Homo sapiens

229 known processes

NIPBL

Nipped-B homolog (Drosophila)

(Aliases: CDLS1,FLJ13354,FLJ13648,IDN3,FLJ11203,Scc2,FLJ44854,CDLS,DKFZp434L1319,IDN3-B,FLJ12597)

NIPBL biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 351 0.898
covalent chromatin modification GO:0016569 254 0.891
chromatin modification GO:0016568 298 0.863
histone modification GO:0016570 251 0.816
macromolecule methylation GO:0043414 97 0.739
post embryonic development GO:0009791 2 0.603
chromatin assembly GO:0031497 61 0.591
organelle fission GO:0048285 149 0.528
cell development GO:0048468 328 0.528
Mouse Worm
nucleosome organization GO:0034728 66 0.477
protein dna complex subunit organization GO:0071824 80 0.463
histone methylation GO:0016571 60 0.414
histone lysine methylation GO:0034968 50 0.413
negative regulation of chromosome organization GO:2001251 48 0.379
cellular amine metabolic process GO:0044106 41 0.344
meiotic chromosome segregation GO:0045132 4 0.322
chromosome segregation GO:0007059 114 0.311
regulation of cell cycle GO:0051726 393 0.284
regulation of chromatin organization GO:1902275 56 0.277
growth GO:0040007 202 0.273
methylation GO:0032259 106 0.264
regulation of dna metabolic process GO:0051052 153 0.263
female gamete generation GO:0007292 2 0.257
mitotic cell cycle GO:0000278 326 0.228
embryonic placenta development GO:0001892 1 0.211
chromatin assembly or disassembly GO:0006333 78 0.209
cellular amino acid metabolic process GO:0006520 116 0.208
reproductive structure development GO:0048608 55 0.182
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.181
amine metabolic process GO:0009308 44 0.178
nucleoside triphosphate metabolic process GO:0009141 422 0.176
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.175
reproductive process GO:0022414 106 0.173
nuclear division GO:0000280 128 0.162
regulation of chromatin modification GO:1903308 51 0.153
regulation of cellular amine metabolic process GO:0033238 11 0.151
cellular ketone metabolic process GO:0042180 80 0.142
nucleotide catabolic process GO:0009166 408 0.141
positive regulation of organelle organization GO:0010638 195 0.139
vesicle mediated transport GO:0016192 371 0.132
protein alkylation GO:0008213 74 0.123
reproductive system development GO:0061458 56 0.123
positive regulation of cellular amine metabolic process GO:0033240 7 0.122
negative regulation of cellular component organization GO:0051129 235 0.117
peptidyl lysine methylation GO:0018022 37 0.116
single organism reproductive process GO:0044702 98 0.116
nucleoside catabolic process GO:0009164 408 0.115
cellular protein complex assembly GO:0043623 188 0.115
Worm
negative regulation of organelle organization GO:0010639 126 0.114
cellular response to dna damage stimulus GO:0006974 379 0.114
purine nucleoside triphosphate catabolic process GO:0009146 392 0.113
negative regulation of cell cycle process GO:0010948 121 0.111
regulation of cell cycle process GO:0010564 266 0.111
oogenesis GO:0048477 2 0.106
ribonucleoside catabolic process GO:0042454 406 0.104
cell morphogenesis GO:0000902 296 0.103
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.101
sex differentiation GO:0007548 45 0.099
regulation of chromosome organization GO:0033044 103 0.099
neurological system process GO:0050877 163 0.098
mitotic sister chromatid segregation GO:0000070 53 0.094
cell projection organization GO:0030030 252 0.091
purine nucleotide catabolic process GO:0006195 405 0.089
regulation of cellular ketone metabolic process GO:0010565 50 0.088
mitotic cell cycle phase transition GO:0044772 162 0.088
protein methylation GO:0006479 74 0.086
cell division GO:0051301 168 0.083
cell morphogenesis involved in differentiation GO:0000904 144 0.083
regulation of cellular amino acid metabolic process GO:0006521 6 0.083
negative regulation of dna metabolic process GO:0051053 57 0.081
positive regulation of protein phosphorylation GO:0001934 313 0.078
negative regulation of chromatin modification GO:1903309 21 0.074
tube morphogenesis GO:0035239 95 0.073
regulation of growth GO:0040008 165 0.072
regulation of anatomical structure morphogenesis GO:0022603 286 0.071
positive regulation of cellular component organization GO:0051130 376 0.071
dna repair GO:0006281 198 0.069
dna conformation change GO:0071103 113 0.068
glycosyl compound catabolic process GO:1901658 413 0.066
regulation of cellular component biogenesis GO:0044087 281 0.065
purine ribonucleotide catabolic process GO:0009154 404 0.063
anatomical structure formation involved in morphogenesis GO:0048646 284 0.062
Worm
intracellular receptor signaling pathway GO:0030522 104 0.062
peptidyl lysine modification GO:0018205 144 0.060
neuron differentiation GO:0030182 138 0.059
negative regulation of apoptotic process GO:0043066 316 0.059
purine containing compound catabolic process GO:0072523 411 0.058
chemotaxis GO:0006935 157 0.058
dna packaging GO:0006323 77 0.057
cellular component morphogenesis GO:0032989 314 0.057
Worm
maintenance of location GO:0051235 112 0.057
internal protein amino acid acetylation GO:0006475 101 0.055
dephosphorylation GO:0016311 209 0.055
sister chromatid segregation GO:0000819 54 0.054
determination of adult lifespan GO:0008340 2 0.054
regulation of histone modification GO:0031056 47 0.053
actin filament organization GO:0007015 128 0.053
nervous system development GO:0007399 293 0.052
protein ubiquitination GO:0016567 314 0.051
ribonucleoside triphosphate catabolic process GO:0009203 391 0.051
nucleoside triphosphate catabolic process GO:0009143 394 0.050
purine nucleoside catabolic process GO:0006152 398 0.049
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.049
cytokinesis GO:0000910 96 0.048
gene silencing GO:0016458 49 0.047
negative regulation of cell death GO:0060548 345 0.046
small gtpase mediated signal transduction GO:0007264 78 0.046
protein acetylation GO:0006473 116 0.046
stem cell development GO:0048864 69 0.045
Mouse
regulation of cytoskeleton organization GO:0051493 177 0.044
purine ribonucleoside metabolic process GO:0046128 437 0.043
viral process GO:0016032 146 0.043
sister chromatid cohesion GO:0007062 24 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.041
regulation of cell division GO:0051302 116 0.040
response to growth factor GO:0070848 205 0.040
purine ribonucleoside catabolic process GO:0046130 398 0.040
cellular response to endogenous stimulus GO:0071495 336 0.040
regulation of nuclear division GO:0051783 65 0.039
centrosome organization GO:0051297 58 0.039
regulation of cell morphogenesis GO:0022604 153 0.039
cytoplasmic transport GO:0016482 379 0.038
mitotic nuclear division GO:0007067 119 0.038
purine nucleoside triphosphate metabolic process GO:0009144 412 0.038
regulation of intracellular transport GO:0032386 195 0.038
embryo development GO:0009790 123 0.038
histone acetylation GO:0016573 93 0.038
cellular response to lipid GO:0071396 127 0.037
reproduction GO:0000003 63 0.036
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.035
regulation of protein processing GO:0070613 150 0.035
neural tube formation GO:0001841 3 0.035
cellular response to oxygen containing compound GO:1901701 276 0.035
behavior GO:0007610 112 0.034
gonad development GO:0008406 34 0.033
positive regulation of cell growth GO:0030307 48 0.033
negative regulation of catalytic activity GO:0043086 335 0.032
positive regulation of rab gtpase activity GO:0032851 39 0.032
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.032
regulation of gene expression epigenetic GO:0040029 73 0.031
viral life cycle GO:0019058 132 0.031
regulation of purine nucleotide metabolic process GO:1900542 264 0.031
histone h3 k9 modification GO:0061647 11 0.030
spermatid differentiation GO:0048515 4 0.030
regulation of small gtpase mediated signal transduction GO:0051056 156 0.030
response to abiotic stimulus GO:0009628 336 0.030
negative regulation of cell cycle GO:0045786 193 0.029
regulation of canonical wnt signaling pathway GO:0060828 88 0.029
neuromuscular junction development GO:0007528 3 0.029
myeloid leukocyte differentiation GO:0002573 60 0.029
memory GO:0007613 3 0.029
positive regulation of phosphorylation GO:0042327 394 0.029
developmental process involved in reproduction GO:0003006 66 0.028
cellular response to nitrogen compound GO:1901699 144 0.028
positive regulation of growth GO:0045927 58 0.028
Mouse
neuron projection development GO:0031175 106 0.028
response to oxygen containing compound GO:1901700 369 0.027
positive regulation of dna metabolic process GO:0051054 73 0.027
regulation of protein complex assembly GO:0043254 147 0.027
immune response GO:0006955 307 0.026
regulation of protein transport GO:0051223 213 0.026
cell projection morphogenesis GO:0048858 129 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
regulation of mitotic cell cycle GO:0007346 189 0.025
neuron development GO:0048666 113 0.025
cell part morphogenesis GO:0032990 137 0.025
negative regulation of cellular catabolic process GO:0031330 83 0.025
spermatid development GO:0007286 4 0.025
meiotic cell cycle GO:0051321 13 0.025
nuclear transport GO:0051169 179 0.025
male meiosis GO:0007140 1 0.025
nucleocytoplasmic transport GO:0006913 176 0.024
mitotic cell cycle process GO:1903047 286 0.024
negative regulation of binding GO:0051100 57 0.024
cell growth GO:0016049 160 0.024
organelle assembly GO:0070925 176 0.024
Worm
ribonucleotide catabolic process GO:0009261 405 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.023
regulation of spindle organization GO:0090224 10 0.023
aging GO:0007568 66 0.023
apoptotic signaling pathway GO:0097190 268 0.023
developmental growth GO:0048589 48 0.023
positive regulation of protein kinase activity GO:0045860 190 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.023
response to radiation GO:0009314 151 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
peptidyl lysine trimethylation GO:0018023 10 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.022
central nervous system development GO:0007417 123 0.022
cellular macromolecular complex assembly GO:0034622 324 0.022
Worm
regulation of cell differentiation GO:0045595 393 0.022
Mouse
neurogenesis GO:0022008 169 0.022
dna templated transcription initiation GO:0006352 35 0.022
vasculature development GO:0001944 181 0.022
dna integrity checkpoint GO:0031570 71 0.022
response to external biotic stimulus GO:0043207 261 0.022
double strand break repair GO:0006302 101 0.022
development of primary sexual characteristics GO:0045137 35 0.021
protein import GO:0017038 130 0.021
generation of neurons GO:0048699 152 0.021
histone h3 k4 demethylation trimethyl h3 k4 specific GO:0034721 1 0.021
microtubule organizing center organization GO:0031023 62 0.021
negative regulation of gene expression epigenetic GO:0045814 19 0.021
response to ketone GO:1901654 19 0.021
histone h3 k4 methylation GO:0051568 27 0.021
regulation of cell growth GO:0001558 135 0.020
negative regulation of proteolysis GO:0045861 132 0.020
ribonucleoside monophosphate catabolic process GO:0009158 158 0.020
regulation of intracellular protein transport GO:0033157 123 0.020
negative regulation of apoptotic signaling pathway GO:2001234 97 0.020
positive regulation of gtpase activity GO:0043547 166 0.020
dendrite development GO:0016358 24 0.020
negative regulation of mitotic cell cycle GO:0045930 102 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
positive regulation of wnt signaling pathway GO:0030177 54 0.020
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.019
cellular response to organic cyclic compound GO:0071407 127 0.019
multicellular organismal reproductive process GO:0048609 40 0.019
organophosphate catabolic process GO:0046434 430 0.019
purine nucleoside monophosphate catabolic process GO:0009128 158 0.019
regulation of peptidyl serine phosphorylation GO:0033135 50 0.019
neuroblast proliferation GO:0007405 4 0.019
positive regulation of intracellular transport GO:0032388 104 0.019
regulation of mitotic cell cycle phase transition GO:1901990 118 0.019
regulation of cellular response to stress GO:0080135 244 0.019
positive regulation of transport GO:0051050 336 0.019
protein localization to nucleus GO:0034504 136 0.019
cell cycle phase transition GO:0044770 173 0.018
morphogenesis of embryonic epithelium GO:0016331 4 0.018
meiotic nuclear division GO:0007126 10 0.018
negative regulation of protein processing GO:0010955 142 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
regulation of meiotic cell cycle GO:0051445 4 0.018
receptor mediated endocytosis GO:0006898 84 0.018
cellular response to radiation GO:0071478 65 0.018
negative regulation of cell cycle phase transition GO:1901988 89 0.018
internal peptidyl lysine acetylation GO:0018393 97 0.018
nucleoside monophosphate catabolic process GO:0009125 159 0.017
nucleus organization GO:0006997 28 0.017
regulation of protein localization GO:0032880 296 0.017
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
protein localization to organelle GO:0033365 280 0.017
rab protein signal transduction GO:0032482 4 0.017
protein modification by small protein removal GO:0070646 92 0.017
dna damage checkpoint GO:0000077 68 0.017
axis elongation GO:0003401 4 0.017
interspecies interaction between organisms GO:0044419 156 0.017
mitotic cell cycle checkpoint GO:0007093 68 0.016
multicellular organism reproduction GO:0032504 42 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.016
microtubule based process GO:0007017 210 0.016
protein glycosylation GO:0006486 62 0.016
heterochromatin assembly GO:0031507 6 0.016
tube closure GO:0060606 3 0.016
multicellular organismal aging GO:0010259 3 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
canonical wnt signaling pathway GO:0060070 116 0.016
peptidyl lysine acetylation GO:0018394 101 0.016
embryonic epithelial tube formation GO:0001838 4 0.016
regulation of developmental growth GO:0048638 30 0.016
intracellular protein transport GO:0006886 270 0.015
regulation of dephosphorylation GO:0035303 96 0.015
chordate embryonic development GO:0043009 34 0.015
Mouse
system process GO:0003008 349 0.015
actin filament based process GO:0030029 224 0.015
Worm
regulation of transcription by chromatin organization GO:0034401 1 0.015
mrna export from nucleus GO:0006406 29 0.015
locomotory behavior GO:0007626 1 0.015
placenta development GO:0001890 10 0.015
mapk cascade GO:0000165 288 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.014
axon development GO:0061564 34 0.014
rho protein signal transduction GO:0007266 26 0.014
wnt signaling pathway GO:0016055 156 0.014
regulation of chromatin assembly GO:0010847 2 0.014
regulation of jak stat cascade GO:0046425 44 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
nuclear export GO:0051168 69 0.014
long term memory GO:0007616 2 0.014
endocytosis GO:0006897 159 0.014
embryo development ending in birth or egg hatching GO:0009792 34 0.014
Mouse Worm
gene silencing by rna GO:0031047 26 0.014
neural tube closure GO:0001843 3 0.014
peptidyl serine phosphorylation GO:0018105 101 0.014
negative regulation of chromatin silencing GO:0031936 4 0.014
primary neural tube formation GO:0014020 3 0.014
g2 dna damage checkpoint GO:0031572 26 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.014
mrna transport GO:0051028 30 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
macromolecule glycosylation GO:0043413 63 0.014
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
regulation of rab gtpase activity GO:0032313 39 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
head development GO:0060322 108 0.013
protein autophosphorylation GO:0046777 123 0.013
ras protein signal transduction GO:0007265 73 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
protein deubiquitination GO:0016579 79 0.013
blood vessel morphogenesis GO:0048514 162 0.012
chromatin remodeling GO:0006338 55 0.012
protein targeting GO:0006605 187 0.012
innate immune response GO:0045087 178 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
atp metabolic process GO:0046034 176 0.012
negative regulation of protein maturation GO:1903318 142 0.012
regulation of rab protein signal transduction GO:0032483 39 0.012
response to hormone GO:0009725 175 0.012
regulation of meiosis GO:0040020 3 0.012
regulation of viral process GO:0050792 103 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
ribonucleoside triphosphate metabolic process GO:0009199 412 0.012
carbohydrate metabolic process GO:0005975 207 0.012
protein k48 linked deubiquitination GO:0071108 19 0.012
erbb signaling pathway GO:0038127 44 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
regulation of gtpase activity GO:0043087 180 0.012
multi organism reproductive process GO:0044703 54 0.012
regulation of ras gtpase activity GO:0032318 128 0.011
male sex differentiation GO:0046661 25 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
regulation of protein maturation GO:1903317 150 0.011
regulation of dna replication GO:0006275 68 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
developmental growth involved in morphogenesis GO:0060560 23 0.011
epithelial cell development GO:0002064 34 0.011
taxis GO:0042330 157 0.011
regulation of phosphatase activity GO:0010921 81 0.011
response to lipid GO:0033993 206 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
negative regulation of transport GO:0051051 176 0.011
nitrogen compound transport GO:0071705 191 0.011
regulation of nervous system development GO:0051960 88 0.010
regulation of cellular component size GO:0032535 82 0.010
regulation of cell activation GO:0050865 125 0.010
mitotic sister chromatid separation GO:0051306 18 0.010
regulation of nucleocytoplasmic transport GO:0046822 98 0.010
lymphocyte activation GO:0046649 133 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
ameboidal type cell migration GO:0001667 135 0.010
regulation of neuron projection development GO:0010975 57 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
response to organic cyclic compound GO:0014070 204 0.010

NIPBL disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.017
cancer DOID:162 167 0.011
cornelia de lange syndrome DOID:11725 5 0.000