Homo sapiens

98 known processes

MED12

mediator complex subunit 12

(Aliases: ARC240,KIAA0192,TNRC11,TRAP230,OKS,FGS1,CAGH45,OPA1,HOPA)

MED12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enteric nervous system development GO:0048484 1 0.930
intracellular receptor signaling pathway GO:0030522 104 0.877
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.866
post embryonic development GO:0009791 2 0.853
chromatin organization GO:0006325 351 0.836
covalent chromatin modification GO:0016569 254 0.623
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.529
eye photoreceptor cell differentiation GO:0001754 2 0.451
neuron differentiation GO:0030182 138 0.426
generation of neurons GO:0048699 152 0.411
androgen receptor signaling pathway GO:0030521 34 0.403
cell development GO:0048468 328 0.397
Mouse
nervous system development GO:0007399 293 0.389
Mouse
histone modification GO:0016570 251 0.379
dna templated transcription initiation GO:0006352 35 0.359
steroid metabolic process GO:0008202 94 0.356
mitotic cell cycle process GO:1903047 286 0.319
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.318
negative regulation of cell differentiation GO:0045596 171 0.314
Mouse
thymus development GO:0048538 3 0.270
neurogenesis GO:0022008 169 0.256
Mouse
positive regulation of developmental process GO:0051094 314 0.243
somitogenesis GO:0001756 2 0.222
Mouse
cell projection organization GO:0030030 252 0.217
chromatin modification GO:0016568 298 0.213
regulation of cell cycle GO:0051726 393 0.208
photoreceptor cell differentiation GO:0046530 2 0.182
memory GO:0007613 3 0.175
neuron projection development GO:0031175 106 0.173
regulation of cell differentiation GO:0045595 393 0.162
Mouse
regulation of cell cycle process GO:0010564 266 0.151
chemotaxis GO:0006935 157 0.150
stem cell development GO:0048864 69 0.148
Mouse
camera type eye photoreceptor cell differentiation GO:0060219 1 0.143
long term memory GO:0007616 2 0.130
segmentation GO:0035282 4 0.129
Mouse
regulation of mitotic cell cycle GO:0007346 189 0.128
mrna metabolic process GO:0016071 175 0.125
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.120
cellular component morphogenesis GO:0032989 314 0.117
regulation of immune response GO:0050776 201 0.115
peptidyl lysine modification GO:0018205 144 0.114
peptidyl lysine acetylation GO:0018394 101 0.113
glycerolipid metabolic process GO:0046486 107 0.111
cellular ketone metabolic process GO:0042180 80 0.111
neuron development GO:0048666 113 0.109
negative regulation of developmental process GO:0051093 247 0.107
Mouse
tissue morphogenesis GO:0048729 96 0.105
Mouse
internal peptidyl lysine acetylation GO:0018393 97 0.103
cell morphogenesis GO:0000902 296 0.102
protein deubiquitination GO:0016579 79 0.102
positive regulation of dna templated transcription elongation GO:0032786 18 0.101
growth GO:0040007 202 0.100
Mouse
embryo development GO:0009790 123 0.100
Mouse
histone deubiquitination GO:0016578 16 0.099
lipid metabolic process GO:0006629 381 0.096
neural tube formation GO:0001841 3 0.095
Mouse
rna processing GO:0006396 255 0.093
regulation of mitotic cell cycle phase transition GO:1901990 118 0.089
organ morphogenesis GO:0009887 147 0.088
Mouse
negative regulation of cell cycle GO:0045786 193 0.086
locomotory behavior GO:0007626 1 0.085
vesicle mediated transport GO:0016192 371 0.084
alcohol metabolic process GO:0006066 114 0.082
response to other organism GO:0051707 261 0.080
stem cell differentiation GO:0048863 93 0.079
Mouse
cellular response to oxygen containing compound GO:1901701 276 0.078
single organism cellular localization GO:1902580 332 0.074
epithelium development GO:0060429 227 0.071
Mouse
response to organonitrogen compound GO:0010243 156 0.068
lipid biosynthetic process GO:0008610 177 0.068
cellular response to endogenous stimulus GO:0071495 336 0.066
regulation of cell cycle phase transition GO:1901987 126 0.064
hindbrain development GO:0030902 3 0.063
regulation of response to external stimulus GO:0032101 222 0.063
embryonic epithelial tube formation GO:0001838 4 0.059
Mouse
internal protein amino acid acetylation GO:0006475 101 0.059
regulation of immune effector process GO:0002697 91 0.059
protein alkylation GO:0008213 74 0.059
tube development GO:0035295 125 0.056
Mouse
cell cycle phase transition GO:0044770 173 0.055
defense response GO:0006952 315 0.054
response to hormone GO:0009725 175 0.054
cellular macromolecule catabolic process GO:0044265 380 0.053
innate immune response GO:0045087 178 0.052
dna replication GO:0006260 116 0.052
g1 s transition of mitotic cell cycle GO:0000082 78 0.052
regulation of protein stability GO:0031647 87 0.052
protein dna complex subunit organization GO:0071824 80 0.051
mitotic cell cycle phase transition GO:0044772 162 0.051
cellular response to hormone stimulus GO:0032870 125 0.050
protein methylation GO:0006479 74 0.050
sex determination GO:0007530 3 0.048
regulation of dna metabolic process GO:0051052 153 0.048
immune response GO:0006955 307 0.047
histone acetylation GO:0016573 93 0.047
response to oxygen containing compound GO:1901700 369 0.047
protein acetylation GO:0006473 116 0.047
dna conformation change GO:0071103 113 0.046
sensory organ morphogenesis GO:0090596 21 0.046
autonomic nervous system development GO:0048483 1 0.046
regulation of cellular amine metabolic process GO:0033238 11 0.045
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
regulation of cellular ketone metabolic process GO:0010565 50 0.045
regulation of cholesterol metabolic process GO:0090181 4 0.045
head development GO:0060322 108 0.044
negative regulation of cell cycle phase transition GO:1901988 89 0.044
response to nitrogen compound GO:1901698 184 0.043
regulation of chromatin modification GO:1903308 51 0.043
cellular response to dna damage stimulus GO:0006974 379 0.042
nitrogen compound transport GO:0071705 191 0.041
sensory organ development GO:0007423 52 0.041
neurological system process GO:0050877 163 0.041
cell projection morphogenesis GO:0048858 129 0.041
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.041
anatomical structure formation involved in morphogenesis GO:0048646 284 0.040
Mouse
determination of adult lifespan GO:0008340 2 0.039
posttranscriptional regulation of gene expression GO:0010608 213 0.039
cellular amino acid metabolic process GO:0006520 116 0.039
primary neural tube formation GO:0014020 3 0.038
Mouse
cytoplasmic transport GO:0016482 379 0.037
system process GO:0003008 349 0.037
metencephalon development GO:0022037 2 0.036
response to biotic stimulus GO:0009607 276 0.036
embryo development ending in birth or egg hatching GO:0009792 34 0.036
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
mitotic cell cycle GO:0000278 326 0.035
positive regulation of cell proliferation GO:0008284 301 0.035
behavior GO:0007610 112 0.035
negative regulation of cell death GO:0060548 345 0.034
cellular lipid metabolic process GO:0044255 303 0.034
circulatory system development GO:0072359 262 0.033
Mouse
cell morphogenesis involved in differentiation GO:0000904 144 0.033
negative regulation of cell cycle process GO:0010948 121 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
amine metabolic process GO:0009308 44 0.032
cellular amine metabolic process GO:0044106 41 0.032
negative regulation of mitotic cell cycle GO:0045930 102 0.031
histone h3 acetylation GO:0043966 45 0.031
oogenesis GO:0048477 2 0.031
protein targeting GO:0006605 187 0.031
response to extracellular stimulus GO:0009991 85 0.030
nucleoside phosphate catabolic process GO:1901292 412 0.030
vesicle organization GO:0016050 62 0.030
regulation of growth GO:0040008 165 0.030
regulation of cell development GO:0060284 161 0.030
protein acylation GO:0043543 138 0.029
mating GO:0007618 1 0.029
blastoderm segmentation GO:0007350 2 0.029
protein modification by small protein removal GO:0070646 92 0.028
endocytosis GO:0006897 159 0.028
defense response to other organism GO:0098542 129 0.028
mrna processing GO:0006397 133 0.028
female gamete generation GO:0007292 2 0.028
positive regulation of cell differentiation GO:0045597 211 0.028
cellular macromolecular complex assembly GO:0034622 324 0.028
regulation of multi organism process GO:0043900 157 0.027
regulation of defense response GO:0031347 154 0.027
purine ribonucleoside metabolic process GO:0046128 437 0.027
establishment of protein localization to organelle GO:0072594 172 0.027
response to insulin GO:0032868 45 0.027
somatic stem cell maintenance GO:0035019 4 0.027
production of molecular mediator of immune response GO:0002440 37 0.027
positive regulation of cell cycle process GO:0090068 106 0.027
purine nucleoside triphosphate metabolic process GO:0009144 412 0.026
embryonic morphogenesis GO:0048598 85 0.026
Mouse
response to abiotic stimulus GO:0009628 336 0.026
taxis GO:0042330 157 0.026
cell part morphogenesis GO:0032990 137 0.026
eye development GO:0001654 42 0.026
purine nucleoside triphosphate catabolic process GO:0009146 392 0.026
camera type eye development GO:0043010 25 0.025
histone h4 acetylation GO:0043967 47 0.025
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.025
positive regulation of immune system process GO:0002684 283 0.025
neuron projection morphogenesis GO:0048812 50 0.025
rna 3 end processing GO:0031123 35 0.025
organic hydroxy compound metabolic process GO:1901615 147 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.024
protein oligomerization GO:0051259 173 0.024
dna integrity checkpoint GO:0031570 71 0.024
rhythmic behavior GO:0007622 2 0.024
macromolecule methylation GO:0043414 97 0.024
chordate embryonic development GO:0043009 34 0.024
Mouse
anterior posterior axis specification GO:0009948 2 0.024
leukocyte activation GO:0045321 164 0.023
small molecule biosynthetic process GO:0044283 157 0.023
positive regulation of mitotic cell cycle GO:0045931 60 0.023
single organism reproductive process GO:0044702 98 0.023
forebrain development GO:0030900 26 0.023
carbon catabolite activation of transcription GO:0045991 3 0.023
positive regulation of proteolysis GO:0045862 142 0.023
response to peptide hormone GO:0043434 61 0.023
guanosine containing compound metabolic process GO:1901068 244 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
brain development GO:0007420 97 0.023
ncrna 3 end processing GO:0043628 4 0.022
morphogenesis of embryonic epithelium GO:0016331 4 0.022
Mouse
regulation of receptor activity GO:0010469 47 0.022
membrane budding GO:0006900 28 0.022
cellular response to organonitrogen compound GO:0071417 124 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
proteasomal protein catabolic process GO:0010498 176 0.022
tube closure GO:0060606 3 0.022
Mouse
circadian behavior GO:0048512 2 0.022
regulation of innate immune response GO:0045088 97 0.022
regulation of hormone levels GO:0010817 125 0.022
immune system development GO:0002520 195 0.022
erythrocyte development GO:0048821 3 0.022
methylation GO:0032259 106 0.021
cranial nerve development GO:0021545 4 0.021
regulation of dna replication GO:0006275 68 0.021
regulation of nervous system development GO:0051960 88 0.021
histone methylation GO:0016571 60 0.021
eye morphogenesis GO:0048592 16 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.020
cellular response to nitrogen compound GO:1901699 144 0.020
regulation of secretion by cell GO:1903530 177 0.020
positive regulation of gtp catabolic process GO:0033126 166 0.020
negative regulation of cell proliferation GO:0008285 228 0.020
wnt signaling pathway GO:0016055 156 0.020
i kappab kinase nf kappab signaling GO:0007249 166 0.020
regulation of leukocyte activation GO:0002694 115 0.019
blastocyst development GO:0001824 3 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
cell division GO:0051301 168 0.019
tripartite regional subdivision GO:0007351 2 0.019
multicellular organismal aging GO:0010259 3 0.018
reproductive process GO:0022414 106 0.018
negative regulation of organelle organization GO:0010639 126 0.018
stem cell maintenance GO:0019827 19 0.018
Mouse
negative regulation of apoptotic process GO:0043066 316 0.018
leukocyte differentiation GO:0002521 98 0.018
nucleoside catabolic process GO:0009164 408 0.018
negative regulation of cellular component organization GO:0051129 235 0.018
response to lipid GO:0033993 206 0.018
cellular carbohydrate metabolic process GO:0044262 84 0.018
modification dependent macromolecule catabolic process GO:0043632 212 0.018
nerve development GO:0021675 4 0.018
pattern specification process GO:0007389 43 0.018
Mouse
response to decreased oxygen levels GO:0036293 96 0.017
dna damage checkpoint GO:0000077 68 0.017
cellular component disassembly GO:0022411 92 0.017
monosaccharide metabolic process GO:0005996 74 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.017
neural tube development GO:0021915 9 0.017
Mouse
heart development GO:0007507 95 0.017
Mouse
regulation of intracellular transport GO:0032386 195 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.017
regulation of chromosome organization GO:0033044 103 0.017
regulation of histone modification GO:0031056 47 0.017
striated muscle tissue development GO:0014706 59 0.017
guanosine containing compound catabolic process GO:1901069 239 0.017
protein k63 linked deubiquitination GO:0070536 21 0.016
neuromuscular junction development GO:0007528 3 0.016
inner ear morphogenesis GO:0042472 4 0.016
protein stabilization GO:0050821 64 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
response to external biotic stimulus GO:0043207 261 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
negative regulation of protein modification process GO:0031400 200 0.016
cardiovascular system development GO:0072358 262 0.016
Mouse
dna templated transcription elongation GO:0006354 25 0.016
purine nucleoside catabolic process GO:0006152 398 0.016
regulation of neurogenesis GO:0050767 82 0.016
central nervous system development GO:0007417 123 0.016
Mouse
intracellular protein transport GO:0006886 270 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
chromatin assembly or disassembly GO:0006333 78 0.016
nuclear transport GO:0051169 179 0.016
epithelial cell proliferation GO:0050673 128 0.016
myeloid leukocyte differentiation GO:0002573 60 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
protein catabolic process GO:0030163 325 0.015
regulation of homeostatic process GO:0032844 121 0.015
response to wounding GO:0009611 168 0.015
snrna metabolic process GO:0016073 15 0.015
endomembrane system organization GO:0010256 196 0.015
hemopoiesis GO:0030097 180 0.015
multicellular organismal reproductive process GO:0048609 40 0.015
forebrain neuron differentiation GO:0021879 3 0.015
anterior posterior axis specification embryo GO:0008595 2 0.014
positive regulation of cell cycle GO:0045787 140 0.014
ncrna processing GO:0034470 83 0.014
negative regulation of growth GO:0045926 97 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
response to oxygen levels GO:0070482 100 0.014
purine ribonucleoside catabolic process GO:0046130 398 0.014
cell activation GO:0001775 213 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
muscle structure development GO:0061061 98 0.014
protein import GO:0017038 130 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of body fluid levels GO:0050878 99 0.014
endosome organization GO:0007032 20 0.014
mrna splicing via spliceosome GO:0000398 89 0.014
mitotic cytokinesis GO:0000281 19 0.014
reproductive structure development GO:0048608 55 0.014
inflammatory response GO:0006954 79 0.014
regulation of growth rate GO:0040009 1 0.014
fatty acid metabolic process GO:0006631 115 0.014
gland development GO:0048732 48 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
antimicrobial humoral response GO:0019730 26 0.013
dna repair GO:0006281 198 0.013
secretion by cell GO:0032940 226 0.013
g2 m transition of mitotic cell cycle GO:0000086 41 0.013
cellular response to peptide hormone stimulus GO:0071375 56 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
cognition GO:0050890 43 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
nucleosome organization GO:0034728 66 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
positive regulation of growth GO:0045927 58 0.013
cell type specific apoptotic process GO:0097285 125 0.013
mapk cascade GO:0000165 288 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
forebrain generation of neurons GO:0021872 3 0.013
response to growth factor GO:0070848 205 0.013
regulation of defense response to bacterium GO:1900424 2 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
ossification GO:0001503 121 0.013
cellular response to extracellular stimulus GO:0031668 72 0.013
nucleotide catabolic process GO:0009166 408 0.013
response to hypoxia GO:0001666 96 0.013
regulation of cell projection organization GO:0031344 107 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
Mouse
purine containing compound catabolic process GO:0072523 411 0.013
regulation of gene expression epigenetic GO:0040029 73 0.012
epithelial cell differentiation GO:0030855 141 0.012
negative regulation of immune system process GO:0002683 136 0.012
organ formation GO:0048645 3 0.012
rna catabolic process GO:0006401 71 0.012
multi organism reproductive process GO:0044703 54 0.012
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 3 0.012
response to peptide GO:1901652 65 0.012
positive regulation of leukocyte differentiation GO:1902107 37 0.012
morphogenesis of an epithelium GO:0002009 60 0.012
Mouse
neural tube closure GO:0001843 3 0.012
Mouse
regulation of response to biotic stimulus GO:0002831 55 0.012
chromatin remodeling GO:0006338 55 0.012
protein dna complex assembly GO:0065004 64 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.012
regulation of production of molecular mediator of immune response GO:0002700 25 0.012
regulation of neuron differentiation GO:0045664 70 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
organophosphate catabolic process GO:0046434 430 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
alcohol biosynthetic process GO:0046165 52 0.012
regulation of mapk cascade GO:0043408 262 0.012
regionalization GO:0003002 29 0.012
Mouse
regulation of ras protein signal transduction GO:0046578 155 0.012
receptor mediated endocytosis GO:0006898 84 0.012
cellular response to lipid GO:0071396 127 0.012
histone lysine methylation GO:0034968 50 0.012
steroid biosynthetic process GO:0006694 46 0.011
cellular amide metabolic process GO:0043603 69 0.011
neuron death GO:0070997 65 0.011
mrna transport GO:0051028 30 0.011
vasculature development GO:0001944 181 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
muscle organ development GO:0007517 56 0.011
regulation of cell adhesion GO:0030155 166 0.011
response to virus GO:0009615 126 0.011
regulation of immunoglobulin production GO:0002637 4 0.011
neurotransmitter secretion GO:0007269 4 0.011
immune effector process GO:0002252 159 0.011
protein localization to nucleus GO:0034504 136 0.011
regulation of lymphocyte activation GO:0051249 103 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
regulation of binding GO:0051098 111 0.011
ameboidal type cell migration GO:0001667 135 0.011
short term memory GO:0007614 1 0.011
regulation of cellular component movement GO:0051270 334 0.011
regulation of fatty acid metabolic process GO:0019217 24 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
embryonic camera type eye formation GO:0060900 2 0.011
endosomal transport GO:0016197 129 0.011
microtubule based process GO:0007017 210 0.011
ras protein signal transduction GO:0007265 73 0.011
lung epithelial cell differentiation GO:0060487 1 0.011
nuclear export GO:0051168 69 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
chemical homeostasis GO:0048878 306 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.011
single organism membrane organization GO:0044802 268 0.011
negative regulation of neuron differentiation GO:0045665 21 0.011
axon development GO:0061564 34 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
compound eye development GO:0048749 1 0.010
negative regulation of cell development GO:0010721 48 0.010
muscle tissue development GO:0060537 62 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
actin filament based movement GO:0030048 17 0.010
urogenital system development GO:0001655 65 0.010
phospholipid metabolic process GO:0006644 99 0.010
nucleobase containing compound transport GO:0015931 51 0.010
endodermal cell fate commitment GO:0001711 4 0.010
mitotic nuclear division GO:0007067 119 0.010
nucleocytoplasmic transport GO:0006913 176 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
regulation of epithelial cell proliferation GO:0050678 113 0.010
regulation of cellular response to stress GO:0080135 244 0.010
somite development GO:0061053 7 0.010
Mouse
associative learning GO:0008306 1 0.010
neuroblast proliferation GO:0007405 4 0.010
startle response GO:0001964 3 0.010
negative regulation of catalytic activity GO:0043086 335 0.010
cell fate determination GO:0001709 3 0.010

MED12 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.029
nervous system disease DOID:863 431 0.029
brain disease DOID:936 73 0.025
neuromuscular disease DOID:440 38 0.015
neuropathy DOID:870 52 0.015
neurodegenerative disease DOID:1289 102 0.011
x linked disease DOID:0050735 14 0.001
fg syndrome DOID:14711 3 0.000