Homo sapiens

38 known processes

NME4

non-metastatic cells 4, protein expressed in

(Aliases: NM23H4,nm23-H4,NDPK-D)

NME4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 38 0.726
positive regulation of camp biosynthetic process GO:0030819 35 0.627
nucleoside diphosphate phosphorylation GO:0006165 12 0.469
nucleoside phosphate biosynthetic process GO:1901293 109 0.380
nucleoside diphosphate metabolic process GO:0009132 16 0.320
pyrimidine ribonucleoside metabolic process GO:0046131 11 0.304
positive regulation of camp metabolic process GO:0030816 41 0.297
cellular amine metabolic process GO:0044106 41 0.261
organonitrogen compound biosynthetic process GO:1901566 200 0.259
positive regulation of epithelial cell proliferation GO:0050679 65 0.254
organophosphate biosynthetic process GO:0090407 163 0.236
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.231
pyrimidine nucleoside triphosphate biosynthetic process GO:0009148 1 0.202
camp biosynthetic process GO:0006171 47 0.200
positive regulation of cell proliferation GO:0008284 301 0.198
regulation of camp biosynthetic process GO:0030817 45 0.197
regulation of camp metabolic process GO:0030814 52 0.194
cyclic nucleotide biosynthetic process GO:0009190 61 0.189
epithelial cell proliferation GO:0050673 128 0.175
cyclic nucleotide metabolic process GO:0009187 82 0.172
positive regulation of developmental process GO:0051094 314 0.169
ribonucleoside triphosphate metabolic process GO:0009199 412 0.147
camp metabolic process GO:0046058 61 0.131
cellular amino acid metabolic process GO:0006520 116 0.129
ribonucleotide biosynthetic process GO:0009260 81 0.126
regulation of cellular amino acid metabolic process GO:0006521 6 0.126
skin development GO:0043588 76 0.121
purine ribonucleotide biosynthetic process GO:0009152 79 0.111
amine metabolic process GO:0009308 44 0.107
positive regulation of cellular component organization GO:0051130 376 0.104
epithelium development GO:0060429 227 0.103
regulation of epithelial cell proliferation GO:0050678 113 0.102
cellular ketone metabolic process GO:0042180 80 0.102
regulation of cellular amine metabolic process GO:0033238 11 0.100
guanosine containing compound metabolic process GO:1901068 244 0.097
negative regulation of multicellular organismal process GO:0051241 317 0.095
regulation of cell motility GO:2000145 299 0.095
keratinocyte differentiation GO:0030216 36 0.093
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.092
regulation of cellular ketone metabolic process GO:0010565 50 0.092
post embryonic development GO:0009791 2 0.092
carboxylic acid biosynthetic process GO:0046394 97 0.091
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.088
positive regulation of cellular amine metabolic process GO:0033240 7 0.087
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.086
hematopoietic or lymphoid organ development GO:0048534 186 0.086
cellular homeostasis GO:0019725 196 0.085
cyclic purine nucleotide metabolic process GO:0052652 60 0.082
regulation of mapk cascade GO:0043408 262 0.080
regulation of nucleotide biosynthetic process GO:0030808 50 0.079
regulation of cell differentiation GO:0045595 393 0.079
lipid biosynthetic process GO:0008610 177 0.078
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.076
positive regulation of phosphorylation GO:0042327 394 0.076
positive regulation of cell differentiation GO:0045597 211 0.075
negative regulation of cell proliferation GO:0008285 228 0.074
epidermis development GO:0008544 59 0.072
purine ribonucleoside biosynthetic process GO:0046129 23 0.072
nucleotide biosynthetic process GO:0009165 109 0.071
signal transduction by phosphorylation GO:0023014 297 0.071
purine ribonucleoside metabolic process GO:0046128 437 0.070
response to oxygen containing compound GO:1901700 369 0.070
regulation of locomotion GO:0040012 329 0.067
organic acid biosynthetic process GO:0016053 97 0.066
mapk cascade GO:0000165 288 0.065
response to hormone GO:0009725 175 0.063
positive regulation of mapk cascade GO:0043410 190 0.063
regulation of nucleotide metabolic process GO:0006140 269 0.062
positive regulation of epidermis development GO:0045684 11 0.061
purine nucleoside triphosphate metabolic process GO:0009144 412 0.059
regulation of cell development GO:0060284 161 0.059
negative regulation of apoptotic process GO:0043066 316 0.059
nucleotide phosphorylation GO:0046939 15 0.058
regulation of transferase activity GO:0051338 355 0.056
nervous system development GO:0007399 293 0.055
epithelial cell differentiation GO:0030855 141 0.055
regulation of cellular component movement GO:0051270 334 0.055
negative regulation of cellular protein metabolic process GO:0032269 353 0.054
cellular response to oxygen containing compound GO:1901701 276 0.054
regulation of cell migration GO:0030334 289 0.053
cellular response to oxidative stress GO:0034599 85 0.052
hemopoiesis GO:0030097 180 0.052
epidermal cell differentiation GO:0009913 45 0.052
carbohydrate derivative biosynthetic process GO:1901137 207 0.051
negative regulation of cell death GO:0060548 345 0.050
gtp metabolic process GO:0046039 239 0.049
protein autophosphorylation GO:0046777 123 0.049
negative regulation of developmental process GO:0051093 247 0.048
response to oxidative stress GO:0006979 121 0.048
positive regulation of cell projection organization GO:0031346 64 0.048
positive regulation of epithelial cell differentiation GO:0030858 14 0.048
cellular response to lipid GO:0071396 127 0.047
regulation of keratinocyte differentiation GO:0045616 11 0.047
pyrimidine ribonucleoside triphosphate metabolic process GO:0009208 2 0.047
positive regulation of cell development GO:0010720 92 0.046
immune system development GO:0002520 195 0.046
regulation of purine nucleotide metabolic process GO:1900542 264 0.046
oogenesis GO:0048477 2 0.046
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.045
negative regulation of phosphate metabolic process GO:0045936 267 0.045
protein oligomerization GO:0051259 173 0.044
Human
pyrimidine containing compound metabolic process GO:0072527 19 0.043
response to lipid GO:0033993 206 0.043
regulation of cell cycle process GO:0010564 266 0.041
peptidyl tyrosine phosphorylation GO:0018108 170 0.041
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.041
ctp metabolic process GO:0046036 1 0.040
negative regulation of programmed cell death GO:0043069 321 0.040
ribose phosphate biosynthetic process GO:0046390 82 0.040
pyrimidine nucleoside metabolic process GO:0006213 13 0.040
regulation of response to external stimulus GO:0032101 222 0.040
cellular response to fatty acid GO:0071398 8 0.039
epithelium migration GO:0090132 119 0.039
positive regulation of protein phosphorylation GO:0001934 313 0.038
regulation of vesicle mediated transport GO:0060627 130 0.037
regeneration GO:0031099 4 0.035
positive regulation of keratinocyte differentiation GO:0045618 6 0.035
tissue migration GO:0090130 119 0.035
mitochondrion organization GO:0007005 156 0.035
leukocyte differentiation GO:0002521 98 0.034
biological adhesion GO:0022610 331 0.033
regulation of binding GO:0051098 111 0.032
alpha amino acid metabolic process GO:1901605 72 0.032
ribonucleoside triphosphate catabolic process GO:0009203 391 0.031
lipid metabolic process GO:0006629 381 0.031
Human
pyrimidine containing compound biosynthetic process GO:0072528 4 0.031
negative regulation of leukocyte differentiation GO:1902106 24 0.031
protein homooligomerization GO:0051260 100 0.031
Human
positive regulation of cellular component movement GO:0051272 181 0.031
cell development GO:0048468 328 0.031
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.031
regulation of epidermis development GO:0045682 19 0.031
regulation of neuron projection development GO:0010975 57 0.031
purine containing compound biosynthetic process GO:0072522 88 0.030
negative regulation of cell differentiation GO:0045596 171 0.030
regulation of myeloid cell differentiation GO:0045637 81 0.029
myeloid leukocyte differentiation GO:0002573 60 0.029
positive regulation of cell migration GO:0030335 172 0.029
positive regulation of neurogenesis GO:0050769 49 0.028
ameboidal type cell migration GO:0001667 135 0.028
nucleoside triphosphate biosynthetic process GO:0009142 20 0.028
cell morphogenesis GO:0000902 296 0.028
negative regulation of immune system process GO:0002683 136 0.028
nitrogen compound transport GO:0071705 191 0.028
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
regulation of cell cycle GO:0051726 393 0.027
pyrimidine nucleotide metabolic process GO:0006220 6 0.027
negative regulation of protein modification process GO:0031400 200 0.027
purine nucleotide biosynthetic process GO:0006164 84 0.027
regulation of anatomical structure morphogenesis GO:0022603 286 0.027
response to acid chemical GO:0001101 66 0.027
regulation of epithelial cell differentiation GO:0030856 24 0.026
apoptotic signaling pathway GO:0097190 268 0.026
regulation of cell projection organization GO:0031344 107 0.026
negative regulation of cellular amine metabolic process GO:0033239 3 0.026
glycerophospholipid biosynthetic process GO:0046474 40 0.026
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.026
peptidyl tyrosine modification GO:0018212 170 0.025
transmembrane transport GO:0055085 399 0.025
response to growth hormone GO:0060416 11 0.025
cellular chemical homeostasis GO:0055082 180 0.025
female gamete generation GO:0007292 2 0.025
cell projection organization GO:0030030 252 0.025
regulation of protein localization GO:0032880 296 0.025
cellular modified amino acid metabolic process GO:0006575 64 0.025
cellular amino acid biosynthetic process GO:0008652 30 0.024
regulation of leukocyte differentiation GO:1902105 61 0.024
response to organonitrogen compound GO:0010243 156 0.024
dna repair GO:0006281 198 0.024
chromatin organization GO:0006325 351 0.023
regulation of mitotic cell cycle GO:0007346 189 0.023
cytokine production GO:0001816 247 0.023
response to nitrogen compound GO:1901698 184 0.023
negative regulation of catalytic activity GO:0043086 335 0.022
positive regulation of neuron differentiation GO:0045666 40 0.022
regulation of epithelial cell migration GO:0010632 93 0.022
positive regulation of cytokine production GO:0001819 167 0.022
purine nucleoside triphosphate catabolic process GO:0009146 392 0.022
growth GO:0040007 202 0.022
ribonucleoside triphosphate biosynthetic process GO:0009201 12 0.022
response to growth factor GO:0070848 205 0.022
cellular response to dna damage stimulus GO:0006974 379 0.022
integrin mediated signaling pathway GO:0007229 32 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.021
regulation of proteolysis GO:0030162 293 0.021
response to fatty acid GO:0070542 13 0.021
regulation of nervous system development GO:0051960 88 0.021
histone modification GO:0016570 251 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
immune response GO:0006955 307 0.021
cell adhesion GO:0007155 325 0.021
negative regulation of myeloid cell differentiation GO:0045638 42 0.021
dephosphorylation GO:0016311 209 0.021
cellular modified amino acid biosynthetic process GO:0042398 15 0.021
neurogenesis GO:0022008 169 0.021
nucleobase containing compound transport GO:0015931 51 0.021
response to other organism GO:0051707 261 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
small molecule biosynthetic process GO:0044283 157 0.020
inflammatory response GO:0006954 79 0.020
regulation of protein kinase activity GO:0045859 289 0.020
negative regulation of cellular component movement GO:0051271 106 0.020
regulation of neurogenesis GO:0050767 82 0.020
epithelial cell migration GO:0010631 119 0.020
purine ribonucleoside triphosphate biosynthetic process GO:0009206 11 0.020
positive regulation of immune system process GO:0002684 283 0.020
mitotic cell cycle phase transition GO:0044772 162 0.020
carbohydrate metabolic process GO:0005975 207 0.019
spermatid development GO:0007286 4 0.019
regulation of secretion by cell GO:1903530 177 0.019
myeloid cell differentiation GO:0030099 117 0.019
response to wounding GO:0009611 168 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
erk1 and erk2 cascade GO:0070371 104 0.019
mesenchyme development GO:0060485 59 0.019
positive regulation of locomotion GO:0040017 186 0.019
positive regulation of cell death GO:0010942 263 0.019
morphogenesis of embryonic epithelium GO:0016331 4 0.019
regulation of cellular response to stress GO:0080135 244 0.019
ion transmembrane transport GO:0034220 338 0.019
cellular lipid metabolic process GO:0044255 303 0.019
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.019
negative regulation of cell cycle GO:0045786 193 0.018
regulation of response to wounding GO:1903034 101 0.018
regulation of growth GO:0040008 165 0.018
organelle fission GO:0048285 149 0.018
positive regulation of transport GO:0051050 336 0.018
positive regulation of nervous system development GO:0051962 54 0.018
mitochondrial transport GO:0006839 60 0.018
endothelial cell proliferation GO:0001935 65 0.018
sensory perception of pain GO:0019233 4 0.018
chemical homeostasis GO:0048878 306 0.018
response to abiotic stimulus GO:0009628 336 0.018
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.018
purine containing compound catabolic process GO:0072523 411 0.018
negative regulation of transferase activity GO:0051348 124 0.017
glycerolipid metabolic process GO:0046486 107 0.017
positive regulation of epidermal cell differentiation GO:0045606 8 0.017
positive regulation of cell motility GO:2000147 177 0.017
atp metabolic process GO:0046034 176 0.017
nucleoside monophosphate catabolic process GO:0009125 159 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
positive regulation of neuron projection development GO:0010976 34 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.016
locomotory behavior GO:0007626 1 0.016
regulation of intracellular transport GO:0032386 195 0.016
oocyte development GO:0048599 1 0.016
glucose homeostasis GO:0042593 31 0.016
keratinization GO:0031424 2 0.016
nucleoside catabolic process GO:0009164 408 0.016
negative regulation of kinase activity GO:0033673 106 0.016
regulation of myeloid leukocyte differentiation GO:0002761 39 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
system process GO:0003008 349 0.016
regulation of erk1 and erk2 cascade GO:0070372 99 0.016
cell activation GO:0001775 213 0.016
regulation of kinase activity GO:0043549 314 0.016
regulation of cytokine production GO:0001817 232 0.016
spermatid differentiation GO:0048515 4 0.015
single organism cell adhesion GO:0098602 179 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
negative regulation of protein phosphorylation GO:0001933 140 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.015
actin filament based process GO:0030029 224 0.015
response to inorganic substance GO:0010035 127 0.015
regulation of reactive oxygen species metabolic process GO:2000377 41 0.015
purine nucleoside biosynthetic process GO:0042451 23 0.015
regulation of epidermal cell differentiation GO:0045604 15 0.015
ribonucleoside biosynthetic process GO:0042455 25 0.015
phospholipid metabolic process GO:0006644 99 0.015
unsaturated fatty acid metabolic process GO:0033559 37 0.015
ras protein signal transduction GO:0007265 73 0.015
chromatin modification GO:0016568 298 0.015
regulation of secretion GO:0051046 194 0.014
regulation of neuron differentiation GO:0045664 70 0.014
cellular macromolecule catabolic process GO:0044265 380 0.014
protein secretion GO:0009306 98 0.014
cellular component morphogenesis GO:0032989 314 0.014
negative regulation of cell migration GO:0030336 102 0.014
regulation of defense response GO:0031347 154 0.014
aminoglycan metabolic process GO:0006022 39 0.014
anion transport GO:0006820 161 0.014
cell type specific apoptotic process GO:0097285 125 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
response to carbohydrate GO:0009743 21 0.014
engulfment of apoptotic cell GO:0043652 2 0.014
organophosphate catabolic process GO:0046434 430 0.014
negative regulation of cell motility GO:2000146 104 0.014
negative regulation of proteolysis GO:0045861 132 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
determination of adult lifespan GO:0008340 2 0.013
regulation of multi organism process GO:0043900 157 0.013
peptidyl serine phosphorylation GO:0018105 101 0.013
purine nucleotide catabolic process GO:0006195 405 0.013
endothelial cell migration GO:0043542 86 0.013
gtp catabolic process GO:0006184 237 0.013
cellular glucose homeostasis GO:0001678 11 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
response to light stimulus GO:0009416 87 0.013
regulation of proteasomal protein catabolic process GO:0061136 87 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
endocytosis GO:0006897 159 0.013
cell growth GO:0016049 160 0.013
muscle tissue development GO:0060537 62 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
cell division GO:0051301 168 0.013
protein localization to organelle GO:0033365 280 0.013
multicellular organismal aging GO:0010259 3 0.013
stress activated protein kinase signaling cascade GO:0031098 94 0.013
multi organism cellular process GO:0044764 156 0.013
fibroblast proliferation GO:0048144 33 0.013
regulation of cell division GO:0051302 116 0.013
cellular response to acid chemical GO:0071229 44 0.013
response to peptide hormone GO:0043434 61 0.013
regulation of cell adhesion GO:0030155 166 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
mitotic nuclear division GO:0007067 119 0.012
response to biotic stimulus GO:0009607 276 0.012
regulation of immune response GO:0050776 201 0.012
regulation of response to dna damage stimulus GO:2001020 94 0.012
cellular response to hydrogen peroxide GO:0070301 37 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
response to monosaccharide GO:0034284 20 0.012
generation of neurons GO:0048699 152 0.012
phospholipid biosynthetic process GO:0008654 44 0.012
response to reactive oxygen species GO:0000302 61 0.012
circadian behavior GO:0048512 2 0.012
response to radiation GO:0009314 151 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
innate immune response GO:0045087 178 0.012
immune effector process GO:0002252 159 0.012
regulation of cell growth GO:0001558 135 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
neuromuscular junction development GO:0007528 3 0.012
neuron projection development GO:0031175 106 0.012
regulation of protein maturation GO:1903317 150 0.012
embryo development GO:0009790 123 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
cytokine secretion GO:0050663 64 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
cellular response to glucose stimulus GO:0071333 10 0.011
vitamin metabolic process GO:0006766 26 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
defense response GO:0006952 315 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
regulation of endocytosis GO:0030100 72 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
neural tube formation GO:0001841 3 0.011
protein kinase b signaling GO:0043491 69 0.011
protein targeting GO:0006605 187 0.011
blastoderm segmentation GO:0007350 2 0.011
response to hexose GO:0009746 20 0.011
regulation of dna metabolic process GO:0051052 153 0.011
cell fate determination GO:0001709 3 0.011
response to peptide GO:1901652 65 0.011
secretion by cell GO:0032940 226 0.011
rna transport GO:0050658 39 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
glycerolipid biosynthetic process GO:0045017 51 0.011
response to axon injury GO:0048678 1 0.011
peptidyl serine modification GO:0018209 106 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
vesicle mediated transport GO:0016192 371 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.011
peripheral nervous system development GO:0007422 2 0.011
meiosis i GO:0007127 4 0.011
rho protein signal transduction GO:0007266 26 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
maintenance of location GO:0051235 112 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
neuron differentiation GO:0030182 138 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.011
blood circulation GO:0008015 113 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.010
glycoprotein metabolic process GO:0009100 110 0.010
regulation of protein catabolic process GO:0042176 155 0.010
negative regulation of protein maturation GO:1903318 142 0.010
establishment of rna localization GO:0051236 39 0.010
positive regulation of kinase activity GO:0033674 204 0.010
positive regulation of transferase activity GO:0051347 227 0.010
cofactor metabolic process GO:0051186 87 0.010
rna processing GO:0006396 255 0.010
regulation of protein serine threonine kinase activity GO:0071900 179 0.010
ribonucleoside catabolic process GO:0042454 406 0.010
single organism cellular localization GO:1902580 332 0.010
sensory perception GO:0007600 103 0.010
negative regulation of catabolic process GO:0009895 104 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
cell cycle phase transition GO:0044770 173 0.010
positive regulation of epithelial cell migration GO:0010634 55 0.010
regulation of angiogenesis GO:0045765 92 0.010
neuron development GO:0048666 113 0.010
myeloid leukocyte migration GO:0097529 62 0.010
monocarboxylic acid metabolic process GO:0032787 185 0.010
Human
chemotaxis GO:0006935 157 0.010
cytoplasmic transport GO:0016482 379 0.010
response to uv GO:0009411 73 0.010
embryonic epithelial tube formation GO:0001838 4 0.010

NME4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.086
amino acid metabolic disorder DOID:9252 50 0.086
inherited metabolic disorder DOID:655 242 0.086
cancer DOID:162 167 0.040
disease of cellular proliferation DOID:14566 174 0.040
organ system cancer DOID:0050686 164 0.025
central nervous system disease DOID:331 186 0.017
nervous system disease DOID:863 431 0.017
musculoskeletal system disease DOID:17 223 0.016
immune system disease DOID:2914 155 0.011
hematopoietic system disease DOID:74 100 0.011