Homo sapiens

167 known processes

PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

(Aliases: MGC130000,MGC130001,PAKalpha)

PAK1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rho protein signal transduction GO:0007266 26 1.000
gtp metabolic process GO:0046039 239 1.000
positive regulation of rho gtpase activity GO:0032321 56 1.000
positive regulation of rac gtpase activity GO:0032855 31 0.999
regulation of intracellular estrogen receptor signaling pathway GO:0033146 13 0.996
gtp catabolic process GO:0006184 237 0.996
nucleoside catabolic process GO:0009164 408 0.995
ribonucleoside triphosphate catabolic process GO:0009203 391 0.994
purine ribonucleoside catabolic process GO:0046130 398 0.994
small gtpase mediated signal transduction GO:0007264 78 0.994
positive regulation of nucleotide catabolic process GO:0030813 185 0.992
regulation of stress fiber assembly GO:0051492 32 0.992
ribonucleoside catabolic process GO:0042454 406 0.990
positive regulation of gtpase activity GO:0043547 166 0.990
regulation of nucleoside metabolic process GO:0009118 209 0.990
guanosine containing compound metabolic process GO:1901068 244 0.989
nucleoside triphosphate metabolic process GO:0009141 422 0.989
positive regulation of gtp catabolic process GO:0033126 166 0.989
ribonucleotide catabolic process GO:0009261 405 0.987
purine nucleoside triphosphate catabolic process GO:0009146 392 0.986
positive regulation of ras gtpase activity GO:0032320 117 0.986
organophosphate catabolic process GO:0046434 430 0.985
positive regulation of fibroblast migration GO:0010763 3 0.985
regulation of cytoskeleton organization GO:0051493 177 0.983
ribonucleoside triphosphate metabolic process GO:0009199 412 0.981
positive regulation of nucleotide metabolic process GO:0045981 230 0.980
regulation of rho gtpase activity GO:0032319 66 0.979
intracellular estrogen receptor signaling pathway GO:0030520 23 0.978
guanosine containing compound catabolic process GO:1901069 239 0.974
nucleoside triphosphate catabolic process GO:0009143 394 0.971
nucleotide catabolic process GO:0009166 408 0.969
purine nucleoside catabolic process GO:0006152 398 0.962
positive regulation of actin filament bundle assembly GO:0032233 25 0.959
purine ribonucleoside metabolic process GO:0046128 437 0.957
glycosyl compound catabolic process GO:1901658 413 0.954
actin cytoskeleton organization GO:0030036 207 0.951
purine nucleoside triphosphate metabolic process GO:0009144 412 0.949
purine containing compound catabolic process GO:0072523 411 0.948
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.938
regulation of actin filament polymerization GO:0030833 50 0.932
Human
regulation of rho protein signal transduction GO:0035023 79 0.931
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.926
positive regulation of actin filament polymerization GO:0030838 38 0.919
positive regulation of cellular component biogenesis GO:0044089 158 0.918
contact inhibition GO:0060242 3 0.910
ras protein signal transduction GO:0007265 73 0.903
purine ribonucleotide catabolic process GO:0009154 404 0.891
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.881
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.880
nucleoside phosphate catabolic process GO:1901292 412 0.876
positive regulation of protein polymerization GO:0032273 45 0.872
cdc42 protein signal transduction GO:0032488 4 0.866
regulation of protein kinase activity GO:0045859 289 0.864
regulation of transferase activity GO:0051338 355 0.863
regulation of actin filament bundle assembly GO:0032231 36 0.849
fibroblast migration GO:0010761 7 0.848
regulation of gtpase activity GO:0043087 180 0.836
regulation of actin cytoskeleton organization GO:0032956 116 0.825
cell adhesion GO:0007155 325 0.817
regulation of small gtpase mediated signal transduction GO:0051056 156 0.814
regulation of cell adhesion GO:0030155 166 0.805
intracellular receptor signaling pathway GO:0030522 104 0.799
regulation of fibroblast migration GO:0010762 7 0.796
negative regulation of catalytic activity GO:0043086 335 0.781
Human
positive regulation of cytoskeleton organization GO:0051495 83 0.735
regulation of protein serine threonine kinase activity GO:0071900 179 0.730
regulation of purine nucleotide catabolic process GO:0033121 205 0.724
purine nucleotide catabolic process GO:0006195 405 0.715
lamellipodium organization GO:0097581 30 0.706
positive regulation of protein complex assembly GO:0031334 86 0.701
regulation of cellular component biogenesis GO:0044087 281 0.679
positive regulation of organelle organization GO:0010638 195 0.662
cellular component morphogenesis GO:0032989 314 0.643
Rat
actin filament based process GO:0030029 224 0.639
positive regulation of catabolic process GO:0009896 310 0.631
cell morphogenesis GO:0000902 296 0.623
Rat
positive regulation of nucleoside metabolic process GO:0045979 186 0.612
regulation of gtp catabolic process GO:0033124 180 0.604
regulation of nucleotide metabolic process GO:0006140 269 0.595
regulation of protein polymerization GO:0032271 63 0.576
Human
regulation of ras gtpase activity GO:0032318 128 0.574
establishment or maintenance of cell polarity GO:0007163 31 0.554
Yeast
regulation of anatomical structure morphogenesis GO:0022603 286 0.542
actin filament polymerization GO:0030041 45 0.541
Human
regulation of lamellipodium morphogenesis GO:2000392 4 0.541
astrocyte cell migration GO:0043615 1 0.537
peptidyl serine phosphorylation GO:0018105 101 0.527
cell projection organization GO:0030030 252 0.517
Mouse Rat
negative regulation of protein metabolic process GO:0051248 391 0.510
Human
endomembrane system organization GO:0010256 196 0.510
regulation of peptidyl serine phosphorylation GO:0033135 50 0.502
negative regulation of phosphate metabolic process GO:0045936 267 0.500
regulation of cell cell adhesion mediated by cadherin GO:2000047 4 0.498
regulation of actin filament based process GO:0032970 141 0.472
apoptotic signaling pathway GO:0097190 268 0.438
Human
tube development GO:0035295 125 0.431
biological adhesion GO:0022610 331 0.429
stress fiber assembly GO:0043149 40 0.425
regulation of cell projection organization GO:0031344 107 0.418
positive regulation of cellular component organization GO:0051130 376 0.408
regulation of kinase activity GO:0043549 314 0.407
generation of neurons GO:0048699 152 0.401
Mouse Rat
negative regulation of hydrolase activity GO:0051346 182 0.394
Human
regulation of cellular component size GO:0032535 82 0.394
Human
dendritic spine morphogenesis GO:0060997 3 0.393
positive regulation of map kinase activity GO:0043406 80 0.372
regulation of ras protein signal transduction GO:0046578 155 0.369
actin filament organization GO:0007015 128 0.364
post embryonic development GO:0009791 2 0.359
Worm
organelle inheritance GO:0048308 2 0.356
Yeast
regulation of nucleotide catabolic process GO:0030811 205 0.338
amine metabolic process GO:0009308 44 0.334
negative regulation of cellular protein metabolic process GO:0032269 353 0.326
Human
positive regulation of apoptotic process GO:0043065 246 0.325
Human Yeast
vacuole organization GO:0007033 44 0.325
Yeast
activation of protein kinase activity GO:0032147 90 0.323
Human Yeast
cellular protein complex assembly GO:0043623 188 0.314
Human
negative regulation of cytoskeleton organization GO:0051494 45 0.304
regulation of purine nucleotide metabolic process GO:1900542 264 0.296
regulation of anatomical structure size GO:0090066 101 0.292
Human
positive regulation of lamellipodium organization GO:1902745 12 0.286
regulation of mitosis GO:0007088 63 0.281
Yeast
cell morphogenesis involved in differentiation GO:0000904 144 0.275
negative regulation of apoptotic process GO:0043066 316 0.272
Human
negative regulation of protein modification process GO:0031400 200 0.269
positive regulation of programmed cell death GO:0043068 249 0.267
Human Yeast
sterol transmembrane transport GO:0035382 4 0.265
Yeast
regulation of cellular ketone metabolic process GO:0010565 50 0.263
regulation of protein complex assembly GO:0043254 147 0.258
Human
regulation of cell shape GO:0008360 48 0.250
regulation of cellular amino acid metabolic process GO:0006521 6 0.250
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.246
ubiquitin dependent protein catabolic process GO:0006511 206 0.246
cellular macromolecular complex assembly GO:0034622 324 0.245
Human Yeast
positive regulation of stress fiber assembly GO:0051496 22 0.237
positive regulation of cell motility GO:2000147 177 0.236
negative regulation of protein maturation GO:1903318 142 0.236
Human
positive regulation of cell death GO:0010942 263 0.235
Human Yeast
positive regulation of protein phosphorylation GO:0001934 313 0.233
muscle structure development GO:0061061 98 0.233
negative regulation of cell death GO:0060548 345 0.228
Human
regulation of peroxidase activity GO:2000468 2 0.225
protein catabolic process GO:0030163 325 0.223
determination of adult lifespan GO:0008340 2 0.223
cell projection morphogenesis GO:0048858 129 0.221
Rat
regulation of stress activated mapk cascade GO:0032872 84 0.221
response to organic cyclic compound GO:0014070 204 0.219
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.214
negative regulation of phosphorylation GO:0042326 174 0.213
spermatid differentiation GO:0048515 4 0.212
single organism cellular localization GO:1902580 332 0.212
Yeast Mouse
positive regulation of protein kinase activity GO:0045860 190 0.210
regulation of apoptotic signaling pathway GO:2001233 175 0.208
Human
eye photoreceptor cell differentiation GO:0001754 2 0.206
positive regulation of hydrolase activity GO:0051345 331 0.199
actin filament bundle organization GO:0061572 54 0.198
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.196
regulation of cell cycle GO:0051726 393 0.192
Yeast
sterol transport GO:0015918 39 0.183
Yeast
negative regulation of catabolic process GO:0009895 104 0.182
positive regulation of kinase activity GO:0033674 204 0.182
response to steroid hormone GO:0048545 80 0.181
actin polymerization or depolymerization GO:0008154 56 0.180
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.180
regulation of protein ubiquitination GO:0031396 95 0.179
positive regulation of jnk cascade GO:0046330 52 0.177
synaptic vesicle endocytosis GO:0048488 2 0.176
regulation of execution phase of apoptosis GO:1900117 11 0.173
Human
regulation of neurotransmitter secretion GO:0046928 3 0.173
mitotic cell cycle GO:0000278 326 0.170
Yeast
single organism nuclear import GO:1902593 104 0.170
Yeast
single organism cell adhesion GO:0098602 179 0.167
regulation of cellular amine metabolic process GO:0033238 11 0.166
cell development GO:0048468 328 0.166
Mouse Rat
nuclear import GO:0051170 106 0.160
Yeast
response to hormone GO:0009725 175 0.157
Rat
cellular response to abiotic stimulus GO:0071214 117 0.156
Yeast
negative regulation of apoptotic signaling pathway GO:2001234 97 0.153
negative regulation of programmed cell death GO:0043069 321 0.152
Human
positive regulation of transferase activity GO:0051347 227 0.151
cellular response to heat GO:0034605 14 0.151
Yeast
neurotransmitter secretion GO:0007269 4 0.149
exit from mitosis GO:0010458 10 0.148
Yeast
vesicle organization GO:0016050 62 0.147
negative regulation of endopeptidase activity GO:0010951 84 0.144
Human
positive regulation of cellular catabolic process GO:0031331 284 0.144
cellular amine metabolic process GO:0044106 41 0.143
anterior posterior axis specification embryo GO:0008595 2 0.139
positive regulation of apoptotic signaling pathway GO:2001235 70 0.138
Human
regulation of protein targeting GO:1903533 91 0.136
Yeast
regulation of jun kinase activity GO:0043506 27 0.136
positive regulation of cell adhesion GO:0045785 84 0.135
positive regulation of cell projection organization GO:0031346 64 0.135
stress activated mapk cascade GO:0051403 93 0.133
locomotory behavior GO:0007626 1 0.132
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.131
Human
positive regulation of lamellipodium morphogenesis GO:2000394 2 0.131
positive regulation of protein transport GO:0051222 135 0.130
Yeast
response to abiotic stimulus GO:0009628 336 0.129
Yeast Rat
regulation of synaptic vesicle transport GO:1902803 3 0.127
cell division GO:0051301 168 0.127
Yeast
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.126
Human
modification dependent protein catabolic process GO:0019941 209 0.125
tripartite regional subdivision GO:0007351 2 0.123
regulation of neuron death GO:1901214 56 0.122
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 3 0.122
positive regulation of phosphorylation GO:0042327 394 0.120
cell projection assembly GO:0030031 126 0.119
regulation of actin polymerization or depolymerization GO:0008064 56 0.119
Human
organic hydroxy compound transport GO:0015850 63 0.116
Yeast
regulation of synaptic vesicle endocytosis GO:1900242 1 0.115
activation of mapkk activity GO:0000186 18 0.111
Yeast
protein polymerization GO:0051258 71 0.109
Human
mitotic cell cycle phase transition GO:0044772 162 0.108
neuromuscular junction development GO:0007528 3 0.107
Mouse
regulation of cdc42 protein signal transduction GO:0032489 14 0.107
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.106
compound eye development GO:0048749 1 0.106
positive regulation of substrate adhesion dependent cell spreading GO:1900026 15 0.105
positive regulation of developmental process GO:0051094 314 0.103
tube morphogenesis GO:0035239 95 0.099
substrate adhesion dependent cell spreading GO:0034446 41 0.098
microtubule cytoskeleton organization GO:0000226 176 0.096
filopodium assembly GO:0046847 18 0.093
cell growth GO:0016049 160 0.093
Yeast
organelle fission GO:0048285 149 0.093
Yeast
epidermal cell differentiation GO:0009913 45 0.092
keratinocyte differentiation GO:0030216 36 0.089
positive regulation of jun kinase activity GO:0043507 23 0.086
negative regulation of transferase activity GO:0051348 124 0.085
regulation of protein transport GO:0051223 213 0.080
Yeast
anterior posterior axis specification GO:0009948 2 0.080
golgi organization GO:0007030 38 0.079
morphogenesis of a branching structure GO:0001763 21 0.079
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.078
regulation of endopeptidase activity GO:0052548 170 0.078
Human
regulation of cell morphogenesis GO:0022604 153 0.078
transmembrane transport GO:0055085 399 0.077
Yeast
branching morphogenesis of an epithelial tube GO:0048754 19 0.076
protein maturation GO:0051604 233 0.076
Human
central nervous system development GO:0007417 123 0.075
regulation of cell substrate adhesion GO:0010810 68 0.072
cell competition in a multicellular organism GO:0035212 1 0.072
cellular amino acid metabolic process GO:0006520 116 0.072
activation of mapk activity GO:0000187 45 0.068
Human
establishment of protein localization to organelle GO:0072594 172 0.068
Yeast
negative regulation of protein kinase activity GO:0006469 98 0.067
protein targeting to nucleus GO:0044744 104 0.066
Yeast
regionalization GO:0003002 29 0.066
oocyte development GO:0048599 1 0.066
cell cell adhesion mediated by cadherin GO:0044331 4 0.066
negative regulation of protein processing GO:0010955 142 0.066
Human
cellular response to ammonium ion GO:0071242 4 0.066
peptidyl serine modification GO:0018209 106 0.066
regulation of synaptic vesicle exocytosis GO:2000300 2 0.065
blastocyst development GO:0001824 3 0.065
cell migration involved in gastrulation GO:0042074 1 0.065
negative regulation of phosphorus metabolic process GO:0010563 267 0.065
positive regulation of cell substrate adhesion GO:0010811 37 0.064
regulation of map kinase activity GO:0043405 108 0.062
segmentation GO:0035282 4 0.061
nervous system development GO:0007399 293 0.061
Mouse Rat
cellular response to metal ion GO:0071248 43 0.061
regulation of mitotic cell cycle GO:0007346 189 0.061
Yeast
negative regulation of protein phosphorylation GO:0001933 140 0.060
g protein coupled receptor signaling pathway GO:0007186 207 0.059
Yeast
regulation of dna metabolic process GO:0051052 153 0.059
cellular ketone metabolic process GO:0042180 80 0.059
negative regulation of neuron apoptotic process GO:0043524 23 0.058
chordate embryonic development GO:0043009 34 0.058
positive regulation of mapk cascade GO:0043410 190 0.057
regulation of protein processing GO:0070613 150 0.057
Human
intracellular protein transport GO:0006886 270 0.057
Yeast
regulation of cell motility GO:2000145 299 0.056
extrinsic apoptotic signaling pathway GO:0097191 119 0.056
Human
nucleocytoplasmic transport GO:0006913 176 0.055
Yeast
dna replication GO:0006260 116 0.054
negative regulation of peptidase activity GO:0010466 91 0.054
Human
actin filament bundle assembly GO:0051017 54 0.054
ribonucleoprotein complex biogenesis GO:0022613 116 0.054
Yeast
stress activated protein kinase signaling cascade GO:0031098 94 0.053
sex determination GO:0007530 3 0.053
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.052
digestive tract development GO:0048565 75 0.052
positive regulation of metalloenzyme activity GO:0048554 2 0.051
neuron projection morphogenesis GO:0048812 50 0.051
Rat
neural tube formation GO:0001841 3 0.050
establishment or maintenance of neuroblast polarity GO:0045196 1 0.049
response to estrogen GO:0043627 47 0.049
regulation of actin filament length GO:0030832 56 0.049
Human
dephosphorylation GO:0016311 209 0.048
regulation of neuron apoptotic process GO:0043523 35 0.048
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.048
circulatory system development GO:0072359 262 0.047
regulation of actin nucleation GO:0051125 10 0.047
regulation of cell cycle process GO:0010564 266 0.047
Yeast
response to metal ion GO:0010038 84 0.047
proteasomal protein catabolic process GO:0010498 176 0.047
microtubule based process GO:0007017 210 0.047
cell type specific apoptotic process GO:0097285 125 0.046
response to peptidoglycan GO:0032494 3 0.046
mitochondrion distribution GO:0048311 3 0.046
embryonic epithelial tube formation GO:0001838 4 0.046
single organism reproductive process GO:0044702 98 0.046
Worm
cellular macromolecule catabolic process GO:0044265 380 0.045
system process GO:0003008 349 0.045
negative regulation of proteolysis GO:0045861 132 0.045
Human
protein import into nucleus GO:0006606 104 0.045
Yeast
protein modification by small protein conjugation GO:0032446 342 0.044
hindbrain development GO:0030902 3 0.044
response to oxygen containing compound GO:1901700 369 0.044
Rat
regulation of jnk cascade GO:0046328 73 0.044
negative regulation of cellular component organization GO:0051129 235 0.044
specification of axis polarity GO:0065001 1 0.043
regulation of protein maturation GO:1903317 150 0.043
Human
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.043
immune system development GO:0002520 195 0.043
endocytosis GO:0006897 159 0.043
organ morphogenesis GO:0009887 147 0.042
Worm
neuron apoptotic process GO:0051402 39 0.042
positive regulation of cellular amine metabolic process GO:0033240 7 0.042
thrombin receptor signaling pathway GO:0070493 5 0.041
protein import GO:0017038 130 0.041
Yeast
mapk cascade GO:0000165 288 0.040
maintenance of cell polarity GO:0030011 2 0.040
growth GO:0040007 202 0.040
Yeast
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.040
positive regulation of neuron apoptotic process GO:0043525 8 0.040
regulation of cell projection assembly GO:0060491 47 0.040
regulation of cell division GO:0051302 116 0.039
Yeast
regulation of autophagy GO:0010506 52 0.039
forebrain neuron development GO:0021884 2 0.038
ribonucleoprotein complex subunit organization GO:0071826 81 0.037
Yeast
regulation of dendrite morphogenesis GO:0048814 11 0.037
establishment of organelle localization GO:0051656 59 0.036
glial cell migration GO:0008347 4 0.036
negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 18 0.036
establishment of cell polarity GO:0030010 22 0.036
Yeast
protein autophosphorylation GO:0046777 123 0.036
positive regulation of mitochondrial calcium ion concentration GO:0051561 8 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
limbic system development GO:0021761 3 0.035
regulation of cell development GO:0060284 161 0.035
protein targeting GO:0006605 187 0.035
Yeast
cell matrix adhesion GO:0007160 85 0.035
regulation of substrate adhesion dependent cell spreading GO:1900024 19 0.034
negative regulation of dephosphorylation GO:0035305 63 0.034
lamellipodium assembly GO:0030032 26 0.033
single organism membrane organization GO:0044802 268 0.033
Mouse
negative regulation of cellular amine metabolic process GO:0033239 3 0.033
regulation of cell differentiation GO:0045595 393 0.033
positive regulation of transport GO:0051050 336 0.033
Yeast
positive regulation of protein localization to nucleus GO:1900182 48 0.032
Yeast
regulation of cdc42 gtpase activity GO:0043088 10 0.032
protein ubiquitination GO:0016567 314 0.032
response to nitrogen compound GO:1901698 184 0.032
Rat
protein localization to organelle GO:0033365 280 0.032
Yeast
regulation of arp2 3 complex mediated actin nucleation GO:0034315 6 0.031
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.031
exocytosis GO:0006887 71 0.031
negative regulation of organelle organization GO:0010639 126 0.031
cytokinesis GO:0000910 96 0.031
Yeast
establishment of planar polarity GO:0001736 3 0.030
negative regulation of nucleotide catabolic process GO:0030812 16 0.030
positive regulation of actin nucleation GO:0051127 6 0.030
regulation of secretion GO:0051046 194 0.030
negative regulation of protein ubiquitination GO:0031397 35 0.030
cloaca development GO:0035844 1 0.030
negative regulation of rho gtpase activity GO:0034259 4 0.030
nuclear division GO:0000280 128 0.029
Yeast
photoreceptor cell differentiation GO:0046530 2 0.029
inner ear morphogenesis GO:0042472 4 0.029
olfactory bulb interneuron differentiation GO:0021889 2 0.028
synaptic vesicle recycling GO:0036465 3 0.028
regulation of mapk cascade GO:0043408 262 0.028
synaptic transmission GO:0007268 61 0.028
vesicle mediated transport GO:0016192 371 0.028
protein localization to nucleus GO:0034504 136 0.028
Yeast
cellular protein catabolic process GO:0044257 261 0.028
response to heat GO:0009408 21 0.027
Yeast
negative regulation of actin nucleation GO:0051126 3 0.026
regulation of proteolysis GO:0030162 293 0.026
Human
multicellular organismal aging GO:0010259 3 0.026
response to temperature stimulus GO:0009266 22 0.026
Yeast
regulation of cell growth GO:0001558 135 0.026
anatomical structure formation involved in morphogenesis GO:0048646 284 0.026
somatic muscle development GO:0007525 1 0.026
regulation of cellular response to stress GO:0080135 244 0.026
neuron death GO:0070997 65 0.026
signal transduction by phosphorylation GO:0023014 297 0.026
cellular response to inorganic substance GO:0071241 45 0.026
morphogenesis of a polarized epithelium GO:0001738 3 0.025
negative regulation of dna metabolic process GO:0051053 57 0.025
cerebral cortex cell migration GO:0021795 3 0.025
regulation of protein tyrosine kinase activity GO:0061097 36 0.025
Human
negative regulation of cellular catabolic process GO:0031330 83 0.025
hemidesmosome assembly GO:0031581 5 0.025
Worm
regulation of growth rate GO:0040009 1 0.025
collateral sprouting GO:0048668 2 0.025
regulation of neuroblast proliferation GO:1902692 3 0.025
macroautophagy GO:0016236 39 0.024
regulation of exit from mitosis GO:0007096 6 0.024
Yeast
response to activity GO:0014823 0 0.024
morphogenesis of embryonic epithelium GO:0016331 4 0.024
epidermis development GO:0008544 59 0.024
negative regulation of neuron death GO:1901215 32 0.024
gonad development GO:0008406 34 0.024
Worm
organelle localization GO:0051640 84 0.024
regulation of carbohydrate metabolic process GO:0006109 54 0.024
rac protein signal transduction GO:0016601 12 0.024
hippocampus development GO:0021766 1 0.023
lipid metabolic process GO:0006629 381 0.023
mitotic cell cycle process GO:1903047 286 0.023
Yeast
cell part morphogenesis GO:0032990 137 0.023
Rat
visual behavior GO:0007632 2 0.023
aging GO:0007568 66 0.023
neuron fate commitment GO:0048663 2 0.023
regulation of developmental growth GO:0048638 30 0.023
rna processing GO:0006396 255 0.023
skin development GO:0043588 76 0.023
establishment of tissue polarity GO:0007164 3 0.022
regulation of protein autoubiquitination GO:1902498 3 0.022
arp2 3 complex mediated actin nucleation GO:0034314 17 0.022
cell fate commitment GO:0045165 27 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
pattern specification process GO:0007389 43 0.022
t cell tolerance induction GO:0002517 4 0.022
dopamine receptor signaling pathway GO:0007212 10 0.022
response to osmotic stress GO:0006970 17 0.022
Yeast
oocyte differentiation GO:0009994 2 0.021
vasculature development GO:0001944 181 0.021
response to fungus GO:0009620 4 0.021
cellular response to calcium ion GO:0071277 19 0.021
mitochondrial calcium ion homeostasis GO:0051560 11 0.021
cerebellum development GO:0021549 2 0.021
cell fate commitment involved in pattern specification GO:0060581 1 0.021
actomyosin structure organization GO:0031032 59 0.021
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.021
primary neural tube formation GO:0014020 3 0.020
leukocyte proliferation GO:0070661 74 0.020
establishment of protein localization to mitochondrion GO:0072655 22 0.020
embryonic morphogenesis GO:0048598 85 0.020
Worm
negative regulation of execution phase of apoptosis GO:1900118 6 0.020
Human
embryonic organ development GO:0048568 36 0.020
regulation of cell cell adhesion GO:0022407 57 0.020
positive regulation of cell migration GO:0030335 172 0.020
myoblast fusion GO:0007520 1 0.020
adherens junction organization GO:0034332 36 0.020
secretory granule organization GO:0033363 2 0.020
peptidyl threonine phosphorylation GO:0018107 41 0.020
negative regulation of blood circulation GO:1903523 4 0.020
positive regulation of cell development GO:0010720 92 0.019
mitotic nuclear division GO:0007067 119 0.019
Yeast
membrane budding GO:0006900 28 0.019
adherens junction assembly GO:0034333 34 0.019
positive regulation of synapse structural plasticity GO:0051835 2 0.019
semaphorin plexin signaling pathway GO:0071526 4 0.019
developmental cell growth GO:0048588 18 0.019
positive regulation of stress activated mapk cascade GO:0032874 60 0.019
sensory organ development GO:0007423 52 0.019
response to lipid GO:0033993 206 0.019
asymmetric stem cell division GO:0098722 1 0.019
cell substrate junction assembly GO:0007044 35 0.019
Worm
embryo development GO:0009790 123 0.018
Worm
synaptic vesicle exocytosis GO:0016079 3 0.018
negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 7 0.018
metencephalon development GO:0022037 2 0.018
negative regulation of kinase activity GO:0033673 106 0.018
regulation of locomotion GO:0040012 329 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
Rat
ectodermal placode development GO:0071696 1 0.018
positive regulation of growth GO:0045927 58 0.018
cell cycle phase transition GO:0044770 173 0.018
negative regulation of map kinase activity GO:0043407 27 0.018
positive regulation of lamellipodium assembly GO:0010592 9 0.018
regulation of growth GO:0040008 165 0.018
gastrulation GO:0007369 51 0.018
developmental growth GO:0048589 48 0.017
glycerolipid metabolic process GO:0046486 107 0.017
response to epidermal growth factor GO:0070849 14 0.017

PAK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 70 0.096
Human
developmental disorder of mental health DOID:0060037 29 0.096
Human
specific developmental disorder DOID:0060038 19 0.096
Human
intellectual disability DOID:1059 13 0.096
Human
non syndromic intellectual disability DOID:0050889 9 0.085
Human
non specific x linked mental retardation DOID:0050776 7 0.085
Human
urinary system disease DOID:18 40 0.033
muscular disease DOID:0080000 114 0.025
musculoskeletal system disease DOID:17 223 0.025
kidney disease DOID:557 36 0.022
disease of metabolism DOID:0014667 295 0.020
inherited metabolic disorder DOID:655 242 0.020
nephrotic syndrome DOID:1184 10 0.018
nephrosis DOID:2527 10 0.018