyrosine phosphorylation GO:0018108 170 0.311
regulation of immune response GO:0050776 201 0.309
cell division GO:0051301 168 0.309
generation of neurons GO:0048699 152 0.309
myoblast fusion GO:0007520 1 0.306
regulation of actin cytoskeleton organization GO:0032956 116 0.305
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.304
positive regulation of cell projection organization GO:0031346 64 0.303
collateral sprouting GO:0048668 2 0.298
positive regulation of cellular protein catabolic process GO:1903364 37 0.297
Mouse
regulation of protein transport GO:0051223 213 0.297
organ morphogenesis GO:0009887 147 0.296
Mouse
positive regulation of organic acid transport GO:0032892 3 0.295
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.295
Mouse
developmental growth GO:0048589 48 0.293
Worm
response to cytokine GO:0034097 232 0.292
neuron projection extension GO:1990138 14 0.291
Worm
guanosine containing compound catabolic process GO:1901069 239 0.291
negative regulation of cell death GO:0060548 345 0.291
positive regulation of protein polymerization GO:0032273 45 0.290
negative regulation of hydrolase activity GO:0051346 182 0.288
purine nucleotide catabolic process GO:0006195 405 0.285
cellular response to metal ion GO:0071248 43 0.283
stem cell division GO:0017145 2 0.278
cellular amine metabolic process GO:0044106 41 0.277
establishment or maintenance of cell polarity GO:0007163 31 0.276
carboxylic acid transport GO:0046942 63 0.276
vesicle organization GO:0016050 62 0.274
mitotic cell cycle GO:0000278 326 0.274
cellular macromolecule catabolic process GO:0044265 380 0.272
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.270
ribonucleoside catabolic process GO:0042454 406 0.269
reproductive process GO:0022414 106 0.268
regulation of cardioblast differentiation GO:0051890 4 0.267
divalent inorganic cation transport GO:0072511 158 0.262
oogenesis GO:0048477 2 0.261
forelimb morphogenesis GO:0035136 4 0.260
neuronal stem cell division GO:0036445 1 0.260
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.260
cell morphogenesis involved in differentiation GO:0000904 144 0.259
protein catabolic process GO:0030163 325 0.257
Mouse
long term memory GO:0007616 2 0.255
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.255
Mouse
neuron projection development GO:0031175 106 0.254
regulation of innate immune response GO:0045088 97 0.253
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.252
negative regulation of protein processing GO:0010955 142 0.252
stress activated mapk cascade GO:0051403 93 0.251
axis elongation GO:0003401 4 0.249
memory GO:0007613 3 0.249
protein localization to nucleus GO:0034504 136 0.249
epithelial tube morphogenesis GO:0060562 38 0.247
positive regulation of nucleotide metabolic process GO:0045981 230 0.246
negative regulation of protein phosphorylation GO:0001933 140 0.244
Mouse
negative regulation of secretion GO:0051048 58 0.244
thalamus development GO:0021794 2 0.242
motor neuron axon guidance GO:0008045 2 0.241
innate immune response activating signal transduction GO:0002758 48 0.239
endocytosis GO:0006897 159 0.238
regulation of gtpase activity GO:0043087 180 0.236
p38mapk cascade GO:0038066 9 0.236
regulation of cell development GO:0060284 161 0.235
nucleoside triphosphate catabolic process GO:0009143 394 0.235
regulation of protein complex assembly GO:0043254 147 0.234
regulation of secretion GO:0051046 194 0.234
cardioblast cell fate specification GO:0042685 1 0.233
long term synaptic potentiation GO:0060291 1 0.232
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.232
single organism reproductive process GO:0044702 98 0.230
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.230
cochlea development GO:0090102 1 0.229
regulation of actin filament polymerization GO:0030833 50 0.225
inner ear morphogenesis GO:0042472 4 0.223
endosomal transport GO:0016197 129 0.222
cardiovascular system development GO:0072358 262 0.221
cytoskeleton dependent intracellular transport GO:0030705 21 0.220
cerebral cortex development GO:0021987 10 0.219
hexose metabolic process GO:0019318 55 0.219
regulation of actin filament bundle assembly GO:0032231 36 0.219
regulation of cell cycle GO:0051726 393 0.216
astrocyte cell migration GO:0043615 1 0.216
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.215
cellular chemical homeostasis GO:0055082 180 0.213
cell surface receptor signaling pathway involved in heart development GO:0061311 8 0.213
retina vasculature development in camera type eye GO:0061298 3 0.208
mitotic cell cycle process GO:1903047 286 0.208
regulation of icosanoid secretion GO:0032303 4 0.207
establishment of cell polarity GO:0030010 22 0.207
positive regulation of immune system process GO:0002684 283 0.206
morphogenesis of an epithelium GO:0002009 60 0.205
actin filament polymerization GO:0030041 45 0.205
positive regulation of protein import into nucleus GO:0042307 46 0.204
response to lipid GO:0033993 206 0.204
defense response GO:0006952 315 0.202
cellular response to mechanical stimulus GO:0071260 39 0.199
digestive tract development GO:0048565 75 0.198
positive regulation of icosanoid secretion GO:0032305 3 0.198
behavior GO:0007610 112 0.197
cardiac cell fate specification GO:0060912 1 0.197
positive regulation of prostaglandin secretion GO:0032308 1 0.195
gtp metabolic process GO:0046039 239 0.195
neural tube patterning GO:0021532 2 0.195
negative regulation of cardiac cell fate specification GO:2000044 1 0.191
cellular macromolecular complex assembly GO:0034622 324 0.190
peptidyl serine modification GO:0018209 106 0.190
nuclear division GO:0000280 128 0.189
cellular ion homeostasis GO:0006873 168 0.188
somatic stem cell division GO:0048103 1 0.188
regulation of apoptotic signaling pathway GO:2001233 175 0.187
atp metabolic process GO:0046034 176 0.187
regulation of cell cell adhesion mediated by cadherin GO:2000047 4 0.187
cell migration involved in gastrulation GO:0042074 1 0.184
cell projection assembly GO:0030031 126 0.184
negative regulation of transferase activity GO:0051348 124 0.182
metal ion homeostasis GO:0055065 169 0.182
startle response GO:0001964 3 0.181
vacuolar transport GO:0007034 34 0.181
endodermal cell fate specification GO:0001714 4 0.179
cation homeostasis GO:0055080 189 0.178
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.178
positive regulation of actin filament polymerization GO:0030838 38 0.176
regulation of lamellipodium morphogenesis GO:2000392 4 0.176
positive regulation of intracellular protein transport GO:0090316 76 0.175
positive regulation of myoblast fusion GO:1901741 1 0.173
cerebral cortex cell migration GO:0021795 3 0.173
digestive system development GO:0055123 75 0.173
regulation of receptor mediated endocytosis GO:0048259 32 0.172
calcium ion homeostasis GO:0055074 122 0.170
cation transport GO:0006812 331 0.170
membrane fusion GO:0061025 43 0.168
apoptotic mitochondrial changes GO:0008637 57 0.168
modification dependent macromolecule catabolic process GO:0043632 212 0.166
Mouse
positive regulation of secretion GO:0051047 116 0.165
regulation of mitochondrion organization GO:0010821 54 0.165
regulation of nervous system development GO:0051960 88 0.161
organic acid transport GO:0015849 65 0.161
regulation of neuron differentiation GO:0045664 70 0.160
negative regulation of kinase activity GO:0033673 106 0.160
fatty acid transport GO:0015908 25 0.159
innate immune response GO:0045087 178 0.157
protein processing GO:0016485 226 0.155
positive regulation of innate immune response GO:0045089 79 0.154
cochlea morphogenesis GO:0090103 1 0.153
negative regulation of phosphorus metabolic process GO:0010563 267 0.153
regulation of synaptic plasticity GO:0048167 3 0.153
regulation of prostaglandin secretion GO:0032306 2 0.153
negative regulation of stem cell differentiation GO:2000737 22 0.151
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.151
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.151
organic anion transport GO:0015711 103 0.150
gastrulation GO:0007369 51 0.150
endosome organization GO:0007032 20 0.149
cellular protein catabolic process GO:0044257 261 0.148
Mouse
mucopolysaccharide metabolic process GO:1903510 27 0.145
metal ion transport GO:0030001 272 0.145
regulation of cell cycle process GO:0010564 266 0.144
regulation of establishment of protein localization GO:0070201 242 0.142
immune response GO:0006955 307 0.141
positive regulation of cell development GO:0010720 92 0.141
filopodium assembly GO:0046847 18 0.141
chromatin organization GO:0006325 351 0.141
retinal blood vessel morphogenesis GO:0061304 2 0.141
cellular lipid metabolic process GO:0044255 303 0.138
digestive tract morphogenesis GO:0048546 56 0.138
mitochondrion transport along microtubule GO:0047497 3 0.138
heart morphogenesis GO:0003007 48 0.137
regulation of lipid transport GO:0032368 44 0.137
negative regulation of transport GO:0051051 176 0.137
calcium ion transport GO:0006816 147 0.137
regulation of gtp catabolic process GO:0033124 180 0.136
hindbrain development GO:0030902 3 0.135
negative regulation of phosphorylation GO:0042326 174 0.135
Mouse
neurological system process GO:0050877 163 0.135
positive regulation of secretion by cell GO:1903532 108 0.134
secretion by cell GO:0032940 226 0.133
female gamete generation GO:0007292 2 0.133
regulation of cardiac muscle tissue development GO:0055024 13 0.133
monosaccharide metabolic process GO:0005996 74 0.133
neuron projection morphogenesis GO:0048812 50 0.133
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 2 0.133
neural tube development GO:0021915 9 0.132
cell part morphogenesis GO:0032990 137 0.131
regulation of ion transmembrane transport GO:0034765 132 0.131
response to organonitrogen compound GO:0010243 156 0.131
axonogenesis GO:0007409 31 0.129
Worm
embryonic camera type eye development GO:0031076 2 0.128
regulation of locomotion GO:0040012 329 0.128
regulation of endopeptidase activity GO:0052548 170 0.127
positive regulation of nucleoside metabolic process GO:0045979 186 0.127
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.127
ion homeostasis GO:0050801 230 0.124
cell cell signaling involved in cell fate commitment GO:0045168 5 0.124
receptor mediated endocytosis GO:0006898 84 0.124
cellular metal ion homeostasis GO:0006875 146 0.123
axon extension GO:0048675 13 0.123
Worm
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.123
embryonic hindlimb morphogenesis GO:0035116 2 0.122
positive regulation of ossification GO:0045778 32 0.122
cell activation GO:0001775 213 0.122
microtubule based process GO:0007017 210 0.120
Fly
regulation of exocytosis GO:0017157 46 0.119
organ induction GO:0001759 4 0.119
positive regulation of apoptotic signaling pathway GO:2001235 70 0.119
regulation of protein processing GO:0070613 150 0.118
embryonic eye morphogenesis GO:0048048 2 0.118
intracellular receptor signaling pathway GO:0030522 104 0.117
morphogenesis of an epithelial sheet GO:0002011 12 0.117
regulation of defense response GO:0031347 154 0.116
activation of mapkk activity GO:0000186 18 0.116
regulation of protein catabolic process GO:0042176 155 0.116
Mouse
oxidation reduction process GO:0055114 396 0.114
metencephalon development GO:0022037 2 0.113
actin filament bundle assembly GO:0051017 54 0.113
positive regulation of gtpase activity GO:0043547 166 0.113
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.112
mitotic nuclear division GO:0007067 119 0.112
regulation of transmembrane transport GO:0034762 139 0.112
single organism membrane fusion GO:0044801 37 0.111
organ formation GO:0048645 3 0.110
protein localization to cytoskeleton GO:0044380 11 0.109
carbohydrate biosynthetic process GO:0016051 42 0.109
lamellipodium assembly GO:0030032 26 0.109
adult locomotory behavior GO:0008344 1 0.109
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.109
regulation of jun kinase activity GO:0043506 27 0.108
meiotic chromosome segregation GO:0045132 4 0.107
regulation of wnt signaling pathway involved in heart development GO:0003307 3 0.106
response to mechanical stimulus GO:0009612 51 0.106
positive regulation of myotube differentiation GO:0010831 3 0.106
cilium organization GO:0044782 68 0.105
activation of mapkkk activity GO:0000185 7 0.105
positive regulation of cell proliferation GO:0008284 301 0.104
positive regulation of protein transport GO:0051222 135 0.104
termination of signal transduction GO:0023021 3 0.104
positive regulation of proteolysis GO:0045862 142 0.104
Mouse
syncytium formation by plasma membrane fusion GO:0000768 2 0.104
protein import GO:0017038 130 0.104
negative regulation of protein metabolic process GO:0051248 391 0.103
circulatory system development GO:0072359 262 0.102
neurogenesis GO:0022008 169 0.102
post golgi vesicle mediated transport GO:0006892 36 0.101
response to oxidative stress GO:0006979 121 0.101
cell growth GO:0016049 160 0.100
Worm
establishment of spindle localization GO:0051293 12 0.100
peptidyl threonine phosphorylation GO:0018107 41 0.099
positive regulation of fat cell differentiation GO:0045600 12 0.099

LRRK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
parkinson s disease DOID:14330 18 0.117
synucleinopathy DOID:0050890 22 0.117
central nervous system disease DOID:331 186 0.117
neurodegenerative disease DOID:1289 102 0.117
nervous system disease DOID:863 431 0.117