Homo sapiens

163 known processes

PHB

prohibitin

(Aliases: PHB1)

PHB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.993
mitochondrion organization GO:0007005 156 0.758
Worm
embryo development GO:0009790 123 0.737
Worm
negative regulation of cell death GO:0060548 345 0.662
ion homeostasis GO:0050801 230 0.544
negative regulation of programmed cell death GO:0043069 321 0.543
receptor mediated endocytosis GO:0006898 84 0.484
vesicle mediated transport GO:0016192 371 0.458
negative regulation of apoptotic process GO:0043066 316 0.358
embryo development ending in birth or egg hatching GO:0009792 34 0.354
Worm
apoptotic signaling pathway GO:0097190 268 0.316
negative regulation of apoptotic signaling pathway GO:2001234 97 0.291
regulation of nucleoside metabolic process GO:0009118 209 0.283
Worm
cytoplasmic transport GO:0016482 379 0.277
oxidation reduction process GO:0055114 396 0.264
regulation of transferase activity GO:0051338 355 0.207
nucleoside triphosphate metabolic process GO:0009141 422 0.196
Worm
multicellular organismal aging GO:0010259 3 0.194
lipid metabolic process GO:0006629 381 0.185
cell type specific apoptotic process GO:0097285 125 0.168
regulation of mitochondrion organization GO:0010821 54 0.164
female gamete generation GO:0007292 2 0.155
Worm
reproductive system development GO:0061458 56 0.148
Worm
endocytosis GO:0006897 159 0.143
regulation of proteolysis GO:0030162 293 0.128
single organism cellular localization GO:1902580 332 0.128
sex differentiation GO:0007548 45 0.125
Worm
mitochondrial transport GO:0006839 60 0.122
determination of adult lifespan GO:0008340 2 0.119
cellular amino acid metabolic process GO:0006520 116 0.115
transmembrane transport GO:0055085 399 0.114
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.113
Worm
oogenesis GO:0048477 2 0.107
Worm
protein maturation GO:0051604 233 0.103
regulation of endopeptidase activity GO:0052548 170 0.102
chemical homeostasis GO:0048878 306 0.096
protein processing GO:0016485 226 0.094
regulation of oxidative phosphorylation GO:0002082 3 0.093
Worm
nucleoside phosphate biosynthetic process GO:1901293 109 0.085
protein localization to organelle GO:0033365 280 0.083
cellular response to dna damage stimulus GO:0006974 379 0.082
regulation of apoptotic signaling pathway GO:2001233 175 0.076
secretion GO:0046903 254 0.075
atp metabolic process GO:0046034 176 0.075
Worm
cation homeostasis GO:0055080 189 0.074
protein targeting GO:0006605 187 0.073
positive regulation of apoptotic process GO:0043065 246 0.072
dna catabolic process GO:0006308 49 0.070
hematopoietic or lymphoid organ development GO:0048534 186 0.069
ribonucleoside triphosphate metabolic process GO:0009199 412 0.067
Worm
cellular cation homeostasis GO:0030003 163 0.067
single organism reproductive process GO:0044702 98 0.064
Worm
single organism membrane organization GO:0044802 268 0.062
growth GO:0040007 202 0.062
positive regulation of peptidase activity GO:0010952 88 0.055
response to external biotic stimulus GO:0043207 261 0.054
positive regulation of catabolic process GO:0009896 310 0.053
hemopoiesis GO:0030097 180 0.053
reproductive structure development GO:0048608 55 0.053
Worm
reproduction GO:0000003 63 0.053
Worm
immune system development GO:0002520 195 0.052
regulation of cysteine type endopeptidase activity GO:2000116 127 0.051
purine nucleoside triphosphate metabolic process GO:0009144 412 0.051
Worm
ribonucleoprotein complex biogenesis GO:0022613 116 0.050
positive regulation of hydrolase activity GO:0051345 331 0.048
regulation of atp metabolic process GO:1903578 29 0.048
Worm
establishment of protein localization to organelle GO:0072594 172 0.047
cellular homeostasis GO:0019725 196 0.047
regulation of cell growth GO:0001558 135 0.046
positive regulation of mitochondrion organization GO:0010822 30 0.046
regulation of anatomical structure morphogenesis GO:0022603 286 0.046
negative regulation of cell growth GO:0030308 83 0.045
monovalent inorganic cation transport GO:0015672 128 0.045
regulation of peptidase activity GO:0052547 180 0.045
cellular response to cytokine stimulus GO:0071345 181 0.045
intrinsic apoptotic signaling pathway GO:0097193 127 0.044
nucleoside triphosphate catabolic process GO:0009143 394 0.042
intracellular protein transport GO:0006886 270 0.042
cellular metal ion homeostasis GO:0006875 146 0.041
reproductive process GO:0022414 106 0.039
Worm
divalent inorganic cation homeostasis GO:0072507 136 0.038
positive regulation of nucleotide metabolic process GO:0045981 230 0.038
intracellular protein transmembrane transport GO:0065002 24 0.037
ion transmembrane transport GO:0034220 338 0.037
regulation of membrane potential GO:0042391 95 0.037
response to other organism GO:0051707 261 0.036
cell part morphogenesis GO:0032990 137 0.035
Worm
regulation of purine nucleotide metabolic process GO:1900542 264 0.034
Worm
positive regulation of programmed cell death GO:0043068 249 0.034
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.034
ribosome biogenesis GO:0042254 48 0.033
negative regulation of intracellular signal transduction GO:1902532 183 0.033
positive regulation of dna metabolic process GO:0051054 73 0.033
purine containing compound biosynthetic process GO:0072522 88 0.032
regulation of neuron apoptotic process GO:0043523 35 0.032
cellular chemical homeostasis GO:0055082 180 0.031
posttranscriptional regulation of gene expression GO:0010608 213 0.031
response to biotic stimulus GO:0009607 276 0.030
nucleoside monophosphate metabolic process GO:0009123 191 0.030
Worm
membrane organization GO:0061024 292 0.029
negative regulation of organelle organization GO:0010639 126 0.029
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.029
cellular ion homeostasis GO:0006873 168 0.029
negative regulation of growth GO:0045926 97 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.027
Worm
cellular divalent inorganic cation homeostasis GO:0072503 128 0.027
secretion by cell GO:0032940 226 0.027
purine ribonucleoside metabolic process GO:0046128 437 0.027
Worm
protein oligomerization GO:0051259 173 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
cytokine production GO:0001816 247 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
positive regulation of endopeptidase activity GO:0010950 84 0.023
cellular amine metabolic process GO:0044106 41 0.022
positive regulation of proteolysis GO:0045862 142 0.022
positive regulation of cell death GO:0010942 263 0.022
purine nucleotide biosynthetic process GO:0006164 84 0.022
mitochondrial membrane organization GO:0007006 40 0.021
cell cell signaling GO:0007267 155 0.021
negative regulation of cellular component organization GO:0051129 235 0.021
positive regulation of immune response GO:0050778 159 0.021
negative regulation of protein modification process GO:0031400 200 0.021
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.020
developmental process involved in reproduction GO:0003006 66 0.020
Worm
mitotic cell cycle process GO:1903047 286 0.020
ribose phosphate biosynthetic process GO:0046390 82 0.020
regulation of dna metabolic process GO:0051052 153 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.019
regulation of mitotic cell cycle spindle assembly checkpoint GO:0090266 8 0.018
regulation of growth GO:0040008 165 0.018
defense response GO:0006952 315 0.018
apoptotic mitochondrial changes GO:0008637 57 0.018
protein import GO:0017038 130 0.018
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
dna damage checkpoint GO:0000077 68 0.018
response to oxidative stress GO:0006979 121 0.017
Worm
cation transport GO:0006812 331 0.017
cellular response to oxidative stress GO:0034599 85 0.017
ribonucleoprotein complex subunit organization GO:0071826 81 0.017
positive regulation of developmental process GO:0051094 314 0.017
Worm
multicellular organismal reproductive process GO:0048609 40 0.016
Worm
establishment of protein localization to membrane GO:0090150 121 0.016
development of primary sexual characteristics GO:0045137 35 0.016
Worm
protein targeting to mitochondrion GO:0006626 19 0.016
response to abiotic stimulus GO:0009628 336 0.016
Fly
purine nucleoside biosynthetic process GO:0042451 23 0.015
nucleotide biosynthetic process GO:0009165 109 0.015
positive regulation of immune system process GO:0002684 283 0.015
calcium ion homeostasis GO:0055074 122 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
cellular component morphogenesis GO:0032989 314 0.015
Worm
negative regulation of catalytic activity GO:0043086 335 0.015
cell growth GO:0016049 160 0.015
cell development GO:0048468 328 0.015
Worm
neuron development GO:0048666 113 0.015
positive regulation of organelle organization GO:0010638 195 0.015
multicellular organism reproduction GO:0032504 42 0.015
Worm
regulation of protein stability GO:0031647 87 0.015
lipid localization GO:0010876 106 0.015
covalent chromatin modification GO:0016569 254 0.015
regulation of cellular response to stress GO:0080135 244 0.014
myeloid cell differentiation GO:0030099 117 0.014
cellular protein catabolic process GO:0044257 261 0.014
nervous system development GO:0007399 293 0.014
amine metabolic process GO:0009308 44 0.014
regulation of inflammatory response GO:0050727 46 0.013
microtubule based process GO:0007017 210 0.013
behavior GO:0007610 112 0.013
Worm
multi organism reproductive process GO:0044703 54 0.013
Worm
cellular response to oxygen containing compound GO:1901701 276 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
aging GO:0007568 66 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
activation of immune response GO:0002253 114 0.013
defense response to virus GO:0051607 71 0.012
regulation of protein kinase activity GO:0045859 289 0.012
epithelium development GO:0060429 227 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
neuron apoptotic process GO:0051402 39 0.012
protein acylation GO:0043543 138 0.012
gonad development GO:0008406 34 0.012
Worm
ribonucleotide biosynthetic process GO:0009260 81 0.012
cellular macromolecular complex assembly GO:0034622 324 0.012
protein localization to membrane GO:0072657 160 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.011
negative regulation of cellular protein metabolic process GO:0032269 353 0.011
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.011
regulation of ion transport GO:0043269 189 0.011
ribonucleoside catabolic process GO:0042454 406 0.011
phospholipid metabolic process GO:0006644 99 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
negative regulation of endopeptidase activity GO:0010951 84 0.011
immune response GO:0006955 307 0.011
small gtpase mediated signal transduction GO:0007264 78 0.010
guanosine containing compound catabolic process GO:1901069 239 0.010
regulation of histone modification GO:0031056 47 0.010
response to oxygen containing compound GO:1901700 369 0.010
regeneration GO:0031099 4 0.010
carbohydrate derivative biosynthetic process GO:1901137 207 0.010
regulation of kinase activity GO:0043549 314 0.010
protein folding GO:0006457 38 0.010

PHB disease predictions

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 431 0.012
central nervous system disease DOID:331 186 0.012
disease of cellular proliferation DOID:14566 174 0.007
cancer DOID:162 167 0.004
organ system cancer DOID:0050686 164 0.004
breast cancer DOID:1612 21 0.000
thoracic cancer DOID:5093 21 0.000