Homo sapiens

251 known processes

NEDD4

neural precursor cell expressed, developmentally down-regulated 4

(Aliases: RPF1,MGC176705,NEDD4-1,KIAA0093)

NEDD4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
drinking behavior GO:0042756 1 1.000
sodium ion transmembrane transport GO:0035725 59 1.000
bud outgrowth involved in lung branching GO:0060447 1 0.999
multicellular organismal response to stress GO:0033555 1 0.999
sodium ion transport GO:0006814 61 0.999
regulation of feeding behavior GO:0060259 3 0.996
mating GO:0007618 1 0.996
sensory perception of pain GO:0019233 4 0.993
inorganic cation transmembrane transport GO:0098662 194 0.993
forebrain generation of neurons GO:0021872 3 0.993
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 1 0.992
secretion by lung epithelial cell involved in lung growth GO:0061033 2 0.988
negative regulation of feeding behavior GO:2000252 1 0.987
sodium ion homeostasis GO:0055078 14 0.985
negative regulation of sodium ion transmembrane transport GO:1902306 2 0.983
Human
ion transmembrane transport GO:0034220 338 0.979
water homeostasis GO:0030104 14 0.969
ribosomal large subunit export from nucleus GO:0000055 3 0.967
Yeast
positive regulation of urothelial cell proliferation GO:0050677 1 0.962
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 0.961
Human
metal ion transport GO:0030001 272 0.961
positive regulation of cell fate specification GO:0042660 2 0.956
response to salt stress GO:0009651 3 0.956
dolichol biosynthetic process GO:0019408 1 0.954
Yeast
negative regulation of sodium ion transport GO:0010766 3 0.951
monovalent inorganic cation transport GO:0015672 128 0.950
cation transport GO:0006812 331 0.950
regulation of ketone biosynthetic process GO:0010566 7 0.949
Yeast
transmembrane transport GO:0055085 399 0.936
organic hydroxy compound biosynthetic process GO:1901617 71 0.934
Yeast
forebrain neuron development GO:0021884 2 0.927
ion homeostasis GO:0050801 230 0.927
Human
mechanosensory behavior GO:0007638 4 0.923
metal ion homeostasis GO:0055065 169 0.921
protein ubiquitination GO:0016567 314 0.920
organic acid biosynthetic process GO:0016053 97 0.911
Yeast
mesodermal cell fate commitment GO:0001710 2 0.909
monocarboxylic acid metabolic process GO:0032787 185 0.908
Yeast
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.905
Mouse
cell cell signaling GO:0007267 155 0.903
Mouse
forebrain neuron differentiation GO:0021879 3 0.902
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.897
receptor internalization GO:0031623 43 0.897
sensory perception of chemical stimulus GO:0007606 38 0.877
regulation of transferase activity GO:0051338 355 0.872
cellular response to water stimulus GO:0071462 1 0.868
positive regulation of lipid biosynthetic process GO:0046889 22 0.857
Yeast
regulation of mrna export from nucleus GO:0010793 3 0.856
Yeast
response to abiotic stimulus GO:0009628 336 0.854
negative regulation of axon extension GO:0030517 2 0.853
development involved in symbiotic interaction GO:0044111 1 0.850
regulation of potassium ion transmembrane transport GO:1901379 20 0.848
inorganic ion transmembrane transport GO:0098660 231 0.847
positive regulation of keratinocyte proliferation GO:0010838 4 0.843
presynaptic membrane assembly GO:0097105 1 0.839
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.837
Yeast
response to growth factor GO:0070848 205 0.835
Human Mouse
enzyme linked receptor protein signaling pathway GO:0007167 303 0.834
Human Mouse
ribonucleoprotein complex export from nucleus GO:0071426 4 0.827
Yeast
outer ear morphogenesis GO:0042473 2 0.826
organic hydroxy compound metabolic process GO:1901615 147 0.819
Yeast
locomotory behavior GO:0007626 1 0.816
ureteric bud elongation GO:0060677 2 0.811
regulation of sodium ion transport GO:0002028 24 0.811
receptor catabolic process GO:0032801 11 0.808
mesodermal cell fate specification GO:0007501 2 0.803
regulation of sensory perception GO:0051931 3 0.799
regulation of kinase activity GO:0043549 314 0.796
alcohol metabolic process GO:0006066 114 0.795
Yeast
polyprenol biosynthetic process GO:0016094 1 0.786
Yeast
cation transmembrane transport GO:0098655 238 0.783
positive regulation of vasculogenesis GO:2001214 1 0.774
coenzyme biosynthetic process GO:0009108 24 0.769
Yeast
postnatal olfactory bulb interneuron migration GO:0021827 2 0.764
ubiquitin dependent protein catabolic process GO:0006511 206 0.763
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling GO:0060665 1 0.762
protein localization to cell surface GO:0034394 28 0.755
Human
response to oxygen containing compound GO:1901700 369 0.754
regulation of endodermal cell fate specification GO:0042663 1 0.743
detection of mechanical stimulus GO:0050982 4 0.732
organ induction GO:0001759 4 0.732
cation homeostasis GO:0055080 189 0.731
cofactor biosynthetic process GO:0051188 31 0.729
Yeast
stem cell differentiation GO:0048863 93 0.722
steroid biosynthetic process GO:0006694 46 0.712
Yeast
quinone metabolic process GO:1901661 18 0.709
Yeast
detection of mechanical stimulus involved in sensory perception GO:0050974 1 0.705
regulation of protein ubiquitination GO:0031396 95 0.702
specification of organ identity GO:0010092 3 0.700
endodermal cell fate specification GO:0001714 4 0.692
regulation of saliva secretion GO:0046877 2 0.687
actin filament based process GO:0030029 224 0.683
Yeast
regulation of ion transport GO:0043269 189 0.678
regulation of protein kinase activity GO:0045859 289 0.677
regulation of endosome size GO:0051036 3 0.677
Yeast
regulation of organ formation GO:0003156 4 0.648
cellular response to cgmp GO:0071321 5 0.642
regulation of mapk cascade GO:0043408 262 0.638
dissemination or transmission of organism from other organism involved in symbiotic interaction GO:0051821 1 0.633
negative regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010768 1 0.631
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 18 0.630
negative regulation of protein transport GO:0051224 75 0.627
Human
protein catabolic process GO:0030163 325 0.621
dissemination or transmission of symbiont from host GO:0044007 1 0.614
small molecule biosynthetic process GO:0044283 157 0.612
Yeast
branching involved in salivary gland morphogenesis GO:0060445 1 0.610
regulation of dendritic cell apoptotic process GO:2000668 4 0.605
regulation of metal ion transport GO:0010959 120 0.604
positive regulation of mapk cascade GO:0043410 190 0.604
cellular response to growth factor stimulus GO:0071363 197 0.601
Human Mouse
protein polyubiquitination GO:0000209 110 0.597
Human Yeast Rat
ribonucleoprotein complex localization GO:0071166 4 0.596
Yeast
regulation of vasculogenesis GO:2001212 3 0.595
epithelium development GO:0060429 227 0.592
negative regulation of cell death GO:0060548 345 0.592
Human
cellular response to abiotic stimulus GO:0071214 117 0.586
cellular amino acid metabolic process GO:0006520 116 0.586
cellular ketone metabolic process GO:0042180 80 0.582
Yeast
lung growth GO:0060437 2 0.578
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.576
establishment of ribosome localization GO:0033753 4 0.572
Yeast
regeneration GO:0031099 4 0.565
response to biotic stimulus GO:0009607 276 0.565
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.564
Yeast
regulation of ubiquitin protein transferase activity GO:0051438 28 0.562
positive regulation of camp dependent protein kinase activity GO:2000481 4 0.561
actin cytoskeleton organization GO:0030036 207 0.559
Yeast
cellular protein catabolic process GO:0044257 261 0.553
positive regulation of kinase activity GO:0033674 204 0.552
quinone biosynthetic process GO:1901663 6 0.552
Yeast
positive regulation of neuron migration GO:2001224 1 0.551
trna export from nucleus GO:0006409 1 0.550
Yeast
bile acid metabolic process GO:0008206 14 0.548
endodermal cell fate commitment GO:0001711 4 0.547
positive regulation of cellular catabolic process GO:0031331 284 0.543
Yeast
regulation of ligase activity GO:0051340 29 0.542
trna transport GO:0051031 1 0.539
Yeast
modification dependent macromolecule catabolic process GO:0043632 212 0.525
dolichol metabolic process GO:0019348 3 0.521
Yeast
brain derived neurotrophic factor receptor signaling pathway GO:0031547 1 0.511
steroid metabolic process GO:0008202 94 0.508
Yeast
negative regulation of apoptotic process GO:0043066 316 0.505
Human
rna processing GO:0006396 255 0.502
Yeast
positive regulation of protein phosphorylation GO:0001934 313 0.498
negative regulation of ion transmembrane transport GO:0034766 26 0.497
Human
oxidoreduction coenzyme metabolic process GO:0006733 19 0.497
Yeast
protein modification by small protein conjugation GO:0032446 342 0.497
branch elongation involved in ureteric bud branching GO:0060681 2 0.493
organ formation GO:0048645 3 0.493
regulation of cellular component biogenesis GO:0044087 281 0.490
Yeast
protein k48 linked ubiquitination GO:0070936 38 0.489
Human
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.483
Human
negative regulation of dendrite development GO:2000171 5 0.482
mammary gland formation GO:0060592 1 0.482
polyprenol metabolic process GO:0016093 3 0.479
Yeast
sensory perception GO:0007600 103 0.478
regulation of protein localization GO:0032880 296 0.477
Human Yeast
regulation of protein serine threonine kinase activity GO:0071900 179 0.474
substrate dependent cerebral cortex tangential migration GO:0021825 2 0.470
cellular macromolecule catabolic process GO:0044265 380 0.468
positive regulation of transferase activity GO:0051347 227 0.464
cerebral cortex tangential migration using cell cell interactions GO:0021823 2 0.454
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 0.451
Human
transmission of virus GO:0019089 1 0.450
regulation of metalloenzyme activity GO:0048552 3 0.449
negative regulation of cell fate commitment GO:0010454 3 0.448
response to wounding GO:0009611 168 0.447
negative regulation of cell differentiation GO:0045596 171 0.443
positive regulation of phosphorylation GO:0042327 394 0.441
positive regulation of cellular component organization GO:0051130 376 0.440
Yeast
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.438
signal transduction by phosphorylation GO:0023014 297 0.436
trna processing GO:0008033 23 0.433
Yeast
multicellular organismal water homeostasis GO:0050891 14 0.432
chondroblast differentiation GO:0060591 2 0.429
ubiquitin dependent endocytosis GO:0070086 1 0.429
Yeast
regulation of defense response GO:0031347 154 0.428
Human
response to inorganic substance GO:0010035 127 0.424
Human
regulation of ribosome biogenesis GO:0090069 1 0.417
Yeast
segmentation GO:0035282 4 0.403
tissue morphogenesis GO:0048729 96 0.403
regulation of cellular ketone metabolic process GO:0010565 50 0.403
Yeast
negative regulation of transport GO:0051051 176 0.401
regulation of behavior GO:0050795 82 0.400
cellular response to endogenous stimulus GO:0071495 336 0.400
Human
regulation of actin cytoskeleton organization GO:0032956 116 0.397
Yeast
positive regulation of locomotion GO:0040017 186 0.394
positive regulation of protein kinase activity GO:0045860 190 0.393
regulation of receptor mediated endocytosis GO:0048259 32 0.392
Yeast
erk1 and erk2 cascade GO:0070371 104 0.391
cell cell junction organization GO:0045216 69 0.388
mesenchymal epithelial cell signaling GO:0060638 1 0.384
negative regulation of multicellular organismal process GO:0051241 317 0.381
protein k29 linked ubiquitination GO:0035519 4 0.380
Human
establishment of protein localization to organelle GO:0072594 172 0.378
negative regulation of developmental process GO:0051093 247 0.376
potassium ion transmembrane transport GO:0071805 60 0.375
negative regulation of axonogenesis GO:0050771 4 0.371
negative regulation of cell proliferation GO:0008285 228 0.366
positive regulation of lipid metabolic process GO:0045834 50 0.365
Yeast
positive regulation of catabolic process GO:0009896 310 0.363
presynaptic membrane organization GO:0097090 3 0.363
secondary metabolite biosynthetic process GO:0044550 2 0.362
epithelial cell differentiation GO:0030855 141 0.361
positive regulation of heart growth GO:0060421 2 0.360
mapk cascade GO:0000165 288 0.357
cell proliferation in forebrain GO:0021846 1 0.357
cellular amine metabolic process GO:0044106 41 0.356
regulation of cellular amine metabolic process GO:0033238 11 0.356
ribonucleoside triphosphate metabolic process GO:0009199 412 0.356
negative regulation of fibroblast migration GO:0010764 3 0.355
positive regulation of keratinocyte migration GO:0051549 4 0.354
vasculature development GO:0001944 181 0.352
Mouse
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010767 1 0.351
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.351
fatty acid metabolic process GO:0006631 115 0.350
Yeast
sensory perception of mechanical stimulus GO:0050954 37 0.346
endothelial cell migration GO:0043542 86 0.345
positive regulation of protein catabolic process GO:0045732 75 0.344
regulation of neuron migration GO:2001222 3 0.342
blood vessel endothelial cell migration GO:0043534 42 0.342
regulation of multivesicular body size GO:0010796 1 0.340
Yeast
proteasomal protein catabolic process GO:0010498 176 0.340
Human Yeast
purine containing compound catabolic process GO:0072523 411 0.338
cardiac muscle cell proliferation GO:0060038 6 0.337
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.334
Yeast
protein autoubiquitination GO:0051865 37 0.331
Human Yeast
detection of abiotic stimulus GO:0009582 15 0.330
negative regulation of cell fate specification GO:0009996 3 0.329
oogenesis GO:0048477 2 0.327
regulation of erk1 and erk2 cascade GO:0070372 99 0.326
late endosome to vacuole transport GO:0045324 2 0.326
Yeast
ribosomal subunit export from nucleus GO:0000054 4 0.325
Yeast
positive regulation of cellular component movement GO:0051272 181 0.323
protein monoubiquitination GO:0006513 39 0.322
Yeast Mouse
regulation of synaptic plasticity GO:0048167 3 0.321
nucleoside catabolic process GO:0009164 408 0.319
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.317
Yeast
regulation of transmembrane transport GO:0034762 139 0.315
cell activation GO:0001775 213 0.309
Mouse
negative regulation of neuron differentiation GO:0045665 21 0.307
wound healing GO:0042060 115 0.306
cardiovascular system development GO:0072358 262 0.305
Mouse
nucleoside triphosphate catabolic process GO:0009143 394 0.305
chemical homeostasis GO:0048878 306 0.302
Human
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.296
Human
post embryonic development GO:0009791 2 0.295
angiogenesis GO:0001525 147 0.294
stem cell development GO:0048864 69 0.288
positive regulation of nucleotide catabolic process GO:0030813 185 0.286
negative regulation of cell projection organization GO:0031345 22 0.285
regulation of activin receptor signaling pathway GO:0032925 14 0.285
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.284
regulation of protein transport GO:0051223 213 0.281
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.280
regulation of urothelial cell proliferation GO:0050675 1 0.280
ketone biosynthetic process GO:0042181 17 0.279
Yeast
intracellular protein transport GO:0006886 270 0.279
negative regulation of response to external stimulus GO:0032102 83 0.278
Human
negative regulation of cellular component movement GO:0051271 106 0.272
modification dependent protein catabolic process GO:0019941 209 0.271
coenzyme metabolic process GO:0006732 65 0.270
Yeast
vesicle mediated transport GO:0016192 371 0.268
negative regulation of endodermal cell differentiation GO:1903225 2 0.266
carboxylic acid biosynthetic process GO:0046394 97 0.264
Yeast
positive regulation of ubiquitin protein transferase activity GO:0051443 18 0.263
stem cell division GO:0017145 2 0.261
anatomical structure formation involved in morphogenesis GO:0048646 284 0.260
Yeast
positive regulation of lipase activity GO:0060193 28 0.260
response to organic cyclic compound GO:0014070 204 0.259
regulation of ion homeostasis GO:2000021 73 0.258
Human
regulation of mesoderm development GO:2000380 4 0.258
cranial nerve formation GO:0021603 1 0.257
negative regulation of neuron projection development GO:0010977 15 0.255
neuron projection regeneration GO:0031102 1 0.254
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 0.253
cell projection organization GO:0030030 252 0.252
regulation of proteolysis GO:0030162 293 0.251
Yeast
regulation of lipid metabolic process GO:0019216 96 0.251
Yeast
defense response GO:0006952 315 0.251
Human
regulation of proteasomal protein catabolic process GO:0061136 87 0.250
Yeast
cellular response to oxygen containing compound GO:1901701 276 0.250
regulation of cell differentiation GO:0045595 393 0.245
Mouse Rat
ribonucleoprotein complex biogenesis GO:0022613 116 0.243
Yeast
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.241
Yeast
regulation of cell morphogenesis GO:0022604 153 0.240
Yeast Mouse Rat
mammary gland specification GO:0060594 1 0.240
detection of stimulus GO:0051606 85 0.240
response to other organism GO:0051707 261 0.239
Human
reproductive process GO:0022414 106 0.237
Yeast
purine ribonucleoside catabolic process GO:0046130 398 0.236
regulation of cofactor metabolic process GO:0051193 3 0.236
Yeast
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 3 0.234
urothelial cell proliferation GO:0050674 1 0.232
sterol biosynthetic process GO:0016126 10 0.232
Yeast
isoprenoid biosynthetic process GO:0008299 9 0.232
Yeast
positive regulation of cardiac muscle tissue growth GO:0055023 2 0.231
regulation of neuron differentiation GO:0045664 70 0.229
Mouse Rat
lipid metabolic process GO:0006629 381 0.229
Yeast
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.228
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.228
regulation of sensory perception of pain GO:0051930 3 0.225
nuclear transport GO:0051169 179 0.224
positive regulation of hair follicle cell proliferation GO:0071338 1 0.222
blood vessel morphogenesis GO:0048514 162 0.221
Mouse
regulation of potassium ion transport GO:0043266 24 0.220
positive regulation of protein ubiquitination GO:0031398 53 0.217
cytoplasmic transport GO:0016482 379 0.215
positive regulation of dendritic cell apoptotic process GO:2000670 1 0.214
protein localization to organelle GO:0033365 280 0.214
regulation of axon extension involved in axon guidance GO:0048841 2 0.212
regulation of secondary metabolic process GO:0043455 2 0.212
axon regeneration GO:0031103 1 0.211
regulation of branching involved in salivary gland morphogenesis GO:0060693 1 0.210
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.210
skin development GO:0043588 76 0.209
interspecies interaction between organisms GO:0044419 156 0.207
negative regulation of defense response to virus GO:0050687 10 0.206
Human
regulation of actin filament based process GO:0032970 141 0.205
Yeast
inner ear morphogenesis GO:0042472 4 0.203
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.203
regulation of cell development GO:0060284 161 0.202
Mouse Rat
positive regulation of blood vessel endothelial cell migration GO:0043536 16 0.198
regulation of potassium ion transmembrane transporter activity GO:1901016 16 0.197
striated muscle cell proliferation GO:0014855 7 0.196
monovalent inorganic cation homeostasis GO:0055067 37 0.196
purine nucleoside triphosphate catabolic process GO:0009146 392 0.196
viral process GO:0016032 146 0.195
receptor mediated endocytosis GO:0006898 84 0.193
regulation of nucleotide catabolic process GO:0030811 205 0.190
positive regulation of developmental process GO:0051094 314 0.189
lipid biosynthetic process GO:0008610 177 0.189
Yeast
positive regulation of cell cycle GO:0045787 140 0.189
purine nucleoside catabolic process GO:0006152 398 0.187
regulation of heart growth GO:0060420 4 0.185
defense response to other organism GO:0098542 129 0.185
Human
pallium development GO:0021543 10 0.184
cell development GO:0048468 328 0.184
g1 s transition of mitotic cell cycle GO:0000082 78 0.183
regulation of isoprenoid metabolic process GO:0019747 1 0.183
Yeast
hard palate development GO:0060022 1 0.183
amine metabolic process GO:0009308 44 0.181
regulation of steroid biosynthetic process GO:0050810 23 0.181
Yeast
regulation of synaptic transmission GO:0050804 11 0.179
positive regulation of fatty acid metabolic process GO:0045923 11 0.178
Yeast
cell junction organization GO:0034330 79 0.177
negative regulation of behavior GO:0048521 15 0.177
epidermal cell differentiation GO:0009913 45 0.177
purine ribonucleoside metabolic process GO:0046128 437 0.176
limbic system development GO:0021761 3 0.176
ureteric bud development GO:0001657 13 0.174
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.172
Human
epidermis development GO:0008544 59 0.171
positive regulation of organ growth GO:0046622 2 0.169
nervous system development GO:0007399 293 0.168
monocarboxylic acid biosynthetic process GO:0072330 67 0.168
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.167
Human Yeast
neuromuscular junction development GO:0007528 3 0.164
Mouse
regulation of cellular protein catabolic process GO:1903362 96 0.163
Yeast
negative regulation of cellular component organization GO:0051129 235 0.162
regulation of body fluid levels GO:0050878 99 0.160
maintenance of location GO:0051235 112 0.159
system process GO:0003008 349 0.158
detection of stimulus involved in sensory perception GO:0050906 43 0.158
regulation of locomotion GO:0040012 329 0.158
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.156
Human
response to light stimulus GO:0009416 87 0.156
hair cell differentiation GO:0035315 2 0.155
mesonephros development GO:0001823 17 0.155
regulation of cellular response to stress GO:0080135 244 0.154
positive regulation of hydrolase activity GO:0051345 331 0.154
cell morphogenesis GO:0000902 296 0.154
Yeast Mouse Rat
receptor metabolic process GO:0043112 81 0.154
regulation of neuron projection regeneration GO:0070570 1 0.154
negative regulation of ion transport GO:0043271 39 0.153
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.152
positive regulation of map kinase activity GO:0043406 80 0.152
positive regulation of nucleoside metabolic process GO:0045979 186 0.149
regulation of axon guidance GO:1902667 3 0.149
organ morphogenesis GO:0009887 147 0.149
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.149
nucleoside phosphate catabolic process GO:1901292 412 0.148
positive regulation of cell division GO:0051781 59 0.148
response to osmotic stress GO:0006970 17 0.147
regulation of leukocyte activation GO:0002694 115 0.147
positive regulation of cell differentiation GO:0045597 211 0.146
positive regulation of camp mediated signaling GO:0043950 10 0.145
negative regulation of gastrulation GO:2000542 4 0.145
forebrain development GO:0030900 26 0.144
negative regulation of protein phosphorylation GO:0001933 140 0.143
ribonucleoside triphosphate catabolic process GO:0009203 391 0.143
defense response to virus GO:0051607 71 0.141
Human
potassium ion transport GO:0006813 62 0.141
response to drug GO:0042493 81 0.141
Yeast
startle response GO:0001964 3 0.141
positive regulation of cell motility GO:2000147 177 0.140
ribosome localization GO:0033750 4 0.139
Yeast
mesonephric epithelium development GO:0072163 14 0.138
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.137
response to acid chemical GO:0001101 66 0.137
actin filament organization GO:0007015 128 0.137
female gamete generation GO:0007292 2 0.136
glycerolipid biosynthetic process GO:0045017 51 0.135
regulation of peptidase activity GO:0052547 180 0.135
glycosyl compound catabolic process GO:1901658 413 0.134
negative regulation of cell development GO:0010721 48 0.134
positive regulation of osteoblast differentiation GO:0045669 23 0.133
regulation of cell migration GO:0030334 289 0.133
regulation of steroid metabolic process GO:0019218 32 0.133
Yeast
sequestering of metal ion GO:0051238 24 0.133
positive regulation of fatty acid biosynthetic process GO:0045723 5 0.133
Yeast
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 2 0.133
protein import into nucleus GO:0006606 104 0.132
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.132
Yeast
positive regulation of cellular protein catabolic process GO:1903364 37 0.131
Yeast
tissue regeneration GO:0042246 3 0.130
second messenger mediated signaling GO:0019932 78 0.130
regulation of melanin biosynthetic process GO:0048021 1 0.127
cellular potassium ion transport GO:0071804 60 0.126
ameboidal type cell migration GO:0001667 135 0.124
adherens junction organization GO:0034332 36 0.123
nerve growth factor signaling pathway GO:0038180 4 0.123
apoptotic signaling pathway GO:0097190 268 0.123
regulation of lipid biosynthetic process GO:0046890 47 0.123
Yeast
regulation of epithelial cell migration GO:0010632 93 0.123
divalent metal ion transport GO:0070838 152 0.122
positive regulation of rap gtpase activity GO:0032854 8 0.122
regulation of intracellular transport GO:0032386 195 0.122
response to metal ion GO:0010038 84 0.121
Human
blastoderm segmentation GO:0007350 2 0.120
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.120
regulation of protein catabolic process GO:0042176 155 0.119
neuropeptide signaling pathway GO:0007218 19 0.119
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.118
regulation of nucleotide metabolic process GO:0006140 269 0.117
long term synaptic potentiation GO:0060291 1 0.117
negative regulation of catalytic activity GO:0043086 335 0.117
head development GO:0060322 108 0.116
neurological system process GO:0050877 163 0.116
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.115
Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.115
ectodermal placode development GO:0071696 1 0.114
protein targeting GO:0006605 187 0.114
regulation of fatty acid metabolic process GO:0019217 24 0.114
Yeast
regulation of anatomical structure morphogenesis GO:0022603 286 0.114
Yeast Mouse Rat
positive regulation of immune system process GO:0002684 283 0.114
muscle tissue development GO:0060537 62 0.114
negative regulation of phosphorus metabolic process GO:0010563 267 0.113
regulation of endocytosis GO:0030100 72 0.112
Yeast
negative regulation of phosphate metabolic process GO:0045936 267 0.112
regulation of response to external stimulus GO:0032101 222 0.112
Human
stress activated mapk cascade GO:0051403 93 0.112
regulation of cardiac muscle tissue growth GO:0055021 4 0.112
hindbrain development GO:0030902 3 0.112
endosomal transport GO:0016197 129 0.111
Yeast
regulation of neuron projection development GO:0010975 57 0.110
Mouse Rat
polyol metabolic process GO:0019751 32 0.110
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.110
small gtpase mediated signal transduction GO:0007264 78 0.110
regulation of establishment of protein localization GO:0070201 242 0.110
Human
response to virus GO:0009615 126 0.109
Human
cellular response to dna damage stimulus GO:0006974 379 0.109
lung alveolus development GO:0048286 4 0.109
positive regulation of cardiac muscle tissue development GO:0055025 6 0.109
negative regulation of phosphorylation GO:0042326 174 0.109
adenylate cyclase activating adrenergic receptor signaling pathway GO:0071880 3 0.109
isoprenoid metabolic process GO:0006720 39 0.109
Yeast
regulation of cellular response to growth factor stimulus GO:0090287 76 0.108
Human Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.107
kidney epithelium development GO:0072073 25 0.107
single organism cellular localization GO:1902580 332 0.107
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.106
memory GO:0007613 3 0.106
response to temperature stimulus GO:0009266 22 0.106
negative regulation of cell migration GO:0030336 102 0.105
cardiac muscle tissue development GO:0048738 39 0.105
negative regulation of neurological system process GO:0031645 2 0.105
nucleocytoplasmic transport GO:0006913 176 0.104
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.104
ribonucleoside monophosphate metabolic process GO:0009161 187 0.104
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.103
Human Mouse
response to organophosphorus GO:0046683 41 0.103
regulation of ossification GO:0030278 58 0.102
negative regulation of neurogenesis GO:0050768 26 0.102
negative regulation of cell cycle process GO:0010948 121 0.101
regulation of ion transmembrane transporter activity GO:0032412 72 0.101

NEDD4 disease predictions

Disease DO term ID Size Probability Func Analog Org
respiratory system disease DOID:1579 14 0.999
lower respiratory tract disease DOID:0050161 13 0.999
kidney disease DOID:557 36 0.806
urinary system disease DOID:18 40 0.806
gonadal disease DOID:2277 8 0.331
endocrine system disease DOID:28 26 0.331
reproductive system disease DOID:15 17 0.331
musculoskeletal system disease DOID:17 223 0.297
connective tissue disease DOID:65 109 0.297
bone disease DOID:0080001 88 0.233
bone development disease DOID:0080006 55 0.167
dysostosis DOID:1934 22 0.167