Homo sapiens

0 known processes

NOTCH3

notch 3

(Aliases: CASIL,CADASIL)

NOTCH3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cardiac right ventricle morphogenesis GO:0003215 3 1.000
notch signaling involved in heart development GO:0061314 2 1.000
Human
cell fate commitment involved in pattern specification GO:0060581 1 1.000
Fly
cell differentiation in spinal cord GO:0021515 1 1.000
neuronal stem cell maintenance GO:0097150 5 1.000
Human Zebrafish
pulmonary valve development GO:0003177 5 1.000
Human
ventral spinal cord interneuron differentiation GO:0021514 1 1.000
neuron fate commitment GO:0048663 2 1.000
Mouse
aortic valve development GO:0003176 3 1.000
Human
spinal cord development GO:0021510 4 1.000
spinal cord dorsal ventral patterning GO:0021513 2 1.000
ventral spinal cord development GO:0021517 1 1.000
positive regulation of cell fate specification GO:0042660 2 1.000
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.999
Human
negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 6 0.999
Human
distal tubule development GO:0072017 4 0.999
loop of henle development GO:0072070 2 0.999
pulmonary valve morphogenesis GO:0003184 5 0.998
Human
hair cell differentiation GO:0035315 2 0.996
pulmonary artery morphogenesis GO:0061156 3 0.995
i kappab phosphorylation GO:0007252 7 0.994
Fly
negative regulation of interleukin 10 production GO:0032693 7 0.992
glial cell migration GO:0008347 4 0.989
Fly
atrial septum morphogenesis GO:0060413 5 0.986
Human
sprouting angiogenesis GO:0002040 29 0.986
Human
cardiac right ventricle formation GO:0003219 1 0.985
mitral valve morphogenesis GO:0003183 2 0.981
Human
cardiac atrium morphogenesis GO:0003209 7 0.981
Human
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.980
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.973
endocardial cushion development GO:0003197 3 0.973
mesodermal cell fate specification GO:0007501 2 0.966
vasculature development GO:0001944 181 0.962
Human Zebrafish Mouse
cardiac cell fate specification GO:0060912 1 0.961
Fly
heart valve development GO:0003170 8 0.959
Human
circulatory system development GO:0072359 262 0.959
Human Zebrafish Mouse Fly
neural crest cell development GO:0014032 3 0.958
cardiac ventricle formation GO:0003211 2 0.955
regulation of cardioblast cell fate specification GO:0042686 1 0.954
Fly
heart valve morphogenesis GO:0003179 8 0.954
Human
cardiac atrium development GO:0003230 10 0.947
Human
regulation of blood vessel endothelial cell migration GO:0043535 30 0.945
Human
pancreas development GO:0031016 19 0.939
cardiac septum morphogenesis GO:0060411 9 0.937
Human
cell migration involved in sprouting angiogenesis GO:0002042 19 0.937
Human
renal tubule development GO:0061326 19 0.931
Fly
cardiac chamber morphogenesis GO:0003206 26 0.928
Human
t cell differentiation in thymus GO:0033077 4 0.927
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 2 0.925
nephron epithelium development GO:0072009 23 0.923
cardiovascular system development GO:0072358 262 0.923
Human Zebrafish Mouse Fly
aortic valve morphogenesis GO:0003180 3 0.919
Human
positive regulation of cell proliferation GO:0008284 301 0.918
Human Mouse Fly
hair follicle morphogenesis GO:0031069 2 0.912
blood vessel development GO:0001568 172 0.908
Human Zebrafish Mouse
urogenital system development GO:0001655 65 0.908
Zebrafish Mouse Fly
epithelial cell fate commitment GO:0072148 3 0.894
cardiac chamber formation GO:0003207 2 0.885
mesodermal cell fate commitment GO:0001710 2 0.882
t cell selection GO:0045058 4 0.877
mesenchymal cell development GO:0014031 50 0.874
Human
organ morphogenesis GO:0009887 147 0.868
Human Fly
regulation of locomotion GO:0040012 329 0.866
Human
aorta morphogenesis GO:0035909 1 0.865
skin development GO:0043588 76 0.861
negative regulation of cellular component movement GO:0051271 106 0.860
Human
angiogenesis GO:0001525 147 0.860
Human Mouse
blood vessel morphogenesis GO:0048514 162 0.859
Human Zebrafish Mouse
negative regulation of developmental process GO:0051093 247 0.859
Human Zebrafish Mouse Fly
regulation of cell differentiation GO:0045595 393 0.854
Human Zebrafish Mouse Fly
digestive tract development GO:0048565 75 0.853
Fly
regulation of endodermal cell fate specification GO:0042663 1 0.851
negative regulation of cell migration GO:0030336 102 0.850
Human
muscle cell fate commitment GO:0042693 4 0.850
Fly
regulation of endothelial cell migration GO:0010594 67 0.836
Human
salivary gland morphogenesis GO:0007435 4 0.829
cardiac vascular smooth muscle cell differentiation GO:0060947 2 0.829
cellular response to vascular endothelial growth factor stimulus GO:0035924 26 0.829
Human
semicircular canal morphogenesis GO:0048752 1 0.828
cardiac ventricle morphogenesis GO:0003208 20 0.827
epithelium development GO:0060429 227 0.827
Zebrafish Fly
mesenchymal cell differentiation GO:0048762 52 0.823
Human
negative regulation of locomotion GO:0040013 118 0.822
Human
artery morphogenesis GO:0048844 7 0.818
blood vessel endothelial cell migration GO:0043534 42 0.818
Human
prostate gland morphogenesis GO:0060512 1 0.815
cuticle development GO:0042335 1 0.811
negative regulation of angiogenesis GO:0016525 39 0.811
Human
negative regulation of epithelial cell migration GO:0010633 38 0.807
Human
regulation of epithelial cell migration GO:0010632 93 0.804
Human
anatomical structure formation involved in morphogenesis GO:0048646 284 0.802
Human Zebrafish Mouse Fly
spinal cord patterning GO:0021511 2 0.799
positive regulation of osteoblast differentiation GO:0045669 23 0.799
negative regulation of vasculature development GO:1901343 43 0.798
Human
atrioventricular valve morphogenesis GO:0003181 2 0.791
Human
mesenchyme development GO:0060485 59 0.785
Human
cardiac septum development GO:0003279 13 0.782
Human
regulation of stem cell differentiation GO:2000736 56 0.780
Human Fly
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.776
kidney development GO:0001822 53 0.775
Zebrafish Mouse
kidney epithelium development GO:0072073 25 0.775
thymic t cell selection GO:0045061 2 0.767
cardioblast cell fate commitment GO:0042684 1 0.757
Fly
positive regulation of notch signaling pathway GO:0045747 6 0.751
Fly
tissue morphogenesis GO:0048729 96 0.749
Fly
ventral spinal cord interneuron fate commitment GO:0060579 1 0.748
epidermal cell differentiation GO:0009913 45 0.748
endodermal cell fate commitment GO:0001711 4 0.743
cellular response to endogenous stimulus GO:0071495 336 0.739
Human
epidermis morphogenesis GO:0048730 3 0.732
cell adhesion GO:0007155 325 0.729
Human Fly
atrioventricular valve formation GO:0003190 1 0.727
Human
negative regulation of stem cell differentiation GO:2000737 22 0.725
Human
organ formation GO:0048645 3 0.715
Fly
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.712
regulation of cell motility GO:2000145 299 0.712
Human
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.711
skeletal system development GO:0001501 79 0.710
memory GO:0007613 3 0.709
Fly
nephron tubule development GO:0072080 17 0.702
morphogenesis of an epithelium GO:0002009 60 0.700
Fly
nervous system development GO:0007399 293 0.699
Zebrafish Mouse Fly
heart formation GO:0060914 2 0.698
embryonic morphogenesis GO:0048598 85 0.685
Fly
response to muramyl dipeptide GO:0032495 4 0.674
regulation of cytokine production GO:0001817 232 0.671
cellular response to growth factor stimulus GO:0071363 197 0.669
Human
tube development GO:0035295 125 0.664
Human Fly
inner ear morphogenesis GO:0042472 4 0.662
nephron development GO:0072006 30 0.654
Mouse
aorta development GO:0035904 2 0.652
epithelial cell migration GO:0010631 119 0.652
Human Fly
cytokine production GO:0001816 247 0.649
endothelial cell migration GO:0043542 86 0.648
Human
actin filament organization GO:0007015 128 0.648
Fly
hindlimb morphogenesis GO:0035137 2 0.641
regulation of endothelial cell differentiation GO:0045601 4 0.640
lymphocyte mediated immunity GO:0002449 48 0.639
muscle structure development GO:0061061 98 0.633
Human Fly
peripheral nervous system development GO:0007422 2 0.625
Zebrafish Fly
negative regulation of endothelial cell migration GO:0010596 29 0.624
Human
regulation of ossification GO:0030278 58 0.624
stem cell development GO:0048864 69 0.620
Human Zebrafish Fly
tissue migration GO:0090130 119 0.618
Human Fly
negative regulation of gliogenesis GO:0014014 3 0.617
negative regulation of cell proliferation GO:0008285 228 0.614
Human
negative regulation of multicellular organismal process GO:0051241 317 0.611
Human Zebrafish Mouse Fly
negative regulation of neuron differentiation GO:0045665 21 0.609
Mouse Fly
heart development GO:0007507 95 0.605
Human Fly
negative regulation of cell differentiation GO:0045596 171 0.596
Human Zebrafish Mouse Fly
immune effector process GO:0002252 159 0.595
ameboidal type cell migration GO:0001667 135 0.588
Human Fly
osteoblast differentiation GO:0001649 92 0.587
stem cell differentiation GO:0048863 93 0.584
Human Zebrafish Fly
system process GO:0003008 349 0.584
Zebrafish Fly
endoderm development GO:0007492 33 0.579
regulation of cell migration GO:0030334 289 0.575
Human
epidermis development GO:0008544 59 0.571
ventricular trabecula myocardium morphogenesis GO:0003222 1 0.566
negative regulation of cell motility GO:2000146 104 0.561
Human
positive regulation of neural precursor cell proliferation GO:2000179 2 0.561
oogenesis GO:0048477 2 0.560
Fly
endocardial cushion cell differentiation GO:0061443 1 0.558
venous blood vessel development GO:0060841 2 0.558
compound eye development GO:0048749 1 0.555
Fly
epithelium migration GO:0090132 119 0.553
Human Fly
regulation of osteoblast differentiation GO:0045667 38 0.550
tube morphogenesis GO:0035239 95 0.548
Human Fly
digestive system development GO:0055123 75 0.545
Fly
regulation of cardiac cell fate specification GO:2000043 1 0.537
Fly
post embryonic development GO:0009791 2 0.529
Worm Fly
negative regulation of muscle cell differentiation GO:0051148 17 0.529
Human
cell morphogenesis involved in differentiation GO:0000904 144 0.528
Human Zebrafish Fly
taxis GO:0042330 157 0.516
Human Fly
endoderm formation GO:0001706 33 0.514
regulation of cell adhesion GO:0030155 166 0.513
Human
morphogenesis of an epithelial sheet GO:0002011 12 0.511
cardiac epithelial to mesenchymal transition GO:0060317 3 0.507
epithelial tube morphogenesis GO:0060562 38 0.504
Fly
kidney interstitial fibroblast differentiation GO:0072071 2 0.504
regulation of cellular component movement GO:0051270 334 0.494
Human
cellular response to gonadotropin stimulus GO:0071371 4 0.493
Human
regulation of astrocyte differentiation GO:0048710 3 0.492
notch signaling pathway GO:0007219 31 0.491
Human Zebrafish Mouse Rat Fly
cell fate determination GO:0001709 3 0.478
Fly
cardiac ventricle development GO:0003231 23 0.473
Human
cell surface receptor signaling pathway involved in heart development GO:0061311 8 0.468
Human
ras protein signal transduction GO:0007265 73 0.468
Human
cell activation GO:0001775 213 0.461
positive regulation of gastrulation GO:2000543 2 0.455
regulation of pro b cell differentiation GO:2000973 1 0.453
somatic stem cell division GO:0048103 1 0.443
endochondral bone morphogenesis GO:0060350 3 0.432
heart morphogenesis GO:0003007 48 0.430
Human
kidney vasculature development GO:0061440 7 0.430
Mouse
negative regulation of neurogenesis GO:0050768 26 0.425
Zebrafish Mouse Fly
segmentation GO:0035282 4 0.424
Fly
negative regulation of cell development GO:0010721 48 0.424
Zebrafish Mouse Fly
regeneration GO:0031099 4 0.417
Rat
regulation of endodermal cell differentiation GO:1903224 3 0.415
cell development GO:0048468 328 0.413
Human Zebrafish Mouse Fly
photoreceptor cell differentiation GO:0046530 2 0.403
Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 16 0.400
Human
cardioblast cell fate specification GO:0042685 1 0.390
Fly
cardiac endothelial cell differentiation GO:0003348 2 0.390
gland development GO:0048732 48 0.386
Human Zebrafish Fly
negative regulation of myoblast differentiation GO:0045662 7 0.386
Human
cardiac conduction system development GO:0003161 2 0.385
mitral valve formation GO:0003192 1 0.383
Human
cell projection organization GO:0030030 252 0.379
Zebrafish Fly
t cell activation GO:0042110 99 0.378
enzyme linked receptor protein signaling pathway GO:0007167 303 0.374
connective tissue development GO:0061448 39 0.374
neuron differentiation GO:0030182 138 0.373
Zebrafish Mouse Fly
immune system development GO:0002520 195 0.373
Fly
glomerulus development GO:0032835 15 0.372
Mouse
apoptotic process involved in morphogenesis GO:0060561 3 0.370
regulation of mesodermal cell fate specification GO:0042661 2 0.369
endodermal cell fate specification GO:0001714 4 0.366
epithelial cell differentiation GO:0030855 141 0.364
Fly
negative regulation of blood vessel morphogenesis GO:2000181 41 0.363
Human
appendage morphogenesis GO:0035107 16 0.362
Fly
regulation of wnt signaling pathway GO:0030111 123 0.359
wound healing GO:0042060 115 0.353
Rat
cardiocyte differentiation GO:0035051 23 0.350
Fly
regulation of chemotaxis GO:0050920 74 0.345
Human
oligodendrocyte differentiation GO:0048709 7 0.345
Zebrafish
astrocyte differentiation GO:0048708 4 0.339
ossification GO:0001503 121 0.338
positive regulation of locomotion GO:0040017 186 0.336
leukocyte activation GO:0045321 164 0.334
multicellular organismal aging GO:0010259 3 0.333
Fly
hemopoiesis GO:0030097 180 0.333
Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.329
Human Fly
hematopoietic or lymphoid organ development GO:0048534 186 0.328
Fly
eye development GO:0001654 42 0.327
Fly
positive regulation of cell differentiation GO:0045597 211 0.325
Human
negative regulation of cell death GO:0060548 345 0.323
Human
negative regulation of glial cell proliferation GO:0060253 2 0.319
regulation of muscle organ development GO:0048634 27 0.316
Human
developmental programmed cell death GO:0010623 3 0.313
immune response GO:0006955 307 0.312
regulation of epithelial to mesenchymal transition GO:0010717 37 0.310
Human
mesangial cell development GO:0072143 1 0.309
cartilage development GO:0051216 31 0.309
gastrulation GO:0007369 51 0.309
generation of neurons GO:0048699 152 0.307
Zebrafish Mouse Fly
proximal tubule development GO:0072014 1 0.301
positive regulation of cell development GO:0010720 92 0.297
Human
determination of adult lifespan GO:0008340 2 0.297
Fly
lymphocyte activation GO:0046649 133 0.296
response to lipid GO:0033993 206 0.295
actin cytoskeleton organization GO:0030036 207 0.291
Fly
positive regulation of developmental process GO:0051094 314 0.290
Human
regulation of vasculature development GO:1901342 97 0.290
Human
atrial septum development GO:0003283 8 0.289
Human
leukocyte mediated immunity GO:0002443 59 0.287
endodermal cell differentiation GO:0035987 31 0.285
canonical wnt signaling pathway GO:0060070 116 0.284
t cell mediated immunity GO:0002456 25 0.284
regulation of canonical wnt signaling pathway GO:0060828 88 0.282
inner ear development GO:0048839 8 0.279
regulation of heart morphogenesis GO:2000826 4 0.275
negative regulation of glial cell differentiation GO:0045686 1 0.275
pericardium development GO:0060039 2 0.272
positive regulation of neuroblast proliferation GO:0002052 2 0.272
renal interstitial fibroblast development GO:0072141 1 0.266
cardiac muscle cell myoblast differentiation GO:0060379 5 0.265
regulation of small gtpase mediated signal transduction GO:0051056 156 0.264
Human
hepaticobiliary system development GO:0061008 10 0.261
Zebrafish
myeloid cell differentiation GO:0030099 117 0.260
regulation of epidermis development GO:0045682 19 0.258
amine metabolic process GO:0009308 44 0.256
pro b cell differentiation GO:0002328 1 0.256
leukocyte differentiation GO:0002521 98 0.254
stem cell maintenance GO:0019827 19 0.253
Human Zebrafish Fly
regulation of myeloid cell differentiation GO:0045637 81 0.252
regulation of cardiac muscle cell proliferation GO:0060043 4 0.251
neuroblast proliferation GO:0007405 4 0.249
regulation of angiogenesis GO:0045765 92 0.247
Human
sensory organ development GO:0007423 52 0.246
Fly
skeletal system morphogenesis GO:0048705 24 0.243
positive regulation of stem cell differentiation GO:2000738 29 0.241
Human
regulation of organ formation GO:0003156 4 0.237
neural tube development GO:0021915 9 0.237
motor neuron axon guidance GO:0008045 2 0.235
Fly
regulation of ras protein signal transduction GO:0046578 155 0.235
Human
epithelial to mesenchymal transition GO:0001837 48 0.234
Human
positive regulation of epithelial cell proliferation GO:0050679 65 0.232
negative regulation of notch signaling pathway GO:0045746 10 0.231
ventricular septum development GO:0003281 5 0.231
Human
chemotaxis GO:0006935 157 0.230
Human Fly
hair cycle GO:0042633 28 0.229
negative regulation of bmp signaling pathway GO:0030514 17 0.226
cardiac cell fate commitment GO:0060911 7 0.226
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.225
regionalization GO:0003002 29 0.225
Fly
positive regulation of cellular component organization GO:0051130 376 0.224
Human
regulation of striated muscle cell differentiation GO:0051153 25 0.224
Human
regulation of myotube differentiation GO:0010830 18 0.222
Human
response to growth factor GO:0070848 205 0.220
Human
response to fibroblast growth factor GO:0071774 39 0.219
cellular component morphogenesis GO:0032989 314 0.217
Human Zebrafish Fly
trabecula morphogenesis GO:0061383 2 0.216
mitotic cell cycle GO:0000278 326 0.215
Fly
neurogenesis GO:0022008 169 0.214
Zebrafish Mouse Fly
negative regulation of programmed cell death GO:0043069 321 0.213
Human
response to oxygen containing compound GO:1901700 369 0.213
positive regulation of cell motility GO:2000147 177 0.209
endocardial cell differentiation GO:0060956 2 0.205
negative regulation of cytokine production GO:0001818 82 0.205
adaptive immune response GO:0002250 49 0.205
regulation of behavior GO:0050795 82 0.204
Human
positive regulation of cellular component movement GO:0051272 181 0.204
artery development GO:0060840 7 0.201
bone development GO:0060348 26 0.200
lymphocyte differentiation GO:0030098 35 0.199
neuron projection development GO:0031175 106 0.198
Zebrafish Fly
response to abiotic stimulus GO:0009628 336 0.197
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.195
Human
left right pattern formation GO:0060972 2 0.193
regulation of meiotic cell cycle GO:0051445 4 0.192
cell cell signaling GO:0007267 155 0.190
Worm Fly
glial cell proliferation GO:0014009 6 0.189
blood vessel remodeling GO:0001974 2 0.187
renal system development GO:0072001 63 0.187
Zebrafish Mouse Fly
regulation of myoblast differentiation GO:0045661 12 0.186
Human
regulation of cell cycle GO:0051726 393 0.186
Human Fly
morphogenesis of a branching structure GO:0001763 21 0.186
gland morphogenesis GO:0022612 8 0.185
chordate embryonic development GO:0043009 34 0.185
Zebrafish
cellular amino acid metabolic process GO:0006520 116 0.184
skin morphogenesis GO:0043589 6 0.184
venous blood vessel morphogenesis GO:0048845 1 0.183
response to nitrogen compound GO:1901698 184 0.183
regulation of stem cell proliferation GO:0072091 15 0.180
positive regulation of ossification GO:0045778 32 0.180
cell projection assembly GO:0030031 126 0.179
Fly
hindbrain development GO:0030902 3 0.178
Zebrafish
regulation of neural precursor cell proliferation GO:2000177 4 0.177
head development GO:0060322 108 0.177
Zebrafish Mouse
cell cell signaling involved in cell fate commitment GO:0045168 5 0.176
Worm Fly
positive regulation of cell death GO:0010942 263 0.174
embryonic organ morphogenesis GO:0048562 24 0.172
small gtpase mediated signal transduction GO:0007264 78 0.171
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.170
morphogenesis of embryonic epithelium GO:0016331 4 0.170
embryonic digit morphogenesis GO:0042733 6 0.170
glomerular mesangial cell differentiation GO:0072008 2 0.169
regulation of muscle tissue development GO:1901861 26 0.169
Human
regulation of glial cell proliferation GO:0060251 4 0.168
embryonic heart tube morphogenesis GO:0003143 8 0.167
epithelial cell proliferation GO:0050673 128 0.167
Fly
neuron development GO:0048666 113 0.167
Zebrafish Fly
regulation of heart growth GO:0060420 4 0.166
defense response GO:0006952 315 0.166
negative regulation of myotube differentiation GO:0010832 4 0.166
response to organonitrogen compound GO:0010243 156 0.165
semicircular canal development GO:0060872 1 0.165
regulation of epithelial cell proliferation GO:0050678 113 0.165
ear development GO:0043583 14 0.164
cell chemotaxis GO:0060326 112 0.163
Human
regulation of nervous system development GO:0051960 88 0.161
Zebrafish Mouse Fly
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.160
Human
pattern specification process GO:0007389 43 0.158
Fly
central nervous system neuron differentiation GO:0021953 9 0.156
vascular smooth muscle cell differentiation GO:0035886 3 0.156
embryonic hindlimb morphogenesis GO:0035116 2 0.156
positive regulation of cell migration GO:0030335 172 0.155
fat cell differentiation GO:0045444 32 0.155
positive regulation of cardiac muscle tissue growth GO:0055023 2 0.154
response to wounding GO:0009611 168 0.153
Rat
regulation of fat cell differentiation GO:0045598 23 0.152
glomerulus vasculature development GO:0072012 6 0.151
Mouse
positive regulation of jak stat cascade GO:0046427 35 0.150
cardiac muscle tissue development GO:0048738 39 0.148
actin filament based process GO:0030029 224 0.146
Fly
regulation of neuron differentiation GO:0045664 70 0.145
Mouse Fly
regulation of neuroblast proliferation GO:1902692 3 0.145
cell growth GO:0016049 160 0.144
Human
regulation of striated muscle tissue development GO:0016202 26 0.143
Human
regulation of glial cell differentiation GO:0045685 3 0.143
cellular amine metabolic process GO:0044106 41 0.142
cardiac chamber development GO:0003205 30 0.140
Human
negative regulation of cell adhesion GO:0007162 64 0.139
Human
regulation of cell proliferation involved in heart morphogenesis GO:2000136 1 0.139
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.139
regulation of cardiac muscle tissue growth GO:0055021 4 0.138
glomerular mesangial cell development GO:0072144 1 0.137
bmp signaling pathway GO:0030509 49 0.136
positive regulation of gliogenesis GO:0014015 4 0.136
ear morphogenesis GO:0042471 7 0.136
behavior GO:0007610 112 0.136
Human Worm Fly
positive regulation of embryonic development GO:0040019 6 0.136
embryo development GO:0009790 123 0.136
Zebrafish Worm Fly
positive regulation of bmp signaling pathway GO:0030513 9 0.135
striated muscle cell differentiation GO:0051146 43 0.135
Human
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.135
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.132
interleukin 10 production GO:0032613 17 0.131
myoblast differentiation GO:0045445 21 0.131
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.131
cell division GO:0051301 168 0.129
Zebrafish
single organism reproductive process GO:0044702 98 0.128
Worm Fly
negative regulation of nervous system development GO:0051961 28 0.127
Zebrafish Mouse Fly
positive regulation of programmed cell death GO:0043068 249 0.127
cell projection morphogenesis GO:0048858 129 0.124
Zebrafish Fly
limb morphogenesis GO:0035108 16 0.123
positive regulation of mesenchymal stem cell differentiation GO:2000741 4 0.122
dorsal ventral pattern formation GO:0009953 15 0.121
Fly
endocrine system development GO:0035270 26 0.119
regulation of cell development GO:0060284 161 0.119
Human Zebrafish Mouse Fly
positive regulation of endothelial cell differentiation GO:0045603 2 0.118
positive regulation of protein phosphorylation GO:0001934 313 0.117
embryonic hemopoiesis GO:0035162 4 0.117
Fly
response to biotic stimulus GO:0009607 276 0.117
Fly
regulation of cytoskeleton organization GO:0051493 177 0.116
negative regulation of cell substrate adhesion GO:0010812 24 0.116
Human
odontogenesis GO:0042476 25 0.116
muscle tissue development GO:0060537 62 0.115
Human Fly
regulation of notch signaling pathway GO:0008593 18 0.114
Fly
gliogenesis GO:0042063 21 0.114
Zebrafish Fly
cellular ketone metabolic process GO:0042180 80 0.111
regulation of purine nucleotide metabolic process GO:1900542 264 0.110
regulation of meiosis GO:0040020 3 0.110
exocytosis GO:0006887 71 0.110
regulation of cardiac muscle tissue development GO:0055024 13 0.109
regulation of secretion GO:0051046 194 0.108
regulation of cardioblast differentiation GO:0051890 4 0.108
Fly
negative regulation of cell cycle GO:0045786 193 0.107
Human
neuromuscular junction development GO:0007528 3 0.105
response to organic cyclic compound GO:0014070 204 0.105
somite development GO:0061053 7 0.104
cell proliferation involved in heart morphogenesis GO:0061323 1 0.102
vesicle mediated transport GO:0016192 371 0.101
Zebrafish Worm
liver development GO:0001889 9 0.101
Zebrafish
positive regulation of myeloid cell differentiation GO:0045639 39 0.101
negative regulation of pro b cell differentiation GO:2000974 1 0.100
regulation of skeletal muscle fiber development GO:0048742 12 0.099
Human
response to peptide GO:1901652 65 0.099
eye morphogenesis GO:0048592 16 0.097
Fly
regulation of exocytosis GO:0017157 46 0.096
cell fate commitment GO:0045165 27 0.096
Mouse Worm Fly
peptidyl tyrosine modification GO:0018212 170 0.096
sensory organ morphogenesis GO:0090596 21 0.096
Fly
myotube cell development GO:0014904 14 0.096
Human
skeletal muscle fiber development GO:0048741 12 0.095
Human
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 19 0.094
Fly
regulation of neurogenesis GO:0050767 82 0.093
Zebrafish Mouse Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.093
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.092
positive regulation of hydrolase activity GO:0051345 331 0.091
gtp catabolic process GO:0006184 237 0.091
tissue remodeling GO:0048771 16 0.090
Human
thyroid gland development GO:0030878 5 0.090
mitral valve development GO:0003174 3 0.089
Human
collecting duct development GO:0072044 2 0.089
mesodermal cell differentiation GO:0048333 10 0.089
endothelial cell chemotaxis GO:0035767 13 0.087
Human
regulation of interleukin 10 production GO:0032653 16 0.085
muscle organ development GO:0007517 56 0.084
Human Fly
ribonucleoside catabolic process GO:0042454 406 0.084
positive regulation of heart growth GO:0060421 2 0.083
cell morphogenesis GO:0000902 296 0.083
Human Zebrafish Fly
positive regulation of cell fate commitment GO:0010455 2 0.083
keratinocyte differentiation GO:0030216 36 0.082
positive regulation of immune system process GO:0002684 283 0.082
reproductive process GO:0022414 106 0.081
Worm Fly
mapk cascade GO:0000165 288 0.081
hair cycle phase GO:0044851 3 0.081
nephric duct development GO:0072176 4 0.080
regulation of growth GO:0040008 165 0.079
Fly
cardiac muscle cell proliferation GO:0060038 6 0.078
negative regulation of apoptotic process GO:0043066 316 0.078
Human
branching morphogenesis of an epithelial tube GO:0048754 19 0.078
regulation of mesoderm development GO:2000380 4 0.077
response to hormone GO:0009725 175 0.077
Human
epithelial cell development GO:0002064 34 0.076
Fly
muscle cell development GO:0055001 29 0.076
Human
purine ribonucleoside metabolic process GO:0046128 437 0.076
blastoderm segmentation GO:0007350 2 0.075
heart looping GO:0001947 7 0.075
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.075
Human
ventricular septum morphogenesis GO:0060412 3 0.075
Human
positive regulation of proteolysis GO:0045862 142 0.075
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.074
negative regulation of response to external stimulus GO:0032102 83 0.074
Human
central nervous system development GO:0007417 123 0.074
Zebrafish Mouse
negative regulation of secretion GO:0051048 58 0.073
regulation of epithelial cell differentiation GO:0030856 24 0.073
regulation of embryonic development GO:0045995 20 0.073

NOTCH3 disease predictions

Disease DO term ID Size Probability Func Analog Org
hepatobiliary disease DOID:3118 7 1.000
Human
gastrointestinal system disease DOID:77 36 1.000
Human
liver disease DOID:409 7 1.000
Human
congenital heart disease DOID:1682 16 0.995
tetralogy of fallot DOID:6419 7 0.995
heart disease DOID:114 68 0.995
Human
cardiovascular system disease DOID:1287 106 0.995
Human