Homo sapiens

0 known processes

PDIA4

protein disulfide isomerase family A, member 4

(Aliases: ERP72,ERP70,ERp-72)

PDIA4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein folding GO:0006457 38 0.999
Yeast Rat
chaperone mediated protein folding GO:0061077 13 0.998
Rat
response to unfolded protein GO:0006986 24 0.961
Worm
response to topologically incorrect protein GO:0035966 29 0.629
Worm
endoplasmic reticulum unfolded protein response GO:0030968 16 0.621
Worm
cellular amino acid metabolic process GO:0006520 116 0.597
cellular response to topologically incorrect protein GO:0035967 19 0.568
Worm
4 hydroxyproline metabolic process GO:0019471 5 0.513
negative regulation of sequestering of calcium ion GO:0051283 41 0.428
regulation of behavior GO:0050795 82 0.371
response to endoplasmic reticulum stress GO:0034976 49 0.367
Worm
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.344
oxidation reduction process GO:0055114 396 0.340
Yeast
cellular modified amino acid metabolic process GO:0006575 64 0.334
cellular response to unfolded protein GO:0034620 16 0.332
Worm
er nucleus signaling pathway GO:0006984 23 0.307
Worm
alpha amino acid metabolic process GO:1901605 72 0.291
sequestering of metal ion GO:0051238 24 0.280
protein hydroxylation GO:0018126 9 0.256
post embryonic development GO:0009791 2 0.234
positive regulation of cell motility GO:2000147 177 0.212
sleep GO:0030431 2 0.182
response to hypoxia GO:0001666 96 0.173
response to decreased oxygen levels GO:0036293 96 0.168
negative regulation of apoptotic process GO:0043066 316 0.167
cardiovascular system development GO:0072358 262 0.159
cellular amine metabolic process GO:0044106 41 0.151
actin filament based process GO:0030029 224 0.151
cell chemotaxis GO:0060326 112 0.151
de novo protein folding GO:0006458 2 0.150
regulation of sequestering of calcium ion GO:0051282 41 0.144
posttranscriptional regulation of gene expression GO:0010608 213 0.142
response to oxygen containing compound GO:1901700 369 0.140
protein stabilization GO:0050821 64 0.140
positive regulation of cellular component organization GO:0051130 376 0.140
peptidyl tyrosine phosphorylation GO:0018108 170 0.135
intrinsic apoptotic signaling pathway GO:0097193 127 0.131
startle response GO:0001964 3 0.119
sequestering of calcium ion GO:0051208 17 0.116
negative regulation of retinoic acid receptor signaling pathway GO:0048387 4 0.114
response to abiotic stimulus GO:0009628 336 0.110
protein glycosylation GO:0006486 62 0.109
lipid localization GO:0010876 106 0.108
positive regulation of developmental growth GO:0048639 16 0.106
Worm
regulation of protein stability GO:0031647 87 0.104
cellular homeostasis GO:0019725 196 0.102
divalent metal ion transport GO:0070838 152 0.101
determination of adult lifespan GO:0008340 2 0.097
dephosphorylation GO:0016311 209 0.095
positive regulation of chemotaxis GO:0050921 57 0.093
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.093
response to oxygen levels GO:0070482 100 0.090
positive regulation of cell death GO:0010942 263 0.089
vesicle mediated transport GO:0016192 371 0.089
system process GO:0003008 349 0.088
actin cytoskeleton organization GO:0030036 207 0.087
glycoprotein biosynthetic process GO:0009101 91 0.086
positive regulation of developmental process GO:0051094 314 0.085
Worm
positive regulation of programmed cell death GO:0043068 249 0.084
regulation of cell motility GO:2000145 299 0.084
regulation of cellular amino acid metabolic process GO:0006521 6 0.080
cytokinesis GO:0000910 96 0.080
regulation of apoptotic signaling pathway GO:2001233 175 0.079
apoptotic signaling pathway GO:0097190 268 0.077
regulation of chemotaxis GO:0050920 74 0.075
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.074
calcium ion transport GO:0006816 147 0.073
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.071
peptidyl proline modification GO:0018208 15 0.067
locomotory behavior GO:0007626 1 0.067
positive regulation of dna metabolic process GO:0051054 73 0.066
chaperone mediated protein folding requiring cofactor GO:0051085 1 0.066
regulation of proteolysis GO:0030162 293 0.065
protein maturation GO:0051604 233 0.062
cellular cation homeostasis GO:0030003 163 0.061
regulation of growth GO:0040008 165 0.060
Worm
positive regulation of phosphorylation GO:0042327 394 0.059
cellular response to decreased oxygen levels GO:0036294 51 0.055
positive regulation of apoptotic process GO:0043065 246 0.055
regulation of ion homeostasis GO:2000021 73 0.054
positive regulation of blood pressure GO:0045777 3 0.054
cytoplasmic transport GO:0016482 379 0.053
cellular response to external stimulus GO:0071496 111 0.051
central nervous system development GO:0007417 123 0.050
proteasomal protein catabolic process GO:0010498 176 0.049
hindbrain development GO:0030902 3 0.049
cellular ketone metabolic process GO:0042180 80 0.048
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.047
male genitalia development GO:0030539 1 0.047
regulation of wnt protein secretion GO:0061356 1 0.046
glycosylation GO:0070085 71 0.045
nervous system development GO:0007399 293 0.044
regulation of developmental growth GO:0048638 30 0.043
Worm
brain morphogenesis GO:0048854 1 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.042
cytosolic calcium ion transport GO:0060401 48 0.041
monocarboxylic acid metabolic process GO:0032787 185 0.041
cellular response to hypoxia GO:0071456 51 0.040
ubiquitin dependent protein catabolic process GO:0006511 206 0.040
regulation of response to external stimulus GO:0032101 222 0.040
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.040
cellular response to oxygen levels GO:0071453 55 0.040
cellular response to organonitrogen compound GO:0071417 124 0.040
positive regulation of multicellular organism growth GO:0040018 6 0.039
Worm
positive regulation of cell proliferation GO:0008284 301 0.039
regulation of locomotion GO:0040012 329 0.039
single organism membrane organization GO:0044802 268 0.038
regulation of cell migration GO:0030334 289 0.038
cellular calcium ion homeostasis GO:0006874 117 0.037
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 2 0.037
regulation of homeostatic process GO:0032844 121 0.037
response to transforming growth factor beta GO:0071559 94 0.037
protein n linked glycosylation GO:0006487 23 0.036
maintenance of location GO:0051235 112 0.036
heart development GO:0007507 95 0.036
peptidyl tyrosine modification GO:0018212 170 0.035
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 4 0.035
regulation of meiotic cell cycle GO:0051445 4 0.034
regulation of protein secretion GO:0050708 86 0.034
negative regulation of protein metabolic process GO:0051248 391 0.034
regulation of cell adhesion GO:0030155 166 0.033
cytosolic calcium ion homeostasis GO:0051480 89 0.033
antigen processing and presentation GO:0019882 33 0.033
negative regulation of cellular protein metabolic process GO:0032269 353 0.033
regulation of multi organism process GO:0043900 157 0.032
regulation of response to oxidative stress GO:1902882 26 0.032
circulatory system development GO:0072359 262 0.032
growth GO:0040007 202 0.031
Worm
positive regulation of growth GO:0045927 58 0.031
Worm
small molecule catabolic process GO:0044282 92 0.031
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.031
regulation of vesicle mediated transport GO:0060627 130 0.030
cellular response to growth factor stimulus GO:0071363 197 0.030
cellular response to lithium ion GO:0071285 2 0.029
cellular divalent inorganic cation homeostasis GO:0072503 128 0.029
cellular response to endogenous stimulus GO:0071495 336 0.029
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.029
negative regulation of homeostatic process GO:0032845 59 0.029
regulation of cell cycle GO:0051726 393 0.029
cell substrate junction assembly GO:0007044 35 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.028
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.027
positive regulation of response to external stimulus GO:0032103 88 0.027
cellular metal ion homeostasis GO:0006875 146 0.027
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.027
positive regulation of transport GO:0051050 336 0.026
neurological system process GO:0050877 163 0.026
calcium ion transport into cytosol GO:0060402 48 0.026
regulation of dna metabolic process GO:0051052 153 0.026
negative regulation of programmed cell death GO:0043069 321 0.026
divalent inorganic cation transport GO:0072511 158 0.026
de novo posttranslational protein folding GO:0051084 2 0.026
release of sequestered calcium ion into cytosol GO:0051209 41 0.026
positive regulation of systemic arterial blood pressure GO:0003084 2 0.025
developmental growth GO:0048589 48 0.025
Worm
extracellular structure organization GO:0043062 41 0.025
ion homeostasis GO:0050801 230 0.025
cellular ion homeostasis GO:0006873 168 0.025
purine nucleoside catabolic process GO:0006152 398 0.025
chemotaxis GO:0006935 157 0.025
cellular protein catabolic process GO:0044257 261 0.025
oocyte development GO:0048599 1 0.024
response to lithium ion GO:0010226 2 0.024
regulation of cell substrate adhesion GO:0010810 68 0.024
dna replication GO:0006260 116 0.024
negative regulation of cell cycle GO:0045786 193 0.024
regulation of dna replication GO:0006275 68 0.024
regulation of cellular component movement GO:0051270 334 0.023
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.023
metencephalon development GO:0022037 2 0.023
regulation of cellular ketone metabolic process GO:0010565 50 0.023
regulation of cell development GO:0060284 161 0.023
cellular macromolecular complex assembly GO:0034622 324 0.023
cell aging GO:0007569 52 0.023
metal ion homeostasis GO:0055065 169 0.022
cardiac muscle tissue development GO:0048738 39 0.022
cell morphogenesis GO:0000902 296 0.022
regulation of leukocyte chemotaxis GO:0002688 46 0.022
synaptic vesicle endocytosis GO:0048488 2 0.022
positive regulation of hydrolase activity GO:0051345 331 0.022
dopaminergic neuron differentiation GO:0071542 1 0.022
protein catabolic process GO:0030163 325 0.022
regulation of protein kinase activity GO:0045859 289 0.021
calcium ion homeostasis GO:0055074 122 0.021
regulation of oxidative stress induced cell death GO:1903201 24 0.021
muscle cell differentiation GO:0042692 63 0.021
divalent inorganic cation homeostasis GO:0072507 136 0.021
cell cycle arrest GO:0007050 71 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
head development GO:0060322 108 0.021
cell junction assembly GO:0034329 67 0.020
reactive oxygen species metabolic process GO:0072593 75 0.020
regulation of peptidase activity GO:0052547 180 0.020
translation GO:0006412 132 0.020
protein homooligomerization GO:0051260 100 0.020
protein ubiquitination GO:0016567 314 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
oocyte differentiation GO:0009994 2 0.019
regulation of cell cycle process GO:0010564 266 0.019
extrinsic apoptotic signaling pathway GO:0097191 119 0.019
vasoconstriction GO:0042310 11 0.019
reproduction GO:0000003 63 0.019
Worm
response to fungus GO:0009620 4 0.019
negative regulation of catalytic activity GO:0043086 335 0.019
post embryonic organ development GO:0048569 1 0.019
cellular response to oxidative stress GO:0034599 85 0.019
monocyte activation GO:0042117 3 0.019
modification dependent macromolecule catabolic process GO:0043632 212 0.019
positive regulation of dna replication GO:0045740 35 0.019
positive regulation of cell adhesion GO:0045785 84 0.019
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.019
peptidyl asparagine modification GO:0018196 11 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
circulatory system process GO:0003013 113 0.018
response to oxidative stress GO:0006979 121 0.018
glycoprotein metabolic process GO:0009100 110 0.018
intracellular receptor signaling pathway GO:0030522 104 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.018
regulation of cell differentiation GO:0045595 393 0.018
regulation of protein localization GO:0032880 296 0.018
rna interference GO:0016246 4 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
cellular component morphogenesis GO:0032989 314 0.018
multicellular organismal aging GO:0010259 3 0.018
modification dependent protein catabolic process GO:0019941 209 0.017
regulation of kinase activity GO:0043549 314 0.017
regulation of meiosis GO:0040020 3 0.017
leukocyte chemotaxis GO:0030595 76 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.017
regulation of binding GO:0051098 111 0.017
regulation of cysteine type endopeptidase activity GO:2000116 127 0.017
response to nitrogen compound GO:1901698 184 0.017
positive regulation of cell migration GO:0030335 172 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
cellular protein complex assembly GO:0043623 188 0.017
response to organic cyclic compound GO:0014070 204 0.017
response to growth factor GO:0070848 205 0.017
carbohydrate metabolic process GO:0005975 207 0.017
positive regulation of embryonic development GO:0040019 6 0.017
neuron differentiation GO:0030182 138 0.017
regulation of cell morphogenesis GO:0022604 153 0.017
behavior GO:0007610 112 0.016
single organism cellular localization GO:1902580 332 0.016
positive regulation of kinase activity GO:0033674 204 0.016
regulation of endocytosis GO:0030100 72 0.016
genitalia morphogenesis GO:0035112 1 0.016
response to testosterone GO:0033574 1 0.016
ribonucleotide catabolic process GO:0009261 405 0.016
negative regulation of translation GO:0017148 37 0.016
multi organism reproductive process GO:0044703 54 0.016
dendritic cell migration GO:0036336 6 0.016
nucleocytoplasmic transport GO:0006913 176 0.016
sensory perception of smell GO:0007608 2 0.016
regulation of translation GO:0006417 89 0.016
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.016
cation transport GO:0006812 331 0.015
regulation of cellular response to stress GO:0080135 244 0.015
cellular response to hormone stimulus GO:0032870 125 0.015
protein oligomerization GO:0051259 173 0.015
regulation of dephosphorylation GO:0035303 96 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
single organism cell adhesion GO:0098602 179 0.015
positive regulation of proteolysis GO:0045862 142 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
protein modification by small protein conjugation GO:0032446 342 0.015
response to organonitrogen compound GO:0010243 156 0.015
cell morphogenesis involved in differentiation GO:0000904 144 0.015
regeneration GO:0031099 4 0.015
protein maturation by protein folding GO:0022417 2 0.015
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.015
response to glucagon GO:0033762 1 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
response to hormone GO:0009725 175 0.014
positive regulation of secretion GO:0051047 116 0.014
generation of neurons GO:0048699 152 0.014
positive regulation of apoptotic signaling pathway GO:2001235 70 0.014
visual behavior GO:0007632 2 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
extracellular matrix organization GO:0030198 41 0.014
membrane organization GO:0061024 292 0.014
response to steroid hormone GO:0048545 80 0.014
regulation of cell division GO:0051302 116 0.014
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.013
endomembrane system organization GO:0010256 196 0.013
endocytosis GO:0006897 159 0.013
response to axon injury GO:0048678 1 0.013
brain development GO:0007420 97 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
tissue homeostasis GO:0001894 63 0.013
pattern specification process GO:0007389 43 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
actin filament organization GO:0007015 128 0.013
negative regulation of growth GO:0045926 97 0.013
bone development GO:0060348 26 0.013
regulation of lymphocyte chemotaxis GO:1901623 12 0.013
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.013
organ morphogenesis GO:0009887 147 0.013
regulation of blood vessel size GO:0050880 18 0.012
regulation of phosphatase activity GO:0010921 81 0.012
cell adhesion GO:0007155 325 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
regulation of protein catabolic process GO:0042176 155 0.012
cellular response to toxic substance GO:0097237 4 0.012
nucleotide catabolic process GO:0009166 408 0.012
segmentation GO:0035282 4 0.012
cellular response to metal ion GO:0071248 43 0.012
neutrophil migration GO:1990266 25 0.012
aging GO:0007568 66 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
maintenance of protein localization in organelle GO:0072595 15 0.011
positive regulation of immune system process GO:0002684 283 0.011
cerebral cortex radially oriented cell migration GO:0021799 1 0.011
response to starvation GO:0042594 59 0.011
signal release GO:0023061 70 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
response to toxic substance GO:0009636 37 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.011
response to extracellular stimulus GO:0009991 85 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of multicellular organism growth GO:0040014 8 0.011
Worm
cellular macromolecule catabolic process GO:0044265 380 0.011
positive regulation of endocytosis GO:0045807 42 0.011
mitochondrion organization GO:0007005 156 0.011
response to estradiol GO:0032355 23 0.011
regulation of phagocytosis GO:0050764 21 0.011
organophosphate ester transport GO:0015748 32 0.010
multicellular organismal reproductive process GO:0048609 40 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
peptide cross linking GO:0018149 12 0.010
response to inorganic substance GO:0010035 127 0.010
regulation of collagen catabolic process GO:0010710 3 0.010
negative regulation of catabolic process GO:0009895 104 0.010

PDIA4 disease predictions

Disease DO term ID Size Probability Func Analog Org
osteochondrodysplasia DOID:2256 35 0.811
osteogenesis imperfecta DOID:12347 13 0.811
bone development disease DOID:0080006 55 0.811
bone disease DOID:0080001 88 0.811
musculoskeletal system disease DOID:17 223 0.811
connective tissue disease DOID:65 109 0.811
disease of cellular proliferation DOID:14566 174 0.050
cancer DOID:162 167 0.041
organ system cancer DOID:0050686 164 0.041
disease of metabolism DOID:0014667 295 0.027
inherited metabolic disorder DOID:655 242 0.027
central nervous system disease DOID:331 186 0.025
neurodegenerative disease DOID:1289 102 0.025
nervous system disease DOID:863 431 0.025
disease of mental health DOID:150 70 0.017
myeloma DOID:0070004 7 0.016
immune system cancer DOID:0060083 36 0.016
hematologic cancer DOID:2531 36 0.016
bone marrow cancer DOID:4960 10 0.016