Homo sapiens

176 known processes

PICALM

phosphatidylinositol binding clathrin assembly protein

(Aliases: LAP,CALM,CLTH)

PICALM biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecular complex assembly GO:0034622 324 0.893
endosomal transport GO:0016197 129 0.885
oogenesis GO:0048477 2 0.840
positive regulation of cellular component organization GO:0051130 376 0.823
Fly
segmentation GO:0035282 4 0.815
cell development GO:0048468 328 0.800
Mouse
female gamete generation GO:0007292 2 0.768
small gtpase mediated signal transduction GO:0007264 78 0.702
actin cytoskeleton organization GO:0030036 207 0.669
regulation of cellular component biogenesis GO:0044087 281 0.666
cell adhesion GO:0007155 325 0.621
post embryonic development GO:0009791 2 0.617
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.608
regulation of cytoskeleton organization GO:0051493 177 0.597
protein localization to organelle GO:0033365 280 0.590
monocyte activation GO:0042117 3 0.582
actin filament based process GO:0030029 224 0.581
positive regulation of developmental process GO:0051094 314 0.578
actin filament organization GO:0007015 128 0.549
cellular component morphogenesis GO:0032989 314 0.531
Mouse
vesicle mediated transport GO:0016192 371 0.511
biological adhesion GO:0022610 331 0.507
synaptic vesicle exocytosis GO:0016079 3 0.474
regulation of protein polymerization GO:0032271 63 0.471
organelle inheritance GO:0048308 2 0.470
positive regulation of transport GO:0051050 336 0.464
Fly
cell substrate adhesion GO:0031589 132 0.455
membrane organization GO:0061024 292 0.445
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.431
oocyte development GO:0048599 1 0.408
anterior posterior axis specification GO:0009948 2 0.399
cellular protein complex assembly GO:0043623 188 0.396
cytoplasmic transport GO:0016482 379 0.386
positive regulation of protein phosphorylation GO:0001934 313 0.382
blastoderm segmentation GO:0007350 2 0.367
ras protein signal transduction GO:0007265 73 0.351
cell morphogenesis involved in differentiation GO:0000904 144 0.347
Mouse
tissue morphogenesis GO:0048729 96 0.341
embryo development GO:0009790 123 0.331
Worm
cell morphogenesis GO:0000902 296 0.328
Mouse
regulation of actin filament based process GO:0032970 141 0.324
exocytosis GO:0006887 71 0.323
cellular chemical homeostasis GO:0055082 180 0.299
positive regulation of hydrolase activity GO:0051345 331 0.296
Mouse
positive regulation of cell differentiation GO:0045597 211 0.293
neurotransmitter secretion GO:0007269 4 0.285
oocyte differentiation GO:0009994 2 0.282
single organism cellular localization GO:1902580 332 0.269
regulation of cell projection organization GO:0031344 107 0.266
multicellular organismal aging GO:0010259 3 0.265
positive regulation of organelle organization GO:0010638 195 0.258
positive regulation of protein complex assembly GO:0031334 86 0.257
glycosyl compound catabolic process GO:1901658 413 0.253
regulation of locomotion GO:0040012 329 0.249
cell activation GO:0001775 213 0.249
lipid localization GO:0010876 106 0.246
organelle localization GO:0051640 84 0.242
Mouse Worm Fly
regulation of cell development GO:0060284 161 0.239
muscle cell differentiation GO:0042692 63 0.238
response to growth factor GO:0070848 205 0.230
response to cytokine GO:0034097 232 0.227
purine ribonucleoside metabolic process GO:0046128 437 0.220
epithelium development GO:0060429 227 0.220
organelle assembly GO:0070925 176 0.214
receptor metabolic process GO:0043112 81 0.210
regulation of actin filament polymerization GO:0030833 50 0.210
determination of adult lifespan GO:0008340 2 0.206
regulation of cell motility GO:2000145 299 0.206
protein catabolic process GO:0030163 325 0.204
regulation of synaptic vesicle transport GO:1902803 3 0.203
nervous system development GO:0007399 293 0.195
Mouse
negative regulation of developmental process GO:0051093 247 0.192
endomembrane system organization GO:0010256 196 0.189
positive regulation of actin nucleation GO:0051127 6 0.184
actin filament polymerization GO:0030041 45 0.182
cell projection organization GO:0030030 252 0.180
Mouse
regulation of protein complex assembly GO:0043254 147 0.180
phospholipid translocation GO:0045332 2 0.177
guanosine containing compound catabolic process GO:1901069 239 0.175
mitotic cell cycle GO:0000278 326 0.174
single organism cell adhesion GO:0098602 179 0.173
regulation of actin cytoskeleton organization GO:0032956 116 0.173
secretion GO:0046903 254 0.172
purine nucleoside catabolic process GO:0006152 398 0.170
regulation of cell migration GO:0030334 289 0.169
protein polymerization GO:0051258 71 0.168
blood vessel development GO:0001568 172 0.161
mitochondrion distribution GO:0048311 3 0.157
positive regulation of cytoskeleton organization GO:0051495 83 0.156
ion homeostasis GO:0050801 230 0.155
secretion by cell GO:0032940 226 0.153
single organism membrane organization GO:0044802 268 0.152
purine nucleoside triphosphate metabolic process GO:0009144 412 0.151
ameboidal type cell migration GO:0001667 135 0.150
regulation of cell adhesion GO:0030155 166 0.150
cellular cation homeostasis GO:0030003 163 0.146
golgi vesicle transport GO:0048193 80 0.140
regulation of actin filament length GO:0030832 56 0.139
positive regulation of cell proliferation GO:0008284 301 0.139
regulation of synaptic vesicle exocytosis GO:2000300 2 0.137
regulation of cell differentiation GO:0045595 393 0.137
microtubule based process GO:0007017 210 0.131
morphogenesis of embryonic epithelium GO:0016331 4 0.125
positive regulation of protein polymerization GO:0032273 45 0.124
neuromuscular junction development GO:0007528 3 0.122
positive regulation of mapk cascade GO:0043410 190 0.120
defense response GO:0006952 315 0.120
growth GO:0040007 202 0.119
regulation of vesicle mediated transport GO:0060627 130 0.118
purine nucleoside triphosphate catabolic process GO:0009146 392 0.117
chemical homeostasis GO:0048878 306 0.116
regulation of cell morphogenesis GO:0022604 153 0.113
peptidyl serine modification GO:0018209 106 0.113
immune response GO:0006955 307 0.112
nucleoside triphosphate catabolic process GO:0009143 394 0.111
tripartite regional subdivision GO:0007351 2 0.110
positive regulation of phosphorylation GO:0042327 394 0.108
embryo development ending in birth or egg hatching GO:0009792 34 0.108
Worm
regulation of mapk cascade GO:0043408 262 0.106
epithelial cell differentiation GO:0030855 141 0.106
endocytosis GO:0006897 159 0.105
regulation of protein localization GO:0032880 296 0.105
synaptic vesicle transport GO:0048489 5 0.103
Mouse Worm Fly
nucleoside triphosphate metabolic process GO:0009141 422 0.103
response to external biotic stimulus GO:0043207 261 0.102
ribonucleoside catabolic process GO:0042454 406 0.102
organelle fission GO:0048285 149 0.102
cell projection morphogenesis GO:0048858 129 0.101
Mouse
intracellular protein transport GO:0006886 270 0.100
peptidyl serine phosphorylation GO:0018105 101 0.100
regulation of cellular component size GO:0032535 82 0.099
regulation of nucleotide metabolic process GO:0006140 269 0.099
cellular response to endogenous stimulus GO:0071495 336 0.097
defense response to fungus GO:0050832 4 0.097
positive regulation of locomotion GO:0040017 186 0.096
regulation of kinase activity GO:0043549 314 0.095
cellular homeostasis GO:0019725 196 0.095
establishment of organelle localization GO:0051656 59 0.094
Mouse Worm Fly
morphogenesis of an epithelium GO:0002009 60 0.094
nuclear division GO:0000280 128 0.094
regulation of neurotransmitter secretion GO:0046928 3 0.093
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.093
nucleoside phosphate catabolic process GO:1901292 412 0.091
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.090
positive regulation of cellular component biogenesis GO:0044089 158 0.090
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.089
rho protein signal transduction GO:0007266 26 0.087
purine containing compound catabolic process GO:0072523 411 0.087
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.086
neural tube formation GO:0001841 3 0.086
anterior posterior axis specification embryo GO:0008595 2 0.086
regulation of actin polymerization or depolymerization GO:0008064 56 0.085
regulation of secretion by cell GO:1903530 177 0.085
regulation of protein maturation GO:1903317 150 0.085
Mouse
muscle cell development GO:0055001 29 0.085
cellular response to oxygen containing compound GO:1901701 276 0.084
regulation of protein kinase activity GO:0045859 289 0.083
single organism membrane fusion GO:0044801 37 0.083
actin filament bundle assembly GO:0051017 54 0.082
regulation of anatomical structure morphogenesis GO:0022603 286 0.082
regulation of nervous system development GO:0051960 88 0.082
purine nucleotide catabolic process GO:0006195 405 0.081
negative regulation of apoptotic process GO:0043066 316 0.081
neurogenesis GO:0022008 169 0.081
Mouse
vesicle fusion GO:0006906 17 0.081
generation of neurons GO:0048699 152 0.080
Mouse
positive regulation of protein kinase activity GO:0045860 190 0.080
actin polymerization or depolymerization GO:0008154 56 0.080
gtp catabolic process GO:0006184 237 0.080
negative regulation of protein maturation GO:1903318 142 0.079
Mouse
regulation of neuron differentiation GO:0045664 70 0.078
protein localization to membrane GO:0072657 160 0.078
response to biotic stimulus GO:0009607 276 0.077
vesicle organization GO:0016050 62 0.076
notch signaling pathway GO:0007219 31 0.076
positive regulation of cell motility GO:2000147 177 0.076
positive regulation of apoptotic process GO:0043065 246 0.076
regulation of lamellipodium morphogenesis GO:2000392 4 0.076
epithelial cell migration GO:0010631 119 0.076
ribonucleoside triphosphate metabolic process GO:0009199 412 0.075
positive regulation of transferase activity GO:0051347 227 0.075
neuron differentiation GO:0030182 138 0.074
Mouse
cellular ketone metabolic process GO:0042180 80 0.074
regulation of peptidase activity GO:0052547 180 0.073
engulfment of apoptotic cell GO:0043652 2 0.073
positive regulation of secretion by cell GO:1903532 108 0.073
positive regulation of programmed cell death GO:0043068 249 0.073
establishment of protein localization to organelle GO:0072594 172 0.072
regulation of neurogenesis GO:0050767 82 0.072
microtubule cytoskeleton organization GO:0000226 176 0.072
heart development GO:0007507 95 0.071
amine metabolic process GO:0009308 44 0.071
maintenance of location GO:0051235 112 0.071
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.071
cardiovascular system development GO:0072358 262 0.071
cellular component assembly involved in morphogenesis GO:0010927 73 0.071
positive regulation of kinase activity GO:0033674 204 0.070
regulation of cellular ketone metabolic process GO:0010565 50 0.070
tube morphogenesis GO:0035239 95 0.069
signal transduction by phosphorylation GO:0023014 297 0.068
reproductive process GO:0022414 106 0.068
cell division GO:0051301 168 0.067
somitogenesis GO:0001756 2 0.067
regulation of stress activated mapk cascade GO:0032872 84 0.067
regulation of cell cycle GO:0051726 393 0.066
metal ion homeostasis GO:0055065 169 0.066
plasma membrane organization GO:0007009 115 0.066
response to oxygen containing compound GO:1901700 369 0.066
pattern specification process GO:0007389 43 0.066
cation homeostasis GO:0055080 189 0.065
regulation of protein localization to plasma membrane GO:1903076 40 0.065
purine ribonucleotide catabolic process GO:0009154 404 0.065
regulation of transferase activity GO:0051338 355 0.065
blood vessel morphogenesis GO:0048514 162 0.065
cytokinesis GO:0000910 96 0.065
system process GO:0003008 349 0.064
chordate embryonic development GO:0043009 34 0.064
regulation of protein transport GO:0051223 213 0.063
post golgi vesicle mediated transport GO:0006892 36 0.062
negative regulation of cellular component organization GO:0051129 235 0.062
muscle structure development GO:0061061 98 0.062
lipid translocation GO:0034204 2 0.061
cell chemotaxis GO:0060326 112 0.060
anion transport GO:0006820 161 0.060
negative regulation of multicellular organismal process GO:0051241 317 0.059
actomyosin structure organization GO:0031032 59 0.059
regulation of anatomical structure size GO:0090066 101 0.059
organ morphogenesis GO:0009887 147 0.059
positive regulation of actin filament polymerization GO:0030838 38 0.059
positive regulation of nucleoside metabolic process GO:0045979 186 0.059
regulation of exocytosis GO:0017157 46 0.058
protein processing GO:0016485 226 0.058
Mouse
neuron projection development GO:0031175 106 0.058
Mouse
cellular ion homeostasis GO:0006873 168 0.057
actin filament bundle organization GO:0061572 54 0.057
response to wounding GO:0009611 168 0.057
regulation of proteolysis GO:0030162 293 0.056
protein localization to plasma membrane GO:0072659 93 0.056
positive regulation of cellular component movement GO:0051272 181 0.055
regulation of small gtpase mediated signal transduction GO:0051056 156 0.055
negative regulation of cellular protein metabolic process GO:0032269 353 0.054
Mouse
microtubule based movement GO:0007018 32 0.053
epithelium migration GO:0090132 119 0.053
positive regulation of cell death GO:0010942 263 0.052
mitotic nuclear division GO:0007067 119 0.052
regulation of cellular amino acid metabolic process GO:0006521 6 0.052
cell part morphogenesis GO:0032990 137 0.050
Mouse
regulation of purine nucleotide catabolic process GO:0033121 205 0.050
filopodium assembly GO:0046847 18 0.050
primary neural tube formation GO:0014020 3 0.050
regulation of intracellular transport GO:0032386 195 0.050
embryonic epithelial tube formation GO:0001838 4 0.050
vesicle localization GO:0051648 26 0.050
Mouse Worm Fly
neuron development GO:0048666 113 0.049
Mouse
regulation of cell activation GO:0050865 125 0.049
cellular amino acid metabolic process GO:0006520 116 0.048
mitotic cell cycle phase transition GO:0044772 162 0.048
receptor mediated endocytosis GO:0006898 84 0.048
lung epithelial cell differentiation GO:0060487 1 0.048
peptidyl tyrosine modification GO:0018212 170 0.048
myosin filament organization GO:0031033 2 0.047
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.047
carbohydrate derivative biosynthetic process GO:1901137 207 0.047
syncytium formation by plasma membrane fusion GO:0000768 2 0.047
protein targeting GO:0006605 187 0.046
mitotic cell cycle process GO:1903047 286 0.046
tube development GO:0035295 125 0.046
cellular response to growth factor stimulus GO:0071363 197 0.046
hematopoietic or lymphoid organ development GO:0048534 186 0.046
Mouse
circulatory system development GO:0072359 262 0.045
positive regulation of cell projection organization GO:0031346 64 0.045
negative regulation of protein processing GO:0010955 142 0.045
Mouse
negative regulation of programmed cell death GO:0043069 321 0.045
cilium morphogenesis GO:0060271 75 0.045
lung cell differentiation GO:0060479 1 0.045
angiogenesis GO:0001525 147 0.044
purine ribonucleoside catabolic process GO:0046130 398 0.044
guanosine containing compound metabolic process GO:1901068 244 0.044
regulation of secretion GO:0051046 194 0.044
regulation of reactive oxygen species metabolic process GO:2000377 41 0.043
positive regulation of exocytosis GO:0045921 35 0.043
regulation of cellular component movement GO:0051270 334 0.043
positive regulation of immune system process GO:0002684 283 0.043
positive regulation of cellular amine metabolic process GO:0033240 7 0.042
regulation of cellular response to stress GO:0080135 244 0.042
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.042
snare complex assembly GO:0035493 3 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.041
atp catabolic process GO:0006200 157 0.041
transmembrane transport GO:0055085 399 0.041
protein ubiquitination GO:0016567 314 0.041
organophosphate catabolic process GO:0046434 430 0.040
meiotic chromosome segregation GO:0045132 4 0.040
receptor internalization GO:0031623 43 0.040
regulation of wnt signaling pathway GO:0030111 123 0.040
regulation of cell projection assembly GO:0060491 47 0.039
macromolecule glycosylation GO:0043413 63 0.039
extrinsic apoptotic signaling pathway GO:0097191 119 0.039
wound healing GO:0042060 115 0.039
positive regulation of cytokine production GO:0001819 167 0.039
negative regulation of transport GO:0051051 176 0.039
carbohydrate metabolic process GO:0005975 207 0.039
cellular component disassembly GO:0022411 92 0.038
regulation of nucleoside metabolic process GO:0009118 209 0.038
cell projection assembly GO:0030031 126 0.038
negative regulation of cell differentiation GO:0045596 171 0.038
regulation of immune response GO:0050776 201 0.037
proteasomal protein catabolic process GO:0010498 176 0.037
regulation of lymphocyte migration GO:2000401 22 0.037
positive regulation of intracellular transport GO:0032388 104 0.037
positive regulation of cell migration GO:0030335 172 0.037
positive regulation of gtpase activity GO:0043547 166 0.037
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.037
positive regulation of nucleotide catabolic process GO:0030813 185 0.036
cellular amine metabolic process GO:0044106 41 0.036
tissue migration GO:0090130 119 0.036
tube closure GO:0060606 3 0.036
regulation of atpase activity GO:0043462 25 0.036
keratinocyte differentiation GO:0030216 36 0.036
gtp metabolic process GO:0046039 239 0.036
intracellular mrna localization GO:0008298 1 0.036
establishment or maintenance of cell polarity GO:0007163 31 0.035
positive regulation of cell development GO:0010720 92 0.035
regulation of nucleotide catabolic process GO:0030811 205 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.035
cell growth GO:0016049 160 0.035
wnt signaling pathway GO:0016055 156 0.035
regulation of ras protein signal transduction GO:0046578 155 0.034
negative regulation of locomotion GO:0040013 118 0.034
mapk cascade GO:0000165 288 0.034
morphogenesis of a polarized epithelium GO:0001738 3 0.034
enzyme linked receptor protein signaling pathway GO:0007167 303 0.034
single organism reproductive process GO:0044702 98 0.034
synaptic vesicle endocytosis GO:0048488 2 0.034
Mouse Worm Fly
embryonic pattern specification GO:0009880 5 0.034
cellular metal ion homeostasis GO:0006875 146 0.034
leukocyte activation GO:0045321 164 0.033
regulation of jnk cascade GO:0046328 73 0.033
compound eye development GO:0048749 1 0.033
developmental growth GO:0048589 48 0.032
neural tube closure GO:0001843 3 0.032
positive regulation of cell adhesion GO:0045785 84 0.032
immune system development GO:0002520 195 0.032
Mouse
skin development GO:0043588 76 0.032
positive regulation of dendrite morphogenesis GO:0050775 3 0.032
multicellular organismal reproductive process GO:0048609 40 0.032
cell cycle g1 s phase transition GO:0044843 80 0.031
embryonic morphogenesis GO:0048598 85 0.031
single organism carbohydrate metabolic process GO:0044723 193 0.031
positive regulation of catabolic process GO:0009896 310 0.031
leukocyte migration GO:0050900 107 0.031
negative regulation of peptidase activity GO:0010466 91 0.031
Mouse
membrane fusion GO:0061025 43 0.031
negative regulation of hydrolase activity GO:0051346 182 0.031
Mouse
nucleotide catabolic process GO:0009166 408 0.031
regulation of response to wounding GO:1903034 101 0.031
actin nucleation GO:0045010 21 0.031
complement activation classical pathway GO:0006958 3 0.030
epithelial cell development GO:0002064 34 0.030
cilium organization GO:0044782 68 0.030
rhythmic behavior GO:0007622 2 0.030
notch receptor processing GO:0007220 2 0.030
cell cell signaling GO:0007267 155 0.030
Mouse Worm Fly
regulation of protein processing GO:0070613 150 0.030
Mouse
negative regulation of cell proliferation GO:0008285 228 0.029
leukocyte mediated immunity GO:0002443 59 0.029
negative regulation of complement activation classical pathway GO:0045959 3 0.029
regulation of cell cycle process GO:0010564 266 0.029
ribonucleotide catabolic process GO:0009261 405 0.029
apoptotic cell clearance GO:0043277 12 0.029
positive regulation of cellular catabolic process GO:0031331 284 0.028
response to bacterium GO:0009617 144 0.028
cell matrix adhesion GO:0007160 85 0.028
actin filament capping GO:0051693 4 0.028
regionalization GO:0003002 29 0.028
digestive tract development GO:0048565 75 0.028
cellular macromolecule catabolic process GO:0044265 380 0.028
response to abiotic stimulus GO:0009628 336 0.027
Fly
chemotaxis GO:0006935 157 0.027
cellular response to organonitrogen compound GO:0071417 124 0.027
behavior GO:0007610 112 0.027
cellular protein catabolic process GO:0044257 261 0.027
regulation of hormone secretion GO:0046883 57 0.027
regulation of growth GO:0040008 165 0.027
positive regulation of keratinocyte migration GO:0051549 4 0.027
regulation of gtp catabolic process GO:0033124 180 0.027
regulation of response to external stimulus GO:0032101 222 0.027
cell migration involved in gastrulation GO:0042074 1 0.027
protein maturation GO:0051604 233 0.026
Mouse
protein targeting to nucleus GO:0044744 104 0.026
negative regulation of cell death GO:0060548 345 0.026
cellular response to cytokine stimulus GO:0071345 181 0.026
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.026
regulation of endopeptidase activity GO:0052548 170 0.026
regulation of cytoplasmic transport GO:1903649 149 0.025
positive regulation of nervous system development GO:0051962 54 0.025
response to hormone GO:0009725 175 0.025
negative regulation of organelle organization GO:0010639 126 0.025
neurological system process GO:0050877 163 0.025
negative regulation of proteolysis GO:0045861 132 0.025
Mouse
regulation of neuron projection development GO:0010975 57 0.025
regulation of endocytosis GO:0030100 72 0.025
regulation of lymphocyte mediated immunity GO:0002706 33 0.025
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 3 0.025
response to fungus GO:0009620 4 0.024
regulation of cell division GO:0051302 116 0.024
locomotory behavior GO:0007626 1 0.024
nucleoside monophosphate catabolic process GO:0009125 159 0.024
reproduction GO:0000003 63 0.024
Worm
regulation of establishment of protein localization GO:0070201 242 0.024
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.024
signal release GO:0023061 70 0.024
developmental process involved in reproduction GO:0003006 66 0.024
circadian behavior GO:0048512 2 0.023
positive regulation of neurogenesis GO:0050769 49 0.023
lipid transport GO:0006869 90 0.023
stress fiber assembly GO:0043149 40 0.023
ossification GO:0001503 121 0.023
negative regulation of cell motility GO:2000146 104 0.023
striated muscle cell development GO:0055002 27 0.023
response to nutrient levels GO:0031667 81 0.023
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.023
atp metabolic process GO:0046034 176 0.023
phagocytosis GO:0006909 42 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
lung epithelium development GO:0060428 7 0.023
peptide secretion GO:0002790 51 0.023
striated muscle tissue development GO:0014706 59 0.022
negative regulation of cellular component movement GO:0051271 106 0.022
organelle fusion GO:0048284 36 0.022
regulation of arp2 3 complex mediated actin nucleation GO:0034315 6 0.022
cation transport GO:0006812 331 0.022
positive regulation of endocytosis GO:0045807 42 0.022
Fly
somatic muscle development GO:0007525 1 0.022
lymphocyte activation GO:0046649 133 0.022
lytic vacuole organization GO:0080171 24 0.022
protein import GO:0017038 130 0.022
response to extracellular stimulus GO:0009991 85 0.022
negative regulation of rho gtpase activity GO:0034259 4 0.022
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
neuron projection morphogenesis GO:0048812 50 0.021
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
regulation of body fluid levels GO:0050878 99 0.021
sequestering of extracellular ligand from receptor GO:0035581 3 0.021
negative regulation of cytoskeleton organization GO:0051494 45 0.021
protein autophosphorylation GO:0046777 123 0.021
multi organism reproductive process GO:0044703 54 0.021
negative regulation of endopeptidase activity GO:0010951 84 0.021
Mouse
myeloid cell differentiation GO:0030099 117 0.021
regulation of developmental growth GO:0048638 30 0.021
striated muscle cell differentiation GO:0051146 43 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.021
leukocyte cell cell adhesion GO:0007159 37 0.021
substrate adhesion dependent cell spreading GO:0034446 41 0.020
adult locomotory behavior GO:0008344 1 0.020
cortical actin cytoskeleton organization GO:0030866 9 0.020
negative regulation of protein metabolic process GO:0051248 391 0.020
Mouse
lipid biosynthetic process GO:0008610 177 0.020
positive regulation of cytoplasmic transport GO:1903651 82 0.020
negative regulation of actin filament polymerization GO:0030837 10 0.020
defense response to other organism GO:0098542 129 0.020
vesicle targeting rough er to cis golgi GO:0048207 2 0.020
spermatid differentiation GO:0048515 4 0.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.020
regulation of neuronal synaptic plasticity GO:0048168 1 0.020
developmental maturation GO:0021700 28 0.020
Mouse
g1 s transition of mitotic cell cycle GO:0000082 78 0.020
peptidyl threonine phosphorylation GO:0018107 41 0.020
nucleoside catabolic process GO:0009164 408 0.019
lymphocyte proliferation GO:0046651 70 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
cellular response to starvation GO:0009267 58 0.019
synaptic transmission GO:0007268 61 0.019
Mouse Worm Fly
response to starvation GO:0042594 59 0.019
stem cell division GO:0017145 2 0.019
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.019
establishment of vesicle localization GO:0051650 23 0.019
Mouse Worm Fly
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.019
epidermis development GO:0008544 59 0.019
monovalent inorganic cation homeostasis GO:0055067 37 0.019
positive regulation of protein transport GO:0051222 135 0.019
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
regulation of hormone levels GO:0010817 125 0.019
axon development GO:0061564 34 0.019
Mouse
endothelial cell differentiation GO:0045446 26 0.019
response to nitrogen compound GO:1901698 184 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.018
phagosome maturation GO:0090382 9 0.018

PICALM disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.061
disease of mental health DOID:150 70 0.043
central nervous system disease DOID:331 186 0.034
neurodegenerative disease DOID:1289 102 0.034
nervous system disease DOID:863 431 0.034
sensory system disease DOID:0050155 203 0.031
cancer DOID:162 167 0.026
organ system cancer DOID:0050686 164 0.026