|
|
adenylate cyclase inhibiting adrenergic receptor signaling pathway
|
GO:0071881 |
1 |
1.000
|
|
|
|
negative regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061179 |
1 |
1.000
|
|
|
|
adenylate cyclase inhibiting serotonin receptor signaling pathway
|
GO:0007198 |
2 |
1.000
|
|
|
|
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure
|
GO:0001999 |
1 |
1.000
|
|
|
|
activation of mapk activity by adrenergic receptor signaling pathway
|
GO:0071883 |
3 |
1.000
|
|
|
|
regulation of saliva secretion
|
GO:0046877 |
2 |
1.000
|
|
|
|
positive regulation of phosphatidylinositol biosynthetic process
|
GO:0010513 |
3 |
1.000
|
|
|
|
positive regulation of digestive system process
|
GO:0060456 |
2 |
1.000
|
|
|
|
phospholipase c activating adrenergic receptor signaling pathway
|
GO:0071882 |
1 |
1.000
|
|
|
|
renin secretion into blood stream
|
GO:0002001 |
1 |
0.999
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.999
|
|
|
|
positive regulation of heart rate
|
GO:0010460 |
4 |
0.999
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.999
|
|
|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.996
|
|
|
|
serotonin receptor signaling pathway
|
GO:0007210 |
11 |
0.992
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.992
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.989
|
|
|
|
intestine smooth muscle contraction
|
GO:0014827 |
2 |
0.989
|
|
|
|
regulation of cardiac muscle tissue development
|
GO:0055024 |
13 |
0.988
|
|
|
|
membrane hyperpolarization
|
GO:0060081 |
1 |
0.988
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.986
|
|
|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.986
|
|
|
|
regulation of heart growth
|
GO:0060420 |
4 |
0.984
|
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.984
|
|
|
|
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
|
GO:0051482 |
6 |
0.963
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.960
|
|
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.958
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.958
|
|
|
|
positive regulation of camp mediated signaling
|
GO:0043950 |
10 |
0.955
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.953
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.947
|
Rat |
|
|
regulation of camp mediated signaling
|
GO:0043949 |
13 |
0.936
|
|
|
|
regulation of lipid catabolic process
|
GO:0050994 |
23 |
0.930
|
|
|
|
adenylate cyclase inhibiting g protein coupled receptor signaling pathway
|
GO:0007193 |
22 |
0.930
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.926
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.923
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.917
|
|
|
|
lipid catabolic process
|
GO:0016042 |
84 |
0.917
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.909
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.908
|
|
|
|
positive regulation of cardiac muscle cell differentiation
|
GO:2000727 |
4 |
0.902
|
|
|
|
negative regulation of muscle contraction
|
GO:0045932 |
3 |
0.900
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.893
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
12 |
0.889
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.887
|
|
|
|
adenylate cyclase activating adrenergic receptor signaling pathway
|
GO:0071880 |
3 |
0.887
|
|
|
|
diet induced thermogenesis
|
GO:0002024 |
2 |
0.882
|
|
|
|
regulation of systemic arterial blood pressure by circulatory renin angiotensin
|
GO:0001991 |
4 |
0.878
|
|
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.877
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.874
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.874
|
|
|
|
adenylate cyclase activating dopamine receptor signaling pathway
|
GO:0007191 |
3 |
0.871
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.867
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
22 |
0.867
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.865
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.864
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.859
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.858
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.857
|
Rat |
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.853
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.852
|
|
|
|
cardiac muscle contraction
|
GO:0060048 |
34 |
0.850
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.846
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.839
|
|
|
|
positive regulation of muscle organ development
|
GO:0048636 |
7 |
0.837
|
|
|
|
activation of phospholipase c activity
|
GO:0007202 |
7 |
0.834
|
|
|
|
dopamine receptor signaling pathway
|
GO:0007212 |
10 |
0.832
|
|
|
|
fear response
|
GO:0042596 |
0 |
0.830
|
|
|
|
positive regulation of ion transmembrane transporter activity
|
GO:0032414 |
29 |
0.825
|
|
|
|
cyclic nucleotide mediated signaling
|
GO:0019935 |
26 |
0.816
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.810
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.809
|
|
|
|
regulation of phospholipase c activity
|
GO:1900274 |
14 |
0.808
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.808
|
|
|
|
regulation of cardiac muscle tissue growth
|
GO:0055021 |
4 |
0.807
|
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.804
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.797
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.797
|
|
|
|
gastro intestinal system smooth muscle contraction
|
GO:0014831 |
2 |
0.797
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.795
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.794
|
|
|
|
regulation of postsynaptic membrane potential
|
GO:0060078 |
1 |
0.793
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.792
|
Rat |
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
15 |
0.792
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.788
|
|
|
|
negative regulation of lipid catabolic process
|
GO:0050995 |
9 |
0.786
|
|
|
|
long term synaptic potentiation
|
GO:0060291 |
1 |
0.785
|
|
|
|
muscle hypertrophy
|
GO:0014896 |
14 |
0.772
|
|
|
|
digestion
|
GO:0007586 |
22 |
0.770
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.767
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.765
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.763
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.763
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.762
|
|
|
|
regulation of phosphatidylinositol biosynthetic process
|
GO:0010511 |
5 |
0.761
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.760
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.756
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.754
|
|
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.753
|
|
|
|
negative regulation of blood pressure
|
GO:0045776 |
3 |
0.749
|
|
|
|
receptor transactivation
|
GO:0035624 |
4 |
0.748
|
|
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.747
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.746
|
|
|
|
memory
|
GO:0007613 |
3 |
0.744
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.744
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.743
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.742
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.740
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.739
|
Rat |
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.737
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.735
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.732
|
|
|
|
regulation of systemic arterial blood pressure by hormone
|
GO:0001990 |
12 |
0.730
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.728
|
|
|
|
regulation of heart rate
|
GO:0002027 |
38 |
0.725
|
|
|
|
positive regulation of heart growth
|
GO:0060421 |
2 |
0.723
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.722
|
Rat |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.720
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.718
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.717
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.717
|
|
|
|
positive regulation of organ growth
|
GO:0046622 |
2 |
0.717
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.714
|
|
|
|
positive regulation of phospholipid biosynthetic process
|
GO:0071073 |
4 |
0.713
|
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.708
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.708
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.706
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.705
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.702
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.702
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.701
|
|
|
|
regulation of lipase activity
|
GO:0060191 |
37 |
0.701
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.700
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.700
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.700
|
Mouse |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.697
|
|
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
25 |
0.696
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.694
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.692
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.690
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.687
|
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.687
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.687
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.684
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.681
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.676
|
|
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.676
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.672
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.671
|
|
|
|
positive regulation of muscle hypertrophy
|
GO:0014742 |
6 |
0.666
|
|
|
|
positive regulation of multicellular organismal metabolic process
|
GO:0044253 |
11 |
0.664
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.663
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.660
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.660
|
|
|
|
regulation of cardiac muscle cell differentiation
|
GO:2000725 |
7 |
0.659
|
|
|
|
regulation of blood vessel size
|
GO:0050880 |
18 |
0.658
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.656
|
|
|
|
developmental cell growth
|
GO:0048588 |
18 |
0.654
|
|
|
|
cellular polysaccharide catabolic process
|
GO:0044247 |
4 |
0.653
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.653
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.651
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.650
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.647
|
|
|
|
response to dietary excess
|
GO:0002021 |
2 |
0.645
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.642
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.641
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.641
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.640
|
Rat |
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.640
|
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.638
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.636
|
Rat |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.634
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.630
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.629
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.628
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.625
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.625
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.624
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.623
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.621
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.620
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.620
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.620
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.618
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.616
|
|
|
|
positive regulation of striated muscle cell differentiation
|
GO:0051155 |
9 |
0.615
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.614
|
|
|
|
vascular process in circulatory system
|
GO:0003018 |
29 |
0.614
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.612
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.611
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.608
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.606
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.605
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.592
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.592
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.586
|
|
|
|
positive regulation of lyase activity
|
GO:0051349 |
16 |
0.584
|
|
|
|
regulation of axon guidance
|
GO:1902667 |
3 |
0.583
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.583
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.581
|
|
|
|
endocrine process
|
GO:0050886 |
25 |
0.575
|
|
|
|
positive regulation of calcium ion transport into cytosol
|
GO:0010524 |
20 |
0.570
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.567
|
|
|
|
regulation of systemic arterial blood pressure mediated by a chemical signal
|
GO:0003044 |
12 |
0.567
|
|
|
|
regulation of muscle adaptation
|
GO:0043502 |
10 |
0.566
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.563
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.563
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.554
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.554
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.544
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.543
|
|
|
|
regulation of multicellular organismal metabolic process
|
GO:0044246 |
17 |
0.543
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.543
|
|
|
|
positive regulation of blood pressure
|
GO:0045777 |
3 |
0.537
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.536
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.536
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.534
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.533
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.532
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.532
|
|
|
|
muscle adaptation
|
GO:0043500 |
12 |
0.532
|
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.532
|
|
|
|
digestive system process
|
GO:0022600 |
17 |
0.528
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.525
|
|
|
|
glycogen catabolic process
|
GO:0005980 |
4 |
0.525
|
|
|
|
regulation of muscle organ development
|
GO:0048634 |
27 |
0.524
|
|
|
|
regulation of cardiac muscle cell contraction
|
GO:0086004 |
23 |
0.521
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.518
|
|
|
|
cellular response to monoamine stimulus
|
GO:0071868 |
7 |
0.516
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.514
|
|
|
|
vasoconstriction
|
GO:0042310 |
11 |
0.509
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.509
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.508
|
Rat |
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.501
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.498
|
|
|
|
striated muscle hypertrophy
|
GO:0014897 |
14 |
0.498
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.497
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.496
|
Rat |
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.494
|
Rat |
|
|
positive regulation of cardiac muscle tissue growth
|
GO:0055023 |
2 |
0.491
|
|
|
|
cellular polysaccharide metabolic process
|
GO:0044264 |
27 |
0.489
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.488
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.487
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.483
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.479
|
|
|
|
adrenergic receptor signaling pathway
|
GO:0071875 |
9 |
0.479
|
|
|
|
phospholipase c activating dopamine receptor signaling pathway
|
GO:0060158 |
2 |
0.479
|
|
|
|
polysaccharide catabolic process
|
GO:0000272 |
4 |
0.476
|
|
|
|
cellular glucan metabolic process
|
GO:0006073 |
22 |
0.475
|
|
|
|
cardiac muscle hypertrophy
|
GO:0003300 |
14 |
0.472
|
|
|
|
negative regulation of systemic arterial blood pressure
|
GO:0003085 |
1 |
0.468
|
|
|
|
cardiac muscle cell differentiation
|
GO:0055007 |
15 |
0.464
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.464
|
|
|
|
regulation of actin filament based movement
|
GO:1903115 |
24 |
0.460
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.459
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.457
|
|
|
|
positive regulation of cyclase activity
|
GO:0031281 |
13 |
0.456
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.454
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.453
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.448
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.447
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.446
|
Rat |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.446
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.445
|
|
|
|
regulation of endocrine process
|
GO:0044060 |
12 |
0.441
|
|
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.438
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.436
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.431
|
|
|
|
positive regulation of epidermal growth factor receptor signaling pathway
|
GO:0045742 |
11 |
0.430
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
45 |
0.428
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.427
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.426
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.421
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.420
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.420
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.420
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.419
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.412
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.411
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.410
|
|
|
|
positive regulation of ion transmembrane transport
|
GO:0034767 |
40 |
0.409
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.408
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.406
|
|
|
|
phasic smooth muscle contraction
|
GO:0014821 |
6 |
0.403
|
|
|
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.402
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.402
|
|
|
|
positive regulation of transmembrane transport
|
GO:0034764 |
41 |
0.401
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.397
|
|
|
|
activation of protein kinase b activity
|
GO:0032148 |
14 |
0.396
|
|
|
|
positive regulation of release of sequestered calcium ion into cytosol
|
GO:0051281 |
16 |
0.395
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.393
|
Rat |
|
|
negative regulation of peptide hormone secretion
|
GO:0090278 |
10 |
0.392
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.391
|
|
|
|
positive regulation of cation channel activity
|
GO:2001259 |
16 |
0.390
|
|
|
|
regulation of striated muscle contraction
|
GO:0006942 |
37 |
0.388
|
|
|
|
negative regulation of g protein coupled receptor protein signaling pathway
|
GO:0045744 |
18 |
0.387
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.387
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.384
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.383
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.381
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.378
|
|
|
|
regulation of digestive system process
|
GO:0044058 |
5 |
0.377
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.377
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.377
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.376
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.375
|
|
|
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.370
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.369
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.366
|
|
|
|
smooth muscle contraction
|
GO:0006939 |
14 |
0.366
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.364
|
|
|
|
regulation of muscle cell differentiation
|
GO:0051147 |
31 |
0.363
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.362
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.362
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.362
|
|
|
|
regulation of tube size
|
GO:0035150 |
18 |
0.360
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.357
|
|
|
|
positive regulation of striated muscle tissue development
|
GO:0045844 |
7 |
0.356
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.356
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.356
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.355
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.353
|
|
|
|
regulation of g protein coupled receptor protein signaling pathway
|
GO:0008277 |
35 |
0.353
|
|
|
|
system process
|
GO:0003008 |
349 |
0.351
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.348
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.348
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.345
|
|
|
|
glycogen metabolic process
|
GO:0005977 |
22 |
0.344
|
|
|
|
regulation of striated muscle tissue development
|
GO:0016202 |
26 |
0.343
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.343
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.341
|
|
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.341
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.336
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.336
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.335
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.333
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.333
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.333
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.332
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.332
|
Rat |
|
|
cellular response to catecholamine stimulus
|
GO:0071870 |
7 |
0.330
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.329
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.329
|
|
|
|
regulation of smooth muscle contraction
|
GO:0006940 |
5 |
0.327
|
|
|
|
positive regulation of muscle cell differentiation
|
GO:0051149 |
15 |
0.327
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.326
|
Rat |
|
|
peptide secretion
|
GO:0002790 |
51 |
0.326
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.326
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.325
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.325
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.323
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.319
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.317
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.315
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.314
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.314
|
|
|
|
energy derivation by oxidation of organic compounds
|
GO:0015980 |
43 |
0.313
|
|
|
|
renal system process
|
GO:0003014 |
25 |
0.312
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.311
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.309
|
|
|
|
negative regulation of camp biosynthetic process
|
GO:0030818 |
9 |
0.309
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.308
|
|
|
|
negative regulation of camp metabolic process
|
GO:0030815 |
9 |
0.308
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.305
|
|
|
|
polysaccharide metabolic process
|
GO:0005976 |
33 |
0.305
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.305
|
|
|
|
saliva secretion
|
GO:0046541 |
2 |
0.305
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.303
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.301
|
|
|
|
multicellular organismal metabolic process
|
GO:0044236 |
34 |
0.300
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.298
|
Rat |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.296
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.294
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.294
|
Rat |
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.293
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.293
|
|
|
|
regulation of muscle hypertrophy
|
GO:0014743 |
10 |
0.293
|
|
|
|
positive regulation of epidermal growth factor activated receptor activity
|
GO:0045741 |
8 |
0.292
|
|
|
|
nerve growth factor signaling pathway
|
GO:0038180 |
4 |
0.292
|
Rat |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.292
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.292
|
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.291
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.289
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.289
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.285
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.283
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.280
|
Rat |
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.280
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.279
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
41 |
0.278
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.274
|
|
|
|
neuropeptide signaling pathway
|
GO:0007218 |
19 |
0.273
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.272
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.271
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
13 |
0.269
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.269
|
|
|
|
positive regulation of camp dependent protein kinase activity
|
GO:2000481 |
4 |
0.269
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.269
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.268
|
|
|
|
negative regulation of hormone secretion
|
GO:0046888 |
15 |
0.266
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.266
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.264
|
|
|
|
fat cell differentiation
|
GO:0045444 |
32 |
0.264
|
|
|
|
positive regulation of monooxygenase activity
|
GO:0032770 |
14 |
0.261
|
|
|
|
renal system process involved in regulation of systemic arterial blood pressure
|
GO:0003071 |
5 |
0.259
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.259
|
|
|
|
carbohydrate catabolic process
|
GO:0016052 |
36 |
0.258
|
|
|
|
cgmp metabolic process
|
GO:0046068 |
19 |
0.258
|
|
|
|
regulation of muscle tissue development
|
GO:1901861 |
26 |
0.257
|
|
|
|
protein kinase c signaling
|
GO:0070528 |
17 |
0.257
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.256
|
|
|
|
regulation of blood pressure
|
GO:0008217 |
30 |
0.255
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.254
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.254
|
|
|
|
positive regulation of blood circulation
|
GO:1903524 |
12 |
0.254
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.248
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.248
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.248
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.247
|
|
|
|
negative regulation of nucleotide metabolic process
|
GO:0045980 |
29 |
0.244
|
|
|
|
single organism carbohydrate catabolic process
|
GO:0044724 |
33 |
0.242
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.241
|
|
|
|
forebrain neuron development
|
GO:0021884 |
2 |
0.240
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.238
|
|
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.237
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.236
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.236
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.233
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.233
|
|
|
|
positive regulation of cardiac muscle tissue development
|
GO:0055025 |
6 |
0.232
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.231
|
|
|
|
heart contraction
|
GO:0060047 |
62 |
0.231
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.227
|
Rat |
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.224
|
|
|
|
response to alkaloid
|
GO:0043279 |
20 |
0.224
|
|
|
|
glucan catabolic process
|
GO:0009251 |
4 |
0.224
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.223
|
|
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.223
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.221
|
|
|
|
adaptation of signaling pathway
|
GO:0023058 |
7 |
0.221
|
|
|
|
regulation of cardiac muscle hypertrophy
|
GO:0010611 |
10 |
0.216
|
|
|
|
regulation of phospholipase activity
|
GO:0010517 |
26 |
0.215
|
|
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.215
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.214
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.213
|
Rat |
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.212
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.212
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.211
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
14 |
0.211
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.210
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.207
|
|
|
|
phosphatidylinositol biosynthetic process
|
GO:0006661 |
25 |
0.207
|
|
|
|
cardiac muscle cell development
|
GO:0055013 |
5 |
0.206
|
|
|
|
negative regulation of insulin secretion
|
GO:0046676 |
9 |
0.205
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.204
|
|
|
|
glucose homeostasis
|
GO:0042593 |
31 |
0.202
|
|
|
|
negative regulation of nucleotide biosynthetic process
|
GO:0030809 |
11 |
0.202
|
|
|
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.202
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.199
|
|
|
|
cellular carbohydrate catabolic process
|
GO:0044275 |
17 |
0.199
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.199
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.198
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.197
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.195
|
|
|
|
heart process
|
GO:0003015 |
62 |
0.189
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.187
|
|
|
|
positive regulation of membrane protein ectodomain proteolysis
|
GO:0051044 |
13 |
0.187
|
|
|
|
response to catecholamine
|
GO:0071869 |
7 |
0.187
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.186
|
Rat |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.186
|
|
|
|
growth
|
GO:0040007 |
202 |
0.184
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.183
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.182
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.181
|
|
|
|
forebrain neuron differentiation
|
GO:0021879 |
3 |
0.180
|
|
|
|
cellular response to alkaloid
|
GO:0071312 |
11 |
0.179
|
|
|
|
lipid homeostasis
|
GO:0055088 |
39 |
0.178
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.177
|
|
|
|
positive regulation of neuron migration
|
GO:2001224 |
1 |
0.176
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.176
|
|
|
|
regulation of dendritic cell apoptotic process
|
GO:2000668 |
4 |
0.175
|
|
|
|
organ growth
|
GO:0035265 |
12 |
0.175
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.174
|
|
|
|
regulation of vasculogenesis
|
GO:2001212 |
3 |
0.173
|
|
|
|
response to hexose
|
GO:0009746 |
20 |
0.172
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.172
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.171
|
|
|
|
response to monoamine
|
GO:0071867 |
7 |
0.171
|
|
|
|
regulation of systemic arterial blood pressure by renin angiotensin
|
GO:0003081 |
6 |
0.168
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.168
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.167
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
23 |
0.165
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.163
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.163
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.163
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.162
|
|
|
|
secretion by tissue
|
GO:0032941 |
9 |
0.161
|
|
|
|
negative regulation of cyclic nucleotide biosynthetic process
|
GO:0030803 |
10 |
0.161
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.158
|
|
|
|
regulation of the force of heart contraction by chemical signal
|
GO:0003057 |
1 |
0.158
|
|