Homo sapiens

0 known processes

PAPOLA

poly(A) polymerase alpha

(Aliases: PAP,MGC5378)

PAPOLA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female gamete generation GO:0007292 2 0.868
Worm
post embryonic development GO:0009791 2 0.706
Worm
nuclear transport GO:0051169 179 0.700
cell development GO:0048468 328 0.438
Worm
regulation of intracellular transport GO:0032386 195 0.432
regulation of protein transport GO:0051223 213 0.423
negative regulation of protein metabolic process GO:0051248 391 0.403
negative regulation of programmed cell death GO:0043069 321 0.402
single organism cellular localization GO:1902580 332 0.393
regulation of protein localization GO:0032880 296 0.386
oogenesis GO:0048477 2 0.356
Worm
organelle assembly GO:0070925 176 0.351
nuclear import GO:0051170 106 0.305
determination of adult lifespan GO:0008340 2 0.302
negative regulation of cell death GO:0060548 345 0.301
vesicle mediated transport GO:0016192 371 0.269
regulation of multi organism process GO:0043900 157 0.266
regulation of intracellular protein transport GO:0033157 123 0.259
protein targeting GO:0006605 187 0.241
intracellular protein transport GO:0006886 270 0.240
protein import GO:0017038 130 0.233
protein targeting to nucleus GO:0044744 104 0.226
regulation of transferase activity GO:0051338 355 0.218
cytoplasmic transport GO:0016482 379 0.216
protein import into nucleus GO:0006606 104 0.209
cellular component morphogenesis GO:0032989 314 0.200
regulation of establishment of protein localization GO:0070201 242 0.195
nitrogen compound transport GO:0071705 191 0.193
negative regulation of apoptotic process GO:0043066 316 0.193
regulation of cytoplasmic transport GO:1903649 149 0.192
lipid biosynthetic process GO:0008610 177 0.190
nucleocytoplasmic transport GO:0006913 176 0.177
single organism nuclear import GO:1902593 104 0.175
regulation of proteolysis GO:0030162 293 0.162
regulation of protein import into nucleus GO:0042306 78 0.158
lipid metabolic process GO:0006629 381 0.154
cell part morphogenesis GO:0032990 137 0.147
positive regulation of transport GO:0051050 336 0.147
multicellular organismal aging GO:0010259 3 0.145
oocyte differentiation GO:0009994 2 0.145
regulation of cell cycle GO:0051726 393 0.141
regulation of cellular ketone metabolic process GO:0010565 50 0.141
endosomal transport GO:0016197 129 0.136
regulation of growth GO:0040008 165 0.132
response to other organism GO:0051707 261 0.132
oocyte development GO:0048599 1 0.132
cellular macromolecular complex assembly GO:0034622 324 0.129
negative regulation of protein phosphorylation GO:0001933 140 0.129
regulation of nucleotide metabolic process GO:0006140 269 0.125
response to external biotic stimulus GO:0043207 261 0.125
response to biotic stimulus GO:0009607 276 0.125
multi organism cellular process GO:0044764 156 0.122
organophosphate biosynthetic process GO:0090407 163 0.122
regulation of protein targeting GO:1903533 91 0.117
cellular macromolecule catabolic process GO:0044265 380 0.116
cellular lipid metabolic process GO:0044255 303 0.116
modification dependent macromolecule catabolic process GO:0043632 212 0.115
carbohydrate metabolic process GO:0005975 207 0.111
regulation of cellular component biogenesis GO:0044087 281 0.105
negative regulation of phosphate metabolic process GO:0045936 267 0.104
negative regulation of protein modification process GO:0031400 200 0.103
protein localization to organelle GO:0033365 280 0.103
amine metabolic process GO:0009308 44 0.094
small molecule biosynthetic process GO:0044283 157 0.094
muscle structure development GO:0061061 98 0.093
establishment of protein localization to organelle GO:0072594 172 0.092
positive regulation of cell death GO:0010942 263 0.091
regulation of meiotic cell cycle GO:0051445 4 0.091
cell morphogenesis GO:0000902 296 0.085
mitotic cell cycle process GO:1903047 286 0.083
regulation of peptidase activity GO:0052547 180 0.082
negative regulation of phosphorylation GO:0042326 174 0.082
system process GO:0003008 349 0.076
generation of neurons GO:0048699 152 0.076
regulation of cell differentiation GO:0045595 393 0.075
regulation of kinase activity GO:0043549 314 0.074
positive regulation of cellular catabolic process GO:0031331 284 0.071
anatomical structure formation involved in morphogenesis GO:0048646 284 0.070
positive regulation of cell proliferation GO:0008284 301 0.069
positive regulation of apoptotic process GO:0043065 246 0.068
positive regulation of growth GO:0045927 58 0.066
neuroblast proliferation GO:0007405 4 0.066
regulation of stress activated mapk cascade GO:0032872 84 0.066
regulation of cellular amine metabolic process GO:0033238 11 0.065
negative regulation of kinase activity GO:0033673 106 0.065
translation GO:0006412 132 0.065
protein localization to nucleus GO:0034504 136 0.065
spermatid development GO:0007286 4 0.065
negative regulation of cellular protein metabolic process GO:0032269 353 0.064
regulation of protein kinase activity GO:0045859 289 0.064
developmental growth GO:0048589 48 0.061
regulation of nucleocytoplasmic transport GO:0046822 98 0.060
protein catabolic process GO:0030163 325 0.059
signal release GO:0023061 70 0.059
response to abiotic stimulus GO:0009628 336 0.059
positive regulation of cellular component organization GO:0051130 376 0.057
receptor mediated endocytosis GO:0006898 84 0.056
maintenance of protein location GO:0045185 57 0.056
cellular ketone metabolic process GO:0042180 80 0.054
cellular amino acid metabolic process GO:0006520 116 0.054
regulation of nervous system development GO:0051960 88 0.050
response to virus GO:0009615 126 0.050
cell cell junction organization GO:0045216 69 0.048
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.047
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.047
behavior GO:0007610 112 0.047
cellular component assembly involved in morphogenesis GO:0010927 73 0.045
defense response to other organism GO:0098542 129 0.045
cellular carbohydrate metabolic process GO:0044262 84 0.045
posttranscriptional regulation of gene expression GO:0010608 213 0.045
regulation of cell cycle process GO:0010564 266 0.045
chemical homeostasis GO:0048878 306 0.044
negative regulation of cellular component organization GO:0051129 235 0.044
positive regulation of catabolic process GO:0009896 310 0.044
protein localization to membrane GO:0072657 160 0.044
negative regulation of protein transport GO:0051224 75 0.044
growth GO:0040007 202 0.044
negative regulation of transferase activity GO:0051348 124 0.043
small gtpase mediated signal transduction GO:0007264 78 0.043
reproductive process GO:0022414 106 0.043
Worm
innate immune response GO:0045087 178 0.043
cellular protein complex assembly GO:0043623 188 0.042
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.042
protein oligomerization GO:0051259 173 0.042
positive regulation of meiotic cell cycle GO:0051446 2 0.041
organelle localization GO:0051640 84 0.041
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.041
actin filament based process GO:0030029 224 0.041
negative regulation of catalytic activity GO:0043086 335 0.040
regulation of lipid metabolic process GO:0019216 96 0.040
lysosomal transport GO:0007041 33 0.040
maintenance of location GO:0051235 112 0.040
positive regulation of programmed cell death GO:0043068 249 0.039
ribonucleoprotein complex subunit organization GO:0071826 81 0.039
secretion by cell GO:0032940 226 0.038
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.038
positive regulation of protein phosphorylation GO:0001934 313 0.037
regulation of cell morphogenesis GO:0022604 153 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
multicellular organism reproduction GO:0032504 42 0.037
Worm
glycerolipid metabolic process GO:0046486 107 0.036
locomotory behavior GO:0007626 1 0.036
ribonucleoprotein complex biogenesis GO:0022613 116 0.035
negative regulation of intracellular signal transduction GO:1902532 183 0.035
mitotic cell cycle GO:0000278 326 0.035
nuclear transcribed mrna catabolic process no go decay GO:0070966 2 0.035
response to light stimulus GO:0009416 87 0.035
regulation of cell development GO:0060284 161 0.034
positive regulation of proteolysis GO:0045862 142 0.034
nucleic acid transport GO:0050657 39 0.034
cell cell signaling GO:0007267 155 0.033
spermatid differentiation GO:0048515 4 0.033
vacuolar transport GO:0007034 34 0.033
regulation of ras protein signal transduction GO:0046578 155 0.033
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.033
response to oxygen containing compound GO:1901700 369 0.032
apoptotic signaling pathway GO:0097190 268 0.032
ncrna metabolic process GO:0034660 108 0.032
cell cycle checkpoint GO:0000075 117 0.032
dephosphorylation GO:0016311 209 0.032
muscle cell differentiation GO:0042692 63 0.032
cellular response to dna damage stimulus GO:0006974 379 0.031
stem cell division GO:0017145 2 0.031
regulation of protein localization to nucleus GO:1900180 85 0.031
single organism carbohydrate metabolic process GO:0044723 193 0.031
microtubule based process GO:0007017 210 0.031
nervous system development GO:0007399 293 0.031
response to radiation GO:0009314 151 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.030
multi organism reproductive process GO:0044703 54 0.030
Worm
membrane organization GO:0061024 292 0.030
mrna metabolic process GO:0016071 175 0.030
signal transduction by phosphorylation GO:0023014 297 0.030
positive regulation of hydrolase activity GO:0051345 331 0.030
secretion GO:0046903 254 0.030
neuron projection development GO:0031175 106 0.030
enzyme linked receptor protein signaling pathway GO:0007167 303 0.030
response to hormone GO:0009725 175 0.029
cell projection morphogenesis GO:0048858 129 0.029
regulation of purine nucleotide catabolic process GO:0033121 205 0.029
neuron development GO:0048666 113 0.029
response to growth factor GO:0070848 205 0.028
regulation of anatomical structure morphogenesis GO:0022603 286 0.028
cilium morphogenesis GO:0060271 75 0.028
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.028
cellular response to endogenous stimulus GO:0071495 336 0.028
positive regulation of intracellular transport GO:0032388 104 0.028
rna 3 end processing GO:0031123 35 0.027
Human Mouse
endocytosis GO:0006897 159 0.027
covalent chromatin modification GO:0016569 254 0.027
cellular response to oxygen containing compound GO:1901701 276 0.027
notch signaling pathway GO:0007219 31 0.026
regulation of cellular response to stress GO:0080135 244 0.026
single organism cell adhesion GO:0098602 179 0.026
dendrite development GO:0016358 24 0.025
cell projection organization GO:0030030 252 0.025
cell junction organization GO:0034330 79 0.025
cell adhesion GO:0007155 325 0.025
embryo development ending in birth or egg hatching GO:0009792 34 0.025
Worm
respiratory tube development GO:0030323 20 0.025
regulation of proteasomal protein catabolic process GO:0061136 87 0.025
positive regulation of cellular component biogenesis GO:0044089 158 0.025
single organism membrane organization GO:0044802 268 0.024
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.023
negative regulation of cell proliferation GO:0008285 228 0.023
regulation of cellular amino acid metabolic process GO:0006521 6 0.023
positive regulation of secretion GO:0051047 116 0.023
pattern specification process GO:0007389 43 0.023
negative regulation of protein kinase activity GO:0006469 98 0.023
regulation of developmental growth GO:0048638 30 0.023
response to steroid hormone GO:0048545 80 0.023
defense response GO:0006952 315 0.023
glycerophospholipid metabolic process GO:0006650 84 0.023
negative regulation of transport GO:0051051 176 0.022
regulation of defense response GO:0031347 154 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
interspecies interaction between organisms GO:0044419 156 0.022
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.022
aging GO:0007568 66 0.022
regulation of protein catabolic process GO:0042176 155 0.022
macromolecule methylation GO:0043414 97 0.021
embryo development GO:0009790 123 0.021
Worm
neurogenesis GO:0022008 169 0.021
regulation of mapk cascade GO:0043408 262 0.021
angiogenesis GO:0001525 147 0.021
neuromuscular junction development GO:0007528 3 0.021
response to transforming growth factor beta GO:0071559 94 0.020
alcohol metabolic process GO:0006066 114 0.020
blood vessel development GO:0001568 172 0.020
establishment of rna localization GO:0051236 39 0.020
neurotransmitter secretion GO:0007269 4 0.020
regulation of cell projection organization GO:0031344 107 0.020
cardiovascular system development GO:0072358 262 0.020
establishment of protein localization to membrane GO:0090150 121 0.020
chromatin organization GO:0006325 351 0.019
golgi vesicle transport GO:0048193 80 0.019
negative regulation of cell cycle GO:0045786 193 0.019
purine nucleotide biosynthetic process GO:0006164 84 0.019
regulation of endopeptidase activity GO:0052548 170 0.019
positive regulation of developmental growth GO:0048639 16 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
viral life cycle GO:0019058 132 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
positive regulation of immune system process GO:0002684 283 0.019
chromatin modification GO:0016568 298 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.018
multicellular organismal reproductive process GO:0048609 40 0.018
Worm
neuron differentiation GO:0030182 138 0.018
response to starvation GO:0042594 59 0.018
regulation of cellular response to growth factor stimulus GO:0090287 76 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
reproduction GO:0000003 63 0.018
Worm
regulation of membrane potential GO:0042391 95 0.018
cell projection assembly GO:0030031 126 0.018
insulin secretion GO:0030073 39 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
positive regulation of multicellular organism growth GO:0040018 6 0.018
regulation of dna templated transcription elongation GO:0032784 23 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.018
negative regulation of cytoplasmic transport GO:1903650 46 0.018
cell growth GO:0016049 160 0.017
ion homeostasis GO:0050801 230 0.017
regulation of mitotic cell cycle GO:0007346 189 0.017
immune response GO:0006955 307 0.017
cell cycle phase transition GO:0044770 173 0.017
regulation of cellular component movement GO:0051270 334 0.017
actin cytoskeleton organization GO:0030036 207 0.017
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.016
gamete generation GO:0007276 25 0.016
Worm
vasculature development GO:0001944 181 0.016
viral process GO:0016032 146 0.016
mitotic cell cycle checkpoint GO:0007093 68 0.016
endomembrane system organization GO:0010256 196 0.016
guanosine containing compound metabolic process GO:1901068 244 0.016
organic hydroxy compound metabolic process GO:1901615 147 0.016
circadian behavior GO:0048512 2 0.016
regulation of anatomical structure size GO:0090066 101 0.016
positive regulation of protein transport GO:0051222 135 0.015
regulation of small gtpase mediated signal transduction GO:0051056 156 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
nucleoside catabolic process GO:0009164 408 0.015
cellular response to organonitrogen compound GO:0071417 124 0.015
ribonucleoprotein complex assembly GO:0022618 78 0.015
regulation of protein serine threonine kinase activity GO:0071900 179 0.015
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
positive regulation of intracellular protein transport GO:0090316 76 0.015
rna export from nucleus GO:0006405 33 0.015
protein folding GO:0006457 38 0.015
positive regulation of cell motility GO:2000147 177 0.015
mapk cascade GO:0000165 288 0.015
mitochondrion organization GO:0007005 156 0.015
cellular amine metabolic process GO:0044106 41 0.015
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
neurological system process GO:0050877 163 0.014
cellular homeostasis GO:0019725 196 0.014
gene silencing by rna GO:0031047 26 0.014
striated muscle tissue development GO:0014706 59 0.014
protein alkylation GO:0008213 74 0.014
ribonucleotide catabolic process GO:0009261 405 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.013
nucleobase containing compound transport GO:0015931 51 0.013
regulation of organelle assembly GO:1902115 40 0.013
regeneration GO:0031099 4 0.013
rna localization GO:0006403 41 0.013
positive regulation of multi organism process GO:0043902 56 0.013
biological adhesion GO:0022610 331 0.013
rna transport GO:0050658 39 0.013
purine nucleoside triphosphate metabolic process GO:0009144 412 0.013
negative regulation of apoptotic signaling pathway GO:2001234 97 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.013
cell activation GO:0001775 213 0.013
regulation of peptide transport GO:0090087 62 0.013
blood vessel morphogenesis GO:0048514 162 0.013
protein dna complex assembly GO:0065004 64 0.012
negative regulation of growth GO:0045926 97 0.012
positive regulation of peptidase activity GO:0010952 88 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
regulation of response to external stimulus GO:0032101 222 0.012
cilium assembly GO:0042384 63 0.012
developmental process involved in reproduction GO:0003006 66 0.012
Worm
regulation of mrna processing GO:0050684 48 0.012
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.012
regulation of cellular protein catabolic process GO:1903362 96 0.012
leukocyte proliferation GO:0070661 74 0.012
cilium organization GO:0044782 68 0.012
organic acid biosynthetic process GO:0016053 97 0.011
protein dephosphorylation GO:0006470 81 0.011
response to organic cyclic compound GO:0014070 204 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
peptide transport GO:0015833 74 0.011
cellular protein catabolic process GO:0044257 261 0.011
negative regulation of developmental process GO:0051093 247 0.011
Worm
cell fate determination GO:0001709 3 0.011
regulation of cellular component size GO:0032535 82 0.011
regulation of oocyte development GO:0060281 1 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
stress activated protein kinase signaling cascade GO:0031098 94 0.011
dna replication GO:0006260 116 0.011
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.011
spindle organization GO:0007051 53 0.011
negative regulation of immune system process GO:0002683 136 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.011
negative regulation of stress activated mapk cascade GO:0032873 19 0.011
positive regulation of cytoplasmic transport GO:1903651 82 0.011
response to oxidative stress GO:0006979 121 0.011
gtp catabolic process GO:0006184 237 0.011
regulation of neurogenesis GO:0050767 82 0.010
purine containing compound catabolic process GO:0072523 411 0.010
skeletal system development GO:0001501 79 0.010
striated muscle cell differentiation GO:0051146 43 0.010
cytokine production GO:0001816 247 0.010
regulation of cell migration GO:0030334 289 0.010
spermatogenesis GO:0007283 22 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
maintenance of location in cell GO:0051651 62 0.010
metal ion transport GO:0030001 272 0.010
amide transport GO:0042886 76 0.010
cellular divalent inorganic cation homeostasis GO:0072503 128 0.010
response to nitrogen compound GO:1901698 184 0.010
carbohydrate biosynthetic process GO:0016051 42 0.010

PAPOLA disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.034
nervous system disease DOID:863 431 0.034
cancer DOID:162 167 0.022
disease of cellular proliferation DOID:14566 174 0.022
organ system cancer DOID:0050686 164 0.022
disease of mental health DOID:150 70 0.011