|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.995
|
Human Rat |
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.995
|
|
|
|
positive regulation of odontogenesis
|
GO:0042482 |
3 |
0.994
|
|
|
|
positive regulation of fibroblast migration
|
GO:0010763 |
3 |
0.991
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.990
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.986
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.983
|
Human Rat |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.981
|
Human Rat |
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.979
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.978
|
Zebrafish Mouse Rat |
|
|
vasculature development
|
GO:0001944 |
181 |
0.974
|
Zebrafish Mouse Rat |
|
|
negative regulation of trophoblast cell migration
|
GO:1901164 |
3 |
0.974
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.971
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.968
|
Human Rat |
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
39 |
0.967
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.967
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.966
|
Rat |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.965
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.963
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.959
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.956
|
Mouse Rat |
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.945
|
Human Rat |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.945
|
Human Rat |
|
|
epithelium migration
|
GO:0090132 |
119 |
0.942
|
Human |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.939
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.939
|
|
|
|
sprouting angiogenesis
|
GO:0002040 |
29 |
0.931
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.931
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.922
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.921
|
Human |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.910
|
Rat |
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.909
|
|
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.906
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.904
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.902
|
Zebrafish Mouse Rat |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.901
|
Rat |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.895
|
Human |
|
|
taxis
|
GO:0042330 |
157 |
0.893
|
Zebrafish |
|
|
regulation of leukocyte chemotaxis
|
GO:0002688 |
46 |
0.889
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.888
|
Rat |
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.886
|
Rat |
|
|
skeletal system development
|
GO:0001501 |
79 |
0.883
|
Mouse |
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.881
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.881
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.880
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.879
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.870
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.870
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.867
|
|
|
|
regulation of macrophage chemotaxis
|
GO:0010758 |
4 |
0.865
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.864
|
Rat |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.851
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.846
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.846
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.844
|
Human Rat |
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.842
|
|
|
|
negative regulation of nitric oxide mediated signal transduction
|
GO:0010751 |
2 |
0.842
|
|
|
|
glial cell migration
|
GO:0008347 |
4 |
0.825
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.824
|
Rat |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.816
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.814
|
|
|
|
positive regulation of blood vessel endothelial cell migration
|
GO:0043536 |
16 |
0.811
|
|
|
|
negative regulation of fibroblast growth factor receptor signaling pathway
|
GO:0040037 |
2 |
0.786
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.785
|
|
|
|
negative regulation of chemotaxis
|
GO:0050922 |
13 |
0.781
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.780
|
|
|
|
muscle cell migration
|
GO:0014812 |
19 |
0.774
|
|
|
|
negative regulation of wound healing
|
GO:0061045 |
25 |
0.770
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.768
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.760
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.755
|
Rat |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.754
|
|
|
|
negative regulation of vasculature development
|
GO:1901343 |
43 |
0.753
|
|
|
|
endothelial cell cell adhesion
|
GO:0071603 |
1 |
0.752
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.750
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.747
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.746
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.745
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.744
|
|
|
|
positive regulation of chemotaxis
|
GO:0050921 |
57 |
0.742
|
|
|
|
negative regulation of endothelial cell chemotaxis
|
GO:2001027 |
4 |
0.737
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.735
|
Mouse Rat |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.731
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.727
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.716
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.704
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.696
|
Human |
|
|
wound healing
|
GO:0042060 |
115 |
0.693
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.691
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.690
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.685
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.680
|
Human |
|
|
protein processing
|
GO:0016485 |
226 |
0.677
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.670
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.667
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.664
|
|
|
|
response to fibroblast growth factor
|
GO:0071774 |
39 |
0.661
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.659
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.657
|
Human |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.654
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.649
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.648
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.646
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
68 |
0.643
|
|
|
|
negative regulation of epithelial cell migration
|
GO:0010633 |
38 |
0.640
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.640
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.638
|
|
|
|
negative regulation of cell substrate adhesion
|
GO:0010812 |
24 |
0.636
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.636
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.633
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.627
|
Human |
|
|
collagen metabolic process
|
GO:0032963 |
28 |
0.627
|
Mouse Rat |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.626
|
Rat |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.625
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.622
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.618
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.617
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.606
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.600
|
Zebrafish |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.600
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.599
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.593
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.571
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.570
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.570
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.564
|
Mouse |
|
|
connective tissue development
|
GO:0061448 |
39 |
0.558
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.545
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.537
|
Rat |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.534
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.532
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.532
|
Rat |
|
|
ossification
|
GO:0001503 |
121 |
0.530
|
Mouse |
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.528
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.523
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.514
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.513
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.504
|
Mouse Rat |
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.504
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.498
|
|
|
|
fibroblast migration
|
GO:0010761 |
7 |
0.491
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.486
|
|
|
|
regulation of nitric oxide mediated signal transduction
|
GO:0010749 |
2 |
0.486
|
|
|
|
endochondral bone morphogenesis
|
GO:0060350 |
3 |
0.481
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.480
|
|
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
38 |
0.479
|
|
|
|
negative regulation of behavior
|
GO:0048521 |
15 |
0.475
|
|
|
|
negative regulation of blood vessel morphogenesis
|
GO:2000181 |
41 |
0.475
|
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.474
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.474
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.471
|
|
|
|
negative regulation of cellular response to growth factor stimulus
|
GO:0090288 |
41 |
0.467
|
|
|
|
positive regulation of hemostasis
|
GO:1900048 |
11 |
0.466
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.464
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.462
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.456
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.452
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.451
|
Rat |
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.451
|
|
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.448
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.446
|
Human |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.445
|
Rat |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.435
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.433
|
|
|
|
regulation of blood vessel endothelial cell migration
|
GO:0043535 |
30 |
0.429
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.428
|
Mouse |
|
|
endoderm formation
|
GO:0001706 |
33 |
0.427
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.419
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.414
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.414
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.409
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.409
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.409
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.407
|
Rat |
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.406
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.405
|
|
|
|
appendage development
|
GO:0048736 |
23 |
0.401
|
|
|
|
regulation of cell matrix adhesion
|
GO:0001952 |
42 |
0.394
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.393
|
Rat |
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
26 |
0.391
|
|
|
|
plasminogen activation
|
GO:0031639 |
11 |
0.391
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.387
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.387
|
|
|
|
regulation of fibroblast migration
|
GO:0010762 |
7 |
0.378
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.367
|
Mouse |
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.366
|
|
|
|
skin development
|
GO:0043588 |
76 |
0.366
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.363
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.362
|
|
|
|
regulation of odontogenesis
|
GO:0042481 |
4 |
0.357
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.356
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.353
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.348
|
Mouse Rat |
|
|
endodermal cell differentiation
|
GO:0035987 |
31 |
0.345
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.345
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.342
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.341
|
Human |
|
|
regulation of biomineral tissue development
|
GO:0070167 |
31 |
0.338
|
|
|
|
regulation of branching involved in ureteric bud morphogenesis
|
GO:0090189 |
3 |
0.338
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.334
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.333
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.325
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.324
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.323
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.311
|
|
|
|
regulation of smooth muscle cell migration
|
GO:0014910 |
15 |
0.305
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.305
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.305
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.304
|
Human |
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.301
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.300
|
|
|
|
endoderm development
|
GO:0007492 |
33 |
0.296
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.296
|
Human |
|
|
regulation of neutrophil chemotaxis
|
GO:0090022 |
10 |
0.295
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.293
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.293
|
Mouse Rat |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.288
|
|
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
46 |
0.288
|
|
|
|
chronic inflammatory response
|
GO:0002544 |
2 |
0.287
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.287
|
|
|
|
regulation of cgmp mediated signaling
|
GO:0010752 |
1 |
0.286
|
|
|
|
granulocyte chemotaxis
|
GO:0071621 |
37 |
0.285
|
|
|
|
negative regulation of leukocyte migration
|
GO:0002686 |
14 |
0.282
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.277
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.276
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.270
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.269
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.268
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.265
|
Mouse Rat |
|
|
regulation of keratinocyte migration
|
GO:0051547 |
4 |
0.264
|
Human |
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.262
|
|
|
|
multicellular organismal macromolecule metabolic process
|
GO:0044259 |
29 |
0.262
|
Mouse Rat |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.261
|
Mouse |
|
|
peptide cross linking
|
GO:0018149 |
12 |
0.261
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.259
|
Human Rat |
|
|
nervous system development
|
GO:0007399 |
293 |
0.258
|
Zebrafish Rat |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.257
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.253
|
|
|
|
negative regulation of endothelial cell migration
|
GO:0010596 |
29 |
0.250
|
|
|
|
positive regulation of macrophage chemotaxis
|
GO:0010759 |
3 |
0.250
|
|
|
|
growth
|
GO:0040007 |
202 |
0.248
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.248
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.247
|
Human |
|
|
extracellular matrix organization
|
GO:0030198 |
41 |
0.246
|
|
|
|
negative regulation of hemostasis
|
GO:1900047 |
22 |
0.244
|
|
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.243
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.239
|
Mouse |
|
|
cell development
|
GO:0048468 |
328 |
0.233
|
Zebrafish Rat |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.226
|
Zebrafish |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.221
|
|
|
|
multicellular organismal metabolic process
|
GO:0044236 |
34 |
0.220
|
Mouse Rat |
|
|
positive regulation of hair follicle maturation
|
GO:0048818 |
2 |
0.219
|
|
|
|
cartilage development involved in endochondral bone morphogenesis
|
GO:0060351 |
2 |
0.215
|
|
|
|
negative regulation of gastrulation
|
GO:2000542 |
4 |
0.212
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.211
|
Mouse Rat |
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.207
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.207
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.204
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.203
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.202
|
Human |
|
|
response to hormone
|
GO:0009725 |
175 |
0.201
|
Rat |
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.200
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.199
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.197
|
|
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.197
|
|
|
|
negative regulation of complement activation lectin pathway
|
GO:0001869 |
2 |
0.197
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.196
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.194
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.191
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.186
|
|
|
|
regulation of cgmp metabolic process
|
GO:0030823 |
9 |
0.186
|
|
|
|
dendritic cell antigen processing and presentation
|
GO:0002468 |
1 |
0.184
|
|
|
|
endocardial cushion development
|
GO:0003197 |
3 |
0.182
|
|
|
|
regulation of neutrophil migration
|
GO:1902622 |
10 |
0.181
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.180
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.179
|
|
|
|
positive regulation of neutrophil chemotaxis
|
GO:0090023 |
7 |
0.179
|
|
|
|
neutrophil migration
|
GO:1990266 |
25 |
0.176
|
|
|
|
regulation of plasminogen activation
|
GO:0010755 |
7 |
0.176
|
|
|
|
positive regulation of blood coagulation
|
GO:0030194 |
11 |
0.174
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.173
|
Mouse Rat |
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.173
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.172
|
Rat |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.172
|
|
|
|
extracellular structure organization
|
GO:0043062 |
41 |
0.172
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.171
|
Rat |
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.170
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.170
|
Rat |
|
|
negative regulation of membrane protein ectodomain proteolysis
|
GO:0051045 |
4 |
0.168
|
|
|
|
craniofacial suture morphogenesis
|
GO:0097094 |
3 |
0.166
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.165
|
|
|
|
canonical wnt signaling pathway involved in osteoblast differentiation
|
GO:0044339 |
2 |
0.165
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.163
|
|
|
|
cgmp mediated signaling
|
GO:0019934 |
5 |
0.161
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.161
|
Human |
|
|
positive regulation of epithelial cell proliferation involved in wound healing
|
GO:0060054 |
3 |
0.160
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.159
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.159
|
Mouse |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.157
|
Rat |
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.154
|
Human |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.154
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.153
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.152
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.151
|
|
|
|
negative regulation of blood vessel endothelial cell migration
|
GO:0043537 |
16 |
0.148
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.146
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.145
|
Zebrafish |
|
|
positive regulation of neutrophil migration
|
GO:1902624 |
7 |
0.143
|
|
|
|
negative regulation of blood coagulation
|
GO:0030195 |
22 |
0.142
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.142
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.142
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.141
|
Human |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.141
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.140
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.136
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.134
|
|
|
|
neutrophil chemotaxis
|
GO:0030593 |
24 |
0.134
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.133
|
|
|
|
regulation of granulocyte chemotaxis
|
GO:0071622 |
16 |
0.133
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.132
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.131
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.129
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.129
|
|
|
|
collagen fibril organization
|
GO:0030199 |
10 |
0.128
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.126
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.126
|
|
|
|
cgmp metabolic process
|
GO:0046068 |
19 |
0.126
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.125
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.124
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.123
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.122
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.122
|
|
|
|
fibrinolysis
|
GO:0042730 |
11 |
0.122
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.121
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.121
|
|
|
|
kidney development
|
GO:0001822 |
53 |
0.120
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.120
|
|
|
|
positive regulation of epithelial to mesenchymal transition
|
GO:0010718 |
22 |
0.119
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.119
|
Rat |
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.119
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.118
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.118
|
Rat |
|
|
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902043 |
3 |
0.118
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.117
|
|
|
|
bone morphogenesis
|
GO:0060349 |
10 |
0.115
|
|
|
|
regulation of hemostasis
|
GO:1900046 |
42 |
0.115
|
|
|
|
endothelial cell chemotaxis
|
GO:0035767 |
13 |
0.114
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.114
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.114
|
Rat |
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.113
|
Mouse Rat |
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.113
|
Human |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.113
|
|
|
|
soft palate development
|
GO:0060023 |
3 |
0.112
|
|
|
|
positive regulation of pathway restricted smad protein phosphorylation
|
GO:0010862 |
22 |
0.111
|
|
|
|
negative regulation of plasminogen activation
|
GO:0010757 |
4 |
0.111
|
|
|
|
negative regulation of angiogenesis
|
GO:0016525 |
39 |
0.109
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.108
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.108
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.107
|
Rat |
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.107
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.107
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.106
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.106
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.105
|
|
|
|
smooth muscle cell migration
|
GO:0014909 |
18 |
0.105
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.102
|
|
|
|
positive regulation of granulocyte chemotaxis
|
GO:0071624 |
9 |
0.102
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.101
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.101
|
|
|
|
negative regulation of protein activation cascade
|
GO:2000258 |
7 |
0.100
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.100
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.100
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.100
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.099
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.099
|
|
|
|
negative regulation of embryonic development
|
GO:0045992 |
4 |
0.099
|
|
|
|
skeletal system morphogenesis
|
GO:0048705 |
24 |
0.097
|
Mouse |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.096
|
|
|
|
chondrocyte differentiation
|
GO:0002062 |
17 |
0.096
|
|
|
|
muscle organ development
|
GO:0007517 |
56 |
0.095
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.095
|
|
|
|
limb development
|
GO:0060173 |
23 |
0.095
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.095
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.094
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.094
|
Mouse Rat |
|
|
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii
|
GO:0002581 |
3 |
0.092
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.092
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.092
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.092
|
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.091
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.091
|
|
|
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.090
|
|
|
|
anion transmembrane transport
|
GO:0098656 |
76 |
0.090
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.090
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.090
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.090
|
|
|
|
regulation of cartilage development
|
GO:0061035 |
12 |
0.090
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.090
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.089
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.089
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.088
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.088
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.088
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.088
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.087
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.085
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.085
|
|
|
|
negative regulation of lipid transport
|
GO:0032369 |
18 |
0.085
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.085
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.085
|
|
|
|
system process
|
GO:0003008 |
349 |
0.084
|
Rat |
|
|
protein targeting
|
GO:0006605 |
187 |
0.083
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.083
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.083
|
|
|
|
positive regulation of keratinocyte migration
|
GO:0051549 |
4 |
0.083
|
Human |
|
|
negative regulation of immune effector process
|
GO:0002698 |
38 |
0.083
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.083
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.082
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.081
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.081
|
|
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.081
|
Human |
|
|
bone mineralization
|
GO:0030282 |
34 |
0.081
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.080
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.080
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.080
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.080
|
|
|
|
macrophage chemotaxis
|
GO:0048246 |
10 |
0.079
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.079
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.079
|
|
|
|
regulation of fibrinolysis
|
GO:0051917 |
8 |
0.079
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.078
|
Rat |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.078
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.078
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.077
|
Zebrafish Rat |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.077
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.076
|
|
|
|
regulation of collagen metabolic process
|
GO:0010712 |
15 |
0.075
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
1 |
0.075
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.075
|
Human |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.075
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.075
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.075
|
|
|
|
myoblast migration
|
GO:0051451 |
1 |
0.075
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.075
|
Mouse Rat |
|
|
blood coagulation
|
GO:0007596 |
76 |
0.074
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.074
|
|
|
|
negative regulation of dendritic cell antigen processing and presentation
|
GO:0002605 |
1 |
0.073
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.073
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.073
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.073
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.072
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.072
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.072
|
Rat |
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.072
|
Rat |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.071
|
|
|
|
basement membrane organization
|
GO:0071711 |
3 |
0.071
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.071
|
|
|
|
regulation of smooth muscle cell proliferation
|
GO:0048660 |
28 |
0.071
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.070
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.070
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.070
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.070
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.070
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.069
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.069
|
|
|
|
cartilage development
|
GO:0051216 |
31 |
0.069
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.068
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.068
|
Zebrafish |
|
|
positive regulation of receptor binding
|
GO:1900122 |
1 |
0.068
|
Human |
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.068
|
Human |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.067
|
|
|
|
epidermis development
|
GO:0008544 |
59 |
0.067
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.067
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.067
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.066
|
|
|
|
endochondral ossification
|
GO:0001958 |
1 |
0.066
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.066
|
|
|
|
negative regulation of metalloenzyme activity
|
GO:0048553 |
1 |
0.066
|
|
|
|
regulation of complement activation lectin pathway
|
GO:0001868 |
2 |
0.066
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.065
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.065
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.065
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.065
|
|
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.065
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.065
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.064
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.064
|
Mouse |
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.064
|
|
