|
|
adenylate cyclase inhibiting serotonin receptor signaling pathway
|
GO:0007198 |
2 |
1.000
|
|
|
|
adenylate cyclase inhibiting adrenergic receptor signaling pathway
|
GO:0071881 |
1 |
1.000
|
|
|
|
negative regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061179 |
1 |
1.000
|
|
|
|
startle response
|
GO:0001964 |
3 |
0.997
|
|
|
|
positive regulation of phosphatidylinositol biosynthetic process
|
GO:0010513 |
3 |
0.976
|
|
|
|
phospholipase c activating adrenergic receptor signaling pathway
|
GO:0071882 |
1 |
0.976
|
|
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.974
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.958
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.911
|
|
|
|
regulation of excitatory postsynaptic membrane potential
|
GO:0060079 |
1 |
0.878
|
|
|
|
adenylate cyclase activating dopamine receptor signaling pathway
|
GO:0007191 |
3 |
0.833
|
|
|
|
dopamine receptor signaling pathway
|
GO:0007212 |
10 |
0.830
|
|
|
|
regulation of adenylate cyclase activity
|
GO:0045761 |
17 |
0.830
|
|
|
|
serotonin receptor signaling pathway
|
GO:0007210 |
11 |
0.816
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.796
|
|
|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.790
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.788
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.778
|
|
|
|
presynaptic membrane assembly
|
GO:0097105 |
1 |
0.770
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.740
|
|
|
|
memory
|
GO:0007613 |
3 |
0.737
|
Worm |
|
|
axon ensheathment in central nervous system
|
GO:0032291 |
1 |
0.709
|
|
|
|
intestine smooth muscle contraction
|
GO:0014827 |
2 |
0.682
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.674
|
|
|
|
presynaptic membrane organization
|
GO:0097090 |
3 |
0.620
|
|
|
|
phospholipase c activating dopamine receptor signaling pathway
|
GO:0060158 |
2 |
0.615
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.611
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.610
|
|
|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.583
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.581
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.558
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.555
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.545
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.528
|
|
|
|
oligodendrocyte development
|
GO:0014003 |
6 |
0.518
|
|
|
|
positive regulation of potassium ion transport
|
GO:0043268 |
15 |
0.518
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.514
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.509
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.499
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.484
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.474
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.470
|
|
|
|
gastro intestinal system smooth muscle contraction
|
GO:0014831 |
2 |
0.465
|
|
|
|
negative regulation of dendritic spine development
|
GO:0061000 |
1 |
0.465
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.451
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.449
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.445
|
|
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
15 |
0.439
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.427
|
|
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.427
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.427
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.417
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.415
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.410
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.403
|
|
|
|
limbic system development
|
GO:0021761 |
3 |
0.398
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.393
|
|
|
|
regulation of the force of heart contraction
|
GO:0002026 |
6 |
0.392
|
|
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.388
|
|
|
|
lipid catabolic process
|
GO:0016042 |
84 |
0.387
|
|
|
|
negative regulation of sodium ion transmembrane transporter activity
|
GO:2000650 |
2 |
0.386
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.385
|
|
|
|
long term synaptic potentiation
|
GO:0060291 |
1 |
0.382
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.381
|
|
|
|
activation of mapk activity by adrenergic receptor signaling pathway
|
GO:0071883 |
3 |
0.381
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.374
|
Mouse |
|
|
regulation of neuron projection regeneration
|
GO:0070570 |
1 |
0.371
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.370
|
Worm |
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.362
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.359
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.355
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.351
|
|
|
|
regulation of phospholipase c activity
|
GO:1900274 |
14 |
0.349
|
|
|
|
regulation of postsynaptic membrane potential
|
GO:0060078 |
1 |
0.348
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.346
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.346
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.346
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.346
|
Human |
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.345
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.344
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.340
|
|
|
|
positive regulation of organic acid transport
|
GO:0032892 |
3 |
0.338
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.337
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.335
|
|
|
|
regulation of ribosome biogenesis
|
GO:0090069 |
1 |
0.332
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.325
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.325
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.323
|
Mouse |
|
|
defense response
|
GO:0006952 |
315 |
0.317
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.317
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.317
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.314
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.311
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.308
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.303
|
|
|
|
vasoconstriction
|
GO:0042310 |
11 |
0.295
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.295
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.293
|
|
|
|
positive regulation of calcium ion transport into cytosol
|
GO:0010524 |
20 |
0.288
|
|
|
|
diet induced thermogenesis
|
GO:0002024 |
2 |
0.287
|
|
|
|
negative regulation of synaptic transmission
|
GO:0050805 |
2 |
0.285
|
|
|
|
negative regulation of lipid catabolic process
|
GO:0050995 |
9 |
0.285
|
|
|
|
positive regulation of bone mineralization
|
GO:0030501 |
19 |
0.284
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.282
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.282
|
|
|
|
negative regulation of nucleotide biosynthetic process
|
GO:0030809 |
11 |
0.275
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.273
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.271
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.270
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.270
|
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.267
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.264
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.263
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.261
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.260
|
|
|
|
regulation of axon regeneration
|
GO:0048679 |
1 |
0.259
|
|
|
|
receptor transactivation
|
GO:0035624 |
4 |
0.259
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.257
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.255
|
|
|
|
negative regulation of excitatory postsynaptic membrane potential
|
GO:0090394 |
1 |
0.253
|
|
|
|
neuron neuron synaptic transmission
|
GO:0007270 |
6 |
0.251
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.250
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.248
|
Mouse |
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.240
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.238
|
|
|
|
regulation of guanylate cyclase activity
|
GO:0031282 |
2 |
0.237
|
|
|
|
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
|
GO:0051482 |
6 |
0.236
|
|
|
|
adenylate cyclase inhibiting g protein coupled receptor signaling pathway
|
GO:0007193 |
22 |
0.236
|
|
|
|
negative regulation of platelet aggregation
|
GO:0090331 |
3 |
0.234
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.233
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.232
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.229
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.227
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.225
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.222
|
|
|
|
negative regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014067 |
4 |
0.221
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.219
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.219
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.216
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.216
|
|
|
|
fear response
|
GO:0042596 |
0 |
0.215
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.214
|
|
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.214
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.214
|
Mouse |
|
|
phasic smooth muscle contraction
|
GO:0014821 |
6 |
0.213
|
|
|
|
response to dietary excess
|
GO:0002021 |
2 |
0.209
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.208
|
Mouse |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.208
|
Human |
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.207
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.206
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.203
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.202
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.201
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.201
|
Mouse |
|
|
modified amino acid transport
|
GO:0072337 |
11 |
0.200
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.200
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.200
|
Worm |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.199
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.198
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.197
|
Human |
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.194
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.193
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.191
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.190
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.189
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.188
|
|
|
|
cgmp metabolic process
|
GO:0046068 |
19 |
0.187
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.187
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.186
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.186
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.185
|
|
|
|
negative regulation of cyclic nucleotide biosynthetic process
|
GO:0030803 |
10 |
0.184
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.184
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.183
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.182
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.182
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.180
|
|
|
|
bone mineralization
|
GO:0030282 |
34 |
0.180
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.180
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.180
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.178
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.177
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.177
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.174
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.174
|
|
|
|
regulation of camp mediated signaling
|
GO:0043949 |
13 |
0.174
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.172
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.171
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.168
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.168
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.168
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.168
|
|
|
|
response to zinc ion
|
GO:0010043 |
12 |
0.166
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.164
|
Mouse |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.163
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.163
|
|
|
|
negative regulation of dendrite development
|
GO:2000171 |
5 |
0.163
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.163
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.162
|
|
|
|
central nervous system myelination
|
GO:0022010 |
1 |
0.161
|
|
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.161
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.160
|
Mouse |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.160
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.160
|
|
|
|
negative regulation of blood pressure
|
GO:0045776 |
3 |
0.158
|
|
|
|
regulation of sodium ion transport
|
GO:0002028 |
24 |
0.158
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.157
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.154
|
|
|
|
negative regulation of homotypic cell cell adhesion
|
GO:0034111 |
3 |
0.154
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.153
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.152
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.150
|
|
|
|
heart process
|
GO:0003015 |
62 |
0.147
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.147
|
|
|
|
vascular process in circulatory system
|
GO:0003018 |
29 |
0.146
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.146
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.146
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.145
|
|
|
|
regulation of blood vessel size
|
GO:0050880 |
18 |
0.144
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.144
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.144
|
|
|
|
response to monosaccharide
|
GO:0034284 |
20 |
0.143
|
|
|
|
negative regulation of systemic arterial blood pressure
|
GO:0003085 |
1 |
0.143
|
|
|
|
regulation of multicellular organismal metabolic process
|
GO:0044246 |
17 |
0.143
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.143
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.143
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.142
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.142
|
|
|
|
phospholipid dephosphorylation
|
GO:0046839 |
10 |
0.142
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.141
|
|
|
|
positive regulation of multicellular organismal metabolic process
|
GO:0044253 |
11 |
0.141
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.141
|
|
|
|
brain morphogenesis
|
GO:0048854 |
1 |
0.140
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.139
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.139
|
|
|
|
establishment of tissue polarity
|
GO:0007164 |
3 |
0.137
|
|
|
|
skeletal muscle tissue growth
|
GO:0048630 |
2 |
0.137
|
|
|
|
negative regulation of cyclic nucleotide metabolic process
|
GO:0030800 |
10 |
0.136
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.135
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.134
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.134
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.134
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.134
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.133
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.133
|
|
|
|
regulation of phosphatidylinositol biosynthetic process
|
GO:0010511 |
5 |
0.133
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.133
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.131
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.128
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.128
|
|
|
|
adenylate cyclase activating adrenergic receptor signaling pathway
|
GO:0071880 |
3 |
0.128
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.128
|
|
|
|
regulation of peptide secretion
|
GO:0002791 |
42 |
0.127
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.127
|
|
|
|
cyclic nucleotide mediated signaling
|
GO:0019935 |
26 |
0.126
|
|
|
|
membrane depolarization
|
GO:0051899 |
26 |
0.126
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.126
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.126
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.125
|
|
|
|
acid secretion
|
GO:0046717 |
12 |
0.125
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.125
|
|
|
|
positive regulation of phospholipid biosynthetic process
|
GO:0071073 |
4 |
0.124
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.123
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.122
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.120
|
|
|
|
lipid modification
|
GO:0030258 |
84 |
0.119
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.119
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.119
|
|
|
|
amino acid transport
|
GO:0006865 |
28 |
0.119
|
|
|
|
regulation of lipid catabolic process
|
GO:0050994 |
23 |
0.119
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.118
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.118
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.117
|
|
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.116
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.116
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.115
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.115
|
|
|
|
cognition
|
GO:0050890 |
43 |
0.115
|
Worm |
|
|
inositol phosphate dephosphorylation
|
GO:0046855 |
4 |
0.115
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.115
|
|
|
|
renal system process
|
GO:0003014 |
25 |
0.114
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.114
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.114
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.114
|
Mouse |
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.113
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.113
|
|
|
|
insulin secretion
|
GO:0030073 |
39 |
0.112
|
|
|
|
regulation of the force of heart contraction by chemical signal
|
GO:0003057 |
1 |
0.112
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.112
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.111
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.111
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.111
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.110
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.110
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.110
|
Mouse |
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.109
|
|
|
|
response to hexose
|
GO:0009746 |
20 |
0.109
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
7 |
0.108
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.108
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.108
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.108
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.107
|
|
|
|
morphogenesis of a polarized epithelium
|
GO:0001738 |
3 |
0.106
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.105
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.105
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.105
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.105
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.105
|
|
|
|
regulation of platelet aggregation
|
GO:0090330 |
4 |
0.104
|
|
|
|
positive regulation of biomineral tissue development
|
GO:0070169 |
20 |
0.104
|
|
|
|
cellular response to alkaloid
|
GO:0071312 |
11 |
0.104
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.104
|
Human |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.103
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.103
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.102
|
|
|
|
system process
|
GO:0003008 |
349 |
0.102
|
Worm |
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.102
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.101
|
Mouse |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.101
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.100
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.100
|
Mouse |
|
|
positive regulation of blood pressure
|
GO:0045777 |
3 |
0.100
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.100
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.100
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.099
|
|
|
|
regulation of excretion
|
GO:0044062 |
1 |
0.099
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.099
|
|
|
|
establishment of planar polarity
|
GO:0001736 |
3 |
0.098
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.097
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.096
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.096
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.096
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.095
|
|
|
|
prepulse inhibition
|
GO:0060134 |
1 |
0.095
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.095
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.093
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.093
|
|
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.093
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.093
|
Human |
|
|
negative regulation of sodium ion transmembrane transport
|
GO:1902306 |
2 |
0.093
|
|
|
|
regulation of myelination
|
GO:0031641 |
1 |
0.093
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.092
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.092
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.091
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.091
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.091
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.091
|
|
|
|
positive regulation of membrane potential
|
GO:0045838 |
2 |
0.090
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.090
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.090
|
|
|
|
renal sodium ion transport
|
GO:0003096 |
2 |
0.090
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.089
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.089
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.089
|
Human |
|
|
potassium ion transmembrane transport
|
GO:0071805 |
60 |
0.089
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.088
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.088
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.088
|
|
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.087
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.087
|
|
|
|
positive regulation of skeletal muscle tissue development
|
GO:0048643 |
1 |
0.086
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
17 |
0.086
|
Human |
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.085
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.085
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.085
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.084
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.083
|
|
|
|
regulation of monooxygenase activity
|
GO:0032768 |
22 |
0.083
|
|
|
|
phosphatidylinositol dephosphorylation
|
GO:0046856 |
7 |
0.083
|
|
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.083
|
|
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
37 |
0.083
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.083
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.083
|
|
|
|
positive regulation of release of sequestered calcium ion into cytosol
|
GO:0051281 |
16 |
0.082
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.082
|
|
|
|
detection of mechanical stimulus
|
GO:0050982 |
4 |
0.082
|
|
|
|
gland development
|
GO:0048732 |
48 |
0.081
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.079
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.079
|
|
|
|
positive regulation of cell division
|
GO:0051781 |
59 |
0.078
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.078
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.077
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.077
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.077
|
|
|
|
pallium development
|
GO:0021543 |
10 |
0.076
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.076
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.076
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.074
|
|
|
|
regulation of sodium ion transmembrane transporter activity
|
GO:2000649 |
17 |
0.074
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.074
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.074
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.073
|
|
|
|
negative regulation of cell size
|
GO:0045792 |
3 |
0.073
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.073
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.072
|
|
|
|
positive regulation of monooxygenase activity
|
GO:0032770 |
14 |
0.072
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.072
|
|
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.072
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.071
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
13 |
0.070
|
|
|
|
cerebellum development
|
GO:0021549 |
2 |
0.070
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.070
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.069
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.068
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.068
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.068
|
|
|
|
positive regulation of cyclase activity
|
GO:0031281 |
13 |
0.068
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.068
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.067
|
Human |
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.067
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.066
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.066
|
|
|
|
focal adhesion assembly
|
GO:0048041 |
30 |
0.066
|
|
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.066
|
|
|
|
respiratory system process
|
GO:0003016 |
3 |
0.065
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.065
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.065
|
|
|
|
regulation of adherens junction organization
|
GO:1903391 |
21 |
0.065
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.065
|
|
|
|
negative regulation of sodium ion transport
|
GO:0010766 |
3 |
0.064
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.064
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.064
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.064
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.064
|
|
|
|
negative regulation of vasculature development
|
GO:1901343 |
43 |
0.063
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.063
|
|
|
|
positive regulation of epidermal growth factor receptor signaling pathway
|
GO:0045742 |
11 |
0.063
|
|
|
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.063
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.063
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.063
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.062
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.062
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.062
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.062
|
|
|
|
hippocampus development
|
GO:0021766 |
1 |
0.062
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.062
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.062
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.062
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.062
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.061
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.061
|
|
|
|
response to transition metal nanoparticle
|
GO:1990267 |
29 |
0.061
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.061
|
|
|
|
negative regulation of myelination
|
GO:0031642 |
1 |
0.061
|
|
|
|
regulation of biomineral tissue development
|
GO:0070167 |
31 |
0.061
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.061
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.060
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.060
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.060
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.060
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.059
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.059
|
|
|
|
phosphatidylinositol biosynthetic process
|
GO:0006661 |
25 |
0.059
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.058
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
22 |
0.058
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.058
|
Mouse |
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.057
|
|
|
|
convergent extension involved in gastrulation
|
GO:0060027 |
1 |
0.057
|
|
|
|
regulation of atp catabolic process
|
GO:1903289 |
25 |
0.057
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.057
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.057
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.057
|
|
|
|
positive regulation of ligase activity
|
GO:0051351 |
19 |
0.056
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.056
|
|
|
|
positive regulation of vasodilation
|
GO:0045909 |
4 |
0.056
|
|
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.056
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.056
|
|
|
|
negative regulation of developmental growth
|
GO:0048640 |
10 |
0.056
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.056
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.056
|
|
|
|
activation of mitotic anaphase promoting complex activity
|
GO:0007092 |
2 |
0.055
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.055
|
|
|
|
response to glucose
|
GO:0009749 |
19 |
0.055
|
|
|
|
positive regulation of ubiquitin protein transferase activity
|
GO:0051443 |
18 |
0.055
|
|
|
|
activation of protein kinase b activity
|
GO:0032148 |
14 |
0.055
|
|
|
|
growth
|
GO:0040007 |
202 |
0.055
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.054
|
|
|
|
negative regulation of purine nucleotide metabolic process
|
GO:1900543 |
28 |
0.054
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.054
|
|
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.054
|
|
|
|
response to atp
|
GO:0033198 |
10 |
0.054
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.053
|
|
|
|
activation of phospholipase c activity
|
GO:0007202 |
7 |
0.053
|
|
|
|
regulation of axon guidance
|
GO:1902667 |
3 |
0.053
|
|
|
|
regulation of receptor activity
|
GO:0010469 |
47 |
0.053
|
|
|
|
positive regulation of epidermal growth factor activated receptor activity
|
GO:0045741 |
8 |
0.053
|
|
