Homo sapiens

30 known processes

PINX1

PIN2/TERF1 interacting, telomerase inhibitor 1

(Aliases: LPTL,MGC8850,FLJ20565,LPTS)

PINX1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
telomere maintenance via telomere lengthening GO:0010833 9 0.954
telomere maintenance via telomerase GO:0007004 8 0.951
carbohydrate derivative biosynthetic process GO:1901137 207 0.405
cellular macromolecular complex assembly GO:0034622 324 0.402
regulation of telomere maintenance via telomerase GO:0032210 6 0.402
regulation of wnt signaling pathway GO:0030111 123 0.318
protein localization to chromosome telomeric region GO:0070198 6 0.308
glycoprotein biosynthetic process GO:0009101 91 0.291
post embryonic development GO:0009791 2 0.265
regulation of telomere maintenance GO:0032204 13 0.260
positive regulation of wnt signaling pathway GO:0030177 54 0.255
rna dependent dna replication GO:0006278 16 0.240
negative regulation of cellular protein metabolic process GO:0032269 353 0.226
regulation of transferase activity GO:0051338 355 0.225
positive regulation of telomere maintenance GO:0032206 4 0.208
rna processing GO:0006396 255 0.203
regulation of microtubule polymerization GO:0031113 12 0.201
telomere maintenance GO:0000723 32 0.201
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.199
dna replication GO:0006260 116 0.189
carbohydrate metabolic process GO:0005975 207 0.156
negative regulation of protein metabolic process GO:0051248 391 0.155
regulation of dna metabolic process GO:0051052 153 0.154
cellular macromolecule catabolic process GO:0044265 380 0.125
mrna metabolic process GO:0016071 175 0.121
anatomical structure homeostasis GO:0060249 100 0.116
positive regulation of organelle organization GO:0010638 195 0.115
regulation of microtubule cytoskeleton organization GO:0070507 61 0.115
macromolecule glycosylation GO:0043413 63 0.107
wnt signaling pathway GO:0016055 156 0.101
protein glycosylation GO:0006486 62 0.094
regulation of cellular component biogenesis GO:0044087 281 0.090
regulation of kinase activity GO:0043549 314 0.085
rna catabolic process GO:0006401 71 0.084
telomere organization GO:0032200 33 0.083
rrna processing GO:0006364 35 0.082
single organism carbohydrate metabolic process GO:0044723 193 0.081
canonical wnt signaling pathway GO:0060070 116 0.079
regulation of canonical wnt signaling pathway GO:0060828 88 0.079
negative regulation of protein processing GO:0010955 142 0.076
glycoprotein metabolic process GO:0009100 110 0.074
negative regulation of binding GO:0051100 57 0.069
ncrna processing GO:0034470 83 0.065
cellular response to nutrient levels GO:0031669 69 0.064
positive regulation of catabolic process GO:0009896 310 0.061
positive regulation of homeostatic process GO:0032846 47 0.061
protein ubiquitination GO:0016567 314 0.059
negative regulation of phosphate metabolic process GO:0045936 267 0.059
negative regulation of protein modification process GO:0031400 200 0.058
protein localization to organelle GO:0033365 280 0.058
regulation of binding GO:0051098 111 0.058
ribonucleoprotein complex subunit organization GO:0071826 81 0.057
maturation of ssu rrna GO:0030490 3 0.057
glycosylation GO:0070085 71 0.055
lipid metabolic process GO:0006629 381 0.053
regulation of cellular response to stress GO:0080135 244 0.053
ribonucleoprotein complex biogenesis GO:0022613 116 0.052
maturation of lsu rrna GO:0000470 3 0.052
regulation of protein serine threonine kinase activity GO:0071900 179 0.050
cell adhesion GO:0007155 325 0.050
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 3 0.049
protein maturation GO:0051604 233 0.049
protein modification by small protein conjugation GO:0032446 342 0.049
cellular lipid metabolic process GO:0044255 303 0.048
regulation of dna replication GO:0006275 68 0.048
mitotic cell cycle process GO:1903047 286 0.048
protein catabolic process GO:0030163 325 0.047
cell aging GO:0007569 52 0.047
negative regulation of programmed cell death GO:0043069 321 0.047
locomotory behavior GO:0007626 1 0.046
female gamete generation GO:0007292 2 0.046
negative regulation of apoptotic process GO:0043066 316 0.045
aging GO:0007568 66 0.045
positive regulation of cellular component organization GO:0051130 376 0.045
negative regulation of telomere maintenance GO:0032205 9 0.044
immune response GO:0006955 307 0.044
peptidyl threonine modification GO:0018210 45 0.044
signal transduction by phosphorylation GO:0023014 297 0.043
defense response GO:0006952 315 0.043
regulation of protein kinase activity GO:0045859 289 0.042
positive regulation of dna metabolic process GO:0051054 73 0.042
regulation of response to external stimulus GO:0032101 222 0.042
negative regulation of phosphorus metabolic process GO:0010563 267 0.042
biological adhesion GO:0022610 331 0.041
segmentation GO:0035282 4 0.040
ncrna metabolic process GO:0034660 108 0.039
regulation of homeostatic process GO:0032844 121 0.039
positive regulation of cellular catabolic process GO:0031331 284 0.039
organophosphate biosynthetic process GO:0090407 163 0.038
peptidyl serine modification GO:0018209 106 0.037
regulation of dna binding GO:0051101 37 0.037
mrna catabolic process GO:0006402 56 0.036
protein adp ribosylation GO:0006471 9 0.036
cellular carbohydrate metabolic process GO:0044262 84 0.036
dephosphorylation GO:0016311 209 0.035
mapk cascade GO:0000165 288 0.035
nuclear transcribed mrna catabolic process GO:0000956 48 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.034
determination of adult lifespan GO:0008340 2 0.034
mitotic cell cycle GO:0000278 326 0.034
negative regulation of jun kinase activity GO:0043508 4 0.034
negative regulation of proteolysis GO:0045861 132 0.034
cellular protein complex assembly GO:0043623 188 0.033
apoptotic signaling pathway GO:0097190 268 0.032
cellular response to extracellular stimulus GO:0031668 72 0.032
rrna metabolic process GO:0016072 40 0.032
stress activated protein kinase signaling cascade GO:0031098 94 0.032
phospholipid metabolic process GO:0006644 99 0.031
phospholipid biosynthetic process GO:0008654 44 0.031
cardiovascular system development GO:0072358 262 0.031
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.029
amine metabolic process GO:0009308 44 0.029
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.029
regulation of mapk cascade GO:0043408 262 0.029
oogenesis GO:0048477 2 0.028
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.028
cation transport GO:0006812 331 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
lipid biosynthetic process GO:0008610 177 0.028
establishment of ribosome localization GO:0033753 4 0.028
regulation of protein processing GO:0070613 150 0.027
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.027
purine containing compound catabolic process GO:0072523 411 0.027
ribonucleoprotein complex assembly GO:0022618 78 0.027
positive regulation of dna replication GO:0045740 35 0.027
modification dependent macromolecule catabolic process GO:0043632 212 0.026
multicellular organismal aging GO:0010259 3 0.026
regulation of cell cycle GO:0051726 393 0.026
ribonucleoside triphosphate metabolic process GO:0009199 412 0.025
positive regulation of cell proliferation GO:0008284 301 0.025
system process GO:0003008 349 0.025
rna interference GO:0016246 4 0.025
purine nucleoside catabolic process GO:0006152 398 0.024
embryo development GO:0009790 123 0.024
negative regulation of apoptotic signaling pathway GO:2001234 97 0.024
memory GO:0007613 3 0.024
modification dependent protein catabolic process GO:0019941 209 0.024
cellular amine metabolic process GO:0044106 41 0.023
regulation of autophagy GO:0010506 52 0.023
ribosomal subunit export from nucleus GO:0000054 4 0.023
regulation of cellular amine metabolic process GO:0033238 11 0.023
glycerolipid metabolic process GO:0046486 107 0.023
negative regulation of transferase activity GO:0051348 124 0.023
negative regulation of cellular catabolic process GO:0031330 83 0.023
ribosomal large subunit biogenesis GO:0042273 10 0.023
regulation of cellular component movement GO:0051270 334 0.023
protein processing GO:0016485 226 0.023
regulation of glycoprotein metabolic process GO:1903018 19 0.023
negative regulation of protein phosphorylation GO:0001933 140 0.022
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.022
regulation of protein complex assembly GO:0043254 147 0.022
regulation of proteolysis GO:0030162 293 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
protein localization to chromosome GO:0034502 30 0.021
stress activated mapk cascade GO:0051403 93 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
ribonucleotide catabolic process GO:0009261 405 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.021
negative regulation of organelle organization GO:0010639 126 0.021
regulation of protein maturation GO:1903317 150 0.021
cell type specific apoptotic process GO:0097285 125 0.021
regulation of chromosome organization GO:0033044 103 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
cellular amino acid metabolic process GO:0006520 116 0.020
regulation of microtubule based process GO:0032886 74 0.020
cell cycle phase transition GO:0044770 173 0.020
positive regulation of cell cycle process GO:0090068 106 0.020
ribonucleoprotein complex export from nucleus GO:0071426 4 0.020
nucleoside triphosphate metabolic process GO:0009141 422 0.020
negative regulation of dna replication GO:0008156 29 0.020
sister chromatid segregation GO:0000819 54 0.020
telomere capping GO:0016233 5 0.020
regulation of apoptotic signaling pathway GO:2001233 175 0.020
organonitrogen compound biosynthetic process GO:1901566 200 0.019
ribosome biogenesis GO:0042254 48 0.019
single organism reproductive process GO:0044702 98 0.019
lymphocyte activation GO:0046649 133 0.019
positive regulation of response to external stimulus GO:0032103 88 0.019
cell cycle g2 m phase transition GO:0044839 43 0.019
positive regulation of autophagy GO:0010508 24 0.019
mitotic sister chromatid segregation GO:0000070 53 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
glycosyl compound catabolic process GO:1901658 413 0.019
cellular protein catabolic process GO:0044257 261 0.019
protein homooligomerization GO:0051260 100 0.019
nucleoside catabolic process GO:0009164 408 0.019
negative regulation of cellular component organization GO:0051129 235 0.018
protein poly adp ribosylation GO:0070212 3 0.018
pituitary gland development GO:0021983 2 0.018
transmembrane transport GO:0055085 399 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
innate immune response GO:0045087 178 0.018
blastocyst formation GO:0001825 3 0.018
anterior posterior axis specification GO:0009948 2 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
negative regulation of cell cycle GO:0045786 193 0.018
chromatin organization GO:0006325 351 0.018
replicative senescence GO:0090399 8 0.018
nuclear transport GO:0051169 179 0.018
chemical homeostasis GO:0048878 306 0.018
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.018
regulation of jnk cascade GO:0046328 73 0.017
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
neurological system process GO:0050877 163 0.017
cellular ketone metabolic process GO:0042180 80 0.017
negative regulation of cell division GO:0051782 31 0.017
purine ribonucleoside metabolic process GO:0046128 437 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
ion transmembrane transport GO:0034220 338 0.017
response to organic cyclic compound GO:0014070 204 0.017
receptor mediated endocytosis GO:0006898 84 0.017
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.017
vesicle mediated transport GO:0016192 371 0.016
regulation of cell cycle process GO:0010564 266 0.016
cellular response to external stimulus GO:0071496 111 0.016
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.016
cellular homeostasis GO:0019725 196 0.016
dna biosynthetic process GO:0071897 40 0.016
ribosome localization GO:0033750 4 0.016
negative regulation of protein kinase activity GO:0006469 98 0.016
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.016
sulfur compound metabolic process GO:0006790 101 0.016
negative regulation of glycoprotein metabolic process GO:1903019 8 0.016
negative regulation of dna metabolic process GO:0051053 57 0.016
neuromuscular junction development GO:0007528 3 0.016
response to nutrient levels GO:0031667 81 0.016
negative regulation of kinase activity GO:0033673 106 0.015
photoreceptor cell maintenance GO:0045494 13 0.015
gtp catabolic process GO:0006184 237 0.015
mitotic spindle checkpoint GO:0071174 18 0.015
cytoplasmic transport GO:0016482 379 0.015
macromolecule methylation GO:0043414 97 0.015
heart development GO:0007507 95 0.015
organelle assembly GO:0070925 176 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
replicative cell aging GO:0001302 3 0.015
negative regulation of cytoskeleton organization GO:0051494 45 0.015
glycerophospholipid biosynthetic process GO:0046474 40 0.015
negative regulation of catabolic process GO:0009895 104 0.014
single organismal cell cell adhesion GO:0016337 148 0.014
developmental process involved in reproduction GO:0003006 66 0.014
positive regulation of chromosome organization GO:2001252 41 0.014
single organism membrane organization GO:0044802 268 0.014
mitotic cell cycle phase transition GO:0044772 162 0.014
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 2 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
leukocyte proliferation GO:0070661 74 0.014
regulation of cell cycle phase transition GO:1901987 126 0.014
macromolecular complex disassembly GO:0032984 60 0.014
mononuclear cell proliferation GO:0032943 71 0.014
glycerolipid biosynthetic process GO:0045017 51 0.014
hemopoiesis GO:0030097 180 0.014
microtubule cytoskeleton organization GO:0000226 176 0.014
ribonucleoprotein complex localization GO:0071166 4 0.014
sensory perception GO:0007600 103 0.014
nucleoside triphosphate catabolic process GO:0009143 394 0.014
oocyte development GO:0048599 1 0.014
protein oligomerization GO:0051259 173 0.014
negative regulation of protein catabolic process GO:0042177 59 0.014
organic hydroxy compound metabolic process GO:1901615 147 0.014
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.014
regulation of protein binding GO:0043393 66 0.014
pyrimidine ribonucleoside metabolic process GO:0046131 11 0.013
leukocyte activation GO:0045321 164 0.013
endocytosis GO:0006897 159 0.013
mitochondrion organization GO:0007005 156 0.013
negative regulation of protein maturation GO:1903318 142 0.013
regulation of ion transport GO:0043269 189 0.013
t cell activation GO:0042110 99 0.013
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.013
secretion GO:0046903 254 0.013
organ formation GO:0048645 3 0.013
immune system development GO:0002520 195 0.013
adult locomotory behavior GO:0008344 1 0.013
regulation of defense response GO:0031347 154 0.013
neurogenesis GO:0022008 169 0.013
ion homeostasis GO:0050801 230 0.013
gtp metabolic process GO:0046039 239 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
chromatin modification GO:0016568 298 0.013
regulation of nuclear division GO:0051783 65 0.013
somitogenesis GO:0001756 2 0.013
epithelial cell proliferation GO:0050673 128 0.013
negative regulation of homeostatic process GO:0032845 59 0.013
organelle fission GO:0048285 149 0.012
positive regulation of developmental process GO:0051094 314 0.012
single organism cell adhesion GO:0098602 179 0.012
regulation of cell adhesion GO:0030155 166 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
coenzyme metabolic process GO:0006732 65 0.012
sensory perception of sound GO:0007605 37 0.012
mrna processing GO:0006397 133 0.012
positive regulation of cell death GO:0010942 263 0.012
regulation of cell division GO:0051302 116 0.012
chromosome segregation GO:0007059 114 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
immune effector process GO:0002252 159 0.012
negative regulation of immune system process GO:0002683 136 0.012
signal transduction by p53 class mediator GO:0072331 72 0.012
glycerophospholipid metabolic process GO:0006650 84 0.012
metal ion transport GO:0030001 272 0.012
regulation of dephosphorylation GO:0035303 96 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
negative regulation of telomerase activity GO:0051974 6 0.012
inorganic ion transmembrane transport GO:0098660 231 0.012
rna 3 end processing GO:0031123 35 0.012
blastocyst development GO:0001824 3 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
regulation of cell cell adhesion GO:0022407 57 0.012
protein polyubiquitination GO:0000209 110 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.011
regulation of metal ion transport GO:0010959 120 0.011
regulation of cellular ketone metabolic process GO:0010565 50 0.011
negative regulation of protein polymerization GO:0032272 16 0.011
blastoderm segmentation GO:0007350 2 0.011
circulatory system development GO:0072359 262 0.011
positive regulation of transport GO:0051050 336 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
peptidyl threonine phosphorylation GO:0018107 41 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
negative regulation of epithelial cell proliferation GO:0050680 48 0.011
negative regulation of chromosome organization GO:2001251 48 0.011
glycosyl compound biosynthetic process GO:1901659 27 0.011
negative regulation of cellular component movement GO:0051271 106 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
cell cycle arrest GO:0007050 71 0.011
cellular cation homeostasis GO:0030003 163 0.011
positive regulation of cellular amine metabolic process GO:0033240 7 0.011
melanin metabolic process GO:0006582 1 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
detection of mechanical stimulus GO:0050982 4 0.011
intracellular protein transport GO:0006886 270 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
mitotic nuclear division GO:0007067 119 0.011
cellular modified amino acid metabolic process GO:0006575 64 0.011
protein polymerization GO:0051258 71 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of phosphatase activity GO:0010921 81 0.010
positive regulation of mitotic cell cycle GO:0045931 60 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
regulation of mitosis GO:0007088 63 0.010
trophectodermal cell differentiation GO:0001829 3 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
ossification GO:0001503 121 0.010
limbic system development GO:0021761 3 0.010
ribonucleoside triphosphate catabolic process GO:0009203 391 0.010
ribose phosphate biosynthetic process GO:0046390 82 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010
cellular chemical homeostasis GO:0055082 180 0.010
protein localization to membrane GO:0072657 160 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
response to extracellular stimulus GO:0009991 85 0.010
protein stabilization GO:0050821 64 0.010
epithelium development GO:0060429 227 0.010
negative regulation of multicellular organismal process GO:0051241 317 0.010
water homeostasis GO:0030104 14 0.010

PINX1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.162
cancer DOID:162 167 0.127
organ system cancer DOID:0050686 164 0.072
immune system cancer DOID:0060083 36 0.025
hematologic cancer DOID:2531 36 0.025
disease of metabolism DOID:0014667 295 0.024
myeloid leukemia DOID:8692 18 0.018
acute myeloid leukemia DOID:9119 17 0.018
leukemia DOID:1240 21 0.018
immune system disease DOID:2914 155 0.018
hematopoietic system disease DOID:74 100 0.018
inherited metabolic disorder DOID:655 242 0.016
amino acid metabolic disorder DOID:9252 50 0.016
central nervous system disease DOID:331 186 0.013
nervous system disease DOID:863 431 0.013
anemia DOID:2355 55 0.011