Homo sapiens

50 known processes

MAP3K14

mitogen-activated protein kinase kinase kinase 14

(Aliases: HS,HSNIK,FTDCR1B,NIK)

MAP3K14 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
i kappab kinase nf kappab signaling GO:0007249 166 0.993
activation of nf kappab inducing kinase activity GO:0007250 9 0.992
nik nf kappab signaling GO:0038061 12 0.962
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.887
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.881
serine phosphorylation of stat protein GO:0042501 4 0.872
regulation of kinase activity GO:0043549 314 0.828
positive regulation of protein phosphorylation GO:0001934 313 0.818
positive regulation of nik nf kappab signaling GO:1901224 10 0.816
cytokine mediated signaling pathway GO:0019221 109 0.788
protein modification by small protein conjugation GO:0032446 342 0.782
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.770
defense response to virus GO:0051607 71 0.762
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.748
positive regulation of protein kinase activity GO:0045860 190 0.742
positive regulation of immune response GO:0050778 159 0.739
activation of protein kinase activity GO:0032147 90 0.731
apoptotic signaling pathway GO:0097190 268 0.727
positive regulation of mapk cascade GO:0043410 190 0.691
positive regulation of programmed cell death GO:0043068 249 0.651
regulation of mapk cascade GO:0043408 262 0.633
regulation of apoptotic signaling pathway GO:2001233 175 0.615
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.613
protein polyubiquitination GO:0000209 110 0.606
regulation of protein serine threonine kinase activity GO:0071900 179 0.599
regulation of immune response GO:0050776 201 0.575
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.565
regulation of stress activated mapk cascade GO:0032872 84 0.561
response to biotic stimulus GO:0009607 276 0.555
positive regulation of defense response GO:0031349 87 0.545
regulation of nik nf kappab signaling GO:1901222 11 0.533
negative regulation of programmed cell death GO:0043069 321 0.527
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.514
positive regulation of cell death GO:0010942 263 0.467
immune response GO:0006955 307 0.465
Mouse
response to lipid GO:0033993 206 0.463
i kappab phosphorylation GO:0007252 7 0.436
regulation of cytokine production GO:0001817 232 0.434
regulation of map kinase activity GO:0043405 108 0.432
response to bacterium GO:0009617 144 0.431
cellular response to cytokine stimulus GO:0071345 181 0.427
cellular response to tumor necrosis factor GO:0071356 63 0.422
extrinsic apoptotic signaling pathway GO:0097191 119 0.420
response to tumor necrosis factor GO:0034612 76 0.418
immune response activating signal transduction GO:0002757 90 0.408
regulation of response to external stimulus GO:0032101 222 0.389
positive regulation of transferase activity GO:0051347 227 0.388
response to other organism GO:0051707 261 0.375
innate immune response GO:0045087 178 0.372
positive regulation of immune system process GO:0002684 283 0.368
regulation of protein kinase activity GO:0045859 289 0.363
positive regulation of stress activated mapk cascade GO:0032874 60 0.349
innate immune response activating signal transduction GO:0002758 48 0.344
activation of innate immune response GO:0002218 55 0.343
regulation of multi organism process GO:0043900 157 0.340
response to virus GO:0009615 126 0.331
positive regulation of jun kinase activity GO:0043507 23 0.328
response to external biotic stimulus GO:0043207 261 0.328
regulation of interferon beta production GO:0032648 22 0.327
negative regulation of multicellular organismal process GO:0051241 317 0.316
regulation of transferase activity GO:0051338 355 0.314
cellular response to oxygen containing compound GO:1901701 276 0.310
regulation of defense response GO:0031347 154 0.309
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.308
positive regulation of cytokine production GO:0001819 167 0.299
positive regulation of map kinase activity GO:0043406 80 0.298
response to oxygen containing compound GO:1901700 369 0.282
pattern recognition receptor signaling pathway GO:0002221 48 0.269
protein autophosphorylation GO:0046777 123 0.265
jnk cascade GO:0007254 80 0.251
activation of immune response GO:0002253 114 0.250
myeloid cell differentiation GO:0030099 117 0.249
positive regulation of kinase activity GO:0033674 204 0.245
interferon beta production GO:0032608 23 0.239
defense response to bacterium GO:0042742 63 0.234
protein ubiquitination GO:0016567 314 0.232
positive regulation of apoptotic signaling pathway GO:2001235 70 0.232
regulation of cell differentiation GO:0045595 393 0.232
positive regulation of interferon alpha production GO:0032727 11 0.228
response to cytokine GO:0034097 232 0.225
ion transmembrane transport GO:0034220 338 0.224
organ morphogenesis GO:0009887 147 0.224
ribonucleoside triphosphate metabolic process GO:0009199 412 0.223
regulation of defense response to virus GO:0050688 33 0.222
regulation of immune effector process GO:0002697 91 0.212
positive regulation of innate immune response GO:0045089 79 0.211
activation of jnkk activity GO:0007256 1 0.207
amide biosynthetic process GO:0043604 15 0.199
purine nucleoside catabolic process GO:0006152 398 0.198
positive regulation of defense response to virus by host GO:0002230 14 0.198
hematopoietic or lymphoid organ development GO:0048534 186 0.196
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.194
type i interferon production GO:0032606 27 0.192
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.191
negative regulation of apoptotic process GO:0043066 316 0.191
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.190
cellular amino acid metabolic process GO:0006520 116 0.189
nucleoside triphosphate metabolic process GO:0009141 422 0.186
defense response GO:0006952 315 0.185
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.184
purine nucleoside triphosphate catabolic process GO:0009146 392 0.182
morphogenesis of embryonic epithelium GO:0016331 4 0.180
ribonucleoside triphosphate catabolic process GO:0009203 391 0.178
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.173
defense response to other organism GO:0098542 129 0.170
epithelial fluid transport GO:0042045 1 0.169
regulation of defense response to bacterium GO:1900424 2 0.168
cellular response to external stimulus GO:0071496 111 0.166
regulation of myeloid cell differentiation GO:0045637 81 0.160
jak stat cascade GO:0007259 46 0.153
positive regulation of jnk cascade GO:0046330 52 0.152
mapk cascade GO:0000165 288 0.151
toll like receptor 2 signaling pathway GO:0034134 4 0.148
negative regulation of intracellular signal transduction GO:1902532 183 0.146
positive regulation of humoral immune response GO:0002922 3 0.144
response to molecule of bacterial origin GO:0002237 82 0.140
ribonucleotide catabolic process GO:0009261 405 0.138
positive regulation of cell proliferation GO:0008284 301 0.137
negative regulation of cellular protein metabolic process GO:0032269 353 0.136
positive regulation of cellular amine metabolic process GO:0033240 7 0.134
dephosphorylation GO:0016311 209 0.129
cytokine production GO:0001816 247 0.128
regulation of cellular amine metabolic process GO:0033238 11 0.128
purine containing compound catabolic process GO:0072523 411 0.126
regulation of cellular amino acid metabolic process GO:0006521 6 0.125
negative regulation of protein metabolic process GO:0051248 391 0.124
nucleotide catabolic process GO:0009166 408 0.121
programmed necrotic cell death GO:0097300 18 0.120
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.119
purine ribonucleoside metabolic process GO:0046128 437 0.117
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.116
regulation of innate immune response GO:0045088 97 0.114
reactive oxygen species metabolic process GO:0072593 75 0.113
intrinsic apoptotic signaling pathway GO:0097193 127 0.112
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.109
regulation of transporter activity GO:0032409 82 0.109
positive regulation of developmental process GO:0051094 314 0.107
regulation of ion transmembrane transport GO:0034765 132 0.106
system process GO:0003008 349 0.106
nervous system development GO:0007399 293 0.100
regulation of ion transmembrane transporter activity GO:0032412 72 0.096
positive regulation of defense response to bacterium GO:1900426 1 0.096
striated muscle contraction GO:0006941 52 0.095
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.095
regulation of response to biotic stimulus GO:0002831 55 0.094
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.093
myeloid leukocyte differentiation GO:0002573 60 0.092
peptidyl serine phosphorylation GO:0018105 101 0.092
cdc42 protein signal transduction GO:0032488 4 0.092
regulation of type i interferon production GO:0032479 26 0.092
positive regulation of t cell cytokine production GO:0002726 4 0.091
peptidyl serine modification GO:0018209 106 0.091
detection of muramyl dipeptide GO:0032498 1 0.090
cellular amide metabolic process GO:0043603 69 0.089
ras protein signal transduction GO:0007265 73 0.087
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.086
transmembrane transport GO:0055085 399 0.084
organonitrogen compound biosynthetic process GO:1901566 200 0.084
negative regulation of cell death GO:0060548 345 0.083
regulation of jnk cascade GO:0046328 73 0.083
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.082
peptide metabolic process GO:0006518 51 0.080
leukocyte differentiation GO:0002521 98 0.079
positive regulation of apoptotic process GO:0043065 246 0.079
stress activated protein kinase signaling cascade GO:0031098 94 0.078
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 12 0.075
response to lipopolysaccharide GO:0032496 70 0.074
regulation of antimicrobial humoral response GO:0002759 1 0.074
cellular response to molecule of bacterial origin GO:0071219 62 0.074
peptidyl serine autophosphorylation GO:0036289 2 0.073
stress activated mapk cascade GO:0051403 93 0.073
protein processing GO:0016485 226 0.072
intracellular receptor signaling pathway GO:0030522 104 0.072
cellular amine metabolic process GO:0044106 41 0.072
negative regulation of phosphorus metabolic process GO:0010563 267 0.070
small gtpase mediated signal transduction GO:0007264 78 0.069
regulation of transmembrane transporter activity GO:0022898 74 0.069
muscle contraction GO:0006936 73 0.067
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.067
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.066
regulation of cellular response to stress GO:0080135 244 0.065
positive regulation of leukocyte differentiation GO:1902107 37 0.065
regulation of cellular ketone metabolic process GO:0010565 50 0.065
cell morphogenesis GO:0000902 296 0.065
regulation of ras protein signal transduction GO:0046578 155 0.065
antibacterial humoral response GO:0019731 24 0.064
regulation of endothelial cell apoptotic process GO:2000351 24 0.064
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.064
cellular ketone metabolic process GO:0042180 80 0.064
muscle system process GO:0003012 81 0.063
lymphocyte homeostasis GO:0002260 4 0.063
regulation of binding GO:0051098 111 0.063
locomotory behavior GO:0007626 1 0.062
positive regulation of adaptive immune response GO:0002821 21 0.061
tube development GO:0035295 125 0.060
carbohydrate derivative transport GO:1901264 20 0.059
nucleoside phosphate catabolic process GO:1901292 412 0.059
regulation of adaptive immune response GO:0002819 33 0.059
immune effector process GO:0002252 159 0.059
positive regulation of interleukin 2 production GO:0032743 11 0.059
cellular response to lipid GO:0071396 127 0.058
positive regulation of interferon beta production GO:0032728 17 0.058
transmission of nerve impulse GO:0019226 11 0.058
regulation of protein secretion GO:0050708 86 0.058
segmentation GO:0035282 4 0.058
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.057
purine nucleoside triphosphate metabolic process GO:0009144 412 0.057
regulation of interferon alpha production GO:0032647 11 0.057
cell projection organization GO:0030030 252 0.057
central nervous system development GO:0007417 123 0.056
regulation of protein localization GO:0032880 296 0.056
secretion by cell GO:0032940 226 0.055
post embryonic development GO:0009791 2 0.055
regulation of endopeptidase activity GO:0052548 170 0.054
positive regulation of antimicrobial humoral response GO:0002760 1 0.054
cytokine biosynthetic process GO:0042089 37 0.054
epiboly involved in gastrulation with mouth forming second GO:0055113 1 0.053
regulation of defense response to virus by host GO:0050691 22 0.053
regulation of jun kinase activity GO:0043506 27 0.053
nucleoside catabolic process GO:0009164 408 0.052
regulation of cell cycle GO:0051726 393 0.052
regulation of lymphocyte activation GO:0051249 103 0.051
skeletal muscle contraction GO:0003009 16 0.051
antimicrobial humoral response GO:0019730 26 0.051
neurological system process GO:0050877 163 0.051
regulation of nucleotide catabolic process GO:0030811 205 0.050
b cell homeostasis GO:0001782 1 0.050
cell development GO:0048468 328 0.050
interferon alpha production GO:0032607 11 0.049
positive regulation of hydrolase activity GO:0051345 331 0.049
regulation of gtpase activity GO:0043087 180 0.049
positive regulation of response to external stimulus GO:0032103 88 0.048
positive regulation of necrotic cell death GO:0010940 4 0.047
negative regulation of necroptotic process GO:0060546 2 0.047
lymphocyte mediated immunity GO:0002449 48 0.047
peptidyl tyrosine phosphorylation GO:0018108 170 0.047
organophosphate catabolic process GO:0046434 430 0.046
response to organonitrogen compound GO:0010243 156 0.046
nuclear transport GO:0051169 179 0.046
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.045
positive regulation of ion transmembrane transport GO:0034767 40 0.045
osteoclast differentiation GO:0030316 21 0.045
oogenesis GO:0048477 2 0.044
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.044
positive regulation of cellular catabolic process GO:0031331 284 0.043
t cell cytokine production GO:0002369 12 0.043
hemopoiesis GO:0030097 180 0.043
regulation of jak stat cascade GO:0046425 44 0.043
signal transduction by phosphorylation GO:0023014 297 0.042
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 97 0.042
anatomical structure formation involved in morphogenesis GO:0048646 284 0.042
regulation of reactive oxygen species metabolic process GO:2000377 41 0.042
production of molecular mediator of immune response GO:0002440 37 0.041
protein catabolic process GO:0030163 325 0.041
sodium ion transport GO:0006814 61 0.041
positive regulation of phosphorylation GO:0042327 394 0.041
regulation of transmembrane transport GO:0034762 139 0.041
mitotic cell cycle GO:0000278 326 0.041
cytoplasmic transport GO:0016482 379 0.041
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.041
regulation of gtp catabolic process GO:0033124 180 0.041
response to organic cyclic compound GO:0014070 204 0.041
positive regulation of endothelial cell apoptotic process GO:2000353 8 0.041
ribonucleoside catabolic process GO:0042454 406 0.040
negative regulation of protein phosphorylation GO:0001933 140 0.040
negative regulation of protein modification process GO:0031400 200 0.040
positive regulation of transport GO:0051050 336 0.039
actin cytoskeleton organization GO:0030036 207 0.039
immune system development GO:0002520 195 0.039
regulation of tumor necrosis factor production GO:0032680 43 0.039
response to abiotic stimulus GO:0009628 336 0.039
peptidyl tyrosine modification GO:0018212 170 0.038
regulation of ion transport GO:0043269 189 0.038
purine ribonucleotide catabolic process GO:0009154 404 0.038
multicellular organismal movement GO:0050879 17 0.038
metal ion transport GO:0030001 272 0.038
intracellular protein transport GO:0006886 270 0.038
regulation of establishment of protein localization GO:0070201 242 0.037
regulation of protein processing GO:0070613 150 0.037
negative regulation of protein processing GO:0010955 142 0.037
gtp metabolic process GO:0046039 239 0.037
cell type specific apoptotic process GO:0097285 125 0.037
glycosyl compound catabolic process GO:1901658 413 0.037
negative regulation of intracellular protein transport GO:0090317 42 0.037
response to interleukin 1 GO:0070555 47 0.036
positive regulation of catabolic process GO:0009896 310 0.036
multicellular organismal aging GO:0010259 3 0.036
antigen receptor mediated signaling pathway GO:0050851 38 0.036
protein secretion GO:0009306 98 0.036
protein homooligomerization GO:0051260 100 0.035
odontogenesis GO:0042476 25 0.035
purine ribonucleoside catabolic process GO:0046130 398 0.035
immune response regulating signaling pathway GO:0002764 97 0.035
purine nucleotide catabolic process GO:0006195 405 0.035
gastrulation with mouth forming second GO:0001702 1 0.035
defense response to gram negative bacterium GO:0050829 14 0.035
toll like receptor signaling pathway GO:0002224 25 0.034
response to extracellular stimulus GO:0009991 85 0.034
embryonic morphogenesis GO:0048598 85 0.034
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.034
neuronal action potential GO:0019228 9 0.033
cellular response to biotic stimulus GO:0071216 71 0.033
nucleoside triphosphate catabolic process GO:0009143 394 0.033
response to muramyl dipeptide GO:0032495 4 0.033
lymphocyte apoptotic process GO:0070227 20 0.033
regulation of rho protein signal transduction GO:0035023 79 0.033
protein targeting GO:0006605 187 0.033
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.033
positive regulation of gtp catabolic process GO:0033126 166 0.032
cellular response to growth factor stimulus GO:0071363 197 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.032
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.032
endothelial cell apoptotic process GO:0072577 26 0.032
tube morphogenesis GO:0035239 95 0.032
cell projection morphogenesis GO:0048858 129 0.032
enzyme linked receptor protein signaling pathway GO:0007167 303 0.032
sterol transport GO:0015918 39 0.031
regulation of cytokine biosynthetic process GO:0042035 35 0.031
negative regulation of cellular component organization GO:0051129 235 0.031
skeletal muscle satellite cell proliferation GO:0014841 1 0.031
negative regulation of immune system process GO:0002683 136 0.031
response to nitrogen compound GO:1901698 184 0.031
adaptive immune response GO:0002250 49 0.030
atp metabolic process GO:0046034 176 0.030
monovalent inorganic cation transport GO:0015672 128 0.030
limbic system development GO:0021761 3 0.030
regulation of cell activation GO:0050865 125 0.030
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.030
cellular response to abiotic stimulus GO:0071214 117 0.030
response to peptidoglycan GO:0032494 3 0.030
ribonucleoside monophosphate catabolic process GO:0009158 158 0.030
positive regulation of sodium ion transport GO:0010765 14 0.030
ossification GO:0001503 121 0.030
chemotaxis GO:0006935 157 0.030
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.030
positive regulation of response to biotic stimulus GO:0002833 18 0.029
regulation of rho gtpase activity GO:0032319 66 0.029
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.029
humoral immune response GO:0006959 49 0.029
cation transport GO:0006812 331 0.029
neural tube formation GO:0001841 3 0.029
regulation of cell growth GO:0001558 135 0.029
neurotransmitter secretion GO:0007269 4 0.029
translation GO:0006412 132 0.028
actin filament based process GO:0030029 224 0.028
positive regulation of cation channel activity GO:2001259 16 0.028
positive regulation of cell differentiation GO:0045597 211 0.028
regulation of necrotic cell death GO:0010939 9 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.028
peptidyl threonine phosphorylation GO:0018107 41 0.028
positive regulation of multi organism process GO:0043902 56 0.028
spindle elongation GO:0051231 4 0.027
regulation of proteolysis GO:0030162 293 0.027
regulation of peptide transport GO:0090087 62 0.027
cellular component morphogenesis GO:0032989 314 0.026
epithelium development GO:0060429 227 0.026
negative regulation of phosphorylation GO:0042326 174 0.026
positive regulation of immune effector process GO:0002699 40 0.026
negative regulation of developmental process GO:0051093 247 0.026
positive regulation of osteoclast differentiation GO:0045672 9 0.026
osteoblast differentiation GO:0001649 92 0.026
positive regulation of synaptic transmission GO:0050806 4 0.026
positive regulation of lymphocyte activation GO:0051251 73 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
immunoglobulin secretion GO:0048305 1 0.025
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.025
cellular response to nutrient levels GO:0031669 69 0.025
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.025
positive regulation of ras gtpase activity GO:0032320 117 0.025
salivary gland morphogenesis GO:0007435 4 0.025
regeneration GO:0031099 4 0.025
response to nutrient levels GO:0031667 81 0.025
regulation of small gtpase mediated signal transduction GO:0051056 156 0.025
regulation of polysaccharide metabolic process GO:0032881 21 0.024
regulation of body fluid levels GO:0050878 99 0.024
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.024
nitrogen compound transport GO:0071705 191 0.024
carbohydrate metabolic process GO:0005975 207 0.024
protein oligomerization GO:0051259 173 0.024
neuron differentiation GO:0030182 138 0.024
regulation of protein ubiquitination GO:0031396 95 0.024
guanosine containing compound catabolic process GO:1901069 239 0.024
negative regulation of kinase activity GO:0033673 106 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
regulation of cell cycle process GO:0010564 266 0.023
response to wounding GO:0009611 168 0.023
interleukin 6 production GO:0032635 37 0.023
response to fungus GO:0009620 4 0.023
purine nucleoside monophosphate metabolic process GO:0009126 186 0.023
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.023
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.023
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 5 0.023
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.023
nucleoside monophosphate metabolic process GO:0009123 191 0.022
lipid metabolic process GO:0006629 381 0.022
cellular protein complex assembly GO:0043623 188 0.022
response to hormone GO:0009725 175 0.022
reproductive process GO:0022414 106 0.022
rho protein signal transduction GO:0007266 26 0.022
neuron development GO:0048666 113 0.022
positive regulation of ion transport GO:0043270 87 0.022
positive regulation of transporter activity GO:0032411 32 0.021
leukocyte activation GO:0045321 164 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.021
negative regulation of protein kinase activity GO:0006469 98 0.021
cell activation GO:0001775 213 0.021
regulation of dna binding GO:0051101 37 0.021
negative regulation of growth GO:0045926 97 0.021
organelle assembly GO:0070925 176 0.021
positive regulation of nucleotide catabolic process GO:0030813 185 0.021
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.021
negative regulation of protein maturation GO:1903318 142 0.021
neuron projection development GO:0031175 106 0.021
regulation of cell cycle phase transition GO:1901987 126 0.021
regulation of protein catabolic process GO:0042176 155 0.021
regulation of interleukin 8 production GO:0032677 49 0.020
regulation of phosphatase activity GO:0010921 81 0.020
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.020
detection of peptidoglycan GO:0032499 1 0.020
regulation of production of molecular mediator of immune response GO:0002700 25 0.020
erk1 and erk2 cascade GO:0070371 104 0.020
actin filament organization GO:0007015 128 0.020
positive regulation of nucleotide metabolic process GO:0045981 230 0.020
mitochondrion organization GO:0007005 156 0.020
protein trimerization GO:0070206 20 0.020
regulation of dephosphorylation GO:0035303 96 0.020
erythrocyte differentiation GO:0030218 28 0.020
nucleoside monophosphate catabolic process GO:0009125 159 0.020
tissue morphogenesis GO:0048729 96 0.020
regulation of peptidase activity GO:0052547 180 0.020
cellular component disassembly GO:0022411 92 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
protein localization to nucleus GO:0034504 136 0.019
cellular metal ion homeostasis GO:0006875 146 0.019
neuromuscular junction development GO:0007528 3 0.019
apoptotic mitochondrial changes GO:0008637 57 0.019
reactive nitrogen species metabolic process GO:2001057 3 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.019
negative regulation of catabolic process GO:0009895 104 0.019
tnfsf11 mediated signaling pathway GO:0071847 2 0.019
response to peptide GO:1901652 65 0.018
covalent chromatin modification GO:0016569 254 0.018
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.018
regulation of neuron death GO:1901214 56 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
cellular response to muramyl dipeptide GO:0071225 3 0.018
regulation of autophagy GO:0010506 52 0.018
regulation of peptidyl serine phosphorylation GO:0033135 50 0.018
atp catabolic process GO:0006200 157 0.018
negative regulation of protein transport GO:0051224 75 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
positive regulation of type i interferon production GO:0032481 20 0.018
internal peptidyl lysine acetylation GO:0018393 97 0.018
maintenance of protein location in cell GO:0032507 56 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
g1 s transition of mitotic cell cycle GO:0000082 78 0.017
positive regulation of cell activation GO:0050867 81 0.017
organic hydroxy compound transport GO:0015850 63 0.017
positive regulation of myeloid cell differentiation GO:0045639 39 0.017
regulation of synaptic plasticity GO:0048167 3 0.017
compound eye development GO:0048749 1 0.017
cellular response to oxidative stress GO:0034599 85 0.017
brain development GO:0007420 97 0.017
protein kinase b signaling GO:0043491 69 0.017
epithelial cell proliferation GO:0050673 128 0.017
positive regulation of jak stat cascade GO:0046427 35 0.017
cellular cation homeostasis GO:0030003 163 0.017
negative regulation of mapk cascade GO:0043409 56 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
somitogenesis GO:0001756 2 0.017
negative regulation of proteolysis GO:0045861 132 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
negative regulation of transferase activity GO:0051348 124 0.017
negative regulation of mitotic cell cycle GO:0045930 102 0.017
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.017
t cell receptor signaling pathway GO:0050852 21 0.017
response to metal ion GO:0010038 84 0.017
zymogen activation GO:0031638 70 0.016
regulation of immunoglobulin production GO:0002637 4 0.016
response to alkaloid GO:0043279 20 0.016
negative regulation of cell cycle process GO:0010948 121 0.016
response to uv GO:0009411 73 0.016
regulation of mononuclear cell proliferation GO:0032944 65 0.016
regulation of ras gtpase activity GO:0032318 128 0.016
regulation of immunoglobulin secretion GO:0051023 1 0.016
negative regulation of t cell apoptotic process GO:0070233 4 0.016

MAP3K14 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.098
hematopoietic system disease DOID:74 100 0.083
cancer DOID:162 167 0.029
disease of cellular proliferation DOID:14566 174 0.029
organ system cancer DOID:0050686 164 0.029
disease of metabolism DOID:0014667 295 0.017
inherited metabolic disorder DOID:655 242 0.017