Homo sapiens

131 known processes

MSH2

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

(Aliases: HNPCC,COCA1,HNPCC1,FCC1,LCFS2)

MSH2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 101 1.000
Mouse
cellular response to dna damage stimulus GO:0006974 379 1.000
dna repair GO:0006281 198 1.000
mismatch repair GO:0006298 15 1.000
nucleotide excision repair GO:0006289 31 0.998
dna catabolic process GO:0006308 49 0.998
Yeast
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.997
Mouse
dna recombination GO:0006310 77 0.997
meiosis i GO:0007127 4 0.995
Yeast
regulation of dna metabolic process GO:0051052 153 0.985
double strand break repair via homologous recombination GO:0000724 50 0.984
purine nucleoside catabolic process GO:0006152 398 0.975
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.974
Yeast
purine nucleotide catabolic process GO:0006195 405 0.964
dna double strand break processing GO:0000729 10 0.957
telomere organization GO:0032200 33 0.956
negative regulation of dna metabolic process GO:0051053 57 0.950
purine nucleoside triphosphate catabolic process GO:0009146 392 0.947
anatomical structure homeostasis GO:0060249 100 0.923
nucleoside triphosphate catabolic process GO:0009143 394 0.923
recombinational repair GO:0000725 50 0.900
cellular macromolecule catabolic process GO:0044265 380 0.896
Yeast
response to uv GO:0009411 73 0.895
Mouse
meiotic nuclear division GO:0007126 10 0.883
Yeast
positive regulation of helicase activity GO:0051096 6 0.881
ribonucleotide catabolic process GO:0009261 405 0.866
double strand break repair via single strand annealing GO:0045002 4 0.848
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.848
Mouse
nucleoside monophosphate catabolic process GO:0009125 159 0.839
dna catabolic process endonucleolytic GO:0000737 37 0.820
Yeast
nervous system development GO:0007399 293 0.806
purine ribonucleoside catabolic process GO:0046130 398 0.804
purine containing compound catabolic process GO:0072523 411 0.795
purine ribonucleotide catabolic process GO:0009154 404 0.790
interstrand cross link repair GO:0036297 3 0.781
Yeast Fly
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.780
Mouse
regulation of meiotic cell cycle GO:0051445 4 0.763
regulation of helicase activity GO:0051095 8 0.756
ribonucleoside catabolic process GO:0042454 406 0.721
ribonucleoside monophosphate catabolic process GO:0009158 158 0.718
telomere maintenance GO:0000723 32 0.703
isotype switching GO:0045190 3 0.652
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.642
Mouse
dna dependent dna replication GO:0006261 44 0.628
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.625
Mouse
nuclear division GO:0000280 128 0.584
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.580
meiotic cell cycle process GO:1903046 8 0.540
Yeast
nucleoside catabolic process GO:0009164 408 0.531
organelle fission GO:0048285 149 0.530
Yeast
glycosyl compound catabolic process GO:1901658 413 0.519
purine ribonucleoside metabolic process GO:0046128 437 0.469
mrna metabolic process GO:0016071 175 0.454
nucleoside phosphate catabolic process GO:1901292 412 0.451
dna integrity checkpoint GO:0031570 71 0.438
Mouse
nucleoside monophosphate metabolic process GO:0009123 191 0.438
meiotic cell cycle GO:0051321 13 0.429
Yeast
regulation of dna recombination GO:0000018 23 0.424
sex determination GO:0007530 3 0.408
Yeast
atp catabolic process GO:0006200 157 0.390
negative regulation of dna recombination GO:0045910 6 0.388
post embryonic development GO:0009791 2 0.358
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.350
somatic diversification of immunoglobulins GO:0016445 6 0.345
Mouse
regulation of meiosis GO:0040020 3 0.324
cell development GO:0048468 328 0.301
Mouse
response to light stimulus GO:0009416 87 0.297
Mouse
regulation of dna replication GO:0006275 68 0.290
intrinsic apoptotic signaling pathway GO:0097193 127 0.270
Mouse Worm
dna damage checkpoint GO:0000077 68 0.254
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.247
dna replication GO:0006260 116 0.247
organophosphate catabolic process GO:0046434 430 0.240
reciprocal meiotic recombination GO:0007131 4 0.236
reproduction GO:0000003 63 0.235
Yeast Mouse Worm
meiotic chromosome segregation GO:0045132 4 0.234
rna dependent dna replication GO:0006278 16 0.227
nucleoside triphosphate metabolic process GO:0009141 422 0.227
dna conformation change GO:0071103 113 0.226
somatic cell dna recombination GO:0016444 6 0.211
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 412 0.202
ribonucleoside triphosphate catabolic process GO:0009203 391 0.202
telomere maintenance via telomerase GO:0007004 8 0.200
response to radiation GO:0009314 151 0.199
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.197
Mouse
regulation of cell cycle phase transition GO:1901987 126 0.195
Mouse
cellular macromolecular complex assembly GO:0034622 324 0.193
response to abiotic stimulus GO:0009628 336 0.191
Mouse
reproductive system development GO:0061458 56 0.186
Mouse
immune system development GO:0002520 195 0.185
Mouse
purine nucleoside monophosphate catabolic process GO:0009128 158 0.182
nucleotide catabolic process GO:0009166 408 0.177
histone modification GO:0016570 251 0.171
response to caffeine GO:0031000 3 0.169
single organism reproductive process GO:0044702 98 0.161
Yeast Mouse
gene conversion GO:0035822 1 0.154
Yeast
purine nucleoside monophosphate metabolic process GO:0009126 186 0.147
adaptive immune response GO:0002250 49 0.144
Mouse
chromatin modification GO:0016568 298 0.143
cellular response to abiotic stimulus GO:0071214 117 0.129
negative regulation of mitotic cell cycle GO:0045930 102 0.128
Mouse
rna processing GO:0006396 255 0.127
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.117
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.113
Mouse
regulation of cell cycle GO:0051726 393 0.112
Mouse
embryo development ending in birth or egg hatching GO:0009792 34 0.112
Mouse
blastocyst development GO:0001824 3 0.109
determination of adult lifespan GO:0008340 2 0.103
Mouse
regulation of double strand break repair GO:2000779 22 0.102
covalent chromatin modification GO:0016569 254 0.102
translesion synthesis GO:0019985 8 0.099
microtubule based process GO:0007017 210 0.090
mitotic recombination GO:0006312 8 0.089
Yeast
ribonucleoside triphosphate metabolic process GO:0009199 412 0.087
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.085
Mouse Worm
mitotic cell cycle GO:0000278 326 0.082
Mouse
atp metabolic process GO:0046034 176 0.079
cell projection organization GO:0030030 252 0.077
leukocyte activation involved in immune response GO:0002366 30 0.077
Mouse
neurogenesis GO:0022008 169 0.074
non recombinational repair GO:0000726 14 0.072
cell division GO:0051301 168 0.070
dna strand elongation involved in dna replication GO:0006271 3 0.068
reproductive process GO:0022414 106 0.067
Yeast Mouse
negative regulation of cell cycle GO:0045786 193 0.067
Mouse
cellular ketone metabolic process GO:0042180 80 0.065
carbohydrate metabolic process GO:0005975 207 0.065
oogenesis GO:0048477 2 0.064
production of molecular mediator of immune response GO:0002440 37 0.062
Mouse
mitotic cell cycle process GO:1903047 286 0.062
Mouse
gene looping GO:0090202 1 0.062
circulatory system development GO:0072359 262 0.061
female gamete generation GO:0007292 2 0.058
b cell activation involved in immune response GO:0002312 5 0.057
Mouse
g2 dna damage checkpoint GO:0031572 26 0.057
regulation of dna repair GO:0006282 47 0.057
developmental process involved in reproduction GO:0003006 66 0.054
Yeast Mouse
double strand break repair via nonhomologous end joining GO:0006303 10 0.053
somatic diversification of immune receptors GO:0002200 8 0.053
Mouse
negative regulation of cell death GO:0060548 345 0.050
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 118 0.048
Mouse
organophosphate biosynthetic process GO:0090407 163 0.048
mrna processing GO:0006397 133 0.047
cell morphogenesis GO:0000902 296 0.047
maintenance of dna repeat elements GO:0043570 4 0.046
internal protein amino acid acetylation GO:0006475 101 0.045
immunoglobulin production GO:0002377 12 0.044
Mouse
cellular amino acid metabolic process GO:0006520 116 0.044
cell type specific apoptotic process GO:0097285 125 0.044
Mouse
dna strand elongation GO:0022616 5 0.044
chromosome segregation GO:0007059 114 0.043
regulation of gene expression epigenetic GO:0040029 73 0.043
Yeast
receptor mediated endocytosis GO:0006898 84 0.042
rna 3 end processing GO:0031123 35 0.041
regulation of mitotic cell cycle GO:0007346 189 0.039
Mouse
regulation of cell cycle process GO:0010564 266 0.039
Mouse
telomere maintenance via recombination GO:0000722 4 0.038
cell fate commitment GO:0045165 27 0.037
Yeast
regeneration GO:0031099 4 0.037
immune response GO:0006955 307 0.036
Mouse
regulation of double strand break repair via homologous recombination GO:0010569 11 0.036
cell activation involved in immune response GO:0002263 30 0.036
Mouse
neuron development GO:0048666 113 0.035
brain development GO:0007420 97 0.035
negative regulation of meiotic cell cycle GO:0051447 2 0.034
apoptotic signaling pathway GO:0097190 268 0.034
Mouse Worm
carbohydrate derivative biosynthetic process GO:1901137 207 0.033
mitotic dna integrity checkpoint GO:0044774 30 0.033
Mouse
lymphocyte mediated immunity GO:0002449 48 0.033
Mouse
leukocyte activation GO:0045321 164 0.033
Mouse
response to nitrogen compound GO:1901698 184 0.031
ribonucleoside monophosphate metabolic process GO:0009161 187 0.031
regulation of cell division GO:0051302 116 0.031
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.030
Mouse
negative regulation of cell cycle phase transition GO:1901988 89 0.029
Mouse
generation of neurons GO:0048699 152 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
cell activation GO:0001775 213 0.028
Mouse
chromatin organization GO:0006325 351 0.027
head development GO:0060322 108 0.026
leukocyte mediated immunity GO:0002443 59 0.026
Mouse
dna catabolic process exonucleolytic GO:0000738 17 0.026
rna splicing GO:0008380 131 0.026
humoral immune response GO:0006959 49 0.026
regulation of chromosome organization GO:0033044 103 0.026
ribosome assembly GO:0042255 9 0.026
dna duplex unwinding GO:0032508 30 0.025
response to organic cyclic compound GO:0014070 204 0.025
cellular response to endogenous stimulus GO:0071495 336 0.024
negative regulation of catalytic activity GO:0043086 335 0.023
internal peptidyl lysine acetylation GO:0018393 97 0.023
response to oxygen containing compound GO:1901700 369 0.022
endocytosis GO:0006897 159 0.022
regulation of transferase activity GO:0051338 355 0.022
embryo development GO:0009790 123 0.022
Mouse
multicellular organismal aging GO:0010259 3 0.022
Mouse
lymphocyte activation GO:0046649 133 0.022
Mouse
cenp a containing chromatin organization GO:0061641 1 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
negative regulation of apoptotic process GO:0043066 316 0.021
Mouse
multicellular organism reproduction GO:0032504 42 0.020
Mouse
peptidyl lysine acetylation GO:0018394 101 0.020
growth GO:0040007 202 0.020
cell cycle phase transition GO:0044770 173 0.019
Mouse
negative regulation of organelle organization GO:0010639 126 0.019
dendrite development GO:0016358 24 0.018
immunoglobulin mediated immune response GO:0016064 10 0.018
Mouse
regulation of kinase activity GO:0043549 314 0.018
regulation of nuclear division GO:0051783 65 0.018
negative regulation of developmental process GO:0051093 247 0.017
response to inorganic substance GO:0010035 127 0.017
regulation of protein kinase activity GO:0045859 289 0.017
negative regulation of transferase activity GO:0051348 124 0.016
mrna 3 end processing GO:0031124 24 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
positive regulation of mitochondrial membrane potential GO:0010918 1 0.016
defense response GO:0006952 315 0.016
immune effector process GO:0002252 159 0.016
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.015
regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:1902165 7 0.015
negative regulation of cell differentiation GO:0045596 171 0.015
base excision repair GO:0006284 21 0.015
positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 6 0.015
peptidyl serine phosphorylation GO:0018105 101 0.015
neuron projection development GO:0031175 106 0.014
dsdna loop formation GO:0090579 1 0.014
regulation of response to dna damage stimulus GO:2001020 94 0.014
b cell activation GO:0042113 33 0.014
Mouse
lymphocyte activation involved in immune response GO:0002285 20 0.014
Mouse
negative regulation of meiosis GO:0045835 1 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
cellular response to ionizing radiation GO:0071479 32 0.014
regulation of cytokine production GO:0001817 232 0.013
reciprocal dna recombination GO:0035825 4 0.013
protein methylation GO:0006479 74 0.013
cell projection morphogenesis GO:0048858 129 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
g2 m transition of mitotic cell cycle GO:0000086 41 0.012
cellular protein complex assembly GO:0043623 188 0.012
regulation of cellular respiration GO:0043457 4 0.012
leading strand elongation GO:0006272 1 0.012
methylation GO:0032259 106 0.012
cellular response to organic cyclic compound GO:0071407 127 0.012
chromatin remodeling GO:0006338 55 0.012
protein ubiquitination GO:0016567 314 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
Mouse
positive regulation of cell death GO:0010942 263 0.012
protein acylation GO:0043543 138 0.011
viral process GO:0016032 146 0.011
protein oligomerization GO:0051259 173 0.011
reproductive structure development GO:0048608 55 0.011
Mouse
cytokine production GO:0001816 247 0.011
nucleosome assembly GO:0006334 50 0.011
peptidyl lysine modification GO:0018205 144 0.011
sex differentiation GO:0007548 45 0.010
Mouse
secretion GO:0046903 254 0.010
response to biotic stimulus GO:0009607 276 0.010
snrna modification GO:0040031 1 0.010
cenp a containing nucleosome assembly GO:0034080 1 0.010
system process GO:0003008 349 0.010

MSH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.429
immune system disease DOID:2914 155 0.208
hematopoietic system disease DOID:74 100 0.054
cancer DOID:162 167 0.050
skin disease DOID:37 33 0.010
integumentary system disease DOID:16 43 0.010
lynch syndrome DOID:3883 3 0.005