Homo sapiens

83 known processes

NOTCH2

notch 2

(Aliases: AGS2,hN2)

NOTCH2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cardiac right ventricle morphogenesis GO:0003215 3 0.995
spinal cord dorsal ventral patterning GO:0021513 2 0.934
notch signaling involved in heart development GO:0061314 2 0.892
Human
cell fate commitment involved in pattern specification GO:0060581 1 0.883
Fly
aortic valve development GO:0003176 3 0.806
Human
spinal cord development GO:0021510 4 0.773
negative regulation of endothelial cell chemotaxis GO:2001027 4 0.757
Human
neuron fate commitment GO:0048663 2 0.755
glial cell migration GO:0008347 4 0.706
Fly
pulmonary artery morphogenesis GO:0061156 3 0.685
loop of henle development GO:0072070 2 0.590
cell differentiation in spinal cord GO:0021515 1 0.506
positive regulation of cell fate specification GO:0042660 2 0.504
hair cell differentiation GO:0035315 2 0.486
neural crest cell development GO:0014032 3 0.477
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.463
Human
ventral spinal cord development GO:0021517 1 0.455
ventral spinal cord interneuron differentiation GO:0021514 1 0.455
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.450
endocardial cushion development GO:0003197 3 0.448
pulmonary valve development GO:0003177 5 0.448
regulation of meiotic cell cycle GO:0051445 4 0.442
distal tubule development GO:0072017 4 0.418
mitral valve development GO:0003174 3 0.393
Human
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.381
negative regulation of stem cell differentiation GO:2000737 22 0.336
Human
segmentation GO:0035282 4 0.324
Fly
mesodermal cell fate commitment GO:0001710 2 0.301
negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 6 0.296
Human
response to growth factor GO:0070848 205 0.261
Human
cardioblast cell fate commitment GO:0042684 1 0.246
Fly
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.225
mesenchymal cell development GO:0014031 50 0.221
Human
regulation of cell migration GO:0030334 289 0.214
Human
regulation of locomotion GO:0040012 329 0.212
Human
motor neuron axon guidance GO:0008045 2 0.206
Fly
peripheral nervous system development GO:0007422 2 0.204
Fly
regulation of cytokine production GO:0001817 232 0.202
regulation of meiosis GO:0040020 3 0.197
kidney epithelium development GO:0072073 25 0.196
Mouse
negative regulation of locomotion GO:0040013 118 0.192
Human
cardiovascular system development GO:0072358 262 0.189
endothelial cell migration GO:0043542 86 0.188
Human
ventricular septum morphogenesis GO:0060412 3 0.188
Human
t cell differentiation in thymus GO:0033077 4 0.183
cellular amine metabolic process GO:0044106 41 0.183
negative regulation of endothelial cell migration GO:0010596 29 0.179
Human
regulation of cardioblast differentiation GO:0051890 4 0.177
Fly
somatic stem cell maintenance GO:0035019 4 0.176
vasculature development GO:0001944 181 0.174
Human Zebrafish Mouse
nephron epithelium development GO:0072009 23 0.173
Mouse
regulation of cell adhesion GO:0030155 166 0.173
Human
circulatory system development GO:0072359 262 0.171
regulation of cellular amine metabolic process GO:0033238 11 0.168
regulation of cellular ketone metabolic process GO:0010565 50 0.167
regulation of cellular amino acid metabolic process GO:0006521 6 0.166
cellular response to growth factor stimulus GO:0071363 197 0.164
Human
immune response GO:0006955 307 0.163
Mouse
negative regulation of interleukin 10 production GO:0032693 7 0.162
negative regulation of developmental process GO:0051093 247 0.161
Human Fly
actin filament based process GO:0030029 224 0.158
Fly
cell development GO:0048468 328 0.157
Human Mouse Fly
blood vessel development GO:0001568 172 0.157
Human Mouse
organ morphogenesis GO:0009887 147 0.154
ras protein signal transduction GO:0007265 73 0.150
positive regulation of protein phosphorylation GO:0001934 313 0.148
heart formation GO:0060914 2 0.147
negative regulation of epithelial cell migration GO:0010633 38 0.147
Human
blood vessel morphogenesis GO:0048514 162 0.145
Human Mouse
regulation of stem cell differentiation GO:2000736 56 0.144
Human Fly
regulation of endothelial cell migration GO:0010594 67 0.144
Human
immune effector process GO:0002252 159 0.143
cellular amino acid metabolic process GO:0006520 116 0.142
amine metabolic process GO:0009308 44 0.141
cardiac right ventricle formation GO:0003219 1 0.140
tube development GO:0035295 125 0.140
Human Mouse Fly
enzyme linked receptor protein signaling pathway GO:0007167 303 0.139
Mouse
epithelial cell differentiation GO:0030855 141 0.139
Mouse Fly
cardiac cell fate specification GO:0060912 1 0.139
Fly
negative regulation of cell migration GO:0030336 102 0.138
Human
kidney development GO:0001822 53 0.137
Mouse
cellular ketone metabolic process GO:0042180 80 0.130
cell division GO:0051301 168 0.130
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.128
Zebrafish
salivary gland morphogenesis GO:0007435 4 0.128
negative regulation of cell proliferation GO:0008285 228 0.127
response to fibroblast growth factor GO:0071774 39 0.127
positive regulation of cell proliferation GO:0008284 301 0.127
Human Mouse Fly
negative regulation of cell differentiation GO:0045596 171 0.125
Human Fly
pulmonary valve morphogenesis GO:0003184 5 0.124
regulation of cell motility GO:2000145 299 0.122
Human
urogenital system development GO:0001655 65 0.121
Mouse Fly
mesodermal cell fate specification GO:0007501 2 0.120
renal tubule development GO:0061326 19 0.116
Mouse Fly
digestive tract development GO:0048565 75 0.115
Fly
muscle cell fate commitment GO:0042693 4 0.115
Fly
mitral valve morphogenesis GO:0003183 2 0.115
Human
negative regulation of cell motility GO:2000146 104 0.115
Human
tissue morphogenesis GO:0048729 96 0.114
Mouse Fly
cell fate determination GO:0001709 3 0.114
Rat Fly
compound eye development GO:0048749 1 0.111
Fly
cell substrate adhesion GO:0031589 132 0.111
Human
cardiac ventricle formation GO:0003211 2 0.110
cytokine production GO:0001816 247 0.109
Mouse
t cell selection GO:0045058 4 0.107
sprouting angiogenesis GO:0002040 29 0.106
Human
actin cytoskeleton organization GO:0030036 207 0.106
Fly
digestive system development GO:0055123 75 0.105
Fly
negative regulation of multicellular organismal process GO:0051241 317 0.105
Human Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.104
Human Fly
aorta morphogenesis GO:0035909 1 0.104
regulation of cellular component movement GO:0051270 334 0.103
Human
negative regulation of cellular component movement GO:0051271 106 0.103
Human
defense response GO:0006952 315 0.102
Mouse
mitotic cell cycle GO:0000278 326 0.101
Fly
endochondral bone morphogenesis GO:0060350 3 0.100
Zebrafish
organ formation GO:0048645 3 0.100
Fly
regulation of epithelial cell migration GO:0010632 93 0.097
Human
post embryonic development GO:0009791 2 0.097
Fly
neuronal stem cell maintenance GO:0097150 5 0.097
Human
cell migration involved in sprouting angiogenesis GO:0002042 19 0.096
Human
negative regulation of vasculature development GO:1901343 43 0.096
Human
heart morphogenesis GO:0003007 48 0.096
response to oxygen containing compound GO:1901700 369 0.094
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.093
tube morphogenesis GO:0035239 95 0.092
Human Mouse Fly
cellular response to endogenous stimulus GO:0071495 336 0.091
Human
positive regulation of developmental process GO:0051094 314 0.091
Human Mouse
neuroblast proliferation GO:0007405 4 0.089
negative regulation of angiogenesis GO:0016525 39 0.088
Human
mesenchymal cell differentiation GO:0048762 52 0.087
Human
regulation of cell cycle GO:0051726 393 0.087
epithelial cell fate commitment GO:0072148 3 0.087
regulation of myeloid cell differentiation GO:0045637 81 0.086
Mouse
blastoderm segmentation GO:0007350 2 0.085
semicircular canal morphogenesis GO:0048752 1 0.085
cellular component morphogenesis GO:0032989 314 0.084
Human Fly
angiogenesis GO:0001525 147 0.083
Human Mouse
ameboidal type cell migration GO:0001667 135 0.082
Human Fly
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.082
regulation of cellular component biogenesis GO:0044087 281 0.082
Fly
memory GO:0007613 3 0.082
Fly
prostate gland morphogenesis GO:0060512 1 0.081
cell projection organization GO:0030030 252 0.080
Fly
regeneration GO:0031099 4 0.080
Zebrafish Rat
anatomical structure formation involved in morphogenesis GO:0048646 284 0.080
Human Mouse Fly
inner ear morphogenesis GO:0042472 4 0.080
ventral spinal cord interneuron fate commitment GO:0060579 1 0.079
pancreas development GO:0031016 19 0.079
regulation of cell differentiation GO:0045595 393 0.079
Human Mouse Fly
oogenesis GO:0048477 2 0.078
Fly
epithelium migration GO:0090132 119 0.078
Human Fly
negative regulation of catalytic activity GO:0043086 335 0.078
thymic t cell selection GO:0045061 2 0.077
cardioblast cell fate specification GO:0042685 1 0.077
Fly
heart valve development GO:0003170 8 0.075
cell proliferation in forebrain GO:0021846 1 0.075
determination of adult lifespan GO:0008340 2 0.075
Fly
mesenchyme development GO:0060485 59 0.075
Human
cardiac chamber formation GO:0003207 2 0.073
cell morphogenesis involved in differentiation GO:0000904 144 0.073
Human Fly
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 2 0.073
digestive tract morphogenesis GO:0048546 56 0.072
Fly
regulation of transferase activity GO:0051338 355 0.072
nervous system development GO:0007399 293 0.072
Fly
positive regulation of cell differentiation GO:0045597 211 0.071
Human Mouse
negative regulation of cell development GO:0010721 48 0.070
Fly
i kappab phosphorylation GO:0007252 7 0.068
Fly
cell adhesion GO:0007155 325 0.067
Human Fly
response to organonitrogen compound GO:0010243 156 0.067
regulation of cell development GO:0060284 161 0.066
Human Fly
pericardium development GO:0060039 2 0.066
response to other organism GO:0051707 261 0.066
Mouse Fly
positive regulation of neural precursor cell proliferation GO:2000179 2 0.065
spinal cord patterning GO:0021511 2 0.065
positive regulation of locomotion GO:0040017 186 0.064
blood vessel endothelial cell migration GO:0043534 42 0.064
Human
cell chemotaxis GO:0060326 112 0.063
Human
system process GO:0003008 349 0.063
Fly
actin filament organization GO:0007015 128 0.063
Fly
negative regulation of programmed cell death GO:0043069 321 0.063
Human
heart valve morphogenesis GO:0003179 8 0.063
hair follicle morphogenesis GO:0031069 2 0.063
renal system development GO:0072001 63 0.062
Mouse Fly
cell projection morphogenesis GO:0048858 129 0.062
Fly
somatic stem cell division GO:0048103 1 0.062
ventricular trabecula myocardium morphogenesis GO:0003222 1 0.061
response to muramyl dipeptide GO:0032495 4 0.061
regulation of cell division GO:0051302 116 0.060
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.060
tissue migration GO:0090130 119 0.060
Human Fly
myeloid cell differentiation GO:0030099 117 0.059
Mouse
regulation of neurogenesis GO:0050767 82 0.059
Fly
notch signaling pathway GO:0007219 31 0.058
Human Fly
organelle fission GO:0048285 149 0.058
cell growth GO:0016049 160 0.057
leukocyte activation GO:0045321 164 0.056
Mouse
head development GO:0060322 108 0.056
Zebrafish
multicellular organismal aging GO:0010259 3 0.056
Fly
canonical wnt signaling pathway GO:0060070 116 0.055
nephron development GO:0072006 30 0.055
Mouse
embryonic morphogenesis GO:0048598 85 0.055
Mouse Fly
stem cell development GO:0048864 69 0.054
Human Fly
cardiac conduction system development GO:0003161 2 0.054
cardiac septum morphogenesis GO:0060411 9 0.054
negative regulation of apoptotic process GO:0043066 316 0.054
Human
positive regulation of notch signaling pathway GO:0045747 6 0.054
Fly
regulation of ossification GO:0030278 58 0.054
cell morphogenesis GO:0000902 296 0.054
Human Fly
positive regulation of transport GO:0051050 336 0.053
neurogenesis GO:0022008 169 0.053
Fly
regulation of heart growth GO:0060420 4 0.053
regulation of endothelial cell differentiation GO:0045601 4 0.052
positive regulation of cellular component movement GO:0051272 181 0.052
negative regulation of bmp signaling pathway GO:0030514 17 0.051
epithelial cell migration GO:0010631 119 0.051
Human Fly
blood vessel remodeling GO:0001974 2 0.051
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.051
purine nucleotide catabolic process GO:0006195 405 0.050
specification of organ identity GO:0010092 3 0.050
regulation of ras protein signal transduction GO:0046578 155 0.050
nucleoside triphosphate catabolic process GO:0009143 394 0.049
purine ribonucleoside metabolic process GO:0046128 437 0.049
embryonic heart tube morphogenesis GO:0003143 8 0.049
Mouse
adaptive immune response GO:0002250 49 0.049
regulation of neural precursor cell proliferation GO:2000177 4 0.049
vesicle mediated transport GO:0016192 371 0.049
endocardial cushion cell differentiation GO:0061443 1 0.049
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.048
Mouse
regulation of angiogenesis GO:0045765 92 0.048
Human
cellular macromolecular complex assembly GO:0034622 324 0.048
chemotaxis GO:0006935 157 0.048
Human Fly
negative regulation of protein metabolic process GO:0051248 391 0.047
generation of neurons GO:0048699 152 0.047
Fly
positive regulation of nucleoside metabolic process GO:0045979 186 0.047
response to nitrogen compound GO:1901698 184 0.047
regulation of blood vessel endothelial cell migration GO:0043535 30 0.046
Human
epidermis morphogenesis GO:0048730 3 0.046
hematopoietic or lymphoid organ development GO:0048534 186 0.046
Mouse Fly
taxis GO:0042330 157 0.046
Human Fly
positive regulation of osteoblast differentiation GO:0045669 23 0.046
central nervous system development GO:0007417 123 0.046
skin development GO:0043588 76 0.045
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.045
morphogenesis of an epithelium GO:0002009 60 0.045
Mouse Fly
regulation of wnt signaling pathway GO:0030111 123 0.045
cell cell signaling GO:0007267 155 0.045
Fly
secretion GO:0046903 254 0.045
Mouse
positive regulation of cellular component organization GO:0051130 376 0.045
Human
regulation of kinase activity GO:0043549 314 0.045
negative regulation of blood vessel endothelial cell migration GO:0043537 16 0.045
Human
heart development GO:0007507 95 0.045
regulation of cardiac muscle cell proliferation GO:0060043 4 0.044
lateral mesoderm development GO:0048368 1 0.044
regulation of organ formation GO:0003156 4 0.044
osteoblast differentiation GO:0001649 92 0.044
positive regulation of phosphorylation GO:0042327 394 0.044
cardiac epithelial to mesenchymal transition GO:0060317 3 0.043
negative regulation of gliogenesis GO:0014014 3 0.043
cardiac endothelial cell differentiation GO:0003348 2 0.043
response to lipid GO:0033993 206 0.043
cellular response to gonadotropin stimulus GO:0071371 4 0.043
Human
t cell activation GO:0042110 99 0.043
positive regulation of cytokine production GO:0001819 167 0.042
regulation of nucleotide metabolic process GO:0006140 269 0.042
purine ribonucleotide catabolic process GO:0009154 404 0.042
stem cell differentiation GO:0048863 93 0.042
Human Fly
ribonucleoside catabolic process GO:0042454 406 0.042
cardiocyte differentiation GO:0035051 23 0.042
Fly
epidermal cell differentiation GO:0009913 45 0.042
neuromuscular junction development GO:0007528 3 0.042
cell projection assembly GO:0030031 126 0.042
Fly
cardiac muscle cell fate commitment GO:0060923 4 0.041
endodermal cell differentiation GO:0035987 31 0.041
t cell mediated immunity GO:0002456 25 0.041
leukocyte mediated immunity GO:0002443 59 0.041
regulation of astrocyte differentiation GO:0048710 3 0.041
atrioventricular valve morphogenesis GO:0003181 2 0.041
Human
ossification GO:0001503 121 0.041
neuron projection development GO:0031175 106 0.041
Fly
wnt signaling pathway GO:0016055 156 0.041
response to abiotic stimulus GO:0009628 336 0.041
regulation of protein localization GO:0032880 296 0.041
gastrulation GO:0007369 51 0.041
regulation of mapk cascade GO:0043408 262 0.041
gland development GO:0048732 48 0.040
Human Zebrafish Fly
cardiac ventricle morphogenesis GO:0003208 20 0.040
mapk cascade GO:0000165 288 0.040
purine nucleoside triphosphate catabolic process GO:0009146 392 0.040
somitogenesis GO:0001756 2 0.039
ribonucleoside triphosphate metabolic process GO:0009199 412 0.039
intracellular protein transport GO:0006886 270 0.039
positive regulation of cell migration GO:0030335 172 0.039
regulation of striated muscle cell differentiation GO:0051153 25 0.039
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.039
epithelial to mesenchymal transition GO:0001837 48 0.039
Human
cytoplasmic transport GO:0016482 379 0.038
regulation of endodermal cell fate specification GO:0042663 1 0.038
epithelium development GO:0060429 227 0.038
Mouse Fly
regulation of proteolysis GO:0030162 293 0.038
organophosphate catabolic process GO:0046434 430 0.038
ribonucleotide catabolic process GO:0009261 405 0.038
positive regulation of ossification GO:0045778 32 0.038
signal transduction by phosphorylation GO:0023014 297 0.038
regulation of cell cycle process GO:0010564 266 0.038
Fly
response to organic cyclic compound GO:0014070 204 0.038
nephric duct development GO:0072176 4 0.037
cardiac vascular smooth muscle cell differentiation GO:0060947 2 0.037
atrioventricular valve formation GO:0003190 1 0.037
Human
proximal tubule development GO:0072014 1 0.036
Mouse
regulation of nervous system development GO:0051960 88 0.036
Fly
regulation of canonical wnt signaling pathway GO:0060828 88 0.036
gtp metabolic process GO:0046039 239 0.036
positive regulation of hydrolase activity GO:0051345 331 0.036
negative regulation of cell adhesion GO:0007162 64 0.036
Human
biological adhesion GO:0022610 331 0.036
Human Fly
regulation of purine nucleotide metabolic process GO:1900542 264 0.035
regulation of epithelial cell proliferation GO:0050678 113 0.035
cell surface receptor signaling pathway involved in heart development GO:0061311 8 0.035
Human
venous blood vessel development GO:0060841 2 0.035
response to biotic stimulus GO:0009607 276 0.035
Mouse Fly
negative regulation of blood vessel morphogenesis GO:2000181 41 0.035
Human
lymphocyte activation GO:0046649 133 0.035
dorsal ventral pattern formation GO:0009953 15 0.035
Fly
cuticle development GO:0042335 1 0.035
regulation of epithelial to mesenchymal transition GO:0010717 37 0.035
Human
positive regulation of cellular catabolic process GO:0031331 284 0.035
neuron differentiation GO:0030182 138 0.035
Fly
photoreceptor cell differentiation GO:0046530 2 0.034
Fly
positive regulation of kinase activity GO:0033674 204 0.034
protein localization to organelle GO:0033365 280 0.034
negative regulation of cytokine production GO:0001818 82 0.034
regulation of small gtpase mediated signal transduction GO:0051056 156 0.034
positive regulation of cell fate commitment GO:0010455 2 0.034
t cell differentiation GO:0030217 29 0.034
negative regulation of phosphate metabolic process GO:0045936 267 0.034
negative regulation of cell cycle GO:0045786 193 0.034
ion transmembrane transport GO:0034220 338 0.034
regulation of cellular response to growth factor stimulus GO:0090287 76 0.034
cell part morphogenesis GO:0032990 137 0.033
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.033
Mouse
trabecula morphogenesis GO:0061383 2 0.033
regulation of neuroblast proliferation GO:1902692 3 0.033
regulation of cell morphogenesis GO:0022604 153 0.033
Human
regulation of nucleoside metabolic process GO:0009118 209 0.033
growth GO:0040007 202 0.033
muscle structure development GO:0061061 98 0.033
Human Fly
negative regulation of phosphorus metabolic process GO:0010563 267 0.032
regulation of muscle cell differentiation GO:0051147 31 0.032
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.032
regulation of osteoblast differentiation GO:0045667 38 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
regulation of cardiac cell fate specification GO:2000043 1 0.031
Fly
regulation of growth GO:0040008 165 0.031
Fly
regulation of nuclear division GO:0051783 65 0.031
developmental programmed cell death GO:0010623 3 0.031
cell cycle phase transition GO:0044770 173 0.031
Fly
cell activation GO:0001775 213 0.031
Mouse
regulation of heart morphogenesis GO:2000826 4 0.031
secretion by cell GO:0032940 226 0.031
Mouse
muscle tissue development GO:0060537 62 0.031
Human Fly
positive regulation of cellular amine metabolic process GO:0033240 7 0.031
positive regulation of myeloid cell differentiation GO:0045639 39 0.031
Mouse
pronephros development GO:0048793 2 0.030
positive regulation of catabolic process GO:0009896 310 0.030
hematopoietic stem cell differentiation GO:0060218 4 0.030
protein targeting GO:0006605 187 0.030
nucleoside catabolic process GO:0009164 408 0.030
chemical homeostasis GO:0048878 306 0.030
purine nucleoside catabolic process GO:0006152 398 0.030
endocardial cell differentiation GO:0060956 2 0.030
negative regulation of hydrolase activity GO:0051346 182 0.030
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.029
negative regulation of protein maturation GO:1903318 142 0.029
regulation of muscle organ development GO:0048634 27 0.029
Human
protein maturation GO:0051604 233 0.029
regulation of nucleotide catabolic process GO:0030811 205 0.029
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.029
nucleotide catabolic process GO:0009166 408 0.029
hemopoiesis GO:0030097 180 0.029
Mouse Fly
regulation of behavior GO:0050795 82 0.029
Human
positive regulation of cell adhesion GO:0045785 84 0.029
protein processing GO:0016485 226 0.029
regulation of glial cell proliferation GO:0060251 4 0.029
regulation of glial cell differentiation GO:0045685 3 0.028
nucleoside phosphate catabolic process GO:1901292 412 0.028
i kappab kinase nf kappab signaling GO:0007249 166 0.028
Fly
regulation of protein maturation GO:1903317 150 0.028
cellular macromolecule catabolic process GO:0044265 380 0.028
g1 s transition of mitotic cell cycle GO:0000082 78 0.028
Fly
positive regulation of protein kinase activity GO:0045860 190 0.028
regulation of chemotaxis GO:0050920 74 0.028
Human
regulation of cardiac muscle tissue growth GO:0055021 4 0.028
leukocyte differentiation GO:0002521 98 0.028
Mouse
regulation of vesicle mediated transport GO:0060627 130 0.028
atrioventricular valve development GO:0003171 3 0.028
Human
transmembrane transport GO:0055085 399 0.028
innate immune response GO:0045087 178 0.028
anterior posterior axis specification GO:0009948 2 0.028
positive regulation of neuroblast proliferation GO:0002052 2 0.028
regulation of mesodermal cell fate specification GO:0042661 2 0.028
positive regulation of cell development GO:0010720 92 0.027
Human
determination of left right asymmetry in lateral mesoderm GO:0003140 1 0.027
negative regulation of glial cell differentiation GO:0045686 1 0.027
connective tissue development GO:0061448 39 0.027
Zebrafish
ribonucleoside triphosphate catabolic process GO:0009203 391 0.027
epidermis development GO:0008544 59 0.027
regulation of ras gtpase activity GO:0032318 128 0.027
response to wounding GO:0009611 168 0.027
Zebrafish Mouse Rat
positive regulation of programmed cell death GO:0043068 249 0.027
Mouse
positive regulation of gliogenesis GO:0014015 4 0.027
cardiac chamber development GO:0003205 30 0.027
negative regulation of cellular amine metabolic process GO:0033239 3 0.027
cation transmembrane transport GO:0098655 238 0.027
positive regulation of nucleotide catabolic process GO:0030813 185 0.026
single organism cellular localization GO:1902580 332 0.026
purine nucleoside triphosphate metabolic process GO:0009144 412 0.026
retinal ganglion cell axon guidance GO:0031290 2 0.026
gtp catabolic process GO:0006184 237 0.026
regulation of neuron differentiation GO:0045664 70 0.026
Fly
regulation of purine nucleotide catabolic process GO:0033121 205 0.026
cation transport GO:0006812 331 0.026
cardiac septum development GO:0003279 13 0.026
regulation of protein transport GO:0051223 213 0.026
regulation of protein catabolic process GO:0042176 155 0.026
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.026
Human
regulation of response to external stimulus GO:0032101 222 0.025
Human
regulation of establishment of protein localization GO:0070201 242 0.025
hepaticobiliary system development GO:0061008 10 0.025
Zebrafish
myoblast differentiation GO:0045445 21 0.025
Human
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.025
artery morphogenesis GO:0048844 7 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.025
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.025
establishment of protein localization to organelle GO:0072594 172 0.025
negative regulation of wnt signaling pathway GO:0030178 69 0.025
epithelial cell proliferation GO:0050673 128 0.025
Fly
bone development GO:0060348 26 0.025
Zebrafish
negative regulation of neuron differentiation GO:0045665 21 0.025
Fly
embryo development GO:0009790 123 0.025
Mouse Fly
negative regulation of cell death GO:0060548 345 0.025
Human
negative regulation of glial cell proliferation GO:0060253 2 0.025
vascular smooth muscle cell development GO:0097084 1 0.025
regulation of epithelial cell differentiation GO:0030856 24 0.025
multi organism cellular process GO:0044764 156 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.024
metal ion transport GO:0030001 272 0.024
oocyte differentiation GO:0009994 2 0.024
regulation of fat cell differentiation GO:0045598 23 0.024
cardiac muscle tissue development GO:0048738 39 0.024
semicircular canal development GO:0060872 1 0.024
nephron tubule development GO:0072080 17 0.024
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.024
regulation of cell growth GO:0001558 135 0.024
astrocyte differentiation GO:0048708 4 0.024
secondary heart field specification GO:0003139 2 0.024
dephosphorylation GO:0016311 209 0.024
cellular response to hormone stimulus GO:0032870 125 0.024
Human
locomotory behavior GO:0007626 1 0.024
female gamete generation GO:0007292 2 0.024
Fly
pituitary gland development GO:0021983 2 0.024
reproductive process GO:0022414 106 0.024
Mouse Fly
response to hormone GO:0009725 175 0.024
Human
response to peptide GO:1901652 65 0.024
fat cell differentiation GO:0045444 32 0.023
protein ubiquitination GO:0016567 314 0.023
hindlimb morphogenesis GO:0035137 2 0.023
positive regulation of cardiac muscle cell differentiation GO:2000727 4 0.023
inorganic cation transmembrane transport GO:0098662 194 0.023
response to external biotic stimulus GO:0043207 261 0.023
Mouse Fly
negative regulation of neurogenesis GO:0050768 26 0.023
Fly
positive regulation of cell death GO:0010942 263 0.023
Mouse
regulation of cytoskeleton organization GO:0051493 177 0.023
sensory organ development GO:0007423 52 0.023
Mouse Fly
regulation of peptidase activity GO:0052547 180 0.023
negative regulation of protein modification process GO:0031400 200 0.023
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.023
aorta development GO:0035904 2 0.023
nucleocytoplasmic transport GO:0006913 176 0.023
epithelial cell development GO:0002064 34 0.023
Mouse Fly
single organism reproductive process GO:0044702 98 0.023
Mouse Fly
regulation of cell substrate adhesion GO:0010810 68 0.023
Human
cilium morphogenesis GO:0060271 75 0.023
glycosyl compound catabolic process GO:1901658 413 0.022

NOTCH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
hepatobiliary disease DOID:3118 7 0.721
gastrointestinal system disease DOID:77 36 0.721
liver disease DOID:409 7 0.721
congenital heart disease DOID:1682 16 0.633
tetralogy of fallot DOID:6419 7 0.633
heart disease DOID:114 68 0.633
Human
cardiovascular system disease DOID:1287 106 0.633
Human
musculoskeletal system disease DOID:17 223 0.035
disease of metabolism DOID:0014667 295 0.033
sensory system disease DOID:0050155 203 0.032
nervous system disease DOID:863 431 0.032
eye and adnexa disease DOID:1492 150 0.031
eye disease DOID:5614 149 0.031