Homo sapiens

42 known processes

PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

(Aliases: GRB1,p85-ALPHA,p85)

PIK3R1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 1.000
positive regulation of map kinase activity GO:0043406 80 1.000
positive regulation of mapk cascade GO:0043410 190 1.000
regulation of cellular amino acid metabolic process GO:0006521 6 1.000
enzyme linked receptor protein signaling pathway GO:0007167 303 1.000
regulation of transferase activity GO:0051338 355 1.000
Rat Fly
cellular response to endogenous stimulus GO:0071495 336 1.000
positive regulation of protein kinase b signaling GO:0051897 42 1.000
cellular lipid metabolic process GO:0044255 303 1.000
Rat Fly
regulation of cellular amine metabolic process GO:0033238 11 1.000
regulation of kinase activity GO:0043549 314 1.000
Rat Fly
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 1.000
Rat
positive regulation of erk1 and erk2 cascade GO:0070374 75 1.000
regulation of cellular ketone metabolic process GO:0010565 50 1.000
phosphatidylinositol mediated signaling GO:0048015 55 1.000
lipid metabolic process GO:0006629 381 1.000
Rat Fly
regulation of mapk cascade GO:0043408 262 1.000
amine metabolic process GO:0009308 44 1.000
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 1.000
cellular amine metabolic process GO:0044106 41 1.000
regulation of immune response GO:0050776 201 1.000
peptidyl tyrosine modification GO:0018212 170 1.000
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 1.000
cell activation GO:0001775 213 1.000
Mouse
associative learning GO:0008306 1 1.000
cellular response to nitrogen compound GO:1901699 144 1.000
positive regulation of jnk cascade GO:0046330 52 1.000
activation of mapk activity GO:0000187 45 1.000
positive regulation of kinase activity GO:0033674 204 1.000
phosphatidylinositol 3 kinase signaling GO:0014065 48 1.000
regulation of map kinase activity GO:0043405 108 1.000
positive regulation of protein kinase activity GO:0045860 190 1.000
lymphocyte activation GO:0046649 133 1.000
Mouse
leukocyte activation GO:0045321 164 1.000
Mouse
phospholipid metabolic process GO:0006644 99 1.000
Rat Fly
positive regulation of immune system process GO:0002684 283 1.000
immune response activating signal transduction GO:0002757 90 1.000
positive regulation of cell proliferation GO:0008284 301 1.000
cellular ketone metabolic process GO:0042180 80 1.000
positive regulation of phosphorylation GO:0042327 394 1.000
Rat
regulation of cellular component biogenesis GO:0044087 281 1.000
actin filament organization GO:0007015 128 1.000
regulation of jnk cascade GO:0046328 73 1.000
mapk cascade GO:0000165 288 1.000
generation of neurons GO:0048699 152 1.000
regulation of protein serine threonine kinase activity GO:0071900 179 1.000
lipid biosynthetic process GO:0008610 177 1.000
Rat
regulation of locomotion GO:0040012 329 1.000
Mouse Rat
positive regulation of lymphocyte activation GO:0051251 73 1.000
peptidyl tyrosine phosphorylation GO:0018108 170 1.000
positive regulation of leukocyte activation GO:0002696 80 1.000
positive regulation of cell migration GO:0030335 172 1.000
Mouse Rat
neurogenesis GO:0022008 169 1.000
glycerolipid metabolic process GO:0046486 107 1.000
Rat Fly
negative regulation of cell proliferation GO:0008285 228 1.000
Rat
nervous system development GO:0007399 293 1.000
leukocyte differentiation GO:0002521 98 1.000
Mouse
erk1 and erk2 cascade GO:0070371 104 1.000
myeloid cell differentiation GO:0030099 117 1.000
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 45 1.000
response to hormone GO:0009725 175 1.000
immune response regulating signaling pathway GO:0002764 97 1.000
regulation of cell migration GO:0030334 289 1.000
Mouse Rat
regulation of cytokine production GO:0001817 232 1.000
Mouse
positive regulation of lipid kinase activity GO:0090218 13 1.000
negative regulation of protein phosphorylation GO:0001933 140 1.000
cellular response to peptide GO:1901653 59 0.999
response to organonitrogen compound GO:0010243 156 0.999
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.999
regulation of cell development GO:0060284 161 0.999
Rat
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.999
erbb signaling pathway GO:0038127 44 0.999
vesicle mediated transport GO:0016192 371 0.999
regulation of cell projection organization GO:0031344 107 0.999
regulation of leukocyte proliferation GO:0070663 67 0.999
cellular response to hormone stimulus GO:0032870 125 0.999
regulation of ras protein signal transduction GO:0046578 155 0.999
jnk cascade GO:0007254 80 0.999
cellular response to peptide hormone stimulus GO:0071375 56 0.999
positive regulation of protein phosphorylation GO:0001934 313 0.999
Rat
regulation of erk1 and erk2 cascade GO:0070372 99 0.999
glycerophospholipid metabolic process GO:0006650 84 0.999
Rat Fly
negative regulation of cell death GO:0060548 345 0.999
Mouse Rat
activation of protein kinase activity GO:0032147 90 0.999
cell development GO:0048468 328 0.999
Rat
behavior GO:0007610 112 0.999
inositol lipid mediated signaling GO:0048017 55 0.999
positive regulation of lipid metabolic process GO:0045834 50 0.999
regulation of neuron differentiation GO:0045664 70 0.999
signal transduction by phosphorylation GO:0023014 297 0.999
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 11 0.999
small gtpase mediated signal transduction GO:0007264 78 0.999
memory GO:0007613 3 0.999
cellular amino acid metabolic process GO:0006520 116 0.999
positive regulation of transferase activity GO:0051347 227 0.999
phosphatidylinositol metabolic process GO:0046488 53 0.999
Rat Fly
regulation of protein kinase activity GO:0045859 289 0.999
regulation of secretion GO:0051046 194 0.998
positive regulation of leukocyte proliferation GO:0070665 48 0.998
growth GO:0040007 202 0.998
guanosine containing compound catabolic process GO:1901069 239 0.998
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 12 0.998
cell projection organization GO:0030030 252 0.998
positive regulation of locomotion GO:0040017 186 0.998
Mouse Rat
positive regulation of stress activated mapk cascade GO:0032874 60 0.998
system process GO:0003008 349 0.998
Rat
negative regulation of apoptotic process GO:0043066 316 0.998
Mouse Rat
antigen receptor mediated signaling pathway GO:0050851 38 0.997
glycerophospholipid biosynthetic process GO:0046474 40 0.997
Rat
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.997
leukocyte proliferation GO:0070661 74 0.997
secretion GO:0046903 254 0.997
response to growth factor GO:0070848 205 0.997
Rat
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.997
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.997
positive regulation of jak stat cascade GO:0046427 35 0.997
cell adhesion GO:0007155 325 0.997
Mouse Rat
actin cytoskeleton organization GO:0030036 207 0.997
regulation of cell differentiation GO:0045595 393 0.997
Mouse Rat
response to peptide hormone GO:0043434 61 0.996
negative regulation of phosphate metabolic process GO:0045936 267 0.996
regulation of cell activation GO:0050865 125 0.995
positive regulation of glucose import in response to insulin stimulus GO:2001275 3 0.995
tor signaling GO:0031929 39 0.995
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.995
positive regulation of cell activation GO:0050867 81 0.995
insulin receptor signaling pathway GO:0008286 23 0.994
Rat Worm
regulation of lipid kinase activity GO:0043550 19 0.994
Rat Fly
cellular response to insulin stimulus GO:0032869 41 0.994
Rat Worm
negative regulation of cellular amine metabolic process GO:0033239 3 0.994
response to nitrogen compound GO:1901698 184 0.994
response to peptide GO:1901652 65 0.994
response to insulin GO:0032868 45 0.994
Rat Worm
neuron projection development GO:0031175 106 0.993
neuron differentiation GO:0030182 138 0.993
positive regulation of immune response GO:0050778 159 0.993
phospholipid biosynthetic process GO:0008654 44 0.993
Rat
regulation of blood coagulation GO:0030193 42 0.993
t cell receptor signaling pathway GO:0050852 21 0.992
activation of immune response GO:0002253 114 0.992
regulation of mononuclear cell proliferation GO:0032944 65 0.992
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.992
positive regulation of developmental process GO:0051094 314 0.992
Rat
response to organic cyclic compound GO:0014070 204 0.992
Rat
regulation of leukocyte activation GO:0002694 115 0.992
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.992
immune system development GO:0002520 195 0.992
Mouse
positive regulation of lymphocyte proliferation GO:0050671 46 0.991
cell morphogenesis GO:0000902 296 0.991
cellular component morphogenesis GO:0032989 314 0.991
cell type specific apoptotic process GO:0097285 125 0.991
Rat
regulation of lymphocyte proliferation GO:0050670 64 0.991
regulation of insulin secretion GO:0050796 33 0.990
regulation of cell motility GO:2000145 299 0.990
Mouse Rat
regulation of stress activated mapk cascade GO:0032872 84 0.990
myeloid leukocyte migration GO:0097529 62 0.990
leukocyte migration GO:0050900 107 0.989
negative regulation of intracellular signal transduction GO:1902532 183 0.989
regulation of lipid metabolic process GO:0019216 96 0.989
Rat Fly
cytokine mediated signaling pathway GO:0019221 109 0.989
negative regulation of epidermal growth factor activated receptor activity GO:0007175 6 0.989
regulation of cytokine mediated signaling pathway GO:0001959 41 0.989
cation homeostasis GO:0055080 189 0.988
positive regulation of secretion by cell GO:1903532 108 0.988
regulation of reactive oxygen species metabolic process GO:2000377 41 0.988
negative regulation of erk1 and erk2 cascade GO:0070373 14 0.988
positive regulation of endothelial cell migration GO:0010595 39 0.987
hemopoiesis GO:0030097 180 0.987
Mouse
cellular response to organonitrogen compound GO:0071417 124 0.987
regulation of cellular response to stress GO:0080135 244 0.986
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.986
response to oxygen containing compound GO:1901700 369 0.985
actin filament polymerization GO:0030041 45 0.985
positive regulation of mononuclear cell proliferation GO:0032946 47 0.985
stress activated mapk cascade GO:0051403 93 0.985
negative regulation of protein metabolic process GO:0051248 391 0.984
Rat
cellular response to oxygen containing compound GO:1901701 276 0.984
regulation of protein kinase b signaling GO:0051896 61 0.984
cellular response to growth factor stimulus GO:0071363 197 0.984
positive regulation of transport GO:0051050 336 0.983
neuron projection morphogenesis GO:0048812 50 0.983
mitotic cell cycle GO:0000278 326 0.983
positive regulation of cellular response to insulin stimulus GO:1900078 6 0.983
neurological system process GO:0050877 163 0.983
platelet derived growth factor receptor beta signaling pathway GO:0035791 4 0.982
response to wounding GO:0009611 168 0.982
regulation of secretion by cell GO:1903530 177 0.982
epidermal growth factor receptor signaling pathway GO:0007173 39 0.982
cellular response to dna damage stimulus GO:0006974 379 0.981
Mouse
protein kinase b signaling GO:0043491 69 0.981
actin filament based process GO:0030029 224 0.981
response to inorganic substance GO:0010035 127 0.981
Rat
negative regulation of phosphorylation GO:0042326 174 0.981
positive regulation of organelle organization GO:0010638 195 0.980
peptide hormone secretion GO:0030072 50 0.980
positive chemotaxis GO:0050918 33 0.978
regulation of erbb signaling pathway GO:1901184 27 0.977
cortisol secretion GO:0043400 4 0.976
stress activated protein kinase signaling cascade GO:0031098 94 0.976
protein autophosphorylation GO:0046777 123 0.976
purine nucleoside triphosphate catabolic process GO:0009146 392 0.975
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.975
positive regulation of cellular component movement GO:0051272 181 0.974
Mouse Rat
regulation of hormone levels GO:0010817 125 0.974
response to oxidative stress GO:0006979 121 0.973
peptide secretion GO:0002790 51 0.972
negative regulation of cell differentiation GO:0045596 171 0.972
Mouse
positive regulation of neurogenesis GO:0050769 49 0.971
negative regulation of kinase activity GO:0033673 106 0.971
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.971
regulation of growth GO:0040008 165 0.971
purine nucleotide catabolic process GO:0006195 405 0.970
response to interleukin 15 GO:0070672 6 0.969
positive regulation of cytoplasmic transport GO:1903651 82 0.969
regulation of actin cytoskeleton organization GO:0032956 116 0.968
biological adhesion GO:0022610 331 0.966
Mouse Rat
positive regulation of catabolic process GO:0009896 310 0.962
regulation of chemotaxis GO:0050920 74 0.960
cell cell signaling GO:0007267 155 0.960
positive regulation of neuron projection development GO:0010976 34 0.960
phosphatidylinositol biosynthetic process GO:0006661 25 0.960
Rat
mononuclear cell proliferation GO:0032943 71 0.959
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.957
regulation of defense response GO:0031347 154 0.956
negative regulation of receptor activity GO:2000272 15 0.956
regulation of response to external stimulus GO:0032101 222 0.955
organophosphate catabolic process GO:0046434 430 0.953
cellular divalent inorganic cation homeostasis GO:0072503 128 0.953
regulation of body fluid levels GO:0050878 99 0.953
regulation of cellular component size GO:0032535 82 0.952
Fly
rap protein signal transduction GO:0032486 7 0.950
regulation of epithelial cell migration GO:0010632 93 0.949
regulation of cardiac muscle tissue growth GO:0055021 4 0.949
cell chemotaxis GO:0060326 112 0.949
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.947
regulation of protein tyrosine kinase activity GO:0061097 36 0.946
positive regulation of hormone secretion GO:0046887 25 0.946
regulation of lymphocyte activation GO:0051249 103 0.945
regulation of neurogenesis GO:0050767 82 0.944
negative regulation of programmed cell death GO:0043069 321 0.943
Mouse Rat
regulation of nucleotide metabolic process GO:0006140 269 0.941
regulation of phagocytosis GO:0050764 21 0.939
interferon gamma production GO:0032609 39 0.939
regulation of intracellular transport GO:0032386 195 0.938
platelet activation GO:0030168 44 0.938
immune response GO:0006955 307 0.936
photoreceptor cell differentiation GO:0046530 2 0.935
glycosyl compound catabolic process GO:1901658 413 0.935
lipid modification GO:0030258 84 0.931
Rat Fly
nitrogen compound transport GO:0071705 191 0.930
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 12 0.930
platelet derived growth factor receptor signaling pathway GO:0048008 14 0.930
regulation of ion homeostasis GO:2000021 73 0.928
positive regulation of cellular component biogenesis GO:0044089 158 0.928
lymphocyte proliferation GO:0046651 70 0.926
wound healing GO:0042060 115 0.923
regulation of mitotic cell cycle GO:0007346 189 0.920
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.920
ephrin receptor signaling pathway GO:0048013 15 0.920
positive regulation of actin filament polymerization GO:0030838 38 0.918
tyrosine phosphorylation of stat protein GO:0007260 33 0.918
regulation of protein complex assembly GO:0043254 147 0.917
hematopoietic or lymphoid organ development GO:0048534 186 0.914
Mouse
guanosine containing compound metabolic process GO:1901068 244 0.912
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.912
gtp metabolic process GO:0046039 239 0.912
second messenger mediated signaling GO:0019932 78 0.911
interleukin 12 mediated signaling pathway GO:0035722 3 0.910
regulation of cellular component movement GO:0051270 334 0.909
Mouse Rat
leukocyte chemotaxis GO:0030595 76 0.909
neuromuscular junction development GO:0007528 3 0.908
negative regulation of t cell receptor signaling pathway GO:0050860 4 0.905
axon development GO:0061564 34 0.904
regulation of peptide secretion GO:0002791 42 0.901
response to fibroblast growth factor GO:0071774 39 0.898
myeloid leukocyte differentiation GO:0002573 60 0.898
Mouse
positive regulation of defense response GO:0031349 87 0.898
glycerolipid biosynthetic process GO:0045017 51 0.898
Rat
regulation of small gtpase mediated signal transduction GO:0051056 156 0.895
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.894
regulation of smooth muscle cell proliferation GO:0048660 28 0.892
Rat
ribonucleoside triphosphate catabolic process GO:0009203 391 0.890
positive regulation of cellular component organization GO:0051130 376 0.890
regulation of cortisol secretion GO:0051462 4 0.888
granulocyte chemotaxis GO:0071621 37 0.887
glucose import in response to insulin stimulus GO:0044381 4 0.884
ribonucleotide catabolic process GO:0009261 405 0.883
regulation of autophagy GO:0010506 52 0.883
Human
endocytosis GO:0006897 159 0.881
circulatory system development GO:0072359 262 0.881
epithelial cell migration GO:0010631 119 0.880
embryonic viscerocranium morphogenesis GO:0048703 1 0.880
regulation of cell morphogenesis GO:0022604 153 0.879
cellular response to starvation GO:0009267 58 0.878
negative regulation of protein kinase activity GO:0006469 98 0.874
cell projection assembly GO:0030031 126 0.874
positive regulation of cytokine production GO:0001819 167 0.871
Mouse
cardiovascular system development GO:0072358 262 0.870
b cell activation GO:0042113 33 0.869
Mouse
regulation of ras gtpase activity GO:0032318 128 0.869
granulocyte migration GO:0097530 40 0.868
positive regulation of cellular catabolic process GO:0031331 284 0.867
positive regulation of jun kinase activity GO:0043507 23 0.866
homeostasis of number of cells GO:0048872 40 0.864
signal release GO:0023061 70 0.864
taxis GO:0042330 157 0.863
apoptotic signaling pathway GO:0097190 268 0.863
Mouse
regulation of glucose import in response to insulin stimulus GO:2001273 4 0.863
positive regulation of protein tyrosine kinase activity GO:0061098 24 0.862
b cell proliferation GO:0042100 22 0.862
purine ribonucleotide catabolic process GO:0009154 404 0.861
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.860
regulation of response to wounding GO:1903034 101 0.856
negative regulation of leukocyte apoptotic process GO:2000107 16 0.855
secretion by cell GO:0032940 226 0.854
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.851
purine nucleoside catabolic process GO:0006152 398 0.850
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.847
regulation of epidermal growth factor receptor signaling pathway GO:0042058 27 0.845
regulation of glucocorticoid secretion GO:2000849 4 0.844
b cell receptor signaling pathway GO:0050853 18 0.843
regulation of actin filament polymerization GO:0030833 50 0.842
negative regulation of calcium mediated signaling GO:0050849 4 0.838
stem cell differentiation GO:0048863 93 0.837
negative regulation of developmental process GO:0051093 247 0.832
Mouse
positive regulation of nucleoside metabolic process GO:0045979 186 0.830
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.830
positive regulation of cell motility GO:2000147 177 0.828
Mouse Rat
metal ion homeostasis GO:0055065 169 0.827
positive regulation of secretion GO:0051047 116 0.825
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.824
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.824
cell part morphogenesis GO:0032990 137 0.823
negative regulation of phosphorus metabolic process GO:0010563 267 0.823
cytoplasmic transport GO:0016482 379 0.823
Mouse
negative regulation of jak stat cascade GO:0046426 4 0.819
purine nucleoside triphosphate metabolic process GO:0009144 412 0.818
cellular response to interleukin 15 GO:0071350 6 0.818
blood coagulation GO:0007596 76 0.816
single organism behavior GO:0044708 28 0.812
organophosphate biosynthetic process GO:0090407 163 0.811
Rat
positive regulation of ras gtpase activity GO:0032320 117 0.810
lymphocyte differentiation GO:0030098 35 0.810
Mouse
regulation of nucleotide catabolic process GO:0030811 205 0.802
single organism carbohydrate metabolic process GO:0044723 193 0.800
Rat
regulation of endothelial cell migration GO:0010594 67 0.800
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.799
response to lipid GO:0033993 206 0.792
Rat
cellular ion homeostasis GO:0006873 168 0.787
ribonucleoside triphosphate metabolic process GO:0009199 412 0.785
response to biotic stimulus GO:0009607 276 0.783
Rat
muscle cell migration GO:0014812 19 0.783
regulation of homeostatic process GO:0032844 121 0.777
rho protein signal transduction GO:0007266 26 0.777
regulation of peptide hormone secretion GO:0090276 41 0.777
regulation of gtpase activity GO:0043087 180 0.775
purine ribonucleoside catabolic process GO:0046130 398 0.772
insulin secretion GO:0030073 39 0.772
nucleotide catabolic process GO:0009166 408 0.770
response to extracellular stimulus GO:0009991 85 0.770
Rat
single organism cell adhesion GO:0098602 179 0.767
Rat
cellular metal ion homeostasis GO:0006875 146 0.767
regulation of glucose import GO:0046324 21 0.767
cellular protein complex assembly GO:0043623 188 0.764
nucleoside triphosphate metabolic process GO:0009141 422 0.759
organ growth GO:0035265 12 0.756
organic hydroxy compound transport GO:0015850 63 0.756
positive regulation of rac gtpase activity GO:0032855 31 0.755
lipid transport GO:0006869 90 0.753
long term memory GO:0007616 2 0.752
mitotic cell cycle process GO:1903047 286 0.752
regulation of anatomical structure morphogenesis GO:0022603 286 0.749
epithelium development GO:0060429 227 0.745
regulation of neuron apoptotic process GO:0043523 35 0.742
regulation of immune effector process GO:0002697 91 0.737
gtp catabolic process GO:0006184 237 0.736
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 9 0.732
negative regulation of catalytic activity GO:0043086 335 0.729
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.726
Rat Fly
t cell activation GO:0042110 99 0.719
regulation of nucleoside metabolic process GO:0009118 209 0.718
defense response GO:0006952 315 0.717
response to starvation GO:0042594 59 0.713
positive regulation of immune effector process GO:0002699 40 0.710
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.708
regulation of nervous system development GO:0051960 88 0.708
negative regulation of growth GO:0045926 97 0.704
negative regulation of map kinase activity GO:0043407 27 0.700
innate immune response GO:0045087 178 0.700
cytosolic calcium ion homeostasis GO:0051480 89 0.695
hormone mediated signaling pathway GO:0009755 22 0.690
cell morphogenesis involved in differentiation GO:0000904 144 0.683
regulation of transporter activity GO:0032409 82 0.683
regulation of cell shape GO:0008360 48 0.681
cellular response to nutrient levels GO:0031669 69 0.681
calcium mediated signaling GO:0019722 44 0.678
short term memory GO:0007614 1 0.678
learning GO:0007612 11 0.671
regulation of apoptotic signaling pathway GO:2001233 175 0.667
anatomical structure formation involved in morphogenesis GO:0048646 284 0.663
regulation of purine nucleotide catabolic process GO:0033121 205 0.662
regulation of cytoplasmic transport GO:1903649 149 0.662
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.659
positive regulation of nucleotide catabolic process GO:0030813 185 0.658
ribonucleoside catabolic process GO:0042454 406 0.656
vascular endothelial growth factor receptor 1 signaling pathway GO:0036323 1 0.655
regulation of b cell proliferation GO:0030888 18 0.655
notch signaling pathway GO:0007219 31 0.651
epithelium migration GO:0090132 119 0.651
regulation of protein localization GO:0032880 296 0.650
hormone secretion GO:0046879 65 0.648
regulation of mast cell degranulation GO:0043304 3 0.648
nucleoside catabolic process GO:0009164 408 0.646
hematopoietic progenitor cell differentiation GO:0002244 38 0.643
neuron apoptotic process GO:0051402 39 0.639
interleukin 2 secretion GO:0070970 3 0.633
interleukin 4 mediated signaling pathway GO:0035771 3 0.632
developmental growth GO:0048589 48 0.631
organ morphogenesis GO:0009887 147 0.628
hormone transport GO:0009914 68 0.628
peptidyl serine modification GO:0018209 106 0.626
cell projection morphogenesis GO:0048858 129 0.618
immune effector process GO:0002252 159 0.618
determination of adult lifespan GO:0008340 2 0.618
Worm
lipid phosphorylation GO:0046834 31 0.617
Rat Fly
regulation of cellular response to insulin stimulus GO:1900076 17 0.615
negative regulation of leukocyte activation GO:0002695 26 0.611
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 2 0.611
protein localization to nucleus GO:0034504 136 0.608
Mouse
regulation of gtp catabolic process GO:0033124 180 0.602
female gamete generation GO:0007292 2 0.601
motor neuron axon guidance GO:0008045 2 0.601
regulation of actin polymerization or depolymerization GO:0008064 56 0.600
cognition GO:0050890 43 0.598
single organism reproductive process GO:0044702 98 0.593
phagocytosis engulfment GO:0006911 7 0.593
nucleoside phosphate catabolic process GO:1901292 412 0.592
negative regulation of multicellular organismal process GO:0051241 317 0.590
Mouse Rat
insulin like growth factor receptor signaling pathway GO:0048009 13 0.586
regulation of insulin receptor signaling pathway GO:0046626 13 0.585
ameboidal type cell migration GO:0001667 135 0.583
epithelial cell differentiation GO:0030855 141 0.582
positive regulation of phagocytosis GO:0050766 15 0.579
activation of mapkk activity GO:0000186 18 0.576
regulation of establishment of protein localization GO:0070201 242 0.571
regulation of protein secretion GO:0050708 86 0.569
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.562
inactivation of mapk activity GO:0000188 5 0.556
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.555
cytokine production GO:0001816 247 0.550
Mouse
negative regulation of protein tyrosine kinase activity GO:0061099 13 0.549
negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 3 0.546
negative regulation of hormone secretion GO:0046888 15 0.545
reproductive process GO:0022414 106 0.544
purine containing compound catabolic process GO:0072523 411 0.534
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.534
glucocorticoid secretion GO:0035933 4 0.533
regulation of nucleocytoplasmic transport GO:0046822 98 0.532
regulation of interferon gamma production GO:0032649 36 0.531
negative regulation of erbb signaling pathway GO:1901185 11 0.528
positive regulation of cell proliferation by vegf activated platelet derived growth factor receptor signaling pathway GO:0038091 3 0.527
regulation of epidermal growth factor activated receptor activity GO:0007176 14 0.527
regulation of lymphocyte differentiation GO:0045619 22 0.525
positive regulation of cellular amine metabolic process GO:0033240 7 0.524
positive regulation of cell matrix adhesion GO:0001954 23 0.523
regulation of hormone secretion GO:0046883 57 0.522
protein polymerization GO:0051258 71 0.512
positive regulation of nucleotide metabolic process GO:0045981 230 0.512
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.508
central nervous system development GO:0007417 123 0.508
learning or memory GO:0007611 13 0.504
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.502
positive regulation of cell adhesion GO:0045785 84 0.502
nucleoside triphosphate catabolic process GO:0009143 394 0.499
regulation of intracellular protein transport GO:0033157 123 0.494
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.493
interleukin 6 mediated signaling pathway GO:0070102 7 0.485
neuron development GO:0048666 113 0.485
tissue regeneration GO:0042246 3 0.484
regulation of smooth muscle cell migration GO:0014910 15 0.484
neuron remodeling GO:0016322 2 0.481
regulation of dna metabolic process GO:0051052 153 0.477
regulation of response to cytokine stimulus GO:0060759 46 0.476
positive regulation of rho gtpase activity GO:0032321 56 0.472
carbohydrate metabolic process GO:0005975 207 0.469
Rat

PIK3R1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.977
disease of cellular proliferation DOID:14566 174 0.977
organ system cancer DOID:0050686 164 0.977
disease of metabolism DOID:0014667 295 0.863
carbohydrate metabolism disease DOID:0050013 32 0.863
acquired metabolic disease DOID:0060158 58 0.863
diabetes mellitus DOID:9351 31 0.580
type 2 diabetes mellitus DOID:9352 28 0.580
glucose metabolism disease DOID:4194 32 0.580
gastrointestinal system cancer DOID:3119 52 0.499