Homo sapiens

6 known processes

MAP3K8

mitogen-activated protein kinase kinase kinase 8

(Aliases: ESTF,FLJ10486,COT,Tpl-2,TPL2,EST,c-COT,MEKK8)

MAP3K8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of humoral immune response GO:0002922 3 0.888
vitamin d metabolic process GO:0042359 10 0.861
interleukin 12 biosynthetic process GO:0042090 1 0.843
negative regulation of endothelial cell apoptotic process GO:2000352 16 0.828
negative regulation of calcidiol 1 monooxygenase activity GO:0010956 3 0.814
female gamete generation GO:0007292 2 0.790
defense response GO:0006952 315 0.776
i kappab kinase nf kappab signaling GO:0007249 166 0.751
defense response to fungus GO:0050832 4 0.748
regulation of vitamin metabolic process GO:0030656 9 0.744
response to molecule of bacterial origin GO:0002237 82 0.685
activation of innate immune response GO:0002218 55 0.683
fat soluble vitamin metabolic process GO:0006775 19 0.675
positive regulation of hyaluronan biosynthetic process GO:1900127 3 0.665
response to radiation GO:0009314 151 0.653
regulation of canonical wnt signaling pathway GO:0060828 88 0.648
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.645
positive regulation of immune system process GO:0002684 283 0.637
positive regulation of defense response GO:0031349 87 0.632
regulation of response to biotic stimulus GO:0002831 55 0.621
immune response activating signal transduction GO:0002757 90 0.614
activation of immune response GO:0002253 114 0.606
positive regulation of antimicrobial humoral response GO:0002760 1 0.588
immune response GO:0006955 307 0.571
response to oxygen containing compound GO:1901700 369 0.561
response to lipopolysaccharide GO:0032496 70 0.555
response to reactive oxygen species GO:0000302 61 0.546
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.526
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.523
cholesterol transport GO:0030301 39 0.522
antifungal humoral response GO:0019732 2 0.518
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.497
vitamin metabolic process GO:0006766 26 0.497
response to interleukin 1 GO:0070555 47 0.488
pattern recognition receptor signaling pathway GO:0002221 48 0.483
response to hydrogen peroxide GO:0042542 40 0.465
cellular response to oxygen containing compound GO:1901701 276 0.463
amide biosynthetic process GO:0043604 15 0.460
immune response regulating signaling pathway GO:0002764 97 0.457
positive regulation of immune response GO:0050778 159 0.450
fat soluble vitamin biosynthetic process GO:0042362 11 0.449
response to biotic stimulus GO:0009607 276 0.442
regulation of defense response GO:0031347 154 0.434
regulation of immune response GO:0050776 201 0.425
canonical wnt signaling pathway GO:0060070 116 0.424
response to virus GO:0009615 126 0.423
cellular response to hydrogen peroxide GO:0070301 37 0.414
cellular response to biotic stimulus GO:0071216 71 0.405
positive regulation of innate immune response GO:0045089 79 0.402
response to external biotic stimulus GO:0043207 261 0.396
regulation of polysaccharide biosynthetic process GO:0032885 20 0.391
response to other organism GO:0051707 261 0.389
intrinsic apoptotic signaling pathway GO:0097193 127 0.388
positive regulation of interleukin 12 production GO:0032735 8 0.370
small molecule biosynthetic process GO:0044283 157 0.368
cytokine biosynthetic process GO:0042089 37 0.366
positive regulation of cytokine production GO:0001819 167 0.355
lipid biosynthetic process GO:0008610 177 0.353
cellular response to lipid GO:0071396 127 0.352
innate immune response activating signal transduction GO:0002758 48 0.338
negative regulation of vitamin metabolic process GO:0046137 6 0.330
peripheral nervous system development GO:0007422 2 0.325
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.315
reactive oxygen species metabolic process GO:0072593 75 0.313
aminoglycan biosynthetic process GO:0006023 29 0.311
negative regulation of apoptotic process GO:0043066 316 0.311
cell activation GO:0001775 213 0.311
response to cytokine GO:0034097 232 0.308
cytokine production GO:0001816 247 0.302
cytokine mediated signaling pathway GO:0019221 109 0.302
response to oxidative stress GO:0006979 121 0.281
regulation of multi organism process GO:0043900 157 0.280
inflammatory response GO:0006954 79 0.276
response to fungus GO:0009620 4 0.276
mucopolysaccharide metabolic process GO:1903510 27 0.274
defense response to other organism GO:0098542 129 0.272
positive regulation of multi organism process GO:0043902 56 0.269
response to uv GO:0009411 73 0.265
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.265
negative regulation of programmed cell death GO:0043069 321 0.263
defense response to gram negative bacterium GO:0050829 14 0.261
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.260
apoptotic signaling pathway GO:0097190 268 0.258
humoral immune response GO:0006959 49 0.258
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.257
regulation of transcription factor import into nucleus GO:0042990 39 0.255
glycosyl compound catabolic process GO:1901658 413 0.250
cellular response to abiotic stimulus GO:0071214 117 0.249
organic anion transport GO:0015711 103 0.249
cellular response to lipopolysaccharide GO:0071222 57 0.246
cellular response to interleukin 1 GO:0071347 35 0.239
positive regulation of wnt signaling pathway GO:0030177 54 0.231
negative regulation of apoptotic signaling pathway GO:2001234 97 0.224
response to lipid GO:0033993 206 0.222
positive regulation of defense response to bacterium GO:1900426 1 0.220
negative regulation of developmental process GO:0051093 247 0.218
regulation of intracellular transport GO:0032386 195 0.216
negative regulation of cell death GO:0060548 345 0.216
lipid metabolic process GO:0006629 381 0.216
b cell activation GO:0042113 33 0.215
cellular response to endogenous stimulus GO:0071495 336 0.214
defense response to bacterium GO:0042742 63 0.214
wnt signaling pathway GO:0016055 156 0.212
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.211
response to nitrogen compound GO:1901698 184 0.211
response to abiotic stimulus GO:0009628 336 0.211
reactive oxygen species biosynthetic process GO:1903409 4 0.209
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.208
innate immune response GO:0045087 178 0.199
cellular amide metabolic process GO:0043603 69 0.197
steroid metabolic process GO:0008202 94 0.197
regulation of sterol transport GO:0032371 21 0.191
organonitrogen compound biosynthetic process GO:1901566 200 0.189
response to bacterium GO:0009617 144 0.188
response to organic cyclic compound GO:0014070 204 0.187
defense response to gram positive bacterium GO:0050830 29 0.187
spleen development GO:0048536 1 0.184
peptide metabolic process GO:0006518 51 0.177
oogenesis GO:0048477 2 0.176
cellular response to organic cyclic compound GO:0071407 127 0.175
nf kappab import into nucleus GO:0042348 22 0.174
regulation of lipid transport GO:0032368 44 0.172
posttranscriptional regulation of gene expression GO:0010608 213 0.168
negative regulation of intracellular signal transduction GO:1902532 183 0.168
regulation of vitamin d biosynthetic process GO:0060556 8 0.166
regulation of defense response to bacterium GO:1900424 2 0.163
negative regulation of interleukin 12 production GO:0032695 6 0.162
cellular response to oxidative stress GO:0034599 85 0.162
reactive nitrogen species metabolic process GO:2001057 3 0.159
organic hydroxy compound biosynthetic process GO:1901617 71 0.156
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 5 0.153
regulation of lipid metabolic process GO:0019216 96 0.152
mirna metabolic process GO:0010586 10 0.152
memory GO:0007613 3 0.152
interleukin 1 mediated signaling pathway GO:0070498 12 0.150
negative regulation of protein transport GO:0051224 75 0.149
negative regulation of cytokine biosynthetic process GO:0042036 11 0.148
regulation of cytokine production GO:0001817 232 0.147
negative regulation of catalytic activity GO:0043086 335 0.146
cellular response to external stimulus GO:0071496 111 0.145
signal transduction in response to dna damage GO:0042770 57 0.144
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.138
aminoglycan metabolic process GO:0006022 39 0.137
antibacterial humoral response GO:0019731 24 0.137
regulation of response to external stimulus GO:0032101 222 0.137
toll like receptor 3 signaling pathway GO:0034138 4 0.134
response to wounding GO:0009611 168 0.133
negative regulation of interleukin 8 production GO:0032717 12 0.131
response to inorganic substance GO:0010035 127 0.130
organic hydroxy compound metabolic process GO:1901615 147 0.129
regulation of antimicrobial humoral response GO:0002759 1 0.128
regulation of endothelial cell apoptotic process GO:2000351 24 0.127
regulation of leukocyte activation GO:0002694 115 0.126
interleukin 8 production GO:0032637 51 0.125
immune effector process GO:0002252 159 0.123
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.119
single organism nuclear import GO:1902593 104 0.111
negative regulation of protein import into nucleus GO:0042308 30 0.111
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.108
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.108
ribonucleoside triphosphate metabolic process GO:0009199 412 0.105
carbohydrate derivative biosynthetic process GO:1901137 207 0.105
positive regulation of response to external stimulus GO:0032103 88 0.104
nervous system development GO:0007399 293 0.104
negative regulation of protein metabolic process GO:0051248 391 0.103
purine ribonucleoside metabolic process GO:0046128 437 0.103
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.103
cellular component morphogenesis GO:0032989 314 0.099
response to mechanical stimulus GO:0009612 51 0.097
immune system development GO:0002520 195 0.096
lymphocyte mediated immunity GO:0002449 48 0.094
response to muramyl dipeptide GO:0032495 4 0.094
polysaccharide biosynthetic process GO:0000271 27 0.092
cellular response to cytokine stimulus GO:0071345 181 0.091
regulation of reactive oxygen species metabolic process GO:2000377 41 0.088
positive regulation of carbohydrate metabolic process GO:0045913 21 0.088
regulation of apoptotic signaling pathway GO:2001233 175 0.088
toll like receptor 9 signaling pathway GO:0034162 1 0.087
nucleoside triphosphate metabolic process GO:0009141 422 0.086
negative regulation of lipid biosynthetic process GO:0051055 22 0.083
positive regulation of response to biotic stimulus GO:0002833 18 0.082
regulation of steroid metabolic process GO:0019218 32 0.082
cell morphogenesis GO:0000902 296 0.080
carbohydrate biosynthetic process GO:0016051 42 0.080
regulation of oxidoreductase activity GO:0051341 43 0.079
regulation of nitric oxide biosynthetic process GO:0045428 17 0.077
cell development GO:0048468 328 0.077
intracellular protein transport GO:0006886 270 0.076
regulation of protein localization GO:0032880 296 0.075
negative regulation of oxidoreductase activity GO:0051354 17 0.075
regulation of lipid biosynthetic process GO:0046890 47 0.074
carbohydrate metabolic process GO:0005975 207 0.073
negative regulation of lipid metabolic process GO:0045833 38 0.073
extracellular matrix organization GO:0030198 41 0.073
leukocyte activation GO:0045321 164 0.072
regulation of intracellular protein transport GO:0033157 123 0.071
maintenance of location GO:0051235 112 0.071
cell type specific apoptotic process GO:0097285 125 0.071
regulation of immune effector process GO:0002697 91 0.070
neuron projection development GO:0031175 106 0.070
interleukin 12 production GO:0032615 15 0.070
positive regulation of lymphocyte activation GO:0051251 73 0.070
vasculature development GO:0001944 181 0.068
nucleoside triphosphate catabolic process GO:0009143 394 0.068
neuron differentiation GO:0030182 138 0.068
negative regulation of vitamin d biosynthetic process GO:0010957 5 0.067
single organism reproductive process GO:0044702 98 0.067
cytokine metabolic process GO:0042107 38 0.066
negative regulation of cytokine production GO:0001818 82 0.065
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.064
cellular response to hormone stimulus GO:0032870 125 0.063
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.062
glycosaminoglycan metabolic process GO:0030203 35 0.061
toll like receptor signaling pathway GO:0002224 25 0.061
hyaluronan metabolic process GO:0030212 15 0.061
endothelial cell apoptotic process GO:0072577 26 0.061
regulation of b cell activation GO:0050864 24 0.060
regulation of protein import into nucleus GO:0042306 78 0.060
ribonucleoside triphosphate catabolic process GO:0009203 391 0.060
oocyte differentiation GO:0009994 2 0.060
positive regulation of translation GO:0045727 35 0.060
hyaluronan biosynthetic process GO:0030213 10 0.058
t helper 1 cell differentiation GO:0045063 1 0.058
alcohol metabolic process GO:0006066 114 0.058
determination of adult lifespan GO:0008340 2 0.057
regulation of lymphocyte activation GO:0051249 103 0.056
positive regulation of epithelial cell proliferation GO:0050679 65 0.055
regulation of protein stability GO:0031647 87 0.054
protein localization to organelle GO:0033365 280 0.054
response to dsrna GO:0043331 25 0.054
regulation of cell activation GO:0050865 125 0.053
negative regulation of multicellular organismal process GO:0051241 317 0.053
regulation of wnt signaling pathway GO:0030111 123 0.053
response to organonitrogen compound GO:0010243 156 0.053
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.053
cell projection morphogenesis GO:0048858 129 0.053
regulation of cellular component movement GO:0051270 334 0.051
post embryonic development GO:0009791 2 0.051
positive regulation of immune effector process GO:0002699 40 0.051
response to tumor necrosis factor GO:0034612 76 0.051
steroid biosynthetic process GO:0006694 46 0.051
cellular response to reactive oxygen species GO:0034614 50 0.050
cellular response to growth factor stimulus GO:0071363 197 0.050
regulation of mirna metabolic process GO:2000628 5 0.050
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.049
regulation of humoral immune response GO:0002920 11 0.048
positive regulation of transport GO:0051050 336 0.048
positive regulation of cell proliferation GO:0008284 301 0.047
hematopoietic or lymphoid organ development GO:0048534 186 0.047
regulation of peptide transport GO:0090087 62 0.046
positive regulation of cholesterol efflux GO:0010875 8 0.046
type 2 immune response GO:0042092 6 0.046
small gtpase mediated signal transduction GO:0007264 78 0.046
regulation of inflammatory response GO:0050727 46 0.045
positive regulation of developmental process GO:0051094 314 0.045
regulation of alcohol biosynthetic process GO:1902930 22 0.045
purine ribonucleotide catabolic process GO:0009154 404 0.044
nucleoside phosphate catabolic process GO:1901292 412 0.043
cytoplasmic sequestering of nf kappab GO:0007253 7 0.043
epithelial cell proliferation GO:0050673 128 0.042
regulation of interleukin 8 production GO:0032677 49 0.042
lymphocyte activation GO:0046649 133 0.042
pharynx development GO:0060465 1 0.042
regulation of locomotion GO:0040012 329 0.042
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.042
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
positive regulation of b cell activation GO:0050871 17 0.041
cell projection organization GO:0030030 252 0.041
regulation of purine nucleotide metabolic process GO:1900542 264 0.040
ribonucleotide catabolic process GO:0009261 405 0.040
production of molecular mediator of immune response GO:0002440 37 0.040
response to light stimulus GO:0009416 87 0.040
cellular response to organonitrogen compound GO:0071417 124 0.039
cellular response to nicotine GO:0071316 4 0.039
cell cycle arrest GO:0007050 71 0.039
regulation of response to wounding GO:1903034 101 0.038
negative regulation of cell proliferation GO:0008285 228 0.038
cellular amino acid metabolic process GO:0006520 116 0.038
cellular response to peptide GO:1901653 59 0.038
epithelium migration GO:0090132 119 0.038
acute phase response GO:0006953 5 0.038
cellular response to mechanical stimulus GO:0071260 39 0.038
positive regulation of cellular component movement GO:0051272 181 0.038
prostate gland development GO:0030850 3 0.038
negative regulation of cell cycle GO:0045786 193 0.037
regulation of stem cell proliferation GO:0072091 15 0.037
negative regulation of cellular protein metabolic process GO:0032269 353 0.037
purine nucleoside catabolic process GO:0006152 398 0.036
cellular response to dna damage stimulus GO:0006974 379 0.036
purine containing compound catabolic process GO:0072523 411 0.036
glycosaminoglycan biosynthetic process GO:0006024 27 0.036
microtubule based process GO:0007017 210 0.036
toll like receptor 4 signaling pathway GO:0034142 12 0.036
negative regulation of alcohol biosynthetic process GO:1902931 13 0.036
positive regulation of cellular catabolic process GO:0031331 284 0.035
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.035
cd40 signaling pathway GO:0023035 3 0.035
positive regulation of cell differentiation GO:0045597 211 0.035
regulation of meiotic cell cycle GO:0051445 4 0.035
antimicrobial humoral response GO:0019730 26 0.035
positive regulation of leukocyte activation GO:0002696 80 0.035
endocytosis GO:0006897 159 0.035
neuron development GO:0048666 113 0.034
negative regulation of stem cell proliferation GO:2000647 3 0.034
chemotaxis GO:0006935 157 0.034
positive regulation of cell migration GO:0030335 172 0.034
guanosine containing compound metabolic process GO:1901068 244 0.034
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.033
nucleotide catabolic process GO:0009166 408 0.033
gtp catabolic process GO:0006184 237 0.033
negative regulation of glial cell differentiation GO:0045686 1 0.032
generation of neurons GO:0048699 152 0.032
response to hexose GO:0009746 20 0.032
regulation of protein transport GO:0051223 213 0.032
single organism cellular localization GO:1902580 332 0.032
ncrna metabolic process GO:0034660 108 0.032
cardiac right ventricle formation GO:0003219 1 0.032
regulation of cell cycle GO:0051726 393 0.031
hemopoiesis GO:0030097 180 0.031
response to nutrient levels GO:0031667 81 0.031
cellular response to extracellular stimulus GO:0031668 72 0.031
peptide biosynthetic process GO:0043043 8 0.031
positive regulation of apoptotic process GO:0043065 246 0.031
purine ribonucleoside catabolic process GO:0046130 398 0.031
protein import GO:0017038 130 0.030
regulation of kinase activity GO:0043549 314 0.030
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.030
cation transport GO:0006812 331 0.030
blastoderm segmentation GO:0007350 2 0.030
regulation of cell migration GO:0030334 289 0.030
cardioblast cell fate commitment GO:0042684 1 0.030
negative regulation of monooxygenase activity GO:0032769 7 0.030
regulation of metal ion transport GO:0010959 120 0.030
regulation of polysaccharide metabolic process GO:0032881 21 0.029
regulation of nucleotide metabolic process GO:0006140 269 0.029
regulation of interleukin 8 biosynthetic process GO:0045414 11 0.029
positive regulation of interleukin 10 biosynthetic process GO:0045082 1 0.029
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.029
cellular response to nitrogen compound GO:1901699 144 0.029
multicellular organismal aging GO:0010259 3 0.028
rna processing GO:0006396 255 0.028
specification of organ identity GO:0010092 3 0.028
response to ionizing radiation GO:0010212 65 0.028
response to hormone GO:0009725 175 0.028
positive regulation of cell activation GO:0050867 81 0.028
peptide transport GO:0015833 74 0.028
spermatid differentiation GO:0048515 4 0.028
regulation of protein targeting GO:1903533 91 0.027
lipid localization GO:0010876 106 0.027
amine metabolic process GO:0009308 44 0.027
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 2 0.027
signal transduction by phosphorylation GO:0023014 297 0.027
negative regulation of phosphorus metabolic process GO:0010563 267 0.027
neurogenesis GO:0022008 169 0.027
regulation of cellular amino acid metabolic process GO:0006521 6 0.027
negative regulation of protein maturation GO:1903318 142 0.027
adaptive immune response GO:0002250 49 0.027
neuron projection morphogenesis GO:0048812 50 0.026
nucleoside catabolic process GO:0009164 408 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
regulation of mapk cascade GO:0043408 262 0.026
ossification GO:0001503 121 0.025
vesicle mediated transport GO:0016192 371 0.025
negative regulation of cell fate specification GO:0009996 3 0.025
eye photoreceptor cell differentiation GO:0001754 2 0.025
erk1 and erk2 cascade GO:0070371 104 0.025
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.025
regulation of cellular amide metabolic process GO:0034248 9 0.025
chemical homeostasis GO:0048878 306 0.025
regulation of defense response to virus by host GO:0050691 22 0.025
regulation of neutrophil mediated killing of symbiont cell GO:0070949 1 0.025
regulation of nf kappab import into nucleus GO:0042345 22 0.025
anterior posterior axis specification embryo GO:0008595 2 0.025
metal ion transport GO:0030001 272 0.025
myeloid leukocyte activation GO:0002274 34 0.025
organophosphate catabolic process GO:0046434 430 0.025
regulation of adaptive immune response GO:0002819 33 0.024
response to growth factor GO:0070848 205 0.024
regulation of leukocyte proliferation GO:0070663 67 0.024
cellular response to nutrient levels GO:0031669 69 0.024
system process GO:0003008 349 0.024
leukocyte mediated immunity GO:0002443 59 0.024
negative regulation of immune system process GO:0002683 136 0.024
cellular response to tumor necrosis factor GO:0071356 63 0.024
ras protein signal transduction GO:0007265 73 0.023
gtp metabolic process GO:0046039 239 0.023
response to peptide GO:1901652 65 0.023
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.023
response to metal ion GO:0010038 84 0.023
positive regulation of gtp catabolic process GO:0033126 166 0.023
positive regulation of catabolic process GO:0009896 310 0.023
protein stabilization GO:0050821 64 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
regulation of purine nucleotide catabolic process GO:0033121 205 0.023
cellular response to molecule of bacterial origin GO:0071219 62 0.023
regulation of cell differentiation GO:0045595 393 0.022
regulation of interleukin 12 production GO:0032655 15 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
regulation of camp metabolic process GO:0030814 52 0.022
behavior GO:0007610 112 0.022
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.022
spermatid development GO:0007286 4 0.022
actin filament based movement GO:0030048 17 0.022
organic acid transport GO:0015849 65 0.022
positive regulation of mirna metabolic process GO:2000630 4 0.021
glycoprotein biosynthetic process GO:0009101 91 0.021
cellular response to alkaloid GO:0071312 11 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
negative regulation of tumor necrosis factor production GO:0032720 20 0.021
response to exogenous dsrna GO:0043330 10 0.021
alpha beta t cell differentiation GO:0046632 7 0.021
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.021
positive regulation of gliogenesis GO:0014015 4 0.020
single organism carbohydrate metabolic process GO:0044723 193 0.020
organic hydroxy compound transport GO:0015850 63 0.020
jak stat cascade GO:0007259 46 0.020
positive regulation of lipid transport GO:0032370 22 0.020
stem cell proliferation GO:0072089 25 0.020
maintenance of location in cell GO:0051651 62 0.020
locomotory behavior GO:0007626 1 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
negative regulation of steroid biosynthetic process GO:0010894 15 0.020
mapk cascade GO:0000165 288 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
extrinsic apoptotic signaling pathway GO:0097191 119 0.020
regulation of steroid biosynthetic process GO:0050810 23 0.020
calcium ion transport GO:0006816 147 0.020
sterol transport GO:0015918 39 0.020
sulfur compound metabolic process GO:0006790 101 0.020
positive regulation of cell death GO:0010942 263 0.020
vitamin biosynthetic process GO:0009110 11 0.019
regulation of cell motility GO:2000145 299 0.019
regulation of cell division GO:0051302 116 0.019
visual behavior GO:0007632 2 0.019
nitrogen compound transport GO:0071705 191 0.019
positive regulation of locomotion GO:0040017 186 0.019
response to fibroblast growth factor GO:0071774 39 0.019
regulation of cell cycle process GO:0010564 266 0.019
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.019
regulation of protein maturation GO:1903317 150 0.019
cellular response to monosaccharide stimulus GO:0071326 10 0.019
maintenance of protein location GO:0045185 57 0.019
positive regulation of cell fate specification GO:0042660 2 0.019
response to interleukin 6 GO:0070741 15 0.018
muscle system process GO:0003012 81 0.018
negative regulation of kinase activity GO:0033673 106 0.018
dendrite development GO:0016358 24 0.018
photoreceptor cell differentiation GO:0046530 2 0.018
respiratory gaseous exchange GO:0007585 3 0.018
negative regulation of phosphorylation GO:0042326 174 0.018
pattern specification process GO:0007389 43 0.018
hindbrain development GO:0030902 3 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
cytoplasmic sequestering of protein GO:0051220 12 0.018
regulation of epithelial cell proliferation GO:0050678 113 0.018
vasodilation GO:0042311 4 0.018
protein targeting GO:0006605 187 0.018
cellular response to peptide hormone stimulus GO:0071375 56 0.018
regulation of cell development GO:0060284 161 0.018
segmentation GO:0035282 4 0.017
venous blood vessel development GO:0060841 2 0.017
regeneration GO:0031099 4 0.017
taxis GO:0042330 157 0.017
reproductive process GO:0022414 106 0.017
negative regulation of cell differentiation GO:0045596 171 0.017
rho protein signal transduction GO:0007266 26 0.017
regulation of complement activation classical pathway GO:0030450 3 0.017
circulatory system development GO:0072359 262 0.017
response to camp GO:0051591 25 0.017
anatomical structure formation involved in morphogenesis GO:0048646 284 0.017
protein localization to nucleus GO:0034504 136 0.017
positive regulation of cytokine biosynthetic process GO:0042108 25 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
regulation of cell growth GO:0001558 135 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
somatic stem cell division GO:0048103 1 0.017
regulation of cytoplasmic transport GO:1903649 149 0.017
neurological system process GO:0050877 163 0.016
acute inflammatory response GO:0002526 21 0.016
regulation of transcription involved in g2 m transition of mitotic cell cycle GO:0000117 1 0.016
cellular response to starvation GO:0009267 58 0.016
negative regulation of blood pressure GO:0045776 3 0.016
regulation of homeostatic process GO:0032844 121 0.016

MAP3K8 disease predictions

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 36 0.148
immune system disease DOID:2914 155 0.148
b cell deficiency DOID:2115 17 0.148
blood protein disease DOID:620 16 0.065
hematopoietic system disease DOID:74 100 0.065
cancer DOID:162 167 0.065
disease of cellular proliferation DOID:14566 174 0.065
organ system cancer DOID:0050686 164 0.065
gastrointestinal system disease DOID:77 36 0.065
disease of metabolism DOID:0014667 295 0.024