|
|
regulation of interferon beta biosynthetic process
|
GO:0045357 |
4 |
0.977
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.947
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.894
|
Yeast |
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.879
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.832
|
Mouse |
|
|
protein sumoylation
|
GO:0016925 |
25 |
0.826
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.797
|
Yeast |
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.784
|
|
|
|
pharynx development
|
GO:0060465 |
1 |
0.776
|
Worm |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.771
|
Fly |
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.756
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.756
|
Mouse |
|
|
interferon beta biosynthetic process
|
GO:0045350 |
4 |
0.746
|
|
|
|
interferon beta production
|
GO:0032608 |
23 |
0.735
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.728
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.713
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.634
|
Worm |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.627
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.585
|
|
|
|
histone h4 k12 acetylation
|
GO:0043983 |
6 |
0.583
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.575
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.571
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.560
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.540
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.533
|
Mouse Worm Fly |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.531
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.522
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.506
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.499
|
|
|
|
positive regulation of type i interferon production
|
GO:0032481 |
20 |
0.470
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.468
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.450
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.442
|
Fly |
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.441
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.436
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.435
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.434
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.414
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.409
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.405
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.388
|
Mouse |
|
|
positive regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030511 |
12 |
0.379
|
|
|
|
neurofilament cytoskeleton organization
|
GO:0060052 |
2 |
0.376
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.367
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.351
|
Yeast |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.351
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.345
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.338
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.336
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.326
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.325
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.320
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.317
|
|
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
9 |
0.307
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.305
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.301
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.299
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.292
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.285
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.283
|
Mouse |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.281
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.268
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.264
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.263
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.262
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.261
|
|
|
|
positive regulation of interferon beta production
|
GO:0032728 |
17 |
0.259
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.259
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.250
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.247
|
|
|
|
histone methylation
|
GO:0016571 |
60 |
0.247
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.245
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.242
|
|
|
|
neurofilament bundle assembly
|
GO:0033693 |
2 |
0.241
|
|
|
|
protein alkylation
|
GO:0008213 |
74 |
0.241
|
|
|
|
chromatin assembly or disassembly
|
GO:0006333 |
78 |
0.237
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.235
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.229
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.223
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.223
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.222
|
|
|
|
positive regulation of interferon beta biosynthetic process
|
GO:0045359 |
4 |
0.221
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.215
|
Fly |
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.209
|
Mouse |
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.207
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.202
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.198
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.196
|
Fly |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.194
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.193
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.189
|
|
|
|
chromatin remodeling
|
GO:0006338 |
55 |
0.188
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.187
|
|
|
|
histone serine phosphorylation
|
GO:0035404 |
4 |
0.181
|
|
|
|
dicarboxylic acid biosynthetic process
|
GO:0043650 |
4 |
0.181
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.180
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.177
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.174
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.171
|
Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.169
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.169
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.169
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.169
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.168
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.167
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.163
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.162
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.161
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.161
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.160
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.160
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.160
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.158
|
Fly |
|
|
type i interferon signaling pathway
|
GO:0060337 |
11 |
0.157
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.156
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.154
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.150
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.145
|
|
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
30 |
0.142
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.141
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.141
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.141
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.138
|
|
|
|
dna damage response detection of dna damage
|
GO:0042769 |
3 |
0.134
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.133
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.132
|
|
|
|
histone h3 acetylation
|
GO:0043966 |
45 |
0.132
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.132
|
|
|
|
type i interferon biosynthetic process
|
GO:0045351 |
4 |
0.131
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
29 |
0.127
|
|
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.122
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.121
|
|
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.120
|
|
|
|
positive regulation of type i interferon mediated signaling pathway
|
GO:0060340 |
4 |
0.120
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.119
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.118
|
Yeast |
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.117
|
|
|
|
protein autoprocessing
|
GO:0016540 |
4 |
0.117
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.116
|
Fly |
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.116
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.116
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.115
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.115
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.110
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.110
|
Fly |
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.109
|
|
|
|
nucleosome assembly
|
GO:0006334 |
50 |
0.109
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.106
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.105
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.104
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.104
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.103
|
Yeast |
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.101
|
|
|
|
positive regulation of chromatin modification
|
GO:1903310 |
30 |
0.101
|
|
|
|
macromolecule methylation
|
GO:0043414 |
97 |
0.099
|
|
|
|
response to dsrna
|
GO:0043331 |
25 |
0.099
|
|
|
|
base excision repair
|
GO:0006284 |
21 |
0.099
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.098
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.097
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.095
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.094
|
|
|
|
histone lysine methylation
|
GO:0034968 |
50 |
0.094
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.094
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.092
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.091
|
Fly |
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.090
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.090
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.088
|
|
|
|
histone h4 acetylation
|
GO:0043967 |
47 |
0.088
|
|
|
|
response to exogenous dsrna
|
GO:0043330 |
10 |
0.088
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.087
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.087
|
Mouse |
|
|
negative regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060633 |
3 |
0.086
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.086
|
Fly |
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.085
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.085
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.084
|
Fly |
|
|
retinal ganglion cell axon guidance
|
GO:0031290 |
2 |
0.084
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.084
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.084
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.084
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.083
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.083
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.080
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.080
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.080
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.080
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.079
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.079
|
|
|
|
histone h3 s10 phosphorylation
|
GO:0043987 |
3 |
0.078
|
|
|
|
positive regulation of calcium ion transmembrane transporter activity
|
GO:1901021 |
13 |
0.078
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.077
|
|
|
|
protein desumoylation
|
GO:0016926 |
4 |
0.077
|
|
|
|
nucleosome organization
|
GO:0034728 |
66 |
0.077
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.077
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.076
|
Human |
|
|
response to virus
|
GO:0009615 |
126 |
0.075
|
|
|
|
ventricular septum morphogenesis
|
GO:0060412 |
3 |
0.075
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.074
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.072
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.072
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.071
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.071
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.071
|
Fly |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.070
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.069
|
Fly |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.069
|
|
|
|
protein methylation
|
GO:0006479 |
74 |
0.069
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.068
|
|
|
|
myd88 independent toll like receptor signaling pathway
|
GO:0002756 |
2 |
0.068
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.067
|
|
|
|
protein dna complex subunit organization
|
GO:0071824 |
80 |
0.067
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.067
|
|
|
|
regionalization
|
GO:0003002 |
29 |
0.066
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.066
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.065
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.064
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.064
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.064
|
|
|
|
negative regulation of intracellular steroid hormone receptor signaling pathway
|
GO:0033144 |
18 |
0.064
|
Human |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.063
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.063
|
|
|
|
positive regulation of chromosome organization
|
GO:2001252 |
41 |
0.062
|
|
|
|
zygotic specification of dorsal ventral axis
|
GO:0007352 |
2 |
0.061
|
|
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.061
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation
|
GO:0003257 |
3 |
0.060
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.058
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.058
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.057
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.057
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.056
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.055
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.055
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.055
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.055
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.054
|
|
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.053
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.052
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.052
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.052
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.052
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.051
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.051
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.051
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.050
|
|
|
|
growth
|
GO:0040007 |
202 |
0.050
|
Worm |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.049
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.049
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.049
|
Mouse |
|
|
definitive hemopoiesis
|
GO:0060216 |
2 |
0.049
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.049
|
|
|
|
positive regulation of smad protein import into nucleus
|
GO:0060391 |
8 |
0.048
|
|
|
|
histone h3 k14 acetylation
|
GO:0044154 |
2 |
0.048
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.047
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.047
|
|
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.047
|
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.047
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.047
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.047
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.047
|
|
|
|
positive regulation of interleukin 13 biosynthetic process
|
GO:0045368 |
1 |
0.046
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.045
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.045
|
|
|
|
histone h3 k9 modification
|
GO:0061647 |
11 |
0.045
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.045
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.045
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.044
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.044
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.044
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.044
|
Fly |
|
|
protein processing
|
GO:0016485 |
226 |
0.044
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.044
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.044
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.043
|
|
|
|
androgen receptor signaling pathway
|
GO:0030521 |
34 |
0.043
|
Human |
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.043
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.043
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.043
|
Mouse |
|
|
cytoskeleton dependent intracellular transport
|
GO:0030705 |
21 |
0.043
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.043
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.043
|
|
|
|
negative regulation of toll signaling pathway
|
GO:0045751 |
1 |
0.042
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.042
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.042
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.041
|
|
|
|
regulation of androgen receptor signaling pathway
|
GO:0060765 |
18 |
0.041
|
Human |
|
|
spindle organization
|
GO:0007051 |
53 |
0.041
|
|
|
|
synaptic vesicle endocytosis
|
GO:0048488 |
2 |
0.041
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.040
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.040
|
|
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.040
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.040
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.040
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.039
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.039
|
Mouse |
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.039
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.039
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.039
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.039
|
|
|
|
dna packaging
|
GO:0006323 |
77 |
0.039
|
Fly |
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.039
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.039
|
|
|
|
negative regulation of androgen receptor activity
|
GO:2000824 |
2 |
0.039
|
|
|
|
positive regulation of interleukin 4 production
|
GO:0032753 |
3 |
0.039
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.039
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.038
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.038
|
|
|
|
common partner smad protein phosphorylation
|
GO:0007182 |
3 |
0.037
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.037
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.037
|
Worm |
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.037
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.037
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.037
|
Fly |
|
|
dna catabolic process
|
GO:0006308 |
49 |
0.036
|
|
|
|
amino acid import
|
GO:0043090 |
4 |
0.036
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.036
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.036
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.035
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.035
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.035
|
|
|
|
chemokine metabolic process
|
GO:0050755 |
4 |
0.035
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.035
|
Fly |
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.034
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.034
|
|
|
|
negative regulation of dna metabolic process
|
GO:0051053 |
57 |
0.034
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.034
|
Fly |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.034
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.033
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.033
|
|
|
|
cellular response to type i interferon
|
GO:0071357 |
12 |
0.033
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.033
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.033
|
|
|
|
toll signaling pathway
|
GO:0008063 |
2 |
0.033
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.032
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.032
|
Fly |
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.032
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.032
|
|
|
|
regulation of ubiquitin protein transferase activity
|
GO:0051438 |
28 |
0.032
|
|
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.032
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.032
|
Fly |
|
|
regulation of dna repair
|
GO:0006282 |
47 |
0.032
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.032
|
|
|
|
axon cargo transport
|
GO:0008088 |
2 |
0.031
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.031
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.031
|
Fly |
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.031
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.031
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.031
|
|
|
|
protein k63 linked deubiquitination
|
GO:0070536 |
21 |
0.030
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.030
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.030
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.030
|
|
|
|
cardiac epithelial to mesenchymal transition
|
GO:0060317 |
3 |
0.030
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.030
|
|
|
|
cardiac chamber development
|
GO:0003205 |
30 |
0.030
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.030
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.030
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.030
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.029
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.029
|
|
|
|
pituitary gland development
|
GO:0021983 |
2 |
0.029
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.029
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.029
|
Worm |
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.029
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.028
|
|
|
|
positive regulation of interleukin 4 biosynthetic process
|
GO:0045404 |
1 |
0.028
|
|
|
|
ultradian rhythm
|
GO:0007624 |
1 |
0.028
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.028
|
Yeast |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.028
|
|
|
|
positive regulation of response to cytokine stimulus
|
GO:0060760 |
13 |
0.028
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.028
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.027
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.027
|
|
|
|
intracellular steroid hormone receptor signaling pathway
|
GO:0030518 |
61 |
0.027
|
Human |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.027
|
Mouse |
|
|
interleukin 4 biosynthetic process
|
GO:0042097 |
2 |
0.027
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.027
|
|
|
|
positive regulation of interferon alpha production
|
GO:0032727 |
11 |
0.027
|
|
|
|
regulation of protein acetylation
|
GO:1901983 |
25 |
0.027
|
|
|
|
natural killer cell activation
|
GO:0030101 |
12 |
0.026
|
|
|
|
n terminal protein amino acid modification
|
GO:0031365 |
13 |
0.026
|
|
|
|
chromatin assembly
|
GO:0031497 |
61 |
0.026
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.026
|
|
|
|
protein dna complex assembly
|
GO:0065004 |
64 |
0.026
|
|
|
|
regulation of interferon alpha production
|
GO:0032647 |
11 |
0.026
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.026
|
Fly |
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.026
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.026
|
|
|
|
response to host defenses
|
GO:0052200 |
2 |
0.026
|
|
|
|
macrophage activation involved in immune response
|
GO:0002281 |
1 |
0.025
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.025
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.025
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.025
|
|
|
|
interferon alpha production
|
GO:0032607 |
11 |
0.025
|
|
|
|
macromolecule glycosylation
|
GO:0043413 |
63 |
0.025
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.025
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.025
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.025
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.025
|
|
|
|
regulation of protein sumoylation
|
GO:0033233 |
13 |
0.024
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.024
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.024
|
|
|
|
regulation of toll signaling pathway
|
GO:0008592 |
1 |
0.024
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.024
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.024
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
10 |
0.024
|
|
|
|
convergent extension
|
GO:0060026 |
1 |
0.024
|
|
|
|
glycosylation
|
GO:0070085 |
71 |
0.024
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.024
|
|
|
|
b cell proliferation
|
GO:0042100 |
22 |
0.023
|
|
|
|
carboxylic acid biosynthetic process
|
GO:0046394 |
97 |
0.023
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.023
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.023
|
Mouse |
|
|
regulation of chromatin modification
|
GO:1903308 |
51 |
0.023
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.023
|
Mouse |
|
|
double strand break repair
|
GO:0006302 |
101 |
0.022
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.022
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.022
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.022
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.022
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.022
|
|
|
|
dendritic spine morphogenesis
|
GO:0060997 |
3 |
0.022
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.022
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.022
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.022
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.022
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
46 |
0.022
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.022
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.022
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.022
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.022
|
|
|
|
positive regulation of mesenchymal stem cell differentiation
|
GO:2000741 |
4 |
0.022
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.022
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.021
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.021
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.021
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.021
|
|
|
|
response to interferon beta
|
GO:0035456 |
11 |
0.021
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.021
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.021
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.021
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.021
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.021
|
|
|
|
negative regulation of androgen receptor signaling pathway
|
GO:0060766 |
10 |
0.021
|
Human |
|
|
positive regulation of alpha beta t cell differentiation
|
GO:0046638 |
4 |
0.021
|
|
|
|
central nervous system projection neuron axonogenesis
|
GO:0021952 |
3 |
0.021
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.021
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.020
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.020
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.020
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.020
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.020
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.020
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.020
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.020
|
|
|
|
pml body organization
|
GO:0030578 |
2 |
0.020
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.020
|
|
|
|
patterning of blood vessels
|
GO:0001569 |
2 |
0.020
|
|
|
|
dna damage response signal transduction resulting in transcription
|
GO:0042772 |
12 |
0.020
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.019
|
|
|
|
l amino acid import
|
GO:0043092 |
4 |
0.019
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.019
|
|
|
|
hippocampus development
|
GO:0021766 |
1 |
0.019
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.019
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.019
|
Mouse |
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.019
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.019
|
|
|
|
methylation
|
GO:0032259 |
106 |
0.019
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.019
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.019
|
Fly |
|
|
endocytosis
|
GO:0006897 |
159 |
0.019
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.019
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.019
|
Yeast |
|
|
spindle assembly
|
GO:0051225 |
29 |
0.019
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.019
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.019
|
|
|
|
negative regulation of notch signaling pathway
|
GO:0045746 |
10 |
0.018
|
|
|
|
regulation of peptidyl lysine acetylation
|
GO:2000756 |
22 |
0.018
|
|
|
|
regulation of gene expression epigenetic
|
GO:0040029 |
73 |
0.018
|
|
|
|
chemokine production
|
GO:0032602 |
32 |
0.018
|
|
|
|
pyridine containing compound biosynthetic process
|
GO:0072525 |
3 |
0.018
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.018
|
|
|
|
positive regulation of interleukin 13 production
|
GO:0032736 |
4 |
0.018
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.018
|
|
|
|
histone h3 k4 methylation
|
GO:0051568 |
27 |
0.018
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
48 |
0.018
|
|
|
|
embryonic organ development
|
GO:0048568 |
36 |
0.018
|
|
|
|
negative regulation of transcription from rna polymerase iii promoter
|
GO:0016480 |
3 |
0.018
|
|
|
|
retrograde vesicle mediated transport golgi to er
|
GO:0006890 |
8 |
0.018
|
|
