Homo sapiens

250 known processes

NPM1

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

(Aliases: MGC104254,NPM,B23)

NPM1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.999
rrna metabolic process GO:0016072 40 0.997
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.997
ribonucleoprotein complex biogenesis GO:0022613 116 0.994
ribonucleoprotein complex subunit organization GO:0071826 81 0.992
negative regulation of apoptotic process GO:0043066 316 0.991
ribosome biogenesis GO:0042254 48 0.984
ncrna processing GO:0034470 83 0.980
ncrna metabolic process GO:0034660 108 0.954
rna processing GO:0006396 255 0.947
chromatin modification GO:0016568 298 0.942
chromatin organization GO:0006325 351 0.914
chromatin assembly or disassembly GO:0006333 78 0.906
ribosomal large subunit biogenesis GO:0042273 10 0.893
cellular macromolecular complex assembly GO:0034622 324 0.892
oogenesis GO:0048477 2 0.892
zymogen activation GO:0031638 70 0.887
posttranscriptional regulation of gene expression GO:0010608 213 0.885
chromatin assembly GO:0031497 61 0.867
chromatin remodeling GO:0006338 55 0.859
embryo development GO:0009790 123 0.855
positive regulation of developmental process GO:0051094 314 0.848
cytoplasmic transport GO:0016482 379 0.825
regulation of cell development GO:0060284 161 0.809
ribonucleoprotein complex assembly GO:0022618 78 0.780
rrna processing GO:0006364 35 0.772
oocyte differentiation GO:0009994 2 0.753
histone modification GO:0016570 251 0.743
oocyte development GO:0048599 1 0.713
regulation of response to external stimulus GO:0032101 222 0.698
sex differentiation GO:0007548 45 0.671
cardiovascular system development GO:0072358 262 0.657
regulation of cell cycle GO:0051726 393 0.656
negative regulation of programmed cell death GO:0043069 321 0.639
translation GO:0006412 132 0.622
response to biotic stimulus GO:0009607 276 0.609
covalent chromatin modification GO:0016569 254 0.588
determination of adult lifespan GO:0008340 2 0.576
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.554
female gamete generation GO:0007292 2 0.547
aging GO:0007568 66 0.546
single organism cellular localization GO:1902580 332 0.539
epithelial cell proliferation GO:0050673 128 0.503
blastoderm segmentation GO:0007350 2 0.495
developmental process involved in reproduction GO:0003006 66 0.491
segmentation GO:0035282 4 0.477
defense response GO:0006952 315 0.469
multicellular organismal aging GO:0010259 3 0.460
response to other organism GO:0051707 261 0.447
nucleosome assembly GO:0006334 50 0.430
reproductive system development GO:0061458 56 0.412
response to external biotic stimulus GO:0043207 261 0.394
negative regulation of cell death GO:0060548 345 0.358
reproduction GO:0000003 63 0.352
regulation of mitotic cell cycle GO:0007346 189 0.313
regulation of endopeptidase activity GO:0052548 170 0.313
single organism reproductive process GO:0044702 98 0.293
cell type specific apoptotic process GO:0097285 125 0.268
nuclear transport GO:0051169 179 0.266
reproductive process GO:0022414 106 0.256
positive regulation of defense response GO:0031349 87 0.251
organelle assembly GO:0070925 176 0.220
heart development GO:0007507 95 0.220
mitotic cell cycle GO:0000278 326 0.220
circulatory system development GO:0072359 262 0.217
growth GO:0040007 202 0.210
vesicle mediated transport GO:0016192 371 0.210
innate immune response GO:0045087 178 0.207
reproductive structure development GO:0048608 55 0.201
establishment of protein localization to organelle GO:0072594 172 0.199
response to abiotic stimulus GO:0009628 336 0.194
meiotic chromosome segregation GO:0045132 4 0.189
regulation of oocyte development GO:0060281 1 0.184
response to virus GO:0009615 126 0.184
wound healing GO:0042060 115 0.182
positive regulation of cell proliferation GO:0008284 301 0.179
receptor mediated endocytosis GO:0006898 84 0.168
positive regulation of proteolysis GO:0045862 142 0.167
negative regulation of neuron apoptotic process GO:0043524 23 0.162
i kappab kinase nf kappab signaling GO:0007249 166 0.160
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.159
embryonic pattern specification GO:0009880 5 0.158
embryo development ending in birth or egg hatching GO:0009792 34 0.155
anterior posterior axis specification GO:0009948 2 0.152
response to wounding GO:0009611 168 0.151
multicellular organismal reproductive process GO:0048609 40 0.149
pattern specification process GO:0007389 43 0.148
microtubule cytoskeleton organization GO:0000226 176 0.146
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.144
mitotic nuclear division GO:0007067 119 0.143
taxis GO:0042330 157 0.141
organ morphogenesis GO:0009887 147 0.141
regulation of transferase activity GO:0051338 355 0.137
regulation of response to wounding GO:1903034 101 0.137
rna localization GO:0006403 41 0.135
regulation of cell migration GO:0030334 289 0.133
regeneration GO:0031099 4 0.128
gonad development GO:0008406 34 0.127
secretion GO:0046903 254 0.123
protein folding GO:0006457 38 0.120
negative regulation of binding GO:0051100 57 0.117
regulation of embryonic development GO:0045995 20 0.115
ribosomal small subunit biogenesis GO:0042274 13 0.111
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.110
mrna metabolic process GO:0016071 175 0.105
cellular macromolecule catabolic process GO:0044265 380 0.104
establishment of protein localization to membrane GO:0090150 121 0.102
mitotic dna integrity checkpoint GO:0044774 30 0.100
atp dependent chromatin remodeling GO:0043044 25 0.097
protein targeting GO:0006605 187 0.096
meiotic nuclear division GO:0007126 10 0.096
positive regulation of innate immune response GO:0045089 79 0.096
regulation of neuron apoptotic process GO:0043523 35 0.095
tissue regeneration GO:0042246 3 0.091
positive regulation of endopeptidase activity GO:0010950 84 0.089
negative regulation of multicellular organismal process GO:0051241 317 0.089
response to organonitrogen compound GO:0010243 156 0.088
dna packaging GO:0006323 77 0.086
response to oxygen levels GO:0070482 100 0.086
regulation of peptidase activity GO:0052547 180 0.084
regulation of intracellular transport GO:0032386 195 0.082
cellular response to cytokine stimulus GO:0071345 181 0.081
regulation of cell differentiation GO:0045595 393 0.081
regulation of protein localization GO:0032880 296 0.079
spindle assembly GO:0051225 29 0.077
neuron apoptotic process GO:0051402 39 0.075
response to bacterium GO:0009617 144 0.073
mitochondrion organization GO:0007005 156 0.073
cell development GO:0048468 328 0.072
immune effector process GO:0002252 159 0.071
intracellular protein transport GO:0006886 270 0.070
regulation of centriole replication GO:0046599 7 0.070
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.069
multicellular organism reproduction GO:0032504 42 0.068
regulation of neurogenesis GO:0050767 82 0.067
positive regulation of transport GO:0051050 336 0.066
nervous system development GO:0007399 293 0.066
intracellular mrna localization GO:0008298 1 0.063
regulation of translational initiation in response to stress GO:0043558 1 0.060
ribosomal large subunit export from nucleus GO:0000055 3 0.059
activation of cysteine type endopeptidase activity GO:0097202 57 0.059
regulation of cellular response to stress GO:0080135 244 0.059
maintenance of location GO:0051235 112 0.058
cellular component morphogenesis GO:0032989 314 0.058
regulation of multi organism process GO:0043900 157 0.058
protein localization to membrane GO:0072657 160 0.056
endocytosis GO:0006897 159 0.056
anterior posterior axis specification embryo GO:0008595 2 0.056
single organism membrane organization GO:0044802 268 0.054
positive regulation of apoptotic process GO:0043065 246 0.053
enzyme linked receptor protein signaling pathway GO:0007167 303 0.052
rna 3 end processing GO:0031123 35 0.052
spindle assembly involved in mitosis GO:0090307 12 0.051
cell morphogenesis involved in differentiation GO:0000904 144 0.051
multi organism cellular process GO:0044764 156 0.049
regulation of immune effector process GO:0002697 91 0.049
secretion by cell GO:0032940 226 0.048
mrna processing GO:0006397 133 0.046
positive regulation of cell death GO:0010942 263 0.045
dna conformation change GO:0071103 113 0.045
mitotic dna damage checkpoint GO:0044773 28 0.045
positive regulation of cell differentiation GO:0045597 211 0.044
regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 8 0.044
multi organism reproductive process GO:0044703 54 0.043
apoptotic signaling pathway GO:0097190 268 0.043
spermatid differentiation GO:0048515 4 0.043
sexual reproduction GO:0019953 37 0.043
development of primary sexual characteristics GO:0045137 35 0.043
rna interference GO:0016246 4 0.042
regulation of nervous system development GO:0051960 88 0.042
regulation of mitotic spindle checkpoint GO:1903504 8 0.042
myeloid leukocyte migration GO:0097529 62 0.042
regulation of anatomical structure morphogenesis GO:0022603 286 0.042
regulation of organ morphogenesis GO:2000027 24 0.041
mitotic cell cycle process GO:1903047 286 0.041
regulation of defense response GO:0031347 154 0.040
circadian rhythm GO:0007623 21 0.039
pattern recognition receptor signaling pathway GO:0002221 48 0.039
trna metabolic process GO:0006399 35 0.039
embryonic morphogenesis GO:0048598 85 0.039
cellular chemical homeostasis GO:0055082 180 0.038
regulation of gene expression epigenetic GO:0040029 73 0.037
inflammatory response GO:0006954 79 0.037
regulation of apoptotic signaling pathway GO:2001233 175 0.036
regulation of protein transport GO:0051223 213 0.035
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.035
establishment of ribosome localization GO:0033753 4 0.035
positive regulation of immune system process GO:0002684 283 0.035
pyrimidine ribonucleoside triphosphate metabolic process GO:0009208 2 0.035
negative regulation of protein metabolic process GO:0051248 391 0.035
response to cytokine GO:0034097 232 0.034
neuron differentiation GO:0030182 138 0.034
cell cycle checkpoint GO:0000075 117 0.032
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.032
de novo protein folding GO:0006458 2 0.031
heart morphogenesis GO:0003007 48 0.031
ossification GO:0001503 121 0.031
negative regulation of cell proliferation GO:0008285 228 0.029
gene silencing by rna GO:0031047 26 0.029
nuclear division GO:0000280 128 0.029
negative regulation of response to external stimulus GO:0032102 83 0.029
negative regulation of neuron death GO:1901215 32 0.028
response to lipid GO:0033993 206 0.028
circadian regulation of gene expression GO:0032922 8 0.028
trna processing GO:0008033 23 0.027
membrane organization GO:0061024 292 0.027
immune response GO:0006955 307 0.027
positive regulation of cell cycle GO:0045787 140 0.027
regulation of protein kinase activity GO:0045859 289 0.027
regulation of innate immune response GO:0045088 97 0.026
regulation of cell motility GO:2000145 299 0.026
regulation of oxidative phosphorylation GO:0002082 3 0.026
system process GO:0003008 349 0.026
regulation of immune response to tumor cell GO:0002837 8 0.026
vasculature development GO:0001944 181 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.025
positive regulation of immune response GO:0050778 159 0.025
response to organic cyclic compound GO:0014070 204 0.025
regulation of neuron death GO:1901214 56 0.025
regulation of dna metabolic process GO:0051052 153 0.024
regulation of locomotion GO:0040012 329 0.023
protein processing GO:0016485 226 0.023
nuclear export GO:0051168 69 0.023
negative regulation of developmental process GO:0051093 247 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
cell part morphogenesis GO:0032990 137 0.022
organelle fission GO:0048285 149 0.022
angiogenesis GO:0001525 147 0.022
striated muscle tissue development GO:0014706 59 0.022
response to lipopolysaccharide GO:0032496 70 0.022
generation of neurons GO:0048699 152 0.022
organelle localization GO:0051640 84 0.022
keratinocyte differentiation GO:0030216 36 0.021
positive regulation of multi organism process GO:0043902 56 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
Zebrafish
response to hypoxia GO:0001666 96 0.020
interspecies interaction between organisms GO:0044419 156 0.020
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.020
skeletal muscle organ development GO:0060538 26 0.020
tube morphogenesis GO:0035239 95 0.020
forebrain neuron differentiation GO:0021879 3 0.019
regulation of proteolysis GO:0030162 293 0.019
cellular hyperosmotic response GO:0071474 4 0.019
neuron development GO:0048666 113 0.019
establishment of organelle localization GO:0051656 59 0.019
regulation of response to biotic stimulus GO:0002831 55 0.019
protein methylation GO:0006479 74 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.019
cellular response to organic cyclic compound GO:0071407 127 0.018
activation of immune response GO:0002253 114 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.018
protein maturation GO:0051604 233 0.017
regulation of binding GO:0051098 111 0.017
g2 dna damage checkpoint GO:0031572 26 0.017
tripartite regional subdivision GO:0007351 2 0.017
meiotic cell cycle GO:0051321 13 0.017
protein secretion GO:0009306 98 0.016
nitrogen compound transport GO:0071705 191 0.016
negative regulation of locomotion GO:0040013 118 0.016
regulation of cell cycle process GO:0010564 266 0.016
regulation of spindle checkpoint GO:0090231 12 0.016
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.016
response to molecule of bacterial origin GO:0002237 82 0.016
ribosome localization GO:0033750 4 0.016
body morphogenesis GO:0010171 11 0.016
negative regulation of growth GO:0045926 97 0.016
gamete generation GO:0007276 25 0.015
neurogenesis GO:0022008 169 0.015
brain development GO:0007420 97 0.015
skeletal muscle tissue development GO:0007519 24 0.015
protein import GO:0017038 130 0.015
pyrimidine ribonucleoside catabolic process GO:0046133 8 0.014
cellular response to oxygen levels GO:0071453 55 0.014
response to decreased oxygen levels GO:0036293 96 0.014
negative regulation of cell cycle process GO:0010948 121 0.014
regulation of androgen receptor signaling pathway GO:0060765 18 0.014
neuron death GO:0070997 65 0.014
head development GO:0060322 108 0.014
organelle inheritance GO:0048308 2 0.014
regulation of cellular component movement GO:0051270 334 0.014
dna replication GO:0006260 116 0.014
epithelial cell differentiation GO:0030855 141 0.014
regulation of growth GO:0040008 165 0.013
cell morphogenesis GO:0000902 296 0.013
protein stabilization GO:0050821 64 0.013
regulation of cellular respiration GO:0043457 4 0.013
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.013
muscle structure development GO:0061061 98 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
regulation of protein localization to nucleus GO:1900180 85 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.013
regulation of immune response GO:0050776 201 0.012
behavior GO:0007610 112 0.012
positive regulation of growth GO:0045927 58 0.012
positive regulation of hydrolase activity GO:0051345 331 0.012
cellular amino acid metabolic process GO:0006520 116 0.012
chromatin silencing GO:0006342 12 0.012
positive regulation of cell development GO:0010720 92 0.012
negative regulation of cell cycle phase transition GO:1901988 89 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 3 0.012
positive regulation of dna dependent dna replication GO:2000105 7 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
endomembrane system organization GO:0010256 196 0.012
regulation of inflammatory response GO:0050727 46 0.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.012
protein targeting to membrane GO:0006612 42 0.011
single organism cell adhesion GO:0098602 179 0.011
dna recombination GO:0006310 77 0.011
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.011
response to oxygen containing compound GO:1901700 369 0.011
regulation of dna binding GO:0051101 37 0.011
amine metabolic process GO:0009308 44 0.011
response to drug GO:0042493 81 0.011
epithelial to mesenchymal transition GO:0001837 48 0.011
cell projection organization GO:0030030 252 0.011
cation homeostasis GO:0055080 189 0.011
embryonic cranial skeleton morphogenesis GO:0048701 6 0.010
regulation of protein binding GO:0043393 66 0.010
negative regulation of cellular component movement GO:0051271 106 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.010
positive regulation of peptidyl lysine acetylation GO:2000758 12 0.010
dna catabolic process GO:0006308 49 0.010
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.010
regulation of dna replication GO:0006275 68 0.010
muscle organ development GO:0007517 56 0.010

NPM1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.008
disease of cellular proliferation DOID:14566 174 0.008
organ system cancer DOID:0050686 164 0.008
immune system cancer DOID:0060083 36 0.003
myeloid leukemia DOID:8692 18 0.003
hematologic cancer DOID:2531 36 0.003
leukemia DOID:1240 21 0.003
acute myeloid leukemia DOID:9119 17 0.000