Homo sapiens

27 known processes

MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

(Aliases: NMDMC)

MTHFD2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
trna aminoacylation for protein translation GO:0006418 8 0.452
cellular amino acid metabolic process GO:0006520 116 0.448
post embryonic development GO:0009791 2 0.370
multicellular organismal aging GO:0010259 3 0.298
nitrogen compound transport GO:0071705 191 0.197
nucleoside phosphate biosynthetic process GO:1901293 109 0.134
determination of adult lifespan GO:0008340 2 0.134
alpha amino acid metabolic process GO:1901605 72 0.133
trna aminoacylation GO:0043039 12 0.129
cellular response to dna damage stimulus GO:0006974 379 0.089
single organism carbohydrate metabolic process GO:0044723 193 0.088
oxidation reduction process GO:0055114 396 0.087
translation GO:0006412 132 0.084
response to oxygen containing compound GO:1901700 369 0.083
hemopoiesis GO:0030097 180 0.071
small molecule biosynthetic process GO:0044283 157 0.070
ribonucleoside catabolic process GO:0042454 406 0.060
organonitrogen compound biosynthetic process GO:1901566 200 0.057
purine ribonucleoside catabolic process GO:0046130 398 0.057
cellular amino acid biosynthetic process GO:0008652 30 0.056
aging GO:0007568 66 0.056
negative regulation of cellular component organization GO:0051129 235 0.055
carbohydrate metabolic process GO:0005975 207 0.053
amino acid activation GO:0043038 12 0.052
cytoplasmic transport GO:0016482 379 0.052
glycosyl compound catabolic process GO:1901658 413 0.052
positive regulation of cellular catabolic process GO:0031331 284 0.052
purine ribonucleoside metabolic process GO:0046128 437 0.052
hematopoietic or lymphoid organ development GO:0048534 186 0.051
guanosine containing compound metabolic process GO:1901068 244 0.051
organic anion transport GO:0015711 103 0.051
nuclear transport GO:0051169 179 0.050
purine nucleoside catabolic process GO:0006152 398 0.048
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.047
regulation of cell differentiation GO:0045595 393 0.045
organic hydroxy compound metabolic process GO:1901615 147 0.045
innate immune response GO:0045087 178 0.045
anion transport GO:0006820 161 0.045
single organism cellular localization GO:1902580 332 0.044
organophosphate biosynthetic process GO:0090407 163 0.044
regulation of cell development GO:0060284 161 0.043
response to nitrogen compound GO:1901698 184 0.043
positive regulation of hydrolase activity GO:0051345 331 0.043
defense response GO:0006952 315 0.043
regulation of nucleoside metabolic process GO:0009118 209 0.042
gtp catabolic process GO:0006184 237 0.041
guanosine containing compound catabolic process GO:1901069 239 0.041
immune response GO:0006955 307 0.040
purine nucleoside triphosphate metabolic process GO:0009144 412 0.040
gtp metabolic process GO:0046039 239 0.040
serine family amino acid metabolic process GO:0009069 12 0.039
regulation of transmembrane transport GO:0034762 139 0.039
regulation of locomotion GO:0040012 329 0.039
organophosphate catabolic process GO:0046434 430 0.038
regulation of translation GO:0006417 89 0.037
ncrna metabolic process GO:0034660 108 0.037
positive regulation of transport GO:0051050 336 0.037
negative regulation of catalytic activity GO:0043086 335 0.037
cellular macromolecule catabolic process GO:0044265 380 0.036
carboxylic acid biosynthetic process GO:0046394 97 0.036
erythrocyte differentiation GO:0030218 28 0.035
regulation of cellular response to stress GO:0080135 244 0.035
ribonucleoside triphosphate catabolic process GO:0009203 391 0.034
regeneration GO:0031099 4 0.034
response to external biotic stimulus GO:0043207 261 0.034
apoptotic signaling pathway GO:0097190 268 0.033
protein catabolic process GO:0030163 325 0.033
monocarboxylic acid metabolic process GO:0032787 185 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
dna templated transcription termination GO:0006353 3 0.033
signal transduction by phosphorylation GO:0023014 297 0.032
regulation of cellular component movement GO:0051270 334 0.032
regulation of purine nucleotide catabolic process GO:0033121 205 0.032
regulation of cell motility GO:2000145 299 0.032
response to organic cyclic compound GO:0014070 204 0.031
purine containing compound catabolic process GO:0072523 411 0.031
amine metabolic process GO:0009308 44 0.031
regulation of mitotic cell cycle GO:0007346 189 0.031
cellular response to endogenous stimulus GO:0071495 336 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
purine ribonucleotide catabolic process GO:0009154 404 0.029
nucleoside catabolic process GO:0009164 408 0.029
mitochondrion organization GO:0007005 156 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
growth GO:0040007 202 0.029
establishment of protein localization to organelle GO:0072594 172 0.029
regulation of dna metabolic process GO:0051052 153 0.028
nucleotide catabolic process GO:0009166 408 0.028
nucleoside triphosphate metabolic process GO:0009141 422 0.027
transmembrane transport GO:0055085 399 0.027
regulation of transferase activity GO:0051338 355 0.027
neurogenesis GO:0022008 169 0.027
female gamete generation GO:0007292 2 0.027
regulation of protein localization GO:0032880 296 0.027
response to wounding GO:0009611 168 0.027
purine containing compound biosynthetic process GO:0072522 88 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
cellular response to oxygen containing compound GO:1901701 276 0.026
dna repair GO:0006281 198 0.026
nucleotide biosynthetic process GO:0009165 109 0.026
organic acid biosynthetic process GO:0016053 97 0.026
regulation of cell migration GO:0030334 289 0.025
leukocyte differentiation GO:0002521 98 0.025
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
regulation of membrane potential GO:0042391 95 0.025
positive regulation of cell death GO:0010942 263 0.025
positive regulation of nucleotide metabolic process GO:0045981 230 0.025
regulation of intracellular transport GO:0032386 195 0.025
negative regulation of cell migration GO:0030336 102 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.024
rna export from nucleus GO:0006405 33 0.024
osteoblast differentiation GO:0001649 92 0.024
positive regulation of transferase activity GO:0051347 227 0.024
cell development GO:0048468 328 0.024
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
negative regulation of cellular component movement GO:0051271 106 0.024
positive regulation of programmed cell death GO:0043068 249 0.024
cell division GO:0051301 168 0.024
positive regulation of dna metabolic process GO:0051054 73 0.023
coenzyme metabolic process GO:0006732 65 0.023
immune system development GO:0002520 195 0.023
positive regulation of cell differentiation GO:0045597 211 0.023
response to biotic stimulus GO:0009607 276 0.023
immune effector process GO:0002252 159 0.023
cation transport GO:0006812 331 0.023
positive regulation of interferon gamma production GO:0032729 26 0.023
mitotic cell cycle process GO:1903047 286 0.023
negative regulation of programmed cell death GO:0043069 321 0.023
negative regulation of cell death GO:0060548 345 0.022
negative regulation of locomotion GO:0040013 118 0.022
regulation of kinase activity GO:0043549 314 0.022
regulation of cell cycle process GO:0010564 266 0.022
nucleobase containing compound transport GO:0015931 51 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.022
positive regulation of nucleoside metabolic process GO:0045979 186 0.022
myeloid cell differentiation GO:0030099 117 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
protein localization to nucleus GO:0034504 136 0.021
cellular carbohydrate metabolic process GO:0044262 84 0.021
protein oligomerization GO:0051259 173 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
response to virus GO:0009615 126 0.021
nucleic acid transport GO:0050657 39 0.021
ossification GO:0001503 121 0.020
reproduction GO:0000003 63 0.020
cellular response to cytokine stimulus GO:0071345 181 0.020
purine nucleoside monophosphate catabolic process GO:0009128 158 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
embryo development GO:0009790 123 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.019
hexose metabolic process GO:0019318 55 0.019
maintenance of location GO:0051235 112 0.019
negative regulation of cell differentiation GO:0045596 171 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
single organism nuclear import GO:1902593 104 0.018
regulation of nucleocytoplasmic transport GO:0046822 98 0.018
regulation of purine nucleotide metabolic process GO:1900542 264 0.018
protein localization to organelle GO:0033365 280 0.018
nervous system development GO:0007399 293 0.018
lipid biosynthetic process GO:0008610 177 0.018
epithelial cell differentiation GO:0030855 141 0.018
response to bacterium GO:0009617 144 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
positive regulation of catabolic process GO:0009896 310 0.018
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.017
purine nucleotide catabolic process GO:0006195 405 0.017
cellular lipid metabolic process GO:0044255 303 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
one carbon metabolic process GO:0006730 1 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
mapk cascade GO:0000165 288 0.017
regulation of proteolysis GO:0030162 293 0.017
negative regulation of apoptotic process GO:0043066 316 0.017
regulation of cytoplasmic transport GO:1903649 149 0.017
single organism cell adhesion GO:0098602 179 0.017
regulation of protein serine threonine kinase activity GO:0071900 179 0.017
pigment biosynthetic process GO:0046148 10 0.017
angiogenesis GO:0001525 147 0.017
regulation of peptidase activity GO:0052547 180 0.017
positive regulation of endopeptidase activity GO:0010950 84 0.016
trna metabolic process GO:0006399 35 0.016
cell activation GO:0001775 213 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.016
nuclear export GO:0051168 69 0.016
protein ubiquitination GO:0016567 314 0.016
cellular amine metabolic process GO:0044106 41 0.016
hormone secretion GO:0046879 65 0.016
ribonucleoside monophosphate metabolic process GO:0009161 187 0.016
cofactor metabolic process GO:0051186 87 0.016
protein maturation GO:0051604 233 0.016
mitotic cell cycle GO:0000278 326 0.016
response to abiotic stimulus GO:0009628 336 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
organelle fission GO:0048285 149 0.016
oogenesis GO:0048477 2 0.016
positive regulation of cytokine production GO:0001819 167 0.016
response to extracellular stimulus GO:0009991 85 0.016
reactive oxygen species metabolic process GO:0072593 75 0.016
intracellular protein transport GO:0006886 270 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
response to other organism GO:0051707 261 0.015
response to axon injury GO:0048678 1 0.015
positive regulation of developmental process GO:0051094 314 0.015
generation of neurons GO:0048699 152 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
regulation of cell cycle GO:0051726 393 0.015
secretion GO:0046903 254 0.015
cellular protein catabolic process GO:0044257 261 0.015
response to lipid GO:0033993 206 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
regulation of protein kinase activity GO:0045859 289 0.015
negative regulation of cell proliferation GO:0008285 228 0.014
cellular response to biotic stimulus GO:0071216 71 0.014
response to molecule of bacterial origin GO:0002237 82 0.014
regulation of response to dna damage stimulus GO:2001020 94 0.014
negative regulation of cell motility GO:2000146 104 0.014
vesicle mediated transport GO:0016192 371 0.014
monosaccharide metabolic process GO:0005996 74 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
cation transmembrane transport GO:0098655 238 0.014
single organism membrane organization GO:0044802 268 0.014
cell part morphogenesis GO:0032990 137 0.014
leukocyte mediated cytotoxicity GO:0001909 27 0.014
chemical homeostasis GO:0048878 306 0.014
single organism reproductive process GO:0044702 98 0.014
ion transmembrane transport GO:0034220 338 0.014
rna transport GO:0050658 39 0.014
locomotory behavior GO:0007626 1 0.014
rho protein signal transduction GO:0007266 26 0.014
protein folding GO:0006457 38 0.013
cellular response to hormone stimulus GO:0032870 125 0.013
mitochondrial translation GO:0032543 17 0.013
regulation of mapk cascade GO:0043408 262 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
sulfur compound metabolic process GO:0006790 101 0.013
regulation of response to external stimulus GO:0032101 222 0.013
regulation of cytokine production GO:0001817 232 0.013
positive regulation of protein transport GO:0051222 135 0.013
regulation of protein complex assembly GO:0043254 147 0.013
response to inorganic substance GO:0010035 127 0.013
response to peptide hormone GO:0043434 61 0.013
positive regulation of kinase activity GO:0033674 204 0.013
nucleoside phosphate catabolic process GO:1901292 412 0.013
segmentation GO:0035282 4 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
sensory perception of pain GO:0019233 4 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
cellular response to lipid GO:0071396 127 0.013
ribonucleoside monophosphate catabolic process GO:0009158 158 0.013
regulation of cellular amine metabolic process GO:0033238 11 0.013
positive regulation of nucleotide catabolic process GO:0030813 185 0.013
trna transport GO:0051031 1 0.013
positive regulation of proteolysis GO:0045862 142 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
cellular ion homeostasis GO:0006873 168 0.012
blood vessel development GO:0001568 172 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
oocyte development GO:0048599 1 0.012
alpha amino acid biosynthetic process GO:1901607 23 0.012
microtubule based process GO:0007017 210 0.012
cellular response to external stimulus GO:0071496 111 0.012
negative regulation of protein modification process GO:0031400 200 0.012
mitotic nuclear division GO:0007067 119 0.012
protein tetramerization GO:0051262 47 0.012
positive regulation of secretion by cell GO:1903532 108 0.012
nuclear import GO:0051170 106 0.012
nucleobase biosynthetic process GO:0046112 4 0.012
system process GO:0003008 349 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
regulation of cell division GO:0051302 116 0.012
cellular chemical homeostasis GO:0055082 180 0.012
ribonucleoprotein complex localization GO:0071166 4 0.012
erythrocyte homeostasis GO:0034101 31 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
protein import into nucleus GO:0006606 104 0.012
regulation of protein import into nucleus GO:0042306 78 0.012
rna localization GO:0006403 41 0.012
dephosphorylation GO:0016311 209 0.011
muscle structure development GO:0061061 98 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
lipid metabolic process GO:0006629 381 0.011
response to hormone GO:0009725 175 0.011
protein import GO:0017038 130 0.011
central nervous system development GO:0007417 123 0.011
negative regulation of developmental process GO:0051093 247 0.011
regulation of map kinase activity GO:0043405 108 0.011
regulation of vasculature development GO:1901342 97 0.011
neurological system process GO:0050877 163 0.011
regulation of protein binding GO:0043393 66 0.011
regulation of binding GO:0051098 111 0.011
leukocyte activation GO:0045321 164 0.011
response to radiation GO:0009314 151 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
compound eye development GO:0048749 1 0.011
lymphocyte activation GO:0046649 133 0.011
cellular response to molecule of bacterial origin GO:0071219 62 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.011
positive regulation of phosphorylation GO:0042327 394 0.010
cell morphogenesis GO:0000902 296 0.010
glucose metabolic process GO:0006006 45 0.010
cytokine production GO:0001816 247 0.010
organic acid transport GO:0015849 65 0.010
neuron differentiation GO:0030182 138 0.010
wound healing GO:0042060 115 0.010
spermatid development GO:0007286 4 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
epithelium development GO:0060429 227 0.010
regulation of protein catabolic process GO:0042176 155 0.010
regulation of dna repair GO:0006282 47 0.010

MTHFD2 disease predictions

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 431 0.088
neuropathy DOID:870 52 0.088
disease of metabolism DOID:0014667 295 0.069
inherited metabolic disorder DOID:655 242 0.069
central nervous system disease DOID:331 186 0.059
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015
motor neuron disease DOID:231 27 0.013
motor neuritis DOID:683 5 0.013
neurodegenerative disease DOID:1289 102 0.013
neuromuscular disease DOID:440 38 0.011
charcot marie tooth disease DOID:10595 33 0.011