|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
1.000
|
Fly |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.999
|
Fly |
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.998
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.998
|
Fly |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.998
|
Mouse |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.997
|
Human |
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.996
|
|
|
|
determination of dorsal identity
|
GO:0048263 |
4 |
0.994
|
Zebrafish Mouse |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.992
|
Mouse Rat |
|
|
collateral sprouting
|
GO:0048668 |
2 |
0.991
|
Fly |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.990
|
Fly |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.990
|
Fly |
|
|
cell development
|
GO:0048468 |
328 |
0.986
|
Yeast Rat Fly |
|
|
growth
|
GO:0040007 |
202 |
0.985
|
Fly |
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.985
|
Fly |
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.982
|
Fly |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.978
|
Fly |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.975
|
Worm |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.973
|
Human |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.972
|
Human |
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.965
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.965
|
Mouse |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.964
|
Yeast Fly |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.958
|
Fly |
|
|
neuron projection extension
|
GO:1990138 |
14 |
0.958
|
Fly |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.955
|
Worm |
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.954
|
Fly |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.953
|
Mouse Rat |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.952
|
Fly |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.951
|
Fly |
|
|
positive regulation of neuron apoptotic process
|
GO:0043525 |
8 |
0.951
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.950
|
Yeast Fly |
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.949
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.949
|
Fly |
|
|
response to cadmium ion
|
GO:0046686 |
10 |
0.947
|
Mouse Fly |
|
|
activation of jun kinase activity
|
GO:0007257 |
7 |
0.942
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.937
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.936
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.933
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.932
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.932
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.931
|
Rat Fly |
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.929
|
Human |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.910
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.909
|
Fly |
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.907
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.907
|
|
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.904
|
Fly |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.902
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.898
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.898
|
|
|
|
negative regulation of trophoblast cell migration
|
GO:1901164 |
3 |
0.897
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.883
|
|
|
|
hyperosmotic response
|
GO:0006972 |
4 |
0.882
|
Yeast Worm |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.881
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.862
|
Fly |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.853
|
|
|
|
jun phosphorylation
|
GO:0007258 |
28 |
0.848
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.848
|
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.843
|
Fly |
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.839
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.839
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.838
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.834
|
Fly |
|
|
chorionic trophoblast cell proliferation
|
GO:0097360 |
2 |
0.830
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.817
|
Fly |
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.812
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.811
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.810
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.809
|
Human Mouse |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.801
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.801
|
Fly |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.800
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.799
|
Zebrafish Mouse Fly |
|
|
neuron projection development
|
GO:0031175 |
106 |
0.798
|
Rat Fly |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.787
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.786
|
Fly |
|
|
response to radiation
|
GO:0009314 |
151 |
0.784
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.783
|
|
|
|
response to temperature stimulus
|
GO:0009266 |
22 |
0.777
|
Yeast Rat Worm Fly |
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.776
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.757
|
Fly |
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.754
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.749
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.746
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.745
|
Fly |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.743
|
Human |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.736
|
Rat Fly |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.731
|
Fly |
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.720
|
Fly |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.710
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.710
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.709
|
|
|
|
regulation of determination of dorsal identity
|
GO:2000015 |
2 |
0.708
|
Mouse |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.708
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.707
|
Fly |
|
|
immune response
|
GO:0006955 |
307 |
0.703
|
Fly |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.699
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.699
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.689
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.689
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.689
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.686
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.680
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.680
|
Fly |
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.668
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.666
|
|
|
|
positive regulation of nitric oxide synthase biosynthetic process
|
GO:0051770 |
3 |
0.662
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.662
|
Rat Fly |
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.661
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.657
|
|
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.651
|
Fly |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.644
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.643
|
Rat |
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.643
|
Mouse Rat Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.642
|
Rat |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.642
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.640
|
Human |
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.636
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.636
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.619
|
Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.617
|
Human |
|
|
activation of mapkk activity
|
GO:0000186 |
18 |
0.599
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.596
|
Fly |
|
|
neurogenesis
|
GO:0022008 |
169 |
0.595
|
Rat Fly |
|
|
developmental growth
|
GO:0048589 |
48 |
0.592
|
Fly |
|
|
antibacterial humoral response
|
GO:0019731 |
24 |
0.584
|
Fly |
|
|
developmental cell growth
|
GO:0048588 |
18 |
0.584
|
Fly |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.583
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.582
|
Rat Fly |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.582
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.580
|
|
|
|
cellular response to arsenic containing substance
|
GO:0071243 |
4 |
0.577
|
Fly |
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.575
|
Mouse Rat Fly |
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.574
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.574
|
Fly |
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.572
|
|
|
|
regulation of axon guidance
|
GO:1902667 |
3 |
0.568
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.566
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.566
|
Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.561
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.552
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.548
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.547
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.547
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.542
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.540
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.539
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.534
|
|
|
|
basement membrane organization
|
GO:0071711 |
3 |
0.531
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.528
|
Fly |
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.523
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.517
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.508
|
Fly |
|
|
autophagy
|
GO:0006914 |
88 |
0.495
|
Fly |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.494
|
Mouse |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.490
|
Fly |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.487
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.486
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.477
|
Rat Fly |
|
|
regionalization
|
GO:0003002 |
29 |
0.474
|
Zebrafish Mouse |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.470
|
Fly |
|
|
wound healing
|
GO:0042060 |
115 |
0.466
|
Fly |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.465
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.464
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.444
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.441
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.440
|
Fly |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.440
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.436
|
Mouse Fly |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.434
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.429
|
|
|
|
patterning of blood vessels
|
GO:0001569 |
2 |
0.426
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.423
|
Worm |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.421
|
Human Yeast |
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.413
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.412
|
|
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.411
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.404
|
Fly |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.403
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.402
|
|
|
|
negative regulation of chorionic trophoblast cell proliferation
|
GO:1901383 |
2 |
0.401
|
|
|
|
response to camp
|
GO:0051591 |
25 |
0.400
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.394
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.390
|
Fly |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.387
|
Human |
|
|
endocardial cushion cell fate commitment
|
GO:0061445 |
1 |
0.385
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
14 |
0.381
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.377
|
Fly |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.377
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.374
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.371
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
7 |
0.369
|
Fly |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.368
|
|
|
|
determination of left right symmetry
|
GO:0007368 |
11 |
0.367
|
Fly |
|
|
neuron development
|
GO:0048666 |
113 |
0.365
|
Rat Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.363
|
Fly |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.355
|
Fly |
|
|
cardiac chamber development
|
GO:0003205 |
30 |
0.355
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.354
|
Fly |
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.354
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.352
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.352
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.350
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.349
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.340
|
|
|
|
phenol containing compound metabolic process
|
GO:0018958 |
12 |
0.339
|
Fly |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.338
|
Fly |
|
|
phagocytosis
|
GO:0006909 |
42 |
0.338
|
Fly |
|
|
positive regulation of erythrocyte differentiation
|
GO:0045648 |
11 |
0.332
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.330
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.329
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.329
|
Fly |
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.326
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.322
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.320
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.311
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.310
|
Yeast Rat |
|
|
response to nitrosative stress
|
GO:0051409 |
4 |
0.308
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.306
|
Fly |
|
|
wound healing spreading of epidermal cells
|
GO:0035313 |
6 |
0.306
|
Fly |
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.303
|
Human |
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.302
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.300
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.299
|
|
|
|
atrial septum primum morphogenesis
|
GO:0003289 |
1 |
0.293
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.288
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.287
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.286
|
|
|
|
regulation of axon extension involved in axon guidance
|
GO:0048841 |
2 |
0.283
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.282
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.279
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.276
|
|
|
|
aging
|
GO:0007568 |
66 |
0.266
|
Human Worm |
|
|
cardiac muscle cell fate commitment
|
GO:0060923 |
4 |
0.261
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.261
|
Worm |
|
|
mitral valve development
|
GO:0003174 |
3 |
0.258
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.255
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.253
|
Rat |
|
|
axon development
|
GO:0061564 |
34 |
0.252
|
Fly |
|
|
epithelial cell fate commitment
|
GO:0072148 |
3 |
0.251
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.250
|
Fly |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.248
|
|
|
|
atrioventricular valve morphogenesis
|
GO:0003181 |
2 |
0.248
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.245
|
Fly |
|
|
membrane organization
|
GO:0061024 |
292 |
0.240
|
Fly |
|
|
axon extension
|
GO:0048675 |
13 |
0.240
|
Fly |
|
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.239
|
Rat |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.237
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.229
|
Fly |
|
|
cell growth
|
GO:0016049 |
160 |
0.228
|
Fly |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.223
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.221
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.218
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.217
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.216
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.215
|
|
|
|
chondrocyte development
|
GO:0002063 |
1 |
0.214
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.214
|
Yeast |
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.212
|
Human |
|
|
somite development
|
GO:0061053 |
7 |
0.210
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.207
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.205
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.205
|
Fly |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.205
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.203
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.203
|
Human |
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.202
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.202
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.202
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.201
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.201
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.200
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
23 |
0.199
|
Fly |
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.198
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.196
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.193
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.193
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.193
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.190
|
|
|
|
extracellular matrix disassembly
|
GO:0022617 |
16 |
0.190
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.189
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.188
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.188
|
|
|
|
endocardial cell differentiation
|
GO:0060956 |
2 |
0.186
|
|
|
|
lung alveolus development
|
GO:0048286 |
4 |
0.184
|
|
|
|
negative regulation of chondrocyte proliferation
|
GO:1902731 |
1 |
0.176
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.176
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.176
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.174
|
|
|
|
positive regulation of autophagy
|
GO:0010508 |
24 |
0.173
|
Fly |
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.171
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.171
|
Fly |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.168
|
Yeast |
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.168
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.167
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.167
|
|
|
|
response to carbohydrate
|
GO:0009743 |
21 |
0.167
|
|
|
|
regulation of synapse organization
|
GO:0050807 |
7 |
0.166
|
|
|
|
macroautophagy
|
GO:0016236 |
39 |
0.166
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.163
|
Fly |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.162
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.160
|
|
|
|
histone serine phosphorylation
|
GO:0035404 |
4 |
0.160
|
|
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.155
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.152
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.151
|
Fly |
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.150
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.150
|
|
|
|
protein deacetylation
|
GO:0006476 |
38 |
0.149
|
|
|
|
vacuole organization
|
GO:0007033 |
44 |
0.149
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.148
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.147
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.145
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.145
|
|
|
|
endodermal cell differentiation
|
GO:0035987 |
31 |
0.145
|
|
|
|
retina vasculature development in camera type eye
|
GO:0061298 |
3 |
0.144
|
|
|
|
venous blood vessel development
|
GO:0060841 |
2 |
0.143
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.143
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.142
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.142
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.142
|
Fly |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.141
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.141
|
|
|
|
positive regulation of axon extension
|
GO:0045773 |
4 |
0.141
|
|
|
|
regulation of viral process
|
GO:0050792 |
103 |
0.141
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.140
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.138
|
|
|
|
endocardial cushion cell differentiation
|
GO:0061443 |
1 |
0.138
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.136
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.134
|
Fly |
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.133
|
Mouse Fly |
|
|
viral process
|
GO:0016032 |
146 |
0.133
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.132
|
|
|
|
regulation of icosanoid secretion
|
GO:0032303 |
4 |
0.132
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.130
|
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.128
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.128
|
|
|
|
smooth muscle cell migration
|
GO:0014909 |
18 |
0.127
|
|
|
|
mitral valve morphogenesis
|
GO:0003183 |
2 |
0.127
|
|
|
|
regulation of symbiosis encompassing mutualism through parasitism
|
GO:0043903 |
109 |
0.126
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.126
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.125
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.125
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.124
|
Yeast Rat |
|
|
foam cell differentiation
|
GO:0090077 |
15 |
0.124
|
Human |
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.124
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.123
|
Yeast Fly |
|
|
positive regulation of pathway restricted smad protein phosphorylation
|
GO:0010862 |
22 |
0.123
|
|
|
|
regulation of chorionic trophoblast cell proliferation
|
GO:1901382 |
2 |
0.123
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.123
|
Fly |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.122
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.122
|
|
|
|
mitochondrial outer membrane permeabilization involved in programmed cell death
|
GO:1902686 |
16 |
0.122
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.122
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.122
|
|
|
|
endothelial cell fate commitment
|
GO:0060839 |
3 |
0.122
|
|
|
|
regulation of activin receptor signaling pathway
|
GO:0032925 |
14 |
0.121
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.121
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.121
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.120
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.119
|
Fly |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.118
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.117
|
|
|
|
regulation of extent of cell growth
|
GO:0061387 |
9 |
0.116
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.115
|
|
|
|
system process
|
GO:0003008 |
349 |
0.114
|
|
|
|
regulation of lung blood pressure
|
GO:0014916 |
1 |
0.113
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.112
|
Yeast Fly |
|
|
regulation of release of cytochrome c from mitochondria
|
GO:0090199 |
29 |
0.112
|
|
|
|
neuron projection guidance
|
GO:0097485 |
12 |
0.112
|
Fly |
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.112
|
Fly |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.111
|
Human |
|
|
regulation of dna replication
|
GO:0006275 |
68 |
0.110
|
Yeast Rat |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.109
|
|
|
|
protein targeting to mitochondrion
|
GO:0006626 |
19 |
0.108
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.107
|
Rat |
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.107
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.107
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.106
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.106
|
Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.105
|
Fly |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.105
|
|
|
|
activin receptor signaling pathway
|
GO:0032924 |
24 |
0.104
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.103
|
Mouse Rat Fly |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.103
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.103
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.103
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.102
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.101
|
|
|
|
triglyceride homeostasis
|
GO:0070328 |
14 |
0.101
|
|
|
|
regulation of nitric oxide synthase biosynthetic process
|
GO:0051769 |
6 |
0.101
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.100
|
Fly |
|
|
epithelium development
|
GO:0060429 |
227 |
0.100
|
Fly |
|
|
regulation of pathway restricted smad protein phosphorylation
|
GO:0060393 |
34 |
0.100
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.099
|
Rat |
|
|
musculoskeletal movement
|
GO:0050881 |
17 |
0.099
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.099
|
Rat |
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.099
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.099
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.098
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.097
|
Rat |
|
|
positive regulation of mitochondrial membrane permeability
|
GO:0035794 |
17 |
0.097
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.097
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.096
|
|
|
|
regulation of muscle organ development
|
GO:0048634 |
27 |
0.096
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.096
|
|
|
|
positive regulation of trophoblast cell migration
|
GO:1901165 |
2 |
0.096
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.096
|
Rat |
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.095
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.095
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.094
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.094
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.094
|
|
|
|
septum primum development
|
GO:0003284 |
1 |
0.094
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.093
|
|
|
|
cardiac septum morphogenesis
|
GO:0060411 |
9 |
0.093
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.092
|
|
|
|
fatty acid derivative biosynthetic process
|
GO:1901570 |
18 |
0.091
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.091
|
|
|
|
apoptotic cell clearance
|
GO:0043277 |
12 |
0.091
|
Fly |
|
|
regulation of membrane permeability
|
GO:0090559 |
25 |
0.090
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.090
|
|
|
|
cellular response to vascular endothelial growth factor stimulus
|
GO:0035924 |
26 |
0.090
|
Human |
|
|
intra s dna damage checkpoint
|
GO:0031573 |
4 |
0.089
|
|
|
|
regulation of smooth muscle cell migration
|
GO:0014910 |
15 |
0.088
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.087
|
|
|
|
axon guidance
|
GO:0007411 |
12 |
0.087
|
Fly |
|
|
skeletal muscle tissue growth
|
GO:0048630 |
2 |
0.086
|
|
|
|
embryonic digestive tract morphogenesis
|
GO:0048557 |
2 |
0.086
|
Fly |
|
|
t cell lineage commitment
|
GO:0002360 |
1 |
0.085
|
|
|
|
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
|
GO:1901030 |
3 |
0.085
|
|
|
|
determination of bilateral symmetry
|
GO:0009855 |
15 |
0.085
|
Zebrafish Mouse Fly |
|
|
homeostasis of number of cells
|
GO:0048872 |
40 |
0.084
|
|
|
|
lamellipodium assembly
|
GO:0030032 |
26 |
0.084
|
|
|
|
positive regulation of determination of dorsal identity
|
GO:2000017 |
1 |
0.083
|
Mouse |
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.083
|
Rat |
|
|
cell activation
|
GO:0001775 |
213 |
0.082
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.082
|
Human |
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.082
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.082
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.082
|
Yeast |
|
|
lysosome organization
|
GO:0007040 |
24 |
0.081
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.081
|
|
|
|
regulation of dna templated transcription in response to stress
|
GO:0043620 |
18 |
0.081
|
Yeast |
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.080
|
|
|
|
cardiac endothelial cell differentiation
|
GO:0003348 |
2 |
0.080
|
|
|
|
secondary metabolic process
|
GO:0019748 |
17 |
0.080
|
Fly |
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
27 |
0.079
|
|
|
|
positive regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902110 |
16 |
0.079
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.079
|
Fly |
|
|
lamellipodium organization
|
GO:0097581 |
30 |
0.079
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.079
|
|
|
|
negative regulation of blood circulation
|
GO:1903523 |
4 |
0.078
|
|
|
|
synapse assembly
|
GO:0007416 |
8 |
0.077
|
|
|
|
synapse organization
|
GO:0050808 |
14 |
0.077
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.076
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.076
|
|
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.075
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.075
|
|
|
|
response to glucocorticoid
|
GO:0051384 |
13 |
0.074
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.074
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.073
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.073
|
|
|
|
positive regulation of release of cytochrome c from mitochondria
|
GO:0090200 |
18 |
0.073
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.072
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.072
|
|
|
|
microtubule based transport
|
GO:0010970 |
21 |
0.072
|
|
|
|
mitochondrial membrane organization
|
GO:0007006 |
40 |
0.071
|
|
|
|
extracellular structure organization
|
GO:0043062 |
41 |
0.071
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.070
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.070
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0036003 |
9 |
0.069
|
Yeast |
|
|
reproductive process
|
GO:0022414 |
106 |
0.069
|
Yeast Fly |
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.069
|
|
|
|
positive regulation of viral transcription
|
GO:0050434 |
13 |
0.068
|
|
|
|
dna dependent dna replication
|
GO:0006261 |
44 |
0.068
|
Yeast |
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.068
|
|
|
|
chondrocyte proliferation
|
GO:0035988 |
4 |
0.068
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.067
|
Rat |
|
|
lytic vacuole organization
|
GO:0080171 |
24 |
0.067
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.067
|
Fly |
|
|
negative regulation of transcription from rna polymerase ii promoter in response to endoplasmic reticulum stress
|
GO:1990441 |
1 |
0.067
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.067
|
|
