Homo sapiens

231 known processes

MDM2

Mdm2 p53 binding protein homolog (mouse)

(Aliases: MGC71221,MGC5370,hdm2,HDMX)

MDM2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
apoptotic signaling pathway GO:0097190 268 1.000
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 1.000
positive regulation of proteolysis GO:0045862 142 1.000
small gtpase mediated signal transduction GO:0007264 78 1.000
regulation of mitotic cell cycle GO:0007346 189 1.000
negative regulation of apoptotic process GO:0043066 316 1.000
Zebrafish
negative regulation of cell death GO:0060548 345 1.000
Zebrafish
positive regulation of programmed cell death GO:0043068 249 1.000
negative regulation of mitotic cell cycle GO:0045930 102 1.000
regulation of cell cycle GO:0051726 393 1.000
mitotic cell cycle checkpoint GO:0007093 68 1.000
posttranscriptional regulation of gene expression GO:0010608 213 1.000
mitotic g1 dna damage checkpoint GO:0031571 17 1.000
dna repair GO:0006281 198 1.000
cell cycle phase transition GO:0044770 173 1.000
protein ubiquitination GO:0016567 314 1.000
g1 s transition of mitotic cell cycle GO:0000082 78 1.000
regulation of proteolysis GO:0030162 293 1.000
positive regulation of cysteine type endopeptidase activity GO:2001056 79 1.000
response to abiotic stimulus GO:0009628 336 1.000
regulation of cell cycle phase transition GO:1901987 126 1.000
regulation of apoptotic signaling pathway GO:2001233 175 1.000
positive regulation of cell death GO:0010942 263 1.000
mitotic cell cycle process GO:1903047 286 1.000
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 1.000
negative regulation of cell cycle GO:0045786 193 0.999
negative regulation of cell cycle process GO:0010948 121 0.999
nervous system development GO:0007399 293 0.999
mitotic cell cycle phase transition GO:0044772 162 0.999
regulation of cell cycle arrest GO:0071156 36 0.999
regulation of cell cycle g1 s phase transition GO:1902806 42 0.999
negative regulation of programmed cell death GO:0043069 321 0.999
Zebrafish
zymogen activation GO:0031638 70 0.999
positive regulation of apoptotic process GO:0043065 246 0.999
regulation of cell cycle process GO:0010564 266 0.999
mitotic dna damage checkpoint GO:0044773 28 0.999
chromatin organization GO:0006325 351 0.999
modification dependent protein catabolic process GO:0019941 209 0.999
intrinsic apoptotic signaling pathway GO:0097193 127 0.999
response to radiation GO:0009314 151 0.999
Zebrafish
cellular macromolecule catabolic process GO:0044265 380 0.999
regulation of peptidase activity GO:0052547 180 0.999
positive regulation of apoptotic signaling pathway GO:2001235 70 0.999
myeloid cell differentiation GO:0030099 117 0.999
mitotic cell cycle GO:0000278 326 0.999
response to hypoxia GO:0001666 96 0.998
activation of cysteine type endopeptidase activity GO:0097202 57 0.998
cell type specific apoptotic process GO:0097285 125 0.998
i kappab kinase nf kappab signaling GO:0007249 166 0.998
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.998
regulation of endopeptidase activity GO:0052548 170 0.998
regulation of cell differentiation GO:0045595 393 0.998
purine nucleotide catabolic process GO:0006195 405 0.998
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.998
ubiquitin dependent protein catabolic process GO:0006511 206 0.997
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.997
rho protein signal transduction GO:0007266 26 0.997
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.997
mitotic dna integrity checkpoint GO:0044774 30 0.997
dna integrity checkpoint GO:0031570 71 0.997
epidermis morphogenesis GO:0048730 3 0.997
cell cell signaling GO:0007267 155 0.996
positive regulation of cellular catabolic process GO:0031331 284 0.996
mitotic g1 s transition checkpoint GO:0044819 17 0.996
hematopoietic or lymphoid organ development GO:0048534 186 0.995
regulation of cytoskeleton organization GO:0051493 177 0.995
g1 dna damage checkpoint GO:0044783 18 0.995
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 13 0.995
positive regulation of cell cycle arrest GO:0071158 23 0.995
response to biotic stimulus GO:0009607 276 0.995
purine ribonucleoside metabolic process GO:0046128 437 0.995
dna replication GO:0006260 116 0.994
regulation of actin filament based process GO:0032970 141 0.994
positive regulation of endopeptidase activity GO:0010950 84 0.994
ribonucleoside triphosphate metabolic process GO:0009199 412 0.994
regulation of mitotic cell cycle phase transition GO:1901990 118 0.993
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.993
embryonic morphogenesis GO:0048598 85 0.993
regulation of myeloid cell differentiation GO:0045637 81 0.993
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.993
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.992
positive regulation of hydrolase activity GO:0051345 331 0.992
positive regulation of cell proliferation GO:0008284 301 0.992
nucleotide catabolic process GO:0009166 408 0.992
cellular response to hypoxia GO:0071456 51 0.991
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.990
ribosome biogenesis GO:0042254 48 0.990
cellular response to abiotic stimulus GO:0071214 117 0.990
glycosyl compound catabolic process GO:1901658 413 0.990
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.989
dna damage checkpoint GO:0000077 68 0.989
epithelium development GO:0060429 227 0.988
ribonucleotide catabolic process GO:0009261 405 0.988
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.988
regulation of proteasomal protein catabolic process GO:0061136 87 0.988
modification dependent macromolecule catabolic process GO:0043632 212 0.988
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.987
proteasomal protein catabolic process GO:0010498 176 0.987
positive regulation of cell cycle GO:0045787 140 0.987
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.987
tube morphogenesis GO:0035239 95 0.986
signal transduction involved in cell cycle checkpoint GO:0072395 16 0.986
cellular response to uv GO:0034644 32 0.985
response to other organism GO:0051707 261 0.985
cell development GO:0048468 328 0.985
protein catabolic process GO:0030163 325 0.985
negative regulation of cell cycle phase transition GO:1901988 89 0.984
positive regulation of cellular protein catabolic process GO:1903364 37 0.983
cytoplasmic transport GO:0016482 379 0.983
nucleoside triphosphate metabolic process GO:0009141 422 0.983
cell cycle arrest GO:0007050 71 0.982
oxidative stress induced premature senescence GO:0090403 3 0.982
leukocyte migration involved in inflammatory response GO:0002523 2 0.982
tissue morphogenesis GO:0048729 96 0.981
regulation of cell migration GO:0030334 289 0.980
ribonucleoside catabolic process GO:0042454 406 0.980
nucleoside catabolic process GO:0009164 408 0.980
positive regulation of peptidase activity GO:0010952 88 0.979
chromatin modification GO:0016568 298 0.978
positive regulation of catabolic process GO:0009896 310 0.978
cellular response to decreased oxygen levels GO:0036294 51 0.977
intracellular receptor signaling pathway GO:0030522 104 0.976
cell junction organization GO:0034330 79 0.976
cell cycle checkpoint GO:0000075 117 0.975
response to oxygen levels GO:0070482 100 0.975
positive regulation of developmental process GO:0051094 314 0.975
neutrophil aggregation GO:0070488 2 0.974
cellular response to endogenous stimulus GO:0071495 336 0.973
regulation of rho gtpase activity GO:0032319 66 0.973
regulation of protein stability GO:0031647 87 0.973
protein destabilization GO:0031648 12 0.973
peptidyl serine modification GO:0018209 106 0.972
monosaccharide metabolic process GO:0005996 74 0.971
gtp catabolic process GO:0006184 237 0.971
tube development GO:0035295 125 0.970
carbohydrate metabolic process GO:0005975 207 0.969
regulation of cell development GO:0060284 161 0.968
positive regulation of cell differentiation GO:0045597 211 0.968
signal transduction in response to dna damage GO:0042770 57 0.967
ribonucleoside triphosphate catabolic process GO:0009203 391 0.966
ras protein signal transduction GO:0007265 73 0.964
organophosphate catabolic process GO:0046434 430 0.964
purine nucleoside triphosphate catabolic process GO:0009146 392 0.962
morphogenesis of a branching structure GO:0001763 21 0.962
regulation of cysteine type endopeptidase activity GO:2000116 127 0.961
protein deubiquitination GO:0016579 79 0.960
regulation of defense response GO:0031347 154 0.960
immune system development GO:0002520 195 0.959
leukocyte migration GO:0050900 107 0.959
nucleoside phosphate catabolic process GO:1901292 412 0.958
cellular component morphogenesis GO:0032989 314 0.958
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.957
guanosine containing compound metabolic process GO:1901068 244 0.957
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.956
positive regulation of defense response GO:0031349 87 0.956
multicellular organismal aging GO:0010259 3 0.955
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.955
regulation of cell adhesion GO:0030155 166 0.955
response to external biotic stimulus GO:0043207 261 0.955
cellular protein catabolic process GO:0044257 261 0.954
protein modification by small protein conjugation GO:0032446 342 0.954
response to xenobiotic stimulus GO:0009410 30 0.951
purine ribonucleoside catabolic process GO:0046130 398 0.951
endomembrane system organization GO:0010256 196 0.951
protein processing GO:0016485 226 0.948
urogenital system development GO:0001655 65 0.947
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.946
regulation of locomotion GO:0040012 329 0.946
organ morphogenesis GO:0009887 147 0.946
head development GO:0060322 108 0.945
signal transduction involved in mitotic dna damage checkpoint GO:1902402 13 0.945
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.944
regulation of kinase activity GO:0043549 314 0.944
response to organic cyclic compound GO:0014070 204 0.944
central nervous system development GO:0007417 123 0.943
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.943
single organism membrane organization GO:0044802 268 0.942
determination of adult lifespan GO:0008340 2 0.941
cellular response to xenobiotic stimulus GO:0071466 29 0.941
cell morphogenesis GO:0000902 296 0.941
response to molecule of bacterial origin GO:0002237 82 0.939
positive regulation of gtpase activity GO:0043547 166 0.939
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.939
epithelial cell development GO:0002064 34 0.934
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 10 0.934
response to decreased oxygen levels GO:0036293 96 0.933
regulation of nucleotide catabolic process GO:0030811 205 0.930
protein heterotetramerization GO:0051290 3 0.930
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.928
response to nitrogen compound GO:1901698 184 0.928
response to lipopolysaccharide GO:0032496 70 0.923
histone modification GO:0016570 251 0.923
response to cytokine GO:0034097 232 0.922
apoptotic mitochondrial changes GO:0008637 57 0.921
protein maturation GO:0051604 233 0.919
aging GO:0007568 66 0.919
regulation of nucleoside metabolic process GO:0009118 209 0.919
hemopoiesis GO:0030097 180 0.918
purine nucleoside triphosphate metabolic process GO:0009144 412 0.916
regulation of nucleotide metabolic process GO:0006140 269 0.913
positive regulation of ras gtpase activity GO:0032320 117 0.912
purine containing compound catabolic process GO:0072523 411 0.911
response to toxic substance GO:0009636 37 0.910
cellular response to ionizing radiation GO:0071479 32 0.906
response to organonitrogen compound GO:0010243 156 0.906
protein autophosphorylation GO:0046777 123 0.905
biological adhesion GO:0022610 331 0.902
brain development GO:0007420 97 0.902
regulation of reactive oxygen species metabolic process GO:2000377 41 0.901
cellular response to radiation GO:0071478 65 0.899
erythrocyte differentiation GO:0030218 28 0.896
granulocyte chemotaxis GO:0071621 37 0.896
regulation of rho protein signal transduction GO:0035023 79 0.895
response to purine containing compound GO:0014074 40 0.895
response to steroid hormone GO:0048545 80 0.894
response to estrogen GO:0043627 47 0.894
regulation of leukocyte differentiation GO:1902105 61 0.892
actin filament based process GO:0030029 224 0.890
positive regulation of nucleoside metabolic process GO:0045979 186 0.890
cellular response to cytokine stimulus GO:0071345 181 0.890
neuron apoptotic process GO:0051402 39 0.888
negative regulation of apoptotic signaling pathway GO:2001234 97 0.888
skin development GO:0043588 76 0.886
regulation of protein kinase activity GO:0045859 289 0.886
regulation of dna metabolic process GO:0051052 153 0.884
cell substrate junction assembly GO:0007044 35 0.883
purine nucleoside catabolic process GO:0006152 398 0.880
cell cycle g1 s phase transition GO:0044843 80 0.879
membrane organization GO:0061024 292 0.878
cardiovascular system development GO:0072358 262 0.877
branching morphogenesis of an epithelial tube GO:0048754 19 0.877
gastrulation GO:0007369 51 0.873
negative regulation of cell proliferation GO:0008285 228 0.870
dna packaging GO:0006323 77 0.869
regulation of cell morphogenesis GO:0022604 153 0.869
embryonic organ development GO:0048568 36 0.868
signal transduction involved in dna integrity checkpoint GO:0072401 15 0.868
wound healing GO:0042060 115 0.865
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.864
regeneration GO:0031099 4 0.862
epithelial tube morphogenesis GO:0060562 38 0.857
response to growth factor GO:0070848 205 0.854
regulation of cell matrix adhesion GO:0001952 42 0.854
cell cell junction organization GO:0045216 69 0.854
regulation of carbohydrate biosynthetic process GO:0043255 27 0.853
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 3 0.852
circulatory system development GO:0072359 262 0.846
regulation of purine nucleotide metabolic process GO:1900542 264 0.845
interleukin 1 alpha secretion GO:0050703 1 0.845
guanosine containing compound catabolic process GO:1901069 239 0.844
blood vessel morphogenesis GO:0048514 162 0.842
positive regulation of protein phosphorylation GO:0001934 313 0.842
regulation of innate immune response GO:0045088 97 0.835
positive regulation of nucleotide metabolic process GO:0045981 230 0.835
actin cytoskeleton organization GO:0030036 207 0.834
regulation of cellular ketone metabolic process GO:0010565 50 0.833
behavior GO:0007610 112 0.829
peptidyl serine phosphorylation GO:0018105 101 0.828
vesicle mediated transport GO:0016192 371 0.827
regulation of cellular component movement GO:0051270 334 0.826
membrane raft assembly GO:0001765 7 0.822
membrane biogenesis GO:0044091 13 0.817
positive regulation of t cell apoptotic process GO:0070234 4 0.814
mitochondrion organization GO:0007005 156 0.814
embryo development GO:0009790 123 0.813
substantia nigra development GO:0021762 45 0.806
leukocyte aggregation GO:0070486 8 0.805
secretion by cell GO:0032940 226 0.801
inflammatory response GO:0006954 79 0.800
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.800
fibroblast proliferation GO:0048144 33 0.797
protein oligomerization GO:0051259 173 0.797
regulation of synaptic plasticity GO:0048167 3 0.795
response to oxygen containing compound GO:1901700 369 0.792
covalent chromatin modification GO:0016569 254 0.791
purine ribonucleotide catabolic process GO:0009154 404 0.788
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.787
regulation of purine nucleotide catabolic process GO:0033121 205 0.787
response to light stimulus GO:0009416 87 0.784
regulation of response to external stimulus GO:0032101 222 0.784
response to hormone GO:0009725 175 0.784
positive regulation of cellular component biogenesis GO:0044089 158 0.784
autophagy GO:0006914 88 0.783
epithelial cell differentiation GO:0030855 141 0.783
negative regulation of multi organism process GO:0043901 92 0.777
positive regulation of rho gtpase activity GO:0032321 56 0.772
positive regulation of cell cycle process GO:0090068 106 0.771
hair follicle morphogenesis GO:0031069 2 0.765
cell matrix adhesion GO:0007160 85 0.765
actomyosin structure organization GO:0031032 59 0.764
response to bacterium GO:0009617 144 0.764
regulation of cell motility GO:2000145 299 0.751
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9 0.750
interleukin 1 production GO:0032612 26 0.740
negative regulation of immune system process GO:0002683 136 0.740
response to ionizing radiation GO:0010212 65 0.738
Zebrafish
protein stabilization GO:0050821 64 0.738
Human
single organism cell adhesion GO:0098602 179 0.735
cellular response to growth factor stimulus GO:0071363 197 0.734
regulation of leukocyte migration GO:0002685 63 0.734
regulation of actin cytoskeleton organization GO:0032956 116 0.730
negative regulation of myeloid cell differentiation GO:0045638 42 0.729
establishment of protein localization to membrane GO:0090150 121 0.729
protein localization to membrane GO:0072657 160 0.728
chromatin assembly or disassembly GO:0006333 78 0.725
cellular senescence GO:0090398 34 0.722
response to lipid GO:0033993 206 0.720
midbrain development GO:0030901 45 0.719
hexose metabolic process GO:0019318 55 0.715
adherens junction organization GO:0034332 36 0.714
positive regulation of nucleotide catabolic process GO:0030813 185 0.714
negative regulation of response to external stimulus GO:0032102 83 0.697
renal system development GO:0072001 63 0.696
monocyte chemotaxis GO:0002548 20 0.695
regulation of cellular amine metabolic process GO:0033238 11 0.691
peptidyl threonine phosphorylation GO:0018107 41 0.691
epidermal cell differentiation GO:0009913 45 0.690
regulation of signal transduction by p53 class mediator GO:1901796 26 0.682
enzyme linked receptor protein signaling pathway GO:0007167 303 0.682
hindbrain development GO:0030902 3 0.679
negative regulation of developmental process GO:0051093 247 0.676
vasculature development GO:0001944 181 0.673
regulation of notch signaling pathway GO:0008593 18 0.673
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.672
regulation of cellular component biogenesis GO:0044087 281 0.670
taxis GO:0042330 157 0.669
positive regulation of focal adhesion assembly GO:0051894 11 0.669
cell junction assembly GO:0034329 67 0.667
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.667
metal ion transport GO:0030001 272 0.665
neutrophil chemotaxis GO:0030593 24 0.664
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.664
negative regulation of protein phosphorylation GO:0001933 140 0.657
positive regulation of cytoskeleton organization GO:0051495 83 0.651
neurogenesis GO:0022008 169 0.647
ion transmembrane transport GO:0034220 338 0.646
negative regulation of catalytic activity GO:0043086 335 0.644
cellular ketone metabolic process GO:0042180 80 0.641
extrinsic apoptotic signaling pathway GO:0097191 119 0.639
dna damage response signal transduction resulting in transcription GO:0042772 12 0.626
cellular response to oxygen containing compound GO:1901701 276 0.621
protein targeting GO:0006605 187 0.619
double strand break repair GO:0006302 101 0.618
gland development GO:0048732 48 0.612
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.607
organelle assembly GO:0070925 176 0.606
single organism cellular localization GO:1902580 332 0.606
oxidation reduction process GO:0055114 396 0.605
digestive tract morphogenesis GO:0048546 56 0.605
regulation of protein catabolic process GO:0042176 155 0.602
regulation of cell junction assembly GO:1901888 29 0.602
blood vessel development GO:0001568 172 0.600
nuclear division GO:0000280 128 0.598
chromosome segregation GO:0007059 114 0.598
single organismal cell cell adhesion GO:0016337 148 0.597
androgen receptor signaling pathway GO:0030521 34 0.597
regulation of gtp catabolic process GO:0033124 180 0.595
regulation of cellular protein catabolic process GO:1903362 96 0.593
stress activated protein kinase signaling cascade GO:0031098 94 0.591
regulation of cellular component size GO:0032535 82 0.589
regulation of ras gtpase activity GO:0032318 128 0.589
negative regulation of phosphorylation GO:0042326 174 0.587
stress fiber assembly GO:0043149 40 0.587
negative regulation of phosphorus metabolic process GO:0010563 267 0.583
actin filament organization GO:0007015 128 0.582
regulation of cellular response to stress GO:0080135 244 0.580
regulation of protein serine threonine kinase activity GO:0071900 179 0.577
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.574
notch signaling pathway GO:0007219 31 0.573
single organism carbohydrate metabolic process GO:0044723 193 0.571
morphogenesis of a branching epithelium GO:0061138 20 0.569
regulation of metal ion transport GO:0010959 120 0.568
histone h4 acetylation GO:0043967 47 0.567
positive regulation of cell development GO:0010720 92 0.566
angiogenesis GO:0001525 147 0.564
positive regulation of organelle organization GO:0010638 195 0.562
t cell activation GO:0042110 99 0.562
leukocyte chemotaxis GO:0030595 76 0.560
positive regulation of cell matrix adhesion GO:0001954 23 0.559
neural nucleus development GO:0048857 47 0.558
regulation of actin filament bundle assembly GO:0032231 36 0.558
digestive system development GO:0055123 75 0.556
signal transduction by p53 class mediator GO:0072331 72 0.553
gtp metabolic process GO:0046039 239 0.548
regulation of gtpase activity GO:0043087 180 0.544
regulation of substrate adhesion dependent cell spreading GO:1900024 19 0.544
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.540
circadian regulation of gene expression GO:0032922 8 0.540
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.538
calcium ion transport GO:0006816 147 0.538
response to fungus GO:0009620 4 0.537
reactive oxygen species metabolic process GO:0072593 75 0.532
positive regulation of mapk cascade GO:0043410 190 0.531
protein polyubiquitination GO:0000209 110 0.529
digestive tract development GO:0048565 75 0.528
focal adhesion assembly GO:0048041 30 0.526
positive regulation of cellular component organization GO:0051130 376 0.523
cell substrate adherens junction assembly GO:0007045 30 0.521
regulation of glucose metabolic process GO:0010906 28 0.517
negative regulation of response to extracellular stimulus GO:0032105 5 0.516
positive regulation of immune response GO:0050778 159 0.511
positive regulation of gtp catabolic process GO:0033126 166 0.510
regulation of translation GO:0006417 89 0.509
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.508
response to estradiol GO:0032355 23 0.504
regulation of ossification GO:0030278 58 0.502
replicative senescence GO:0090399 8 0.497
organelle fission GO:0048285 149 0.496
regulation of neural precursor cell proliferation GO:2000177 4 0.495
cell chemotaxis GO:0060326 112 0.494
response to uv GO:0009411 73 0.493
response to antibiotic GO:0046677 15 0.491
regulation of stress fiber assembly GO:0051492 32 0.491
positive regulation of immune system process GO:0002684 283 0.490
neuron development GO:0048666 113 0.489
negative regulation of protein metabolic process GO:0051248 391 0.489
Human
female gamete generation GO:0007292 2 0.489
immune response regulating signaling pathway GO:0002764 97 0.487
chromatin assembly GO:0031497 61 0.486
protein tetramerization GO:0051262 47 0.482
mitotic nuclear division GO:0007067 119 0.476
positive regulation of fibroblast apoptotic process GO:2000271 6 0.471
canonical wnt signaling pathway GO:0060070 116 0.467
positive regulation of phosphorylation GO:0042327 394 0.466
vesicle organization GO:0016050 62 0.466
pml body organization GO:0030578 2 0.464
leukocyte differentiation GO:0002521 98 0.463
adherens junction assembly GO:0034333 34 0.463
regulation of transferase activity GO:0051338 355 0.459
immune response GO:0006955 307 0.455
leukocyte cell cell adhesion GO:0007159 37 0.453
lens development in camera type eye GO:0002088 2 0.452
glucose homeostasis GO:0042593 31 0.451
positive regulation of response to wounding GO:1903036 28 0.448
cellular polysaccharide biosynthetic process GO:0033692 21 0.447
regulation of epithelial cell proliferation GO:0050678 113 0.445
regulation of response to wounding GO:1903034 101 0.441
muscle tissue development GO:0060537 62 0.440
actin filament bundle assembly GO:0051017 54 0.437
negative regulation of cellular carbohydrate metabolic process GO:0010677 14 0.435
response to inorganic substance GO:0010035 127 0.434
embryonic hemopoiesis GO:0035162 4 0.431
toll like receptor 4 signaling pathway GO:0034142 12 0.428
ossification GO:0001503 121 0.428
skin morphogenesis GO:0043589 6 0.427
positive regulation of cell motility GO:2000147 177 0.427
negative regulation of cardiac muscle tissue growth GO:0055022 2 0.426
negative regulation of protein transport GO:0051224 75 0.424
regulation of potassium ion transmembrane transport GO:1901379 20 0.422
carbohydrate biosynthetic process GO:0016051 42 0.420
cellular component disassembly GO:0022411 92 0.416
epithelial cell proliferation GO:0050673 128 0.416
actin filament bundle organization GO:0061572 54 0.414
metencephalon development GO:0022037 2 0.413
negative regulation of multicellular organismal process GO:0051241 317 0.409
male sex differentiation GO:0046661 25 0.406
positive regulation of actin filament bundle assembly GO:0032233 25 0.406
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.405
centrosome cycle GO:0007098 32 0.404
regulation of focal adhesion assembly GO:0051893 20 0.395
activation of innate immune response GO:0002218 55 0.394
response to alcohol GO:0097305 64 0.392
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.387
cellular response to lipid GO:0071396 127 0.385
eye development GO:0001654 42 0.383
xenobiotic metabolic process GO:0006805 28 0.382
membrane raft organization GO:0031579 10 0.380
regulation of wnt signaling pathway GO:0030111 123 0.379
regulation of carbohydrate metabolic process GO:0006109 54 0.379
regulation of behavior GO:0050795 82 0.378
positive regulation of protein ubiquitination GO:0031398 53 0.378
ameboidal type cell migration GO:0001667 135 0.378
patterning of blood vessels GO:0001569 2 0.378
myeloid leukocyte differentiation GO:0002573 60 0.376
male meiosis GO:0007140 1 0.375
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.373
signal transduction involved in dna damage checkpoint GO:0072422 15 0.373
generation of precursor metabolites and energy GO:0006091 68 0.370
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.364
cell adhesion GO:0007155 325 0.360
regulation of neuroblast proliferation GO:1902692 3 0.360
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.360
establishment of protein localization to plasma membrane GO:0090002 68 0.360
positive regulation of cellular component movement GO:0051272 181 0.358
regulation of cardiac muscle cell apoptotic process GO:0010665 3 0.353
neutrophil migration GO:1990266 25 0.351

MDM2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.987
disease of cellular proliferation DOID:14566 174 0.987
organ system cancer DOID:0050686 164 0.981
gastrointestinal system cancer DOID:3119 52 0.655
hepatocellular carcinoma DOID:684 9 0.655
liver carcinoma DOID:686 9 0.655
liver cancer DOID:3571 9 0.655