Homo sapiens

44 known processes

PDHA1

pyruvate dehydrogenase (lipoamide) alpha 1

(Aliases: PDHA,PDHCE1A,PHE1A)

PDHA1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
acetyl coa biosynthetic process from pyruvate GO:0006086 4 0.960
cofactor biosynthetic process GO:0051188 31 0.929
oxidation reduction process GO:0055114 396 0.909
acyl coa metabolic process GO:0006637 23 0.830
citrate metabolic process GO:0006101 2 0.823
generation of precursor metabolites and energy GO:0006091 68 0.802
sulfur compound biosynthetic process GO:0044272 38 0.795
monocarboxylic acid metabolic process GO:0032787 185 0.761
tricarboxylic acid cycle GO:0006099 4 0.737
cofactor metabolic process GO:0051186 87 0.648
coenzyme metabolic process GO:0006732 65 0.624
thioester metabolic process GO:0035383 23 0.607
sulfur compound metabolic process GO:0006790 101 0.574
coenzyme biosynthetic process GO:0009108 24 0.573
acyl coa biosynthetic process GO:0071616 6 0.480
vesicle mediated transport GO:0016192 371 0.468
Worm
determination of adult lifespan GO:0008340 2 0.464
Worm
glycerol metabolic process GO:0006071 4 0.461
thioester biosynthetic process GO:0035384 6 0.403
aspartate family amino acid catabolic process GO:0009068 5 0.399
multicellular organismal aging GO:0010259 3 0.356
Worm
regulation of peptidase activity GO:0052547 180 0.347
tricarboxylic acid metabolic process GO:0072350 4 0.320
dicarboxylic acid catabolic process GO:0043649 9 0.293
post embryonic development GO:0009791 2 0.275
aspartate metabolic process GO:0006531 4 0.242
purine nucleoside monophosphate metabolic process GO:0009126 186 0.175
acetyl coa biosynthetic process GO:0006085 6 0.170
cellular respiration GO:0045333 21 0.169
energy derivation by oxidation of organic compounds GO:0015980 43 0.168
fatty acid metabolic process GO:0006631 115 0.157
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.154
positive regulation of peptidase activity GO:0010952 88 0.142
pyruvate metabolic process GO:0006090 26 0.124
receptor mediated endocytosis GO:0006898 84 0.122
Worm
protein maturation GO:0051604 233 0.116
mitochondrial membrane organization GO:0007006 40 0.113
cellular amino acid metabolic process GO:0006520 116 0.113
protein processing GO:0016485 226 0.112
small molecule catabolic process GO:0044282 92 0.110
positive regulation of programmed cell death GO:0043068 249 0.110
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.106
cell cell signaling GO:0007267 155 0.100
positive regulation of hydrolase activity GO:0051345 331 0.094
glutamate metabolic process GO:0006536 10 0.093
embryo development GO:0009790 123 0.088
Worm
dicarboxylic acid metabolic process GO:0043648 29 0.087
aerobic respiration GO:0009060 7 0.087
purine nucleoside triphosphate metabolic process GO:0009144 412 0.083
organic acid catabolic process GO:0016054 71 0.083
small molecule biosynthetic process GO:0044283 157 0.079
lipid metabolic process GO:0006629 381 0.077
alditol metabolic process GO:0019400 5 0.074
organonitrogen compound biosynthetic process GO:1901566 200 0.070
cellular ketone metabolic process GO:0042180 80 0.069
positive regulation of proteolysis GO:0045862 142 0.068
acetyl coa metabolic process GO:0006084 8 0.067
nucleotide biosynthetic process GO:0009165 109 0.064
positive regulation of apoptotic process GO:0043065 246 0.063
endocytosis GO:0006897 159 0.063
Worm
activation of cysteine type endopeptidase activity GO:0097202 57 0.062
mitochondrion organization GO:0007005 156 0.059
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.056
zymogen activation GO:0031638 70 0.056
nucleoside monophosphate metabolic process GO:0009123 191 0.054
regulation of endopeptidase activity GO:0052548 170 0.051
regulation of cysteine type endopeptidase activity GO:2000116 127 0.051
single organism membrane organization GO:0044802 268 0.050
glutamine family amino acid metabolic process GO:0009064 17 0.050
glutamate biosynthetic process GO:0006537 3 0.049
atp metabolic process GO:0046034 176 0.048
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.047
response to hormone GO:0009725 175 0.047
system process GO:0003008 349 0.046
positive regulation of cell death GO:0010942 263 0.046
cellular amino acid biosynthetic process GO:0008652 30 0.044
dicarboxylic acid biosynthetic process GO:0043650 4 0.044
cellular protein complex assembly GO:0043623 188 0.042
negative regulation of transport GO:0051051 176 0.041
carbohydrate metabolic process GO:0005975 207 0.041
defense response GO:0006952 315 0.041
cellular macromolecular complex assembly GO:0034622 324 0.041
microtubule cytoskeleton organization GO:0000226 176 0.040
sleep GO:0030431 2 0.039
adult locomotory behavior GO:0008344 1 0.039
alpha amino acid metabolic process GO:1901605 72 0.038
spermatid differentiation GO:0048515 4 0.037
alpha amino acid biosynthetic process GO:1901607 23 0.036
neuromuscular junction development GO:0007528 3 0.036
regulation of membrane potential GO:0042391 95 0.035
nervous system development GO:0007399 293 0.035
organic acid biosynthetic process GO:0016053 97 0.034
nucleoside triphosphate metabolic process GO:0009141 422 0.034
membrane organization GO:0061024 292 0.033
negative regulation of cell death GO:0060548 345 0.032
apoptotic mitochondrial changes GO:0008637 57 0.031
microtubule based process GO:0007017 210 0.031
embryo development ending in birth or egg hatching GO:0009792 34 0.031
Worm
cell development GO:0048468 328 0.030
Worm
dna catabolic process GO:0006308 49 0.029
cellular carbohydrate metabolic process GO:0044262 84 0.029
response to endoplasmic reticulum stress GO:0034976 49 0.029
regulation of proteolysis GO:0030162 293 0.029
positive regulation of endopeptidase activity GO:0010950 84 0.028
purine ribonucleoside metabolic process GO:0046128 437 0.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.027
negative regulation of intracellular signal transduction GO:1902532 183 0.027
cellular lipid metabolic process GO:0044255 303 0.026
nucleoside catabolic process GO:0009164 408 0.026
regulation of cellular ketone metabolic process GO:0010565 50 0.026
locomotory behavior GO:0007626 1 0.025
carboxylic acid biosynthetic process GO:0046394 97 0.024
innate immune response GO:0045087 178 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
growth GO:0040007 202 0.023
negative regulation of programmed cell death GO:0043069 321 0.023
chemical homeostasis GO:0048878 306 0.023
cellular amino acid catabolic process GO:0009063 31 0.023
response to oxidative stress GO:0006979 121 0.022
carboxylic acid catabolic process GO:0046395 71 0.022
cellular amine metabolic process GO:0044106 41 0.021
ion homeostasis GO:0050801 230 0.021
protein targeting GO:0006605 187 0.021
organelle fusion GO:0048284 36 0.021
organic hydroxy compound biosynthetic process GO:1901617 71 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
aging GO:0007568 66 0.020
Worm
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
nadh dehydrogenase complex assembly GO:0010257 16 0.020
ribonucleotide catabolic process GO:0009261 405 0.020
regeneration GO:0031099 4 0.020
protein localization to organelle GO:0033365 280 0.020
response to wounding GO:0009611 168 0.019
purine ribonucleoside catabolic process GO:0046130 398 0.019
response to abiotic stimulus GO:0009628 336 0.019
cation transport GO:0006812 331 0.019
segmentation GO:0035282 4 0.019
amine metabolic process GO:0009308 44 0.018
tissue regeneration GO:0042246 3 0.018
central nervous system development GO:0007417 123 0.018
behavior GO:0007610 112 0.018
negative regulation of multicellular organismal process GO:0051241 317 0.018
wound healing GO:0042060 115 0.018
reproduction GO:0000003 63 0.018
Worm
regulation of response to external stimulus GO:0032101 222 0.017
actin filament based process GO:0030029 224 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
regulation of cell adhesion GO:0030155 166 0.017
biological adhesion GO:0022610 331 0.017
atp synthesis coupled electron transport GO:0042773 4 0.017
female gamete generation GO:0007292 2 0.017
Worm
epithelium development GO:0060429 227 0.016
spermatid development GO:0007286 4 0.016
response to nitrogen compound GO:1901698 184 0.016
organophosphate catabolic process GO:0046434 430 0.016
reactive oxygen species metabolic process GO:0072593 75 0.016
glutamine family amino acid biosynthetic process GO:0009084 5 0.016
dephosphorylation GO:0016311 209 0.016
alpha amino acid catabolic process GO:1901606 26 0.016
positive regulation of developmental process GO:0051094 314 0.016
mitochondrial atp synthesis coupled electron transport GO:0042775 4 0.015
execution phase of apoptosis GO:0097194 32 0.015
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.015
response to organic cyclic compound GO:0014070 204 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
nucleotide catabolic process GO:0009166 408 0.015
generation of neurons GO:0048699 152 0.015
response to oxygen containing compound GO:1901700 369 0.015
maintenance of location GO:0051235 112 0.015
neuron differentiation GO:0030182 138 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
apoptotic nuclear changes GO:0030262 13 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
cellular component morphogenesis GO:0032989 314 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.014
regulation of growth GO:0040008 165 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
regulation of protein kinase activity GO:0045859 289 0.014
mitochondrial respiratory chain complex assembly GO:0033108 23 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
immune system development GO:0002520 195 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.013
response to external biotic stimulus GO:0043207 261 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
apoptotic signaling pathway GO:0097190 268 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
cellular response to oxidative stress GO:0034599 85 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
secretion by cell GO:0032940 226 0.013
response to organonitrogen compound GO:0010243 156 0.013
tissue homeostasis GO:0001894 63 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
cell adhesion GO:0007155 325 0.012
response to hypoxia GO:0001666 96 0.012
receptor metabolic process GO:0043112 81 0.012
cellular amide metabolic process GO:0043603 69 0.012
muscle system process GO:0003012 81 0.012
actin cytoskeleton organization GO:0030036 207 0.012
lipid oxidation GO:0034440 33 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
mitochondrial transport GO:0006839 60 0.012
oxidative phosphorylation GO:0006119 10 0.012
response to lipid GO:0033993 206 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
cellular response to organonitrogen compound GO:0071417 124 0.012
embryonic morphogenesis GO:0048598 85 0.012
neurological system process GO:0050877 163 0.012
oogenesis GO:0048477 2 0.012
Worm
regulation of kinase activity GO:0043549 314 0.012
negative regulation of apoptotic signaling pathway GO:2001234 97 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
intracellular protein transport GO:0006886 270 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
negative regulation of protein modification process GO:0031400 200 0.011
anterior posterior axis specification GO:0009948 2 0.011
protein stabilization GO:0050821 64 0.011
cellular ion homeostasis GO:0006873 168 0.011
ossification GO:0001503 121 0.011
alcohol biosynthetic process GO:0046165 52 0.011
immune response GO:0006955 307 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
negative regulation of peptidase activity GO:0010466 91 0.011
cytoplasmic transport GO:0016482 379 0.011
negative regulation of transferase activity GO:0051348 124 0.011
head development GO:0060322 108 0.011
spinal cord development GO:0021510 4 0.011
neurogenesis GO:0022008 169 0.011
cellular macromolecule catabolic process GO:0044265 380 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
regulation of cytokine production GO:0001817 232 0.011
circulatory system development GO:0072359 262 0.010
single organism reproductive process GO:0044702 98 0.010
Worm
glycosyl compound catabolic process GO:1901658 413 0.010
synaptic transmission GO:0007268 61 0.010
cardiovascular system development GO:0072358 262 0.010
signal peptide processing GO:0006465 3 0.010
regulation of nucleoside metabolic process GO:0009118 209 0.010
protein acylation GO:0043543 138 0.010
oxaloacetate metabolic process GO:0006107 1 0.010
regulation of defense response GO:0031347 154 0.010
response to biotic stimulus GO:0009607 276 0.010
nitrogen compound transport GO:0071705 191 0.010
developmental process involved in reproduction GO:0003006 66 0.010
Worm
cell part morphogenesis GO:0032990 137 0.010

PDHA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.206
amino acid metabolic disorder DOID:9252 50 0.197
inherited metabolic disorder DOID:655 242 0.197
central nervous system disease DOID:331 186 0.108
nervous system disease DOID:863 431 0.108
immune system disease DOID:2914 155 0.035
neurodegenerative disease DOID:1289 102 0.019
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015
neuromuscular disease DOID:440 38 0.014
neuropathy DOID:870 52 0.014
leigh disease DOID:3652 16 0.014
mitochondrial metabolism disease DOID:700 29 0.014
carbohydrate metabolic disorder DOID:2978 55 0.003