Homo sapiens

0 known processes

MDC1

mediator of DNA-damage checkpoint 1

(Aliases: DKFZp781A0122,KIAA0170,NFBD1,MGC166888)

MDC1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 101 1.000
covalent chromatin modification GO:0016569 254 0.999
Human
dna repair GO:0006281 198 0.999
cellular response to dna damage stimulus GO:0006974 379 0.999
Human
mitotic cell cycle checkpoint GO:0007093 68 0.989
dna recombination GO:0006310 77 0.980
dna double strand break processing GO:0000729 10 0.978
regulation of protein autophosphorylation GO:0031952 15 0.956
v d j recombination GO:0033151 3 0.954
nucleotide excision repair GO:0006289 31 0.951
telomere capping GO:0016233 5 0.947
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.942
base excision repair GO:0006284 21 0.928
cell cycle checkpoint GO:0000075 117 0.915
chromatin modification GO:0016568 298 0.891
Human
g2 dna damage checkpoint GO:0031572 26 0.884
chromatin organization GO:0006325 351 0.868
Human
dna damage induced protein phosphorylation GO:0006975 5 0.860
regulation of dna repair GO:0006282 47 0.845
positive regulation of protein autophosphorylation GO:0031954 9 0.843
double strand break repair via homologous recombination GO:0000724 50 0.837
regulation of chromosome segregation GO:0051983 44 0.836
g2 m transition of mitotic cell cycle GO:0000086 41 0.825
blastocyst development GO:0001824 3 0.825
dna integrity checkpoint GO:0031570 71 0.816
negative regulation of cell cycle process GO:0010948 121 0.811
signal transduction in response to dna damage GO:0042770 57 0.806
Human
regulation of mitotic cell cycle GO:0007346 189 0.781
mitotic cell cycle phase transition GO:0044772 162 0.780
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.770
double strand break repair via single strand annealing GO:0045002 4 0.763
regulation of response to dna damage stimulus GO:2001020 94 0.758
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.755
isotype switching GO:0045190 3 0.729
double strand break repair via nonhomologous end joining GO:0006303 10 0.721
dna geometric change GO:0032392 32 0.716
meiotic chromosome segregation GO:0045132 4 0.680
non recombinational repair GO:0000726 14 0.680
regulation of cell cycle process GO:0010564 266 0.667
regulation of cell cycle phase transition GO:1901987 126 0.667
histone ubiquitination GO:0016574 31 0.661
regulation of sister chromatid segregation GO:0033045 27 0.646
mitotic cell cycle process GO:1903047 286 0.644
regulation of cell cycle GO:0051726 393 0.640
dna damage checkpoint GO:0000077 68 0.633
oocyte differentiation GO:0009994 2 0.617
regulation of dna metabolic process GO:0051052 153 0.609
meiosis i GO:0007127 4 0.600
negative regulation of cell cycle GO:0045786 193 0.586
regulation of double strand break repair GO:2000779 22 0.584
response to abiotic stimulus GO:0009628 336 0.582
Human
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.543
reciprocal meiotic recombination GO:0007131 4 0.542
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.535
Human
anterior posterior axis specification GO:0009948 2 0.520
regulation of mitotic cell cycle phase transition GO:1901990 118 0.508
dna catabolic process exonucleolytic GO:0000738 17 0.503
negative regulation of mitotic cell cycle GO:0045930 102 0.477
histone modification GO:0016570 251 0.459
Human
cell cycle phase transition GO:0044770 173 0.457
dna duplex unwinding GO:0032508 30 0.455
nuclear division GO:0000280 128 0.422
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.421
regulation of cellular response to stress GO:0080135 244 0.420
dna dependent dna replication GO:0006261 44 0.418
atrial septum primum morphogenesis GO:0003289 1 0.414
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.400
recombinational repair GO:0000725 50 0.390
positive regulation of dna repair GO:0045739 25 0.387
replication fork processing GO:0031297 13 0.386
intracellular protein transport GO:0006886 270 0.377
segmentation GO:0035282 4 0.375
chromosome segregation GO:0007059 114 0.366
somatic diversification of immunoglobulins GO:0016445 6 0.362
sister chromatid cohesion GO:0007062 24 0.361
positive regulation of response to dna damage stimulus GO:2001022 43 0.361
dna conformation change GO:0071103 113 0.346
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.333
adaptive immune response GO:0002250 49 0.329
negative regulation of cell cycle phase transition GO:1901988 89 0.325
cell activation involved in immune response GO:0002263 30 0.322
response to ionizing radiation GO:0010212 65 0.321
Human
positive regulation of dna metabolic process GO:0051054 73 0.319
mitotic cell cycle GO:0000278 326 0.317
somatic diversification of immune receptors GO:0002200 8 0.315
anterior posterior axis specification embryo GO:0008595 2 0.312
positive regulation of isotype switching GO:0045830 2 0.305
positive regulation of b cell mediated immunity GO:0002714 4 0.304
organelle fission GO:0048285 149 0.297
septum secundum development GO:0003285 2 0.280
signal transduction involved in dna damage checkpoint GO:0072422 15 0.275
lymphocyte mediated immunity GO:0002449 48 0.274
oocyte development GO:0048599 1 0.273
negative regulation of cell death GO:0060548 345 0.264
microtubule based process GO:0007017 210 0.256
anatomical structure homeostasis GO:0060249 100 0.247
oogenesis GO:0048477 2 0.244
regulation of protein maturation GO:1903317 150 0.240
protein ubiquitination GO:0016567 314 0.236
ribonucleoside catabolic process GO:0042454 406 0.235
negative regulation of megakaryocyte differentiation GO:0045653 16 0.234
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.228
sister chromatid segregation GO:0000819 54 0.223
proteasomal protein catabolic process GO:0010498 176 0.217
mitotic dna damage checkpoint GO:0044773 28 0.211
response to radiation GO:0009314 151 0.197
Human
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.187
mitotic nuclear division GO:0007067 119 0.185
mrna metabolic process GO:0016071 175 0.180
purine ribonucleoside catabolic process GO:0046130 398 0.174
dna synthesis involved in dna repair GO:0000731 6 0.173
neuromuscular process controlling balance GO:0050885 7 0.172
regulation of proteolysis GO:0030162 293 0.167
cellular macromolecular complex assembly GO:0034622 324 0.164
positive regulation of phosphorylation GO:0042327 394 0.163
cellular amino acid metabolic process GO:0006520 116 0.162
heart development GO:0007507 95 0.162
cardiovascular system development GO:0072358 262 0.161
telomere maintenance via telomere lengthening GO:0010833 9 0.160
cell aging GO:0007569 52 0.158
purine nucleoside monophosphate catabolic process GO:0009128 158 0.150
response to gamma radiation GO:0010332 14 0.148
macromolecule methylation GO:0043414 97 0.147
Human
positive regulation of transferase activity GO:0051347 227 0.146
histone h2a phosphorylation GO:1990164 3 0.145
production of molecular mediator of immune response GO:0002440 37 0.141
positive regulation of isotype switching to iga isotypes GO:0048298 2 0.140
regulation of mitosis GO:0007088 63 0.137
lymphocyte activation involved in immune response GO:0002285 20 0.137
leukocyte activation involved in immune response GO:0002366 30 0.134
reciprocal dna recombination GO:0035825 4 0.130
leukocyte activation GO:0045321 164 0.130
regulation of intracellular protein transport GO:0033157 123 0.129
regulation of kinase activity GO:0043549 314 0.124
regulation of lymphocyte activation GO:0051249 103 0.123
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.119
chordate embryonic development GO:0043009 34 0.116
leukocyte mediated immunity GO:0002443 59 0.113
dna catabolic process GO:0006308 49 0.112
purine nucleoside triphosphate metabolic process GO:0009144 412 0.109
response to nitrogen compound GO:1901698 184 0.106
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.104
positive regulation of cell death GO:0010942 263 0.102
response to biotic stimulus GO:0009607 276 0.101
female gamete generation GO:0007292 2 0.101
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.101
positive regulation of kinase activity GO:0033674 204 0.099
regulation of cellular ketone metabolic process GO:0010565 50 0.098
somatic cell dna recombination GO:0016444 6 0.098
regionalization GO:0003002 29 0.095
negative regulation of dna endoreduplication GO:0032876 5 0.094
cardiac atrium morphogenesis GO:0003209 7 0.093
immune response GO:0006955 307 0.093
regulation of immunoglobulin production GO:0002637 4 0.092
cellular response to abiotic stimulus GO:0071214 117 0.091
cell cycle g2 m phase transition GO:0044839 43 0.090
protein localization to organelle GO:0033365 280 0.090
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.090
dna replication GO:0006260 116 0.089
epithelium development GO:0060429 227 0.088
cellular amine metabolic process GO:0044106 41 0.087
signal transduction involved in mitotic dna damage checkpoint GO:1902402 13 0.086
protein deubiquitination GO:0016579 79 0.084
lipid metabolic process GO:0006629 381 0.084
regulation of leukocyte activation GO:0002694 115 0.084
negative regulation of organelle organization GO:0010639 126 0.082
positive regulation of dna replication GO:0045740 35 0.081
septum primum development GO:0003284 1 0.079
negative regulation of cellular protein catabolic process GO:1903363 38 0.078
intracellular mrna localization GO:0008298 1 0.077
peptidyl serine modification GO:0018209 106 0.077
ubiquitin dependent protein catabolic process GO:0006511 206 0.076
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.074
negative regulation of chromosome organization GO:2001251 48 0.074
single organism cellular localization GO:1902580 332 0.073
cellular component morphogenesis GO:0032989 314 0.073
positive regulation of cellular amine metabolic process GO:0033240 7 0.072
regulation of meiotic cell cycle GO:0051445 4 0.072
mitotic sister chromatid segregation GO:0000070 53 0.072
positive regulation of dna damage response signal transduction by p53 class mediator GO:0043517 8 0.072
circulatory system development GO:0072359 262 0.071
regulation of b cell activation GO:0050864 24 0.070
mitotic dna integrity checkpoint GO:0044774 30 0.069
cell projection organization GO:0030030 252 0.069
determination of adult lifespan GO:0008340 2 0.069
regulation of protein localization GO:0032880 296 0.069
negative regulation of cellular amine metabolic process GO:0033239 3 0.068
embryo development GO:0009790 123 0.068
nucleoside triphosphate catabolic process GO:0009143 394 0.068
regulation of dna recombination GO:0000018 23 0.068
regulation of mitotic sister chromatid separation GO:0010965 27 0.067
regulation of immune response GO:0050776 201 0.066
mitotic g2 m transition checkpoint GO:0044818 9 0.066
immune system development GO:0002520 195 0.066
actin filament based process GO:0030029 224 0.065
protein k48 linked ubiquitination GO:0070936 38 0.065
positive regulation of cell cycle GO:0045787 140 0.065
negative regulation of sister chromatid segregation GO:0033046 17 0.064
purine nucleoside catabolic process GO:0006152 398 0.064
regulation of multi organism process GO:0043900 157 0.062
gene silencing GO:0016458 49 0.061
mismatch repair GO:0006298 15 0.059
protein import into nucleus GO:0006606 104 0.058
protein autophosphorylation GO:0046777 123 0.058
cell division GO:0051301 168 0.056
central nervous system development GO:0007417 123 0.055
neuromuscular process GO:0050905 15 0.054
protein polyubiquitination GO:0000209 110 0.053
negative regulation of cellular component organization GO:0051129 235 0.052
establishment of nucleus localization GO:0040023 1 0.052
histone lysine methylation GO:0034968 50 0.051
Human
negative regulation of histone h3 k9 methylation GO:0051573 3 0.051
protein modification by small protein conjugation GO:0032446 342 0.051
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.050
regulation of transferase activity GO:0051338 355 0.050
lymphocyte activation GO:0046649 133 0.049
histone h2a k63 linked ubiquitination GO:0070535 5 0.049
peptidyl serine phosphorylation GO:0018105 101 0.049
atrial septum secundum morphogenesis GO:0003290 1 0.049
immune effector process GO:0002252 159 0.049
mitotic spindle checkpoint GO:0071174 18 0.049
spindle checkpoint GO:0031577 26 0.048
cell activation GO:0001775 213 0.048
negative regulation of developmental process GO:0051093 247 0.048
meiotic cell cycle process GO:1903046 8 0.047
mitotic g2 dna damage checkpoint GO:0007095 7 0.047
rna dependent dna replication GO:0006278 16 0.047
protein catabolic process GO:0030163 325 0.046
nucleosome organization GO:0034728 66 0.046
regulation of b cell mediated immunity GO:0002712 7 0.046
chromosome condensation GO:0030261 15 0.046
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
mitotic recombination GO:0006312 8 0.044
negative regulation of mitosis GO:0045839 24 0.043
negative regulation of b cell proliferation GO:0030889 5 0.043
cell morphogenesis GO:0000902 296 0.043
positive regulation of protein phosphorylation GO:0001934 313 0.043
negative regulation of protein maturation GO:1903318 142 0.042
neuron death GO:0070997 65 0.042
dna damage response signal transduction resulting in transcription GO:0042772 12 0.042
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.042
ribonucleotide catabolic process GO:0009261 405 0.042
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.042
protein methylation GO:0006479 74 0.041
Human
regulation of establishment of protein localization GO:0070201 242 0.041
positive regulation of cell activation GO:0050867 81 0.041
cell part morphogenesis GO:0032990 137 0.040
positive regulation of catabolic process GO:0009896 310 0.040
regulation of neuron apoptotic process GO:0043523 35 0.040
positive regulation of leukocyte activation GO:0002696 80 0.039
intra s dna damage checkpoint GO:0031573 4 0.039
histone h3 k36 methylation GO:0010452 5 0.039
somitogenesis GO:0001756 2 0.039
amine metabolic process GO:0009308 44 0.038
blastoderm segmentation GO:0007350 2 0.038
cellular lipid metabolic process GO:0044255 303 0.038
regulation of protein processing GO:0070613 150 0.038
regulation of cellular amino acid metabolic process GO:0006521 6 0.037
nucleoside triphosphate metabolic process GO:0009141 422 0.037
regulation of viral process GO:0050792 103 0.037
centrosome organization GO:0051297 58 0.036
positive regulation of dna recombination GO:0045911 3 0.036
nuclear migration GO:0007097 1 0.036
cellular ketone metabolic process GO:0042180 80 0.036
negative regulation of apoptotic process GO:0043066 316 0.035
intrinsic apoptotic signaling pathway GO:0097193 127 0.035
cell cycle arrest GO:0007050 71 0.034
response to hypoxia GO:0001666 96 0.034
regulation of microtubule cytoskeleton organization GO:0070507 61 0.034
negative regulation of cellular catabolic process GO:0031330 83 0.034
chromosome separation GO:0051304 23 0.034
positive regulation of transcription factor import into nucleus GO:0042993 25 0.034
regulation of protein targeting GO:1903533 91 0.033
intracellular receptor signaling pathway GO:0030522 104 0.032
regulation of production of molecular mediator of immune response GO:0002700 25 0.032
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.032
Human
immunoglobulin mediated immune response GO:0016064 10 0.032
methylation GO:0032259 106 0.031
Human
histone h4 k20 methylation GO:0034770 1 0.031
regulation of transcription by chromatin organization GO:0034401 1 0.031
regulation of isotype switching GO:0045191 2 0.030
negative regulation of mitotic sister chromatid segregation GO:0033048 17 0.030
b cell activation GO:0042113 33 0.030
regulation of dna endoreduplication GO:0032875 5 0.030
nucleus localization GO:0051647 1 0.029
mrna processing GO:0006397 133 0.029
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.029
metaphase anaphase transition of cell cycle GO:0044784 21 0.029
protein k63 linked ubiquitination GO:0070534 31 0.029
protein import GO:0017038 130 0.028
telomere maintenance GO:0000723 32 0.028
cellular response to organonitrogen compound GO:0071417 124 0.028
negative regulation of programmed cell death GO:0043069 321 0.028
regulation of cytoplasmic transport GO:1903649 149 0.028
regulation of dna dependent dna replication GO:0090329 19 0.028
regulation of cellular component movement GO:0051270 334 0.027
cell projection morphogenesis GO:0048858 129 0.027
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.027
interstrand cross link repair GO:0036297 3 0.027
organelle assembly GO:0070925 176 0.027
dna strand elongation involved in dna replication GO:0006271 3 0.026
dna catabolic process endonucleolytic GO:0000737 37 0.026
positive regulation of cytoplasmic transport GO:1903651 82 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.026
regulation of nucleocytoplasmic transport GO:0046822 98 0.026
purine nucleoside monophosphate metabolic process GO:0009126 186 0.026
pattern specification process GO:0007389 43 0.026
nucleoside monophosphate catabolic process GO:0009125 159 0.026
positive regulation of protein localization to nucleus GO:1900182 48 0.026
cellular protein complex assembly GO:0043623 188 0.025
negative regulation of proteolysis GO:0045861 132 0.025
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.025
purine nucleotide catabolic process GO:0006195 405 0.025
maintenance of location GO:0051235 112 0.025
dna replication independent nucleosome organization GO:0034724 27 0.025
positive regulation of immune effector process GO:0002699 40 0.025
isotype switching to iga isotypes GO:0048290 2 0.024
regulation of chromosome organization GO:0033044 103 0.024
cellular macromolecule catabolic process GO:0044265 380 0.024
protein targeting GO:0006605 187 0.024
single organism nuclear import GO:1902593 104 0.024
regulation of histone methylation GO:0031060 16 0.023
telomere maintenance via recombination GO:0000722 4 0.023
protein maturation GO:0051604 233 0.023
response to oxygen containing compound GO:1901700 369 0.023
positive regulation of histone h3 k4 methylation GO:0051571 8 0.023
modification dependent protein catabolic process GO:0019941 209 0.023
microtubule anchoring GO:0034453 24 0.023
spindle assembly checkpoint GO:0071173 17 0.023
b cell mediated immunity GO:0019724 10 0.023
reproductive process GO:0022414 106 0.023
brain development GO:0007420 97 0.023
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.022
regulation of mononuclear cell proliferation GO:0032944 65 0.022
ribonucleoside monophosphate catabolic process GO:0009158 158 0.022
chromatin silencing GO:0006342 12 0.022
actin cytoskeleton organization GO:0030036 207 0.022
regulation of protein localization to nucleus GO:1900180 85 0.022
nuclear transport GO:0051169 179 0.022
tissue morphogenesis GO:0048729 96 0.022
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 4 0.022
nuclear import GO:0051170 106 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
regulation of adaptive immune response GO:0002819 33 0.021
regulation of cellular protein catabolic process GO:1903362 96 0.021
regulation of cell activation GO:0050865 125 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
protein modification by small protein removal GO:0070646 92 0.021
positive regulation of immune response GO:0050778 159 0.021
tissue homeostasis GO:0001894 63 0.021
phospholipid metabolic process GO:0006644 99 0.021
leukocyte differentiation GO:0002521 98 0.020
single organism reproductive process GO:0044702 98 0.020
response to organonitrogen compound GO:0010243 156 0.020
positive regulation of programmed cell death GO:0043068 249 0.020
reproduction GO:0000003 63 0.020
oocyte maturation GO:0001556 1 0.020
response to decreased oxygen levels GO:0036293 96 0.020
establishment of protein localization to organelle GO:0072594 172 0.020
response to hyperoxia GO:0055093 4 0.020
mitotic g1 dna damage checkpoint GO:0031571 17 0.020
positive regulation of adaptive immune response GO:0002821 21 0.020
endothelial cell migration GO:0043542 86 0.020
signal transduction by p53 class mediator GO:0072331 72 0.019
Human
response to purine containing compound GO:0014074 40 0.019
dna strand elongation GO:0022616 5 0.019
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.019
anterior posterior pattern specification GO:0009952 9 0.019
regulation of chromatin organization GO:1902275 56 0.019
cytoplasmic transport GO:0016482 379 0.019
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
purine nucleoside triphosphate catabolic process GO:0009146 392 0.019
regulation of cell division GO:0051302 116 0.019
regulation of protein catabolic process GO:0042176 155 0.019
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.019
specification of axis polarity GO:0065001 1 0.018
establishment of organelle localization GO:0051656 59 0.018
embryo development ending in birth or egg hatching GO:0009792 34 0.018
positive regulation of intracellular protein transport GO:0090316 76 0.018
positive regulation of protein transport GO:0051222 135 0.018
connective tissue development GO:0061448 39 0.018
mitotic spindle assembly checkpoint GO:0007094 14 0.018
regulation of telomere maintenance GO:0032204 13 0.018
mitotic sister chromatid separation GO:0051306 18 0.017
single strand break repair GO:0000012 6 0.017
lipid biosynthetic process GO:0008610 177 0.017
male meiosis GO:0007140 1 0.017
nervous system development GO:0007399 293 0.017
multicellular organismal aging GO:0010259 3 0.017
negative regulation of transport GO:0051051 176 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
neurogenesis GO:0022008 169 0.017
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
compound eye development GO:0048749 1 0.017
nucleoside catabolic process GO:0009164 408 0.017
negative regulation of transferase activity GO:0051348 124 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.016
peptide metabolic process GO:0006518 51 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.016
regulation of signal transduction by p53 class mediator GO:1901796 26 0.016
neuron projection morphogenesis GO:0048812 50 0.016
chemical homeostasis GO:0048878 306 0.016
regulation of transcription factor import into nucleus GO:0042990 39 0.016
nucleotide catabolic process GO:0009166 408 0.016
generation of neurons GO:0048699 152 0.015
telomere maintenance via telomerase GO:0007004 8 0.015
neuron remodeling GO:0016322 2 0.015
glycerolipid biosynthetic process GO:0045017 51 0.015
cellular protein catabolic process GO:0044257 261 0.015
adipose tissue development GO:0060612 2 0.015
microtubule organizing center organization GO:0031023 62 0.015
protein alkylation GO:0008213 74 0.015
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.015
membrane organization GO:0061024 292 0.015
epithelial cell development GO:0002064 34 0.015
regulation of histone acetylation GO:0035065 19 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
post embryonic development GO:0009791 2 0.015
lipoprotein metabolic process GO:0042157 42 0.015
head development GO:0060322 108 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
regulation of gene expression epigenetic GO:0040029 73 0.014
response to external biotic stimulus GO:0043207 261 0.014
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.014
negative regulation of protein modification process GO:0031400 200 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
protein localization to nucleus GO:0034504 136 0.014
protein k63 linked deubiquitination GO:0070536 21 0.014
regulation of nuclear division GO:0051783 65 0.014
neuron development GO:0048666 113 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
negative regulation of protein metabolic process GO:0051248 391 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
male gonad development GO:0008584 23 0.013
telomere organization GO:0032200 33 0.013
regulation of oxidative stress induced cell death GO:1903201 24 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.013
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.013
positive regulation of telomere maintenance GO:0032206 4 0.013
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.013
detection of stimulus GO:0051606 85 0.013
ras protein signal transduction GO:0007265 73 0.013
protein k11 linked ubiquitination GO:0070979 24 0.013
vascular smooth muscle cell differentiation GO:0035886 3 0.013
maintenance of dna repeat elements GO:0043570 4 0.013
regulation of dna templated transcription elongation GO:0032784 23 0.012
multi organism reproductive process GO:0044703 54 0.012
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 10 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
response to alkaloid GO:0043279 20 0.012
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.012
dna unwinding involved in dna replication GO:0006268 2 0.012
peptidyl lysine acetylation GO:0018394 101 0.012
regulation of microtubule based process GO:0032886 74 0.012
cell development GO:0048468 328 0.012
mitotic nuclear envelope reassembly GO:0007084 3 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
regulation of chromatin modification GO:1903308 51 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
regulation of intracellular transport GO:0032386 195 0.012
protein homooligomerization GO:0051260 100 0.012
histone h3 k9 methylation GO:0051567 10 0.011
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.011
hematopoietic progenitor cell differentiation GO:0002244 38 0.011

MDC1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.865
cancer DOID:162 167 0.631
organ system cancer DOID:0050686 164 0.335
immune system disease DOID:2914 155 0.297
bone marrow disease DOID:4961 31 0.179
hematopoietic system disease DOID:74 100 0.179
thoracic cancer DOID:5093 21 0.088
aplastic anemia DOID:12449 30 0.076
anemia DOID:2355 55 0.076
disease of mental health DOID:150 70 0.057
Human
breast cancer DOID:1612 21 0.056
cognitive disorder DOID:1561 29 0.041
Human
central nervous system disease DOID:331 186 0.034
Human
nervous system disease DOID:863 431 0.034
Human
immune system cancer DOID:0060083 36 0.026
hematologic cancer DOID:2531 36 0.026
gastrointestinal system cancer DOID:3119 52 0.022
tauopathy DOID:680 16 0.021
Human
neurodegenerative disease DOID:1289 102 0.021
Human
dementia DOID:1307 19 0.015
Human
alzheimer s disease DOID:10652 16 0.015
Human
reproductive organ cancer DOID:193 23 0.014
female reproductive organ cancer DOID:120 10 0.014
prostate cancer DOID:10283 13 0.012
male reproductive organ cancer DOID:3856 16 0.012