Homo sapiens

114 known processes

PITX2

paired-like homeodomain 2

(Aliases: IRID2,MGC111022,IGDS,RS,PTX2,RIEG,IHG2,Otlx2,RGS,RIEG1,IDG2,Brx1,MGC20144,ARP1,IGDS2)

PITX2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extraocular skeletal muscle development GO:0002074 1 0.786
Mouse
circulatory system development GO:0072359 262 0.326
Zebrafish Mouse
anatomical structure formation involved in morphogenesis GO:0048646 284 0.266
Zebrafish Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.258
cardiovascular system development GO:0072358 262 0.239
Zebrafish Mouse
cranial nerve development GO:0021545 4 0.218
organ morphogenesis GO:0009887 147 0.212
skeletal system development GO:0001501 79 0.190
epithelium development GO:0060429 227 0.174
Zebrafish Mouse
regulation of cell differentiation GO:0045595 393 0.169
nerve development GO:0021675 4 0.159
vasculature development GO:0001944 181 0.156
Mouse
blood vessel development GO:0001568 172 0.150
Mouse
negative regulation of developmental process GO:0051093 247 0.144
tube morphogenesis GO:0035239 95 0.143
Mouse
cellular ketone metabolic process GO:0042180 80 0.140
negative regulation of multicellular organismal process GO:0051241 317 0.135
hindbrain development GO:0030902 3 0.135
negative regulation of cell differentiation GO:0045596 171 0.134
cellular component morphogenesis GO:0032989 314 0.133
Worm Fly
stem cell differentiation GO:0048863 93 0.131
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.131
neuron fate commitment GO:0048663 2 0.131
system process GO:0003008 349 0.127
Zebrafish
positive regulation of developmental process GO:0051094 314 0.117
epithelial cell differentiation GO:0030855 141 0.116
amine metabolic process GO:0009308 44 0.110
embryonic morphogenesis GO:0048598 85 0.110
Zebrafish Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.110
tube development GO:0035295 125 0.110
Zebrafish Mouse
cell morphogenesis GO:0000902 296 0.109
Worm Fly
post embryonic development GO:0009791 2 0.109
organ formation GO:0048645 3 0.108
segmentation GO:0035282 4 0.108
regulation of cellular component movement GO:0051270 334 0.107
Mouse
menstrual cycle phase GO:0022601 2 0.106
regulation of anatomical structure morphogenesis GO:0022603 286 0.104
cell development GO:0048468 328 0.103
Mouse Worm Fly
stem cell development GO:0048864 69 0.101
Mouse
mesenchyme development GO:0060485 59 0.100
Mouse
nervous system development GO:0007399 293 0.098
Zebrafish Mouse Rat Worm Fly
embryonic forelimb morphogenesis GO:0035115 4 0.098
specification of organ identity GO:0010092 3 0.096
cell fate determination GO:0001709 3 0.096
enzyme linked receptor protein signaling pathway GO:0007167 303 0.095
forelimb morphogenesis GO:0035136 4 0.095
positive regulation of aldosterone metabolic process GO:0032346 2 0.093
regulation of cell cycle GO:0051726 393 0.093
regulation of cell motility GO:2000145 299 0.093
Mouse
positive regulation of cell proliferation GO:0008284 301 0.092
Mouse
response to lipid GO:0033993 206 0.089
Rat
regulation of locomotion GO:0040012 329 0.084
Mouse Worm
cellular amine metabolic process GO:0044106 41 0.083
tissue morphogenesis GO:0048729 96 0.083
Zebrafish Mouse
positive regulation of cell differentiation GO:0045597 211 0.082
forebrain regionalization GO:0021871 3 0.080
cardiac right ventricle morphogenesis GO:0003215 3 0.078
negative regulation of cell death GO:0060548 345 0.076
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.076
regulation of hormone levels GO:0010817 125 0.076
digestive tract development GO:0048565 75 0.075
Zebrafish Mouse
lipid metabolic process GO:0006629 381 0.075
muscle structure development GO:0061061 98 0.075
Mouse
negative regulation of apoptotic process GO:0043066 316 0.075
positive regulation of cell death GO:0010942 263 0.075
cellular amino acid metabolic process GO:0006520 116 0.072
mesenchymal cell differentiation GO:0048762 52 0.071
Mouse
cardiac cell fate determination GO:0060913 3 0.070
response to oxygen containing compound GO:1901700 369 0.070
embryonic camera type eye development GO:0031076 2 0.069
Zebrafish Mouse
positive regulation of apoptotic process GO:0043065 246 0.069
kidney development GO:0001822 53 0.069
ossification GO:0001503 121 0.068
regulation of cellular amino acid metabolic process GO:0006521 6 0.066
heart development GO:0007507 95 0.066
Zebrafish Mouse
cell morphogenesis involved in differentiation GO:0000904 144 0.066
Worm Fly
regulation of cell development GO:0060284 161 0.065
bmp signaling pathway involved in heart development GO:0061312 3 0.065
negative regulation of cellular component organization GO:0051129 235 0.065
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.064
positive regulation of programmed cell death GO:0043068 249 0.063
regulation of cell migration GO:0030334 289 0.060
Mouse
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.060
positive regulation of transport GO:0051050 336 0.059
negative regulation of cell proliferation GO:0008285 228 0.059
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.058
regulation of cellular amine metabolic process GO:0033238 11 0.057
somatic stem cell maintenance GO:0035019 4 0.057
regionalization GO:0003002 29 0.057
Zebrafish Mouse
negative regulation of kidney development GO:0090185 2 0.057
positive regulation of cellular amine metabolic process GO:0033240 7 0.057
mitotic cell cycle GO:0000278 326 0.057
urogenital system development GO:0001655 65 0.057
locomotory behavior GO:0007626 1 0.056
positive regulation of hormone biosynthetic process GO:0046886 4 0.055
immune system development GO:0002520 195 0.055
Mouse
neural crest cell development GO:0014032 3 0.054
Mouse
pancreas development GO:0031016 19 0.054
pattern specification process GO:0007389 43 0.054
Zebrafish Mouse
mesenchymal cell development GO:0014031 50 0.053
Mouse
negative regulation of programmed cell death GO:0043069 321 0.053
regulation of ossification GO:0030278 58 0.053
inner ear morphogenesis GO:0042472 4 0.053
single organism cellular localization GO:1902580 332 0.053
blood vessel morphogenesis GO:0048514 162 0.052
Mouse
heart morphogenesis GO:0003007 48 0.051
Mouse
negative regulation of protein metabolic process GO:0051248 391 0.050
cytoplasmic transport GO:0016482 379 0.050
digestive system development GO:0055123 75 0.050
Zebrafish Mouse
neurogenesis GO:0022008 169 0.050
Mouse Rat Worm Fly
neuron differentiation GO:0030182 138 0.050
Rat Worm Fly
protein localization to organelle GO:0033365 280 0.049
heart formation GO:0060914 2 0.049
striated muscle tissue development GO:0014706 59 0.048
Mouse
generation of neurons GO:0048699 152 0.048
Mouse Rat Worm Fly
morphogenesis of embryonic epithelium GO:0016331 4 0.048
Zebrafish
regulation of mitotic cell cycle GO:0007346 189 0.048
cellular response to oxygen containing compound GO:1901701 276 0.048
negative regulation of locomotion GO:0040013 118 0.048
regulation of stem cell differentiation GO:2000736 56 0.048
negative regulation of cellular protein metabolic process GO:0032269 353 0.048
mesendoderm development GO:0048382 1 0.047
Zebrafish
biological adhesion GO:0022610 331 0.047
negative regulation of cell cycle GO:0045786 193 0.047
somitogenesis GO:0001756 2 0.047
signal transduction by phosphorylation GO:0023014 297 0.047
regulation of protein transport GO:0051223 213 0.046
brain development GO:0007420 97 0.046
Mouse Rat
endocrine system development GO:0035270 26 0.046
Mouse
response to organic cyclic compound GO:0014070 204 0.046
secretion GO:0046903 254 0.046
secretion by cell GO:0032940 226 0.046
positive regulation of phosphorylation GO:0042327 394 0.046
response to abiotic stimulus GO:0009628 336 0.045
testosterone biosynthetic process GO:0061370 2 0.045
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.045
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.045
peripheral nervous system development GO:0007422 2 0.044
regulation of endopeptidase activity GO:0052548 170 0.044
forebrain generation of neurons GO:0021872 3 0.043
regulation of protein localization GO:0032880 296 0.043
regulation of proteolysis GO:0030162 293 0.043
nitrogen compound transport GO:0071705 191 0.043
renal system development GO:0072001 63 0.043
hematopoietic or lymphoid organ development GO:0048534 186 0.043
Mouse
motor neuron axon guidance GO:0008045 2 0.042
cellular lipid metabolic process GO:0044255 303 0.042
mapk cascade GO:0000165 288 0.042
embryonic organ development GO:0048568 36 0.042
Zebrafish Mouse
osteoblast differentiation GO:0001649 92 0.042
positive regulation of protein phosphorylation GO:0001934 313 0.042
regulation of peptidase activity GO:0052547 180 0.042
taxis GO:0042330 157 0.042
Worm
muscle tissue development GO:0060537 62 0.042
Mouse
pharynx development GO:0060465 1 0.042
regulation of secretion by cell GO:1903530 177 0.042
negative regulation of phosphate metabolic process GO:0045936 267 0.041
metencephalon development GO:0022037 2 0.041
embryonic epithelial tube formation GO:0001838 4 0.041
soft palate development GO:0060023 3 0.041
hormone secretion GO:0046879 65 0.041
central nervous system development GO:0007417 123 0.041
Mouse Rat
regulation of heart induction by regulation of canonical wnt signaling pathway GO:0090081 1 0.041
cell projection organization GO:0030030 252 0.040
Worm Fly
negative regulation of phosphorus metabolic process GO:0010563 267 0.040
regulation of establishment of protein localization GO:0070201 242 0.040
cell cell signaling GO:0007267 155 0.040
negative regulation of cell migration GO:0030336 102 0.040
embryo development GO:0009790 123 0.039
Zebrafish Mouse
pituitary gland development GO:0021983 2 0.039
Mouse
regulation of cellular component biogenesis GO:0044087 281 0.039
response to hormone GO:0009725 175 0.039
Rat
head development GO:0060322 108 0.039
Zebrafish Mouse Rat
regulation of secretion GO:0051046 194 0.039
anterior posterior axis specification GO:0009948 2 0.039
female gamete generation GO:0007292 2 0.039
cell adhesion GO:0007155 325 0.038
regulation of kinase activity GO:0043549 314 0.038
regulation of cell morphogenesis GO:0022604 153 0.038
blood circulation GO:0008015 113 0.038
Zebrafish
actin filament based process GO:0030029 224 0.038
regulation of cell cycle process GO:0010564 266 0.038
determination of adult lifespan GO:0008340 2 0.038
negative regulation of cellular component movement GO:0051271 106 0.038
regulation of transferase activity GO:0051338 355 0.037
regulation of mapk cascade GO:0043408 262 0.037
multicellular organismal aging GO:0010259 3 0.037
negative regulation of catalytic activity GO:0043086 335 0.037
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.037
regulation of cytokine production GO:0001817 232 0.037
intracellular protein transport GO:0006886 270 0.037
epithelial to mesenchymal transition GO:0001837 48 0.036
spinal cord development GO:0021510 4 0.036
blastoderm segmentation GO:0007350 2 0.036
lipid biosynthetic process GO:0008610 177 0.036
wnt signaling pathway GO:0016055 156 0.036
Mouse
connective tissue development GO:0061448 39 0.036
small molecule biosynthetic process GO:0044283 157 0.036
positive regulation of organelle organization GO:0010638 195 0.035
cytokine production GO:0001816 247 0.035
growth GO:0040007 202 0.035
chordate embryonic development GO:0043009 34 0.035
Zebrafish Mouse
skeletal system morphogenesis GO:0048705 24 0.035
Zebrafish
cellular response to dna damage stimulus GO:0006974 379 0.035
positive regulation of protein transport GO:0051222 135 0.035
chromatin organization GO:0006325 351 0.034
muscle organ development GO:0007517 56 0.034
Mouse
positive regulation of cell development GO:0010720 92 0.034
oogenesis GO:0048477 2 0.034
cellular response to hormone stimulus GO:0032870 125 0.034
response to growth factor GO:0070848 205 0.034
apoptotic signaling pathway GO:0097190 268 0.034
hard palate development GO:0060022 1 0.034
oxidation reduction process GO:0055114 396 0.034
canonical wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 2 0.033
positive regulation of cellular component organization GO:0051130 376 0.033
immune response GO:0006955 307 0.033
endodermal cell fate commitment GO:0001711 4 0.033
menstruation GO:0042703 1 0.033
hindlimb morphogenesis GO:0035137 2 0.033
Mouse
cellular response to lipid GO:0071396 127 0.033
limbic system development GO:0021761 3 0.032
Mouse
photoreceptor cell differentiation GO:0046530 2 0.032
positive regulation of hydrolase activity GO:0051345 331 0.032
regulation of protein kinase activity GO:0045859 289 0.032
chromatin modification GO:0016568 298 0.032
epithelial cell proliferation GO:0050673 128 0.032
positive regulation of tooth mineralization GO:0070172 2 0.032
cellular macromolecule catabolic process GO:0044265 380 0.031
canonical wnt signaling pathway GO:0060070 116 0.031
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.030
aortic valve development GO:0003176 3 0.030
negative regulation of protein modification process GO:0031400 200 0.030
outflow tract septum morphogenesis GO:0003148 4 0.030
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.030
negative regulation of glomerulus development GO:0090194 2 0.030
nucleocytoplasmic transport GO:0006913 176 0.030
thymus development GO:0048538 3 0.030
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.030
regulation of heart morphogenesis GO:2000826 4 0.030
adult locomotory behavior GO:0008344 1 0.030
regulation of cysteine type endopeptidase activity GO:2000116 127 0.030
positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 3 0.029
muscle contraction GO:0006936 73 0.029
detection of chemical stimulus involved in sensory perception of smell GO:0050911 2 0.029
positive regulation of peptidase activity GO:0010952 88 0.029
intracellular receptor signaling pathway GO:0030522 104 0.029
Zebrafish
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.029
regulation of epithelial to mesenchymal transition GO:0010717 37 0.029
reproductive process GO:0022414 106 0.029
Rat
cell division GO:0051301 168 0.029
negative regulation of cell motility GO:2000146 104 0.029
mesonephros development GO:0001823 17 0.029
regulation of growth GO:0040008 165 0.029
cellular response to growth factor stimulus GO:0071363 197 0.029
regulation of organ formation GO:0003156 4 0.028
regulation of cellular response to stress GO:0080135 244 0.028
regulation of intracellular transport GO:0032386 195 0.028
positive regulation of proteolysis GO:0045862 142 0.028
gland development GO:0048732 48 0.028
Mouse
posttranscriptional regulation of gene expression GO:0010608 213 0.028
protein localization to nucleus GO:0034504 136 0.028
positive regulation of immune system process GO:0002684 283 0.028
response to biotic stimulus GO:0009607 276 0.028
positive regulation of glucocorticoid biosynthetic process GO:0031948 1 0.028
nuclear transport GO:0051169 179 0.028
negative regulation of phosphorylation GO:0042326 174 0.028
bmp signaling pathway GO:0030509 49 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.027
cell projection morphogenesis GO:0048858 129 0.027
Worm Fly
cell growth GO:0016049 160 0.027
neurological system process GO:0050877 163 0.027
response to wounding GO:0009611 168 0.027
positive regulation of cardioblast differentiation GO:0051891 2 0.027
neuron projection development GO:0031175 106 0.027
Worm Fly
positive regulation of mapk cascade GO:0043410 190 0.027
developmental programmed cell death GO:0010623 3 0.027
hemopoiesis GO:0030097 180 0.027
sensory organ development GO:0007423 52 0.027
retinal ganglion cell axon guidance GO:0031290 2 0.027
negative regulation of vasculature development GO:1901343 43 0.027
negative regulation of transport GO:0051051 176 0.026
regeneration GO:0031099 4 0.026
covalent chromatin modification GO:0016569 254 0.026
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.026
hair follicle morphogenesis GO:0031069 2 0.026
defense response GO:0006952 315 0.026
response to steroid hormone GO:0048545 80 0.026
hormone metabolic process GO:0042445 61 0.026
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.026
negative regulation of cell growth GO:0030308 83 0.026
monocarboxylic acid metabolic process GO:0032787 185 0.026
protein targeting GO:0006605 187 0.026
forebrain neuron differentiation GO:0021879 3 0.026
endodermal cell fate specification GO:0001714 4 0.026
cranial nerve morphogenesis GO:0021602 1 0.026
regulation of lipid metabolic process GO:0019216 96 0.026
muscle system process GO:0003012 81 0.025
positive regulation of cytokine production GO:0001819 167 0.025
sex determination GO:0007530 3 0.025
regulation of cytoplasmic transport GO:1903649 149 0.025
negative regulation of protein phosphorylation GO:0001933 140 0.025
organic hydroxy compound metabolic process GO:1901615 147 0.025
dermatome development GO:0061054 3 0.025
positive regulation of cell cycle GO:0045787 140 0.025
establishment of protein localization to organelle GO:0072594 172 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.025
cerebellum development GO:0021549 2 0.025
negative regulation of mitotic cell cycle GO:0045930 102 0.025
positive regulation of cellular component movement GO:0051272 181 0.025
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.025
mitotic cell cycle process GO:1903047 286 0.025
positive regulation of cell motility GO:2000147 177 0.025
canonical wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061317 3 0.025
positive regulation of secretion by cell GO:1903532 108 0.025
mesodermal cell fate commitment GO:0001710 2 0.025
regulation of homeostatic process GO:0032844 121 0.025
neuromuscular junction development GO:0007528 3 0.024
positive regulation of ossification GO:0045778 32 0.024
regulation of wnt signaling pathway GO:0030111 123 0.024
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.024
regulation of response to external stimulus GO:0032101 222 0.024
cellular response to organic cyclic compound GO:0071407 127 0.024
positive regulation of cellular component biogenesis GO:0044089 158 0.024
negative regulation of cell proliferation involved in kidney development GO:1901723 2 0.024
vesicle mediated transport GO:0016192 371 0.024
endocrine pancreas development GO:0031018 11 0.024
regulation of cell growth GO:0001558 135 0.024
regulation of protein serine threonine kinase activity GO:0071900 179 0.024
neuron development GO:0048666 113 0.024
Worm Fly
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.024
alcohol metabolic process GO:0006066 114 0.024
steroid metabolic process GO:0008202 94 0.023
cardiac ventricle formation GO:0003211 2 0.023
regulation of cell proliferation involved in kidney development GO:1901722 3 0.023
compound eye development GO:0048749 1 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
neural tube formation GO:0001841 3 0.023
embryonic camera type eye formation GO:0060900 2 0.023
Zebrafish
regulation of apoptotic signaling pathway GO:2001233 175 0.023
androgen biosynthetic process GO:0006702 3 0.023
cell differentiation in spinal cord GO:0021515 1 0.023
signal release GO:0023061 70 0.023
protein import GO:0017038 130 0.023
single organism reproductive process GO:0044702 98 0.023
Rat
embryonic skeletal system development GO:0048706 13 0.023
Zebrafish
positive regulation of odontogenesis GO:0042482 3 0.023
regulation of osteoblast differentiation GO:0045667 38 0.023
cardiac muscle contraction GO:0060048 34 0.023
regulation of canonical wnt signaling pathway GO:0060828 88 0.022
positive regulation of secretion GO:0051047 116 0.022
single organism carbohydrate metabolic process GO:0044723 193 0.022
response to other organism GO:0051707 261 0.022
small gtpase mediated signal transduction GO:0007264 78 0.022
positive regulation of osteoblast differentiation GO:0045669 23 0.022
positive regulation of epithelial cell proliferation GO:0050679 65 0.022
negative regulation of gliogenesis GO:0014014 3 0.022
chemotaxis GO:0006935 157 0.022
Worm
hormone transport GO:0009914 68 0.022
regulation of nervous system development GO:0051960 88 0.022
regulation of intracellular protein transport GO:0033157 123 0.022
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.022
cell part morphogenesis GO:0032990 137 0.022
Worm Fly
ras protein signal transduction GO:0007265 73 0.022
peptide transport GO:0015833 74 0.022
response to fungus GO:0009620 4 0.022
transmembrane transport GO:0055085 399 0.022
memory GO:0007613 3 0.022
embryonic camera type eye morphogenesis GO:0048596 2 0.022
Zebrafish
circulatory system process GO:0003013 113 0.022
Zebrafish
tongue development GO:0043586 1 0.022
single organism membrane organization GO:0044802 268 0.022
histone modification GO:0016570 251 0.022
cardiac muscle cell contraction GO:0086003 4 0.022
mating GO:0007618 1 0.021
regulation of cell adhesion GO:0030155 166 0.021
purine containing compound catabolic process GO:0072523 411 0.021
regulation of epithelial cell proliferation GO:0050678 113 0.021
positive regulation of neural precursor cell proliferation GO:2000179 2 0.021
single organism nuclear import GO:1902593 104 0.021
organophosphate catabolic process GO:0046434 430 0.021
type b pancreatic cell development GO:0003323 4 0.021
visual behavior GO:0007632 2 0.021
cell proliferation in forebrain GO:0021846 1 0.021
trophectodermal cell differentiation GO:0001829 3 0.021
response to external biotic stimulus GO:0043207 261 0.021
membrane organization GO:0061024 292 0.021
myeloid cell differentiation GO:0030099 117 0.021
regulation of testosterone biosynthetic process GO:2000224 2 0.021
regulation of dna metabolic process GO:0051052 153 0.021
embryonic hindlimb morphogenesis GO:0035116 2 0.021
Mouse
positive regulation of stem cell differentiation GO:2000738 29 0.021
positive regulation of endopeptidase activity GO:0010950 84 0.021
amide transport GO:0042886 76 0.021
heart field specification GO:0003128 2 0.021
cardiac muscle tissue development GO:0048738 39 0.021
Mouse
regulation of multi organism process GO:0043900 157 0.021
negative regulation of organelle organization GO:0010639 126 0.021
organonitrogen compound biosynthetic process GO:1901566 200 0.021
organelle assembly GO:0070925 176 0.021
nuclear import GO:0051170 106 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.021
morphogenesis of an epithelium GO:0002009 60 0.021
Zebrafish Mouse
positive regulation of catabolic process GO:0009896 310 0.021
positive regulation of dermatome development GO:0061184 3 0.021
odontogenesis GO:0042476 25 0.021
cartilage development GO:0051216 31 0.021
angiogenesis GO:0001525 147 0.021
Mouse
forebrain dorsal ventral pattern formation GO:0021798 1 0.021
positive regulation of locomotion GO:0040017 186 0.021
purine nucleoside triphosphate metabolic process GO:0009144 412 0.021
limb bud formation GO:0060174 1 0.021
negative regulation of growth GO:0045926 97 0.021
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.020
tissue migration GO:0090130 119 0.020
regulation of cell division GO:0051302 116 0.020
negative regulation of glucocorticoid biosynthetic process GO:0031947 4 0.020
striated muscle contraction GO:0006941 52 0.020
nucleoside triphosphate metabolic process GO:0009141 422 0.020
regulation of vasculature development GO:1901342 97 0.020
salivary gland morphogenesis GO:0007435 4 0.020
blastocyst development GO:0001824 3 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
peptide secretion GO:0002790 51 0.020
regulation of neurogenesis GO:0050767 82 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
purine nucleoside triphosphate catabolic process GO:0009146 392 0.020
optic nerve development GO:0021554 2 0.020
wound healing GO:0042060 115 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
epidermis morphogenesis GO:0048730 3 0.020
regulation of neural precursor cell proliferation GO:2000177 4 0.020
protein targeting to nucleus GO:0044744 104 0.020
protein ubiquitination GO:0016567 314 0.020
anterior posterior axis specification embryo GO:0008595 2 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
ameboidal type cell migration GO:0001667 135 0.020
Mouse
blastocyst formation GO:0001825 3 0.020
negative regulation of monocyte differentiation GO:0045656 3 0.020
pulmonary vein morphogenesis GO:0060577 1 0.020
Mouse
cartilage condensation GO:0001502 1 0.020
epidermis development GO:0008544 59 0.020
formation of primary germ layer GO:0001704 42 0.020
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.020
epidermal cell differentiation GO:0009913 45 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
syncytium formation by plasma membrane fusion GO:0000768 2 0.020
Mouse
actin cytoskeleton organization GO:0030036 207 0.020
positive regulation of transferase activity GO:0051347 227 0.019
male genitalia development GO:0030539 1 0.019
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.019
epithelial cell migration GO:0010631 119 0.019
digestive tract morphogenesis GO:0048546 56 0.019
Mouse
tripartite regional subdivision GO:0007351 2 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
cation transport GO:0006812 331 0.019
blood coagulation GO:0007596 76 0.019
chemical homeostasis GO:0048878 306 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
carbohydrate metabolic process GO:0005975 207 0.019
mesodermal cell fate specification GO:0007501 2 0.019
startle response GO:0001964 3 0.019
rhythmic behavior GO:0007622 2 0.019
negative regulation of cell development GO:0010721 48 0.019
negative regulation of transferase activity GO:0051348 124 0.019
morphogenesis of a polarized epithelium GO:0001738 3 0.019
protein catabolic process GO:0030163 325 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
myoblast fusion GO:0007520 1 0.019
Mouse
negative regulation of androgen biosynthetic process GO:2000180 1 0.019
negative regulation of epidermal cell differentiation GO:0045605 4 0.019
luteinizing hormone secretion GO:0032275 1 0.019
primary neural tube formation GO:0014020 3 0.019
leukocyte differentiation GO:0002521 98 0.019

PITX2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.072
Human
sensory system disease DOID:0050155 203 0.051
Human
nervous system disease DOID:863 431 0.051
Human
eye and adnexa disease DOID:1492 150 0.043
Human
eye disease DOID:5614 149 0.043
Human
disease of metabolism DOID:0014667 295 0.040
muscular disease DOID:0080000 114 0.029
muscle tissue disease DOID:66 113 0.029
bone disease DOID:0080001 88 0.028
Human
connective tissue disease DOID:65 109 0.028
Human
retinal disease DOID:5679 118 0.027
inherited metabolic disorder DOID:655 242 0.025
disease of cellular proliferation DOID:14566 174 0.024
myopathy DOID:423 104 0.024
cancer DOID:162 167 0.024
organ system cancer DOID:0050686 164 0.022
cardiovascular system disease DOID:1287 106 0.021