Homo sapiens

99 known processes

MCL1

myeloid cell leukemia sequence 1 (BCL2-related)

(Aliases: BCL2L3,MCL1S,MCL1-ES,mcl1/EAT,MGC104264,Mcl-1,bcl2-L-3,MGC1839,MCL1L,EAT,TM)

MCL1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
neuron death in response to oxidative stress GO:0036475 9 1.000
mitochondrial membrane organization GO:0007006 40 1.000
Human
positive regulation of cellular response to oxidative stress GO:1900409 7 0.999
regulation of oxidative stress induced neuron death GO:1903203 9 0.999
positive regulation of fibroblast apoptotic process GO:2000271 6 0.997
positive regulation of endoplasmic reticulum unfolded protein response GO:1900103 4 0.996
Human
modulation by virus of host morphology or physiology GO:0019048 10 0.996
Human
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 3 0.996
fibroblast apoptotic process GO:0044346 8 0.995
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.995
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.992
intrinsic apoptotic signaling pathway GO:0097193 127 0.990
positive regulation of response to oxidative stress GO:1902884 7 0.989
positive regulation of oxidative stress induced cell death GO:1903209 5 0.989
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 0.988
Human
positive regulation of mitochondrion organization GO:0010822 30 0.988
Human Worm
response to endoplasmic reticulum stress GO:0034976 49 0.981
Human
regulation of apoptotic dna fragmentation GO:1902510 3 0.979
Human
regulation of oxidative stress induced cell death GO:1903201 24 0.979
positive regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903378 2 0.975
modulation of programmed cell death in other organism involved in symbiotic interaction GO:0052248 1 0.971
Human
apoptotic mitochondrial changes GO:0008637 57 0.968
Human Mouse
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.967
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 2 0.967
Human
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.961
negative regulation of apoptotic process GO:0043066 316 0.960
regulation of cellular response to oxidative stress GO:1900407 26 0.960
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 2 0.958
positive regulation of mitochondrial membrane permeability GO:0035794 17 0.957
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.956
Human
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.955
positive regulation of peptidase activity GO:0010952 88 0.954
Human
negative regulation of programmed cell death GO:0043069 321 0.952
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 16 0.952
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.942
Human
zymogen activation GO:0031638 70 0.940
Human
cellular response to hypoxia GO:0071456 51 0.935
positive regulation of apoptotic process GO:0043065 246 0.929
endoplasmic reticulum unfolded protein response GO:0030968 16 0.928
Human
establishment or maintenance of transmembrane electrochemical gradient GO:0010248 2 0.928
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.923
Human
immune response activating signal transduction GO:0002757 90 0.918
Human
release of cytochrome c from mitochondria GO:0001836 35 0.918
Human
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 12 0.915
Human
fibroblast proliferation GO:0048144 33 0.914
positive regulation of protein oligomerization GO:0032461 17 0.901
Human
regulation of protein heterodimerization activity GO:0043497 5 0.891
Human
protein maturation GO:0051604 233 0.888
Human Zebrafish
t cell homeostasis GO:0043029 3 0.885
regulation of execution phase of apoptosis GO:1900117 11 0.884
Human
cell type specific apoptotic process GO:0097285 125 0.882
defense response GO:0006952 315 0.876
Human
apoptotic process involved in morphogenesis GO:0060561 3 0.868
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 16 0.867
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.867
protein ubiquitination GO:0016567 314 0.866
Human
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.866
regulation of mitochondrial membrane permeability GO:0046902 25 0.865
Human
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.862
Human Mouse
activation of immune response GO:0002253 114 0.862
Human
viral process GO:0016032 146 0.862
Human
response to external biotic stimulus GO:0043207 261 0.859
Human
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 7 0.858
response to uv GO:0009411 73 0.857
Human
lymphocyte homeostasis GO:0002260 4 0.855
leukocyte apoptotic process GO:0071887 31 0.850
Human
interspecies interaction between organisms GO:0044419 156 0.850
Human
regulation of mitochondrion organization GO:0010821 54 0.850
Human Worm
protein localization to membrane GO:0072657 160 0.847
Human
cellular response to dna damage stimulus GO:0006974 379 0.845
response to organic cyclic compound GO:0014070 204 0.840
Human
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.839
membrane organization GO:0061024 292 0.838
Human Worm
fear response GO:0042596 0 0.831
regulation of mitochondrial membrane potential GO:0051881 23 0.831
Human
execution phase of apoptosis GO:0097194 32 0.828
Human
modulation by symbiont of host programmed cell death GO:0052040 1 0.826
Human
mitochondrial outer membrane permeabilization GO:0097345 15 0.823
protein modification by small protein conjugation GO:0032446 342 0.823
Human
protein polyubiquitination GO:0000209 110 0.820
Human
modulation by virus of host process GO:0019054 2 0.816
Human
modulation of apoptotic process in other organism GO:0044532 1 0.810
Human
mitochondrial fragmentation involved in apoptotic process GO:0043653 7 0.809
Human
lymphocyte apoptotic process GO:0070227 20 0.801
Human
multi organism cellular process GO:0044764 156 0.799
Human
mitochondrion organization GO:0007005 156 0.798
Human Mouse Worm
regulation of endopeptidase activity GO:0052548 170 0.797
Human Zebrafish
regulation of membrane permeability GO:0090559 25 0.776
Human
mitotic cell cycle phase transition GO:0044772 162 0.765
Human
regulation of peptidase activity GO:0052547 180 0.765
Human Zebrafish
regulation of establishment of protein localization GO:0070201 242 0.765
Human
reactive oxygen species metabolic process GO:0072593 75 0.762
response to virus GO:0009615 126 0.758
Human
cellular response to topologically incorrect protein GO:0035967 19 0.757
Human
positive regulation of oxidative stress induced neuron death GO:1903223 2 0.756
post embryonic development GO:0009791 2 0.756
positive regulation of neuron apoptotic process GO:0043525 8 0.746
response to nitrogen compound GO:1901698 184 0.743
Human
positive regulation of apoptotic signaling pathway GO:2001235 70 0.742
negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction GO:0052490 1 0.736
Human
regulation of response to dna damage stimulus GO:2001020 94 0.734
response to cytokine GO:0034097 232 0.730
purine ribonucleoside metabolic process GO:0046128 437 0.715
Worm
neuron apoptotic process GO:0051402 39 0.714
negative regulation of execution phase of apoptosis GO:1900118 6 0.712
Human
protein processing GO:0016485 226 0.711
Human Zebrafish
negative regulation of cell proliferation GO:0008285 228 0.692
hematopoietic or lymphoid organ development GO:0048534 186 0.686
response to biotic stimulus GO:0009607 276 0.683
Human
membrane fusion GO:0061025 43 0.683
Human Worm
modulation by symbiont of host apoptotic process GO:0052150 1 0.683
Human
defense response to virus GO:0051607 71 0.671
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.668
Human
modulation by symbiont of host cellular process GO:0044068 3 0.666
Human
positive regulation of neuron death GO:1901216 14 0.655
transformed cell apoptotic process GO:0006927 3 0.654
Human
regulation of protein localization to plasma membrane GO:1903076 40 0.654
Human
blood vessel morphogenesis GO:0048514 162 0.647
regulation of intracellular ph GO:0051453 16 0.644
Human
er nucleus signaling pathway GO:0006984 23 0.637
Human
negative regulation of apoptotic signaling pathway GO:2001234 97 0.632
regulation of endoplasmic reticulum unfolded protein response GO:1900101 5 0.628
Human
b cell homeostasis GO:0001782 1 0.625
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.604
mitotic cell cycle GO:0000278 326 0.604
Human Zebrafish
single organism membrane organization GO:0044802 268 0.603
Human Worm
positive regulation of programmed cell death GO:0043068 249 0.602
modulation by organism of apoptotic process in other organism involved in symbiotic interaction GO:0052433 1 0.594
Human
cellular response to external stimulus GO:0071496 111 0.591
Human
thymus development GO:0048538 3 0.588
extrinsic apoptotic signaling pathway GO:0097191 119 0.584
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 1 0.581
regulation of cellular ph reduction GO:0032847 1 0.578
Human
establishment of protein localization to membrane GO:0090150 121 0.577
Human
response to abiotic stimulus GO:0009628 336 0.576
Human
modification of morphology or physiology of other organism GO:0035821 43 0.576
Human
regulation of membrane potential GO:0042391 95 0.564
Human
negative regulation of cell cycle GO:0045786 193 0.559
Human Zebrafish
regulation of proteolysis GO:0030162 293 0.558
Human Zebrafish
regulation of cellular response to stress GO:0080135 244 0.557
regulation of neuron apoptotic process GO:0043523 35 0.557
positive regulation of endopeptidase activity GO:0010950 84 0.542
Human
positive regulation of hydrolase activity GO:0051345 331 0.538
Human Worm
positive regulation of protein complex assembly GO:0031334 86 0.537
Human
apoptotic signaling pathway GO:0097190 268 0.533
cell death in response to oxidative stress GO:0036473 29 0.510
regulation of protein complex assembly GO:0043254 147 0.506
Human
protein insertion into mitochondrial membrane GO:0051204 3 0.502
positive regulation of leukocyte proliferation GO:0070665 48 0.499
Human
positive regulation of developmental process GO:0051094 314 0.497
Worm
cell cycle phase transition GO:0044770 173 0.489
Human
negative regulation of protein metabolic process GO:0051248 391 0.489
Zebrafish
endomembrane system organization GO:0010256 196 0.488
Human
modulation of programmed cell death in other organism GO:0044531 1 0.484
Human
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.482
Human
purine ribonucleotide catabolic process GO:0009154 404 0.480
Worm
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.480
neuron projection regeneration GO:0031102 1 0.476
neuron death GO:0070997 65 0.472
regulation of growth GO:0040008 165 0.463
Human
regulation of cell motility GO:2000145 299 0.459
positive regulation of immune system process GO:0002684 283 0.459
Human
response to radiation GO:0009314 151 0.453
Human
protein catabolic process GO:0030163 325 0.448
negative regulation of cell differentiation GO:0045596 171 0.447
cellular response to oxidative stress GO:0034599 85 0.442
mitochondrial transport GO:0006839 60 0.436
Human
regulation of protein localization GO:0032880 296 0.436
Human
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.436
positive regulation of intracellular transport GO:0032388 104 0.433
apoptotic dna fragmentation GO:0006309 6 0.432
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.422
regulation of mitotic cell cycle phase transition GO:1901990 118 0.413
Human
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.410
negative regulation of cell death GO:0060548 345 0.408
regulation of fibroblast apoptotic process GO:2000269 8 0.404
regulation of calcium ion transport GO:0051924 79 0.400
Human
positive regulation of pigment cell differentiation GO:0050942 2 0.399
regulation of anoikis GO:2000209 19 0.394
negative regulation of organelle organization GO:0010639 126 0.393
Human Zebrafish
regulation of cell migration GO:0030334 289 0.392
positive regulation of cell death GO:0010942 263 0.392
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.390
Human
regulation of b cell activation GO:0050864 24 0.388
Human
positive regulation of apoptotic dna fragmentation GO:1902512 1 0.382
Human
thymocyte apoptotic process GO:0070242 2 0.380
carbohydrate metabolic process GO:0005975 207 0.380
response to cycloheximide GO:0046898 1 0.373
negative regulation of calcium ion transport into cytosol GO:0010523 3 0.366
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.366
organelle fusion GO:0048284 36 0.363
Human Worm
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.360
homeostasis of number of cells GO:0048872 40 0.355
protein oligomerization GO:0051259 173 0.339
Human
glycosyl compound catabolic process GO:1901658 413 0.339
Worm
cell division GO:0051301 168 0.337
Human Zebrafish
cytoplasmic transport GO:0016482 379 0.333
regulation of cysteine type endopeptidase activity GO:2000116 127 0.328
Human Zebrafish
protein localization to mitochondrion GO:0070585 25 0.325
regulation of protein oligomerization GO:0032459 26 0.323
Human
response to reactive oxygen species GO:0000302 61 0.316
cell cycle checkpoint GO:0000075 117 0.314
Human
regulation of fibroblast proliferation GO:0048145 32 0.312
regulation of apoptotic signaling pathway GO:2001233 175 0.311
activation of cysteine type endopeptidase activity GO:0097202 57 0.308
Human
regulation of reactive oxygen species metabolic process GO:2000377 41 0.308
kidney development GO:0001822 53 0.305
response to light stimulus GO:0009416 87 0.304
Human
leukocyte homeostasis GO:0001776 7 0.302
regulation of cell cycle GO:0051726 393 0.299
Human Zebrafish
response to oxygen levels GO:0070482 100 0.297
anoikis GO:0043276 22 0.296
response to oxygen containing compound GO:1901700 369 0.296
post embryonic organ development GO:0048569 1 0.295
nucleoside triphosphate metabolic process GO:0009141 422 0.292
Worm
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.292
regulation of homeostatic process GO:0032844 121 0.288
Human
response to other organism GO:0051707 261 0.284
Human
dna catabolic process GO:0006308 49 0.282
Human
regulation of developmental pigmentation GO:0048070 2 0.280
positive regulation of muscle cell differentiation GO:0051149 15 0.276
positive regulation of b cell proliferation GO:0030890 12 0.276
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.276
regulation of cell cycle process GO:0010564 266 0.275
Human Zebrafish
amine metabolic process GO:0009308 44 0.275
calcium ion transport GO:0006816 147 0.267
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.263
Human
positive regulation of proteolysis GO:0045862 142 0.262
Human
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.260
Worm
negative regulation of fibroblast proliferation GO:0048147 12 0.257
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.253
Human Zebrafish
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.248
protein deubiquitination GO:0016579 79 0.248
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.246
Human
establishment of protein localization to mitochondrion GO:0072655 22 0.240
immune response GO:0006955 307 0.238
Human
establishment of protein localization to organelle GO:0072594 172 0.236
positive regulation of developmental pigmentation GO:0048087 2 0.236
organophosphate catabolic process GO:0046434 430 0.235
Worm
cellular amine metabolic process GO:0044106 41 0.235
positive regulation of dna catabolic process GO:1903626 2 0.234
Human
ribonucleoside triphosphate metabolic process GO:0009199 412 0.233
Worm
negative regulation by symbiont of host programmed cell death GO:0052041 1 0.233
Human
modification by symbiont of host morphology or physiology GO:0044003 12 0.226
Human
multicellular organismal aging GO:0010259 3 0.226
cell development GO:0048468 328 0.221
single organism cellular localization GO:1902580 332 0.221
Human
urogenital system development GO:0001655 65 0.221
regulation of mitochondrial fusion GO:0010635 5 0.220
Worm
immune response regulating signaling pathway GO:0002764 97 0.219
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.218
Zebrafish
negative regulation of cellular component organization GO:0051129 235 0.218
Human Zebrafish
anatomical structure formation involved in morphogenesis GO:0048646 284 0.217
proteasomal protein catabolic process GO:0010498 176 0.216
limbic system development GO:0021761 3 0.215
t cell apoptotic process GO:0070231 12 0.214
regulation of metal ion transport GO:0010959 120 0.213
Human
response to oxidative stress GO:0006979 121 0.210
negative regulation of cell cycle phase transition GO:1901988 89 0.210
Human
cellular component disassembly GO:0022411 92 0.208
Human
negative regulation of anoikis GO:2000811 15 0.206
response to topologically incorrect protein GO:0035966 29 0.205
Human
cellular macromolecule catabolic process GO:0044265 380 0.202
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.198
response to inorganic substance GO:0010035 127 0.198
Human
nucleotide catabolic process GO:0009166 408 0.195
Worm
regulation of response to oxidative stress GO:1902882 26 0.188
osteoblast proliferation GO:0033687 8 0.188
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.186
ribonucleoside catabolic process GO:0042454 406 0.186
Worm
response to wounding GO:0009611 168 0.185
positive regulation of cellular component organization GO:0051130 376 0.183
Human Worm
regeneration GO:0031099 4 0.180
cellular response to starvation GO:0009267 58 0.179
positive regulation of protein homooligomerization GO:0032464 7 0.177
response to glucocorticoid GO:0051384 13 0.175
response to iron ion GO:0010039 6 0.175
Human
protein k48 linked ubiquitination GO:0070936 38 0.172
ribonucleotide catabolic process GO:0009261 405 0.172
Worm
positive regulation of killing of cells of other organism GO:0051712 4 0.172
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 1 0.170
regulation of killing of cells of other organism GO:0051709 4 0.166
rna processing GO:0006396 255 0.163
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.162
Worm
negative regulation of cell cycle process GO:0010948 121 0.162
Human Zebrafish
regulation of intracellular transport GO:0032386 195 0.162
cellular response to unfolded protein GO:0034620 16 0.160
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.159
negative regulation of mitotic cell cycle GO:0045930 102 0.156
Human Zebrafish
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.154
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.153
Human
antigen receptor mediated signaling pathway GO:0050851 38 0.152
Human
glucose metabolic process GO:0006006 45 0.150
multicellular organismal response to stress GO:0033555 1 0.150
vasculature development GO:0001944 181 0.150
regulation of neuron death GO:1901214 56 0.149
organ morphogenesis GO:0009887 147 0.149
cellular lipid metabolic process GO:0044255 303 0.149
negative regulation of proteolysis GO:0045861 132 0.147
Zebrafish
response to extracellular stimulus GO:0009991 85 0.145
response to electrical stimulus GO:0051602 1 0.145
hair follicle morphogenesis GO:0031069 2 0.144
regulation of immune response GO:0050776 201 0.141
Human
mitotic cell cycle checkpoint GO:0007093 68 0.141
Human
regulation of cell cycle phase transition GO:1901987 126 0.141
Human
positive regulation of execution phase of apoptosis GO:1900119 5 0.141
Human
nucleocytoplasmic transport GO:0006913 176 0.140
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901028 9 0.139
regulation of b cell proliferation GO:0030888 18 0.136
Human
regulation of cell maturation GO:1903429 3 0.134
response to ionizing radiation GO:0010212 65 0.133
cytosolic calcium ion homeostasis GO:0051480 89 0.132
nucleoside phosphate catabolic process GO:1901292 412 0.132
Worm
negative regulation of phosphate metabolic process GO:0045936 267 0.130
regulation of lymphocyte apoptotic process GO:0070228 15 0.130
purine ribonucleoside catabolic process GO:0046130 398 0.128
Worm
regulation of cell growth GO:0001558 135 0.127
Human
negative regulation of mitochondrion organization GO:0010823 22 0.127
Human
t cell activation GO:0042110 99 0.126
positive regulation of apoptotic process involved in morphogenesis GO:1902339 1 0.125
protein homooligomerization GO:0051260 100 0.125
Human
immune effector process GO:0002252 159 0.123
Human
lymphocyte proliferation GO:0046651 70 0.123
Human
regulation of transferase activity GO:0051338 355 0.122
single organism carbohydrate metabolic process GO:0044723 193 0.122
muscle cell differentiation GO:0042692 63 0.121
regulation of carbohydrate metabolic process GO:0006109 54 0.120
behavioral defense response GO:0002209 0 0.119
regulation of cellular component size GO:0032535 82 0.117
regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902229 20 0.116
Human
cell adhesion GO:0007155 325 0.115
rna phosphodiester bond hydrolysis GO:0090501 35 0.113
positive regulation of lymphocyte proliferation GO:0050671 46 0.110
Human
response to mechanical stimulus GO:0009612 51 0.110
Human
posttranscriptional regulation of gene expression GO:0010608 213 0.108
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.108
Human
regulation of viral process GO:0050792 103 0.107
cardiovascular system development GO:0072358 262 0.104
divalent metal ion transport GO:0070838 152 0.102
Human
negative regulation of protein maturation GO:1903318 142 0.101
Zebrafish
nuclear division GO:0000280 128 0.100
Zebrafish
regulation of ion homeostasis GO:2000021 73 0.099
Human
ribonucleoside triphosphate catabolic process GO:0009203 391 0.098
Worm
response to drug GO:0042493 81 0.098
Human
cell growth GO:0016049 160 0.098
Human
ncrna metabolic process GO:0034660 108 0.096
development of primary male sexual characteristics GO:0046546 23 0.096
hemopoiesis GO:0030097 180 0.095
developmental pigmentation GO:0048066 12 0.095
generation of neurons GO:0048699 152 0.095
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.095
cell projection organization GO:0030030 252 0.094
positive regulation of cell growth GO:0030307 48 0.093
Human
regulation of myeloid cell differentiation GO:0045637 81 0.092
negative regulation of protein modification process GO:0031400 200 0.092
oogenesis GO:0048477 2 0.091
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.091
Human
hexose metabolic process GO:0019318 55 0.091
response to dsrna GO:0043331 25 0.091
response to hypoxia GO:0001666 96 0.088
regulation of protein binding GO:0043393 66 0.088
Human
positive regulation of dna metabolic process GO:0051054 73 0.088
Human
response to gamma radiation GO:0010332 14 0.088
positive regulation of homeostatic process GO:0032846 47 0.088
response to organonitrogen compound GO:0010243 156 0.088
Human
dna catabolic process endonucleolytic GO:0000737 37 0.086
Human
regulation of response to external stimulus GO:0032101 222 0.085
growth GO:0040007 202 0.084
Human
patterning of blood vessels GO:0001569 2 0.084
mrna metabolic process GO:0016071 175 0.083
cytokinesis GO:0000910 96 0.082
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.081
viral life cycle GO:0019058 132 0.081
regulation of neuron differentiation GO:0045664 70 0.081
b cell proliferation GO:0042100 22 0.080
Human
response to organophosphorus GO:0046683 41 0.080
immune system development GO:0002520 195 0.079
monosaccharide metabolic process GO:0005996 74 0.079
myeloid cell differentiation GO:0030099 117 0.078
response to axon injury GO:0048678 1 0.077
peptidyl tyrosine dephosphorylation GO:0035335 36 0.077
positive regulation of signal transduction by p53 class mediator GO:1901798 10 0.077
regulation of leukocyte apoptotic process GO:2000106 25 0.077
mitochondrial fusion GO:0008053 13 0.077
Human Worm
regulation of anatomical structure size GO:0090066 101 0.077
male gonad development GO:0008584 23 0.077
cellular response to decreased oxygen levels GO:0036294 51 0.076
cellular ion homeostasis GO:0006873 168 0.075
Human
protein insertion into membrane GO:0051205 9 0.075
metencephalon development GO:0022037 2 0.074
rhythmic process GO:0048511 31 0.074
b cell apoptotic process GO:0001783 6 0.074
Human
regulation of cellular amine metabolic process GO:0033238 11 0.073
negative regulation of protein binding GO:0032091 35 0.073
Human
regulation of dna metabolic process GO:0051052 153 0.073
Human
rna 5 end processing GO:0000966 2 0.073
cellular amino acid metabolic process GO:0006520 116 0.072
response to purine containing compound GO:0014074 40 0.072
regulation of cellular component movement GO:0051270 334 0.071
cell activation GO:0001775 213 0.071
Human
regulation of cell differentiation GO:0045595 393 0.071
regulation of apoptotic process involved in morphogenesis GO:1902337 1 0.071
regulation of mitotic cell cycle GO:0007346 189 0.070
Human Zebrafish
cellular protein catabolic process GO:0044257 261 0.069
leukocyte proliferation GO:0070661 74 0.069
Human
response to unfolded protein GO:0006986 24 0.069
Human
cellular carbohydrate metabolic process GO:0044262 84 0.069
regulation of cell activation GO:0050865 125 0.069
Human
positive regulation of cell migration GO:0030335 172 0.068
regulation of cellular component biogenesis GO:0044087 281 0.068
Human
ossification GO:0001503 121 0.067
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.067
response to nitrosative stress GO:0051409 4 0.066
tube development GO:0035295 125 0.065
negative regulation of chemokine c x c motif ligand 2 production GO:2000342 1 0.065
negative regulation of transport GO:0051051 176 0.064
negative regulation of cellular amine metabolic process GO:0033239 3 0.063
positive regulation of dna damage response signal transduction by p53 class mediator GO:0043517 8 0.063
positive regulation of transport GO:0051050 336 0.063
sequestering of calcium ion GO:0051208 17 0.062
regulation of b cell apoptotic process GO:0002902 5 0.062
guanosine containing compound metabolic process GO:1901068 244 0.062
Worm
cation transport GO:0006812 331 0.062
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.062
nitrogen compound transport GO:0071705 191 0.061
regulation of anatomical structure morphogenesis GO:0022603 286 0.061
Worm
response to hydrogen peroxide GO:0042542 40 0.061
nucleus organization GO:0006997 28 0.061
enzyme linked receptor protein signaling pathway GO:0007167 303 0.061
behavioral fear response GO:0001662 0 0.061
pigment granule organization GO:0048753 7 0.061
regulation of binding GO:0051098 111 0.060
Human
regulation of establishment of protein localization to plasma membrane GO:0090003 30 0.060
Human
pigmentation GO:0043473 22 0.060
cellular response to light stimulus GO:0071482 34 0.060
Human
determination of adult lifespan GO:0008340 2 0.060
cellular homeostasis GO:0019725 196 0.059
Human
maturation of ssu rrna GO:0030490 3 0.059
spleen development GO:0048536 1 0.059
regulation of mononuclear cell proliferation GO:0032944 65 0.059
Human
ovulation cycle process GO:0022602 9 0.058
anatomical structure homeostasis GO:0060249 100 0.058
Zebrafish
cellular divalent inorganic cation homeostasis GO:0072503 128 0.058
response to decreased oxygen levels GO:0036293 96 0.058
apoptotic process in bone marrow GO:0071839 1 0.057
regulation of gtp catabolic process GO:0033124 180 0.057
Worm
regulation of multi organism process GO:0043900 157 0.056
gtp metabolic process GO:0046039 239 0.056
Worm
negative regulation of intracellular signal transduction GO:1902532 183 0.056
Human
positive regulation of organelle organization GO:0010638 195 0.056
Human Worm
male sex differentiation GO:0046661 25 0.055
regulation of peptidyl serine phosphorylation GO:0033135 50 0.055
positive regulation of cellular component biogenesis GO:0044089 158 0.055
Human
regulation of lymphocyte proliferation GO:0050670 64 0.055
Human
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.055
ribosomal small subunit biogenesis GO:0042274 13 0.055
muscle tissue development GO:0060537 62 0.054
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 38 0.054
Human
regulation of response to wounding GO:1903034 101 0.054
purine nucleoside triphosphate catabolic process GO:0009146 392 0.054
Worm
response to nutrient levels GO:0031667 81 0.054
interaction with host GO:0051701 42 0.054
Human
retinal cell apoptotic process GO:1990009 1 0.053
Human
negative regulation of transferase activity GO:0051348 124 0.053
nucleoside triphosphate catabolic process GO:0009143 394 0.053
Worm
reactive nitrogen species metabolic process GO:2001057 3 0.052
oxidation reduction process GO:0055114 396 0.052
regulation of nucleoside metabolic process GO:0009118 209 0.052
Worm
negative regulation of systemic arterial blood pressure GO:0003085 1 0.052
single organism membrane fusion GO:0044801 37 0.052
Human Worm
cellular response to uv GO:0034644 32 0.051
Human
ribonucleoside monophosphate catabolic process GO:0009158 158 0.051
biological adhesion GO:0022610 331 0.050
striated muscle tissue development GO:0014706 59 0.050
erk1 and erk2 cascade GO:0070371 104 0.050
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.050
regulation of dna catabolic process GO:1903624 7 0.050
Human
inflammatory response GO:0006954 79 0.049
spermatid differentiation GO:0048515 4 0.049
mononuclear cell proliferation GO:0032943 71 0.049
Human
t cell selection GO:0045058 4 0.048
multicellular organismal homeostasis GO:0048871 67 0.048
Zebrafish
guanosine containing compound catabolic process GO:1901069 239 0.047
Worm
developmental programmed cell death GO:0010623 3 0.046
blood vessel development GO:0001568 172 0.046
response to starvation GO:0042594 59 0.046
cellular response to glucose starvation GO:0042149 8 0.046
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.046
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 3 0.045
actin cytoskeleton organization GO:0030036 207 0.045
negative regulation of protein processing GO:0010955 142 0.045
Zebrafish
protein modification by small protein removal GO:0070646 92 0.045
regulation of leukocyte activation GO:0002694 115 0.044
Human
rhythmic behavior GO:0007622 2 0.044
positive regulation of gtpase activity GO:0043547 166 0.044
Worm

MCL1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.158
Human
gastrointestinal system cancer DOID:3119 52 0.148
Human
cancer DOID:162 167 0.148
Human
organ system cancer DOID:0050686 164 0.148
Human