Homo sapiens

179 known processes

MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

(Aliases: MAD2,HSMAD2)

MAD2L1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
chromosome segregation GO:0007059 114 0.985
regulation of nuclear division GO:0051783 65 0.970
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.963
regulation of chromosome segregation GO:0051983 44 0.959
metaphase anaphase transition of cell cycle GO:0044784 21 0.952
nuclear division GO:0000280 128 0.949
regulation of mitotic sister chromatid separation GO:0010965 27 0.945
mitotic sister chromatid segregation GO:0000070 53 0.932
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.931
organelle fission GO:0048285 149 0.928
regulation of sister chromatid segregation GO:0033045 27 0.912
regulation of proteasomal protein catabolic process GO:0061136 87 0.911
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.910
oogenesis GO:0048477 2 0.902
regulation of mitosis GO:0007088 63 0.898
mitotic cell cycle process GO:1903047 286 0.890
mitotic sister chromatid separation GO:0051306 18 0.883
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 4 0.871
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.856
regulation of cell cycle phase transition GO:1901987 126 0.837
cell division GO:0051301 168 0.820
negative regulation of cell cycle GO:0045786 193 0.812
sister chromatid segregation GO:0000819 54 0.793
ubiquitin dependent protein catabolic process GO:0006511 206 0.772
regulation of proteolysis GO:0030162 293 0.771
mitotic cell cycle GO:0000278 326 0.771
regulation of cellular protein catabolic process GO:1903362 96 0.764
meiotic chromosome segregation GO:0045132 4 0.760
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.740
negative regulation of cell cycle phase transition GO:1901988 89 0.684
regulation of mitotic sister chromatid segregation GO:0033047 27 0.680
negative regulation of mitotic cell cycle GO:0045930 102 0.679
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.678
protein modification by small protein conjugation GO:0032446 342 0.676
mitotic nuclear division GO:0007067 119 0.672
regulation of mitotic cell cycle GO:0007346 189 0.662
cell cycle phase transition GO:0044770 173 0.652
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.646
cell cycle checkpoint GO:0000075 117 0.629
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.596
regulation of transferase activity GO:0051338 355 0.586
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.570
protein catabolic process GO:0030163 325 0.556
regulation of chromosome organization GO:0033044 103 0.477
modification dependent macromolecule catabolic process GO:0043632 212 0.463
negative regulation of chromosome organization GO:2001251 48 0.445
regulation of cell cycle GO:0051726 393 0.443
positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 6 0.433
chromosome separation GO:0051304 23 0.403
cellular macromolecule catabolic process GO:0044265 380 0.364
oocyte differentiation GO:0009994 2 0.351
regulation of cell division GO:0051302 116 0.335
negative regulation of proteolysis GO:0045861 132 0.322
microtubule based process GO:0007017 210 0.319
protein polyubiquitination GO:0000209 110 0.319
response to oxidative stress GO:0006979 121 0.293
meiotic nuclear division GO:0007126 10 0.289
female gamete generation GO:0007292 2 0.286
regulation of meiotic cell cycle GO:0051445 4 0.286
regulation of mitotic cell cycle phase transition GO:1901990 118 0.274
protein ubiquitination GO:0016567 314 0.274
regulation of cell cycle process GO:0010564 266 0.261
metaphase plate congression GO:0051310 18 0.253
negative regulation of protein processing GO:0010955 142 0.241
negative regulation of organelle organization GO:0010639 126 0.228
regulation of meiosis GO:0040020 3 0.227
establishment of organelle localization GO:0051656 59 0.223
microtubule cytoskeleton organization GO:0000226 176 0.218
proteasomal protein catabolic process GO:0010498 176 0.218
mitotic cell cycle phase transition GO:0044772 162 0.209
maintenance of location GO:0051235 112 0.209
negative regulation of cellular protein metabolic process GO:0032269 353 0.205
regulation of protein catabolic process GO:0042176 155 0.197
dna repair GO:0006281 198 0.193
protein k11 linked ubiquitination GO:0070979 24 0.188
cellular protein complex assembly GO:0043623 188 0.175
establishment of chromosome localization GO:0051303 20 0.175
spindle stabilization GO:0043146 4 0.170
meiosis i GO:0007127 4 0.168
organelle assembly GO:0070925 176 0.166
protein polymerization GO:0051258 71 0.160
centromeric sister chromatid cohesion GO:0070601 3 0.157
cellular response to oxygen containing compound GO:1901701 276 0.154
negative regulation of cellular catabolic process GO:0031330 83 0.153
epithelium development GO:0060429 227 0.150
regulation of cellular amine metabolic process GO:0033238 11 0.147
mitotic spindle checkpoint GO:0071174 18 0.141
reproductive process GO:0022414 106 0.137
Worm
protein processing GO:0016485 226 0.137
positive regulation of chromosome segregation GO:0051984 9 0.133
negative regulation of cellular component organization GO:0051129 235 0.132
cellular protein catabolic process GO:0044257 261 0.127
protein maturation GO:0051604 233 0.117
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.116
chromatin organization GO:0006325 351 0.113
negative regulation of cell cycle process GO:0010948 121 0.108
attachment of spindle microtubules to kinetochore GO:0008608 17 0.093
regeneration GO:0031099 4 0.089
cellular macromolecular complex assembly GO:0034622 324 0.087
regulation of cellular ketone metabolic process GO:0010565 50 0.085
post embryonic development GO:0009791 2 0.084
positive regulation of cellular catabolic process GO:0031331 284 0.083
negative regulation of protein maturation GO:1903318 142 0.082
protein localization to organelle GO:0033365 280 0.079
meiotic cell cycle process GO:1903046 8 0.078
spindle assembly checkpoint GO:0071173 17 0.077
negative regulation of mitotic anaphase promoting complex activity GO:0060564 4 0.076
negative regulation of protein catabolic process GO:0042177 59 0.076
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.076
oocyte development GO:0048599 1 0.072
maintenance of location in cell GO:0051651 62 0.071
organelle localization GO:0051640 84 0.071
negative regulation of protein metabolic process GO:0051248 391 0.071
oocyte maturation GO:0001556 1 0.069
cellular amine metabolic process GO:0044106 41 0.067
regulation of cellular amino acid metabolic process GO:0006521 6 0.064
regulation of protein processing GO:0070613 150 0.064
embryo development GO:0009790 123 0.063
Worm
cellular response to dna damage stimulus GO:0006974 379 0.062
positive regulation of cell cycle GO:0045787 140 0.059
maintenance of protein location in cell GO:0032507 56 0.058
chromosome localization GO:0050000 20 0.057
microtubule organizing center organization GO:0031023 62 0.057
positive regulation of organelle organization GO:0010638 195 0.054
reproduction GO:0000003 63 0.053
negative regulation of catalytic activity GO:0043086 335 0.052
mitotic spindle assembly checkpoint GO:0007094 14 0.051
negative regulation of apoptotic process GO:0043066 316 0.051
regulation of response to dna damage stimulus GO:2001020 94 0.050
cytoskeleton dependent cytokinesis GO:0061640 22 0.050
negative regulation of meiotic cell cycle GO:0051447 2 0.049
developmental process involved in reproduction GO:0003006 66 0.048
Worm
organophosphate biosynthetic process GO:0090407 163 0.047
peptidyl serine phosphorylation GO:0018105 101 0.047
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 6 0.047
response to abiotic stimulus GO:0009628 336 0.046
Worm
positive regulation of transferase activity GO:0051347 227 0.045
positive regulation of mitotic cell cycle GO:0045931 60 0.045
negative regulation of programmed cell death GO:0043069 321 0.044
single organism cellular localization GO:1902580 332 0.041
negative regulation of catabolic process GO:0009895 104 0.041
amine metabolic process GO:0009308 44 0.041
response to other organism GO:0051707 261 0.041
mitotic cell cycle checkpoint GO:0007093 68 0.040
positive regulation of transcription of nuclear large rrna transcript from rna polymerase i promoter GO:1901838 2 0.039
secretion by cell GO:0032940 226 0.039
negative regulation of mitotic sister chromatid segregation GO:0033048 17 0.039
negative regulation of cellular protein catabolic process GO:1903363 38 0.039
mrna processing GO:0006397 133 0.039
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.039
positive regulation of cellular component organization GO:0051130 376 0.039
reproductive system development GO:0061458 56 0.038
Worm
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.037
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.036
ribosome assembly GO:0042255 9 0.035
spindle assembly involved in mitosis GO:0090307 12 0.034
regulation of kinase activity GO:0043549 314 0.034
snrna modification GO:0040031 1 0.034
negative regulation of chromosome segregation GO:0051985 18 0.034
enzyme linked receptor protein signaling pathway GO:0007167 303 0.034
positive regulation of protein catabolic process GO:0045732 75 0.033
negative regulation of mitosis GO:0045839 24 0.033
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.033
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.033
nervous system development GO:0007399 293 0.033
negative regulation of protein modification process GO:0031400 200 0.032
meiotic cell cycle GO:0051321 13 0.032
histone h3 s10 phosphorylation GO:0043987 3 0.031
cell projection organization GO:0030030 252 0.031
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.030
spindle assembly GO:0051225 29 0.029
blastocyst development GO:0001824 3 0.029
reproductive structure development GO:0048608 55 0.029
Worm
cellular response to hormone stimulus GO:0032870 125 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
single organism reproductive process GO:0044702 98 0.027
Worm
positive regulation of phosphorylation GO:0042327 394 0.027
regulation of spindle checkpoint GO:0090231 12 0.027
negative regulation of sister chromatid segregation GO:0033046 17 0.026
regulation of protein ubiquitination GO:0031396 95 0.026
hemopoiesis GO:0030097 180 0.025
wound healing GO:0042060 115 0.025
defense response GO:0006952 315 0.025
regulation of binding GO:0051098 111 0.025
polynucleotide dephosphorylation GO:0098501 3 0.025
immune response GO:0006955 307 0.025
growth GO:0040007 202 0.024
regulation of apoptotic signaling pathway GO:2001233 175 0.024
cell cell signaling GO:0007267 155 0.024
regulation of dna metabolic process GO:0051052 153 0.023
regulation of ligase activity GO:0051340 29 0.023
nucleotide biosynthetic process GO:0009165 109 0.023
secretion GO:0046903 254 0.023
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.023
mitotic metaphase plate congression GO:0007080 14 0.023
response to biotic stimulus GO:0009607 276 0.023
receptor mediated endocytosis GO:0006898 84 0.023
cell morphogenesis GO:0000902 296 0.023
neurogenesis GO:0022008 169 0.022
positive regulation of mitosis GO:0045840 25 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
spindle organization GO:0007051 53 0.021
microtubule anchoring GO:0034453 24 0.021
taxis GO:0042330 157 0.021
negative regulation of binding GO:0051100 57 0.021
histone modification GO:0016570 251 0.020
covalent chromatin modification GO:0016569 254 0.020
behavior GO:0007610 112 0.020
regulation of spindle assembly involved in mitosis GO:1901673 1 0.020
centrosome cycle GO:0007098 32 0.019
cell adhesion GO:0007155 325 0.019
positive regulation of histone h4 k16 acetylation GO:2000620 1 0.019
nucleoside phosphate biosynthetic process GO:1901293 109 0.019
cellular component morphogenesis GO:0032989 314 0.019
small gtpase mediated signal transduction GO:0007264 78 0.019
apoptotic signaling pathway GO:0097190 268 0.019
oxidation reduction process GO:0055114 396 0.019
maintenance of protein location GO:0045185 57 0.018
protein oligomerization GO:0051259 173 0.018
cell projection morphogenesis GO:0048858 129 0.018
sex differentiation GO:0007548 45 0.018
Worm
positive regulation of nuclear division GO:0051785 27 0.018
cellular ketone metabolic process GO:0042180 80 0.018
positive regulation of cell division GO:0051781 59 0.018
single organism cell adhesion GO:0098602 179 0.018
biological adhesion GO:0022610 331 0.018
cell development GO:0048468 328 0.018
positive regulation of protein ubiquitination GO:0031398 53 0.018
regulation of protein serine threonine kinase activity GO:0071900 179 0.017
chemotaxis GO:0006935 157 0.017
regulation of cellular response to growth factor stimulus GO:0090287 76 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.017
multicellular organismal reproductive process GO:0048609 40 0.017
regulation of locomotion GO:0040012 329 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
cell growth GO:0016049 160 0.016
regulation of cell motility GO:2000145 299 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.016
regulation of cellular response to stress GO:0080135 244 0.016
regulation of cellular respiration GO:0043457 4 0.016
response to oxygen containing compound GO:1901700 369 0.015
regulation of response to external stimulus GO:0032101 222 0.015
sister chromatid cohesion GO:0007062 24 0.015
gonad development GO:0008406 34 0.015
Worm
regulation of protein kinase activity GO:0045859 289 0.015
multicellular organism reproduction GO:0032504 42 0.015
protein localization to chromosome GO:0034502 30 0.015
locomotory behavior GO:0007626 1 0.015
peptidyl serine modification GO:0018209 106 0.015
chordate embryonic development GO:0043009 34 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
cyclin catabolic process GO:0008054 6 0.015
neuron development GO:0048666 113 0.014
regulation of multi organism process GO:0043900 157 0.014
response to wounding GO:0009611 168 0.014
multicellular organismal aging GO:0010259 3 0.014
cell activation GO:0001775 213 0.014
regulation of exit from mitosis GO:0007096 6 0.014
sexual reproduction GO:0019953 37 0.014
regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:1902165 7 0.013
positive regulation of proteolysis GO:0045862 142 0.013
circulatory system development GO:0072359 262 0.013
regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 8 0.013
rna processing GO:0006396 255 0.013
spermatid differentiation GO:0048515 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
negative regulation of protein ubiquitination GO:0031397 35 0.012
negative regulation of cell division GO:0051782 31 0.012
regulation of mitotic recombination GO:0000019 1 0.012
positive regulation of ligase activity GO:0051351 19 0.012
purine nucleoside triphosphate catabolic process GO:0009146 392 0.012
positive regulation of catabolic process GO:0009896 310 0.012
cellular response to lipid GO:0071396 127 0.012
regulation of gene expression epigenetic GO:0040029 73 0.012
positive regulation of chromosome organization GO:2001252 41 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
anterior posterior axis specification GO:0009948 2 0.012
positive regulation of protein transport GO:0051222 135 0.012
spermatid development GO:0007286 4 0.011
regulation of protein localization GO:0032880 296 0.011
positive regulation of mitochondrial membrane potential GO:0010918 1 0.011
regulation of cellular component movement GO:0051270 334 0.011
multi organism reproductive process GO:0044703 54 0.011
protein secretion GO:0009306 98 0.011
immune system development GO:0002520 195 0.010
developmental maturation GO:0021700 28 0.010
positive regulation of protein phosphorylation GO:0001934 313 0.010
response to oxygen levels GO:0070482 100 0.010
Worm
chromatin assembly or disassembly GO:0006333 78 0.010
cardiovascular system development GO:0072358 262 0.010
endocytosis GO:0006897 159 0.010
innate immune response GO:0045087 178 0.010
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 7 0.010
mrna metabolic process GO:0016071 175 0.010
ameboidal type cell migration GO:0001667 135 0.010
cytokinesis GO:0000910 96 0.010
negative regulation of hydrolase activity GO:0051346 182 0.010
cellular response to oxidative stress GO:0034599 85 0.010

MAD2L1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
disease of metabolism DOID:0014667 295 0.028
inherited metabolic disorder DOID:655 242 0.028
colon carcinoma DOID:1520 25 0.020
large intestine cancer DOID:5672 29 0.020
colon cancer DOID:219 25 0.020
gastrointestinal system cancer DOID:3119 52 0.020
intestinal cancer DOID:10155 29 0.020
organ system cancer DOID:0050686 164 0.020
colorectal cancer DOID:9256 29 0.020