Homo sapiens

70 known processes

PLEKHA1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

(Aliases: TAPP1)

PLEKHA1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 2 0.951
phospholipase c activating adrenergic receptor signaling pathway GO:0071882 1 0.947
adenylate cyclase inhibiting adrenergic receptor signaling pathway GO:0071881 1 0.928
desensitization of g protein coupled receptor protein signaling pathway by arrestin GO:0002032 2 0.819
positive regulation of phosphatidylinositol biosynthetic process GO:0010513 3 0.724
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.614
regulation of cellular amine metabolic process GO:0033238 11 0.554
gtp metabolic process GO:0046039 239 0.549
purine containing compound catabolic process GO:0072523 411 0.511
ribonucleotide catabolic process GO:0009261 405 0.490
ribonucleoside catabolic process GO:0042454 406 0.451
regulation of gtp catabolic process GO:0033124 180 0.436
adenylate cyclase inhibiting opioid receptor signaling pathway GO:0031635 1 0.429
organophosphate catabolic process GO:0046434 430 0.428
regulation of cellular ketone metabolic process GO:0010565 50 0.428
nucleotide catabolic process GO:0009166 408 0.407
somatostatin receptor signaling pathway GO:0038169 1 0.404
nucleoside catabolic process GO:0009164 408 0.384
guanosine containing compound metabolic process GO:1901068 244 0.380
positive regulation of glucocorticoid secretion GO:2000851 4 0.377
purine nucleotide catabolic process GO:0006195 405 0.375
phosphatidylinositol mediated signaling GO:0048015 55 0.366
purine ribonucleotide catabolic process GO:0009154 404 0.360
somatostatin signaling pathway GO:0038170 1 0.359
nucleoside triphosphate metabolic process GO:0009141 422 0.354
regulation of cellular amino acid metabolic process GO:0006521 6 0.352
camp mediated signaling GO:0019933 23 0.344
neuropeptide signaling pathway GO:0007218 19 0.308
negative regulation of wnt protein secretion GO:0061358 1 0.300
ribonucleoside triphosphate catabolic process GO:0009203 391 0.297
cellular amine metabolic process GO:0044106 41 0.290
regulation of purine nucleotide catabolic process GO:0033121 205 0.277
serotonin receptor signaling pathway GO:0007210 11 0.273
guanosine containing compound catabolic process GO:1901069 239 0.272
adenylate cyclase activating adrenergic receptor signaling pathway GO:0071880 3 0.256
nucleoside triphosphate catabolic process GO:0009143 394 0.244
opioid receptor signaling pathway GO:0038003 4 0.239
regulation of camp mediated signaling GO:0043949 13 0.228
regulation of purine nucleotide metabolic process GO:1900542 264 0.218
regulation of large conductance calcium activated potassium channel activity GO:1902606 2 0.216
positive regulation of nucleotide catabolic process GO:0030813 185 0.212
inositol lipid mediated signaling GO:0048017 55 0.211
positive regulation of ras gtpase activity GO:0032320 117 0.208
cellular lipid metabolic process GO:0044255 303 0.199
positive regulation of large conductance calcium activated potassium channel activity GO:1902608 2 0.199
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.194
positive regulation of phosphorylation GO:0042327 394 0.186
intestine smooth muscle contraction GO:0014827 2 0.180
cellular response to endogenous stimulus GO:0071495 336 0.173
cell adhesion GO:0007155 325 0.173
Human
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway GO:0035625 4 0.168
ras protein signal transduction GO:0007265 73 0.155
positive regulation of cellular amine metabolic process GO:0033240 7 0.152
nucleoside phosphate catabolic process GO:1901292 412 0.148
regulation of ras protein signal transduction GO:0046578 155 0.145
cellular response to organic cyclic compound GO:0071407 127 0.143
negative regulation of phosphorus metabolic process GO:0010563 267 0.141
g protein coupled receptor signaling pathway GO:0007186 207 0.141
regulation of autophagy GO:0010506 52 0.137
glycosyl compound catabolic process GO:1901658 413 0.137
signal transduction by phosphorylation GO:0023014 297 0.135
regulation of phospholipase c activity GO:1900274 14 0.134
purine ribonucleoside catabolic process GO:0046130 398 0.134
lipid metabolic process GO:0006629 381 0.132
Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.129
chemical homeostasis GO:0048878 306 0.126
protein modification by small protein conjugation GO:0032446 342 0.123
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.121
positive regulation of protein kinase activity GO:0045860 190 0.118
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.116
positive regulation of nucleoside metabolic process GO:0045979 186 0.116
second messenger mediated signaling GO:0019932 78 0.116
autophagy GO:0006914 88 0.112
cellular ion homeostasis GO:0006873 168 0.112
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.111
regulation of gtpase activity GO:0043087 180 0.109
neuronal action potential GO:0019228 9 0.106
purine nucleoside triphosphate catabolic process GO:0009146 392 0.105
erk1 and erk2 cascade GO:0070371 104 0.105
metal ion transport GO:0030001 272 0.104
sequestering of calcium ion GO:0051208 17 0.102
cytosolic calcium ion homeostasis GO:0051480 89 0.095
positive regulation of mapk cascade GO:0043410 190 0.095
receptor transactivation GO:0035624 4 0.095
small gtpase mediated signal transduction GO:0007264 78 0.094
positive regulation of catabolic process GO:0009896 310 0.093
post embryonic development GO:0009791 2 0.092
Mouse
cytoplasmic transport GO:0016482 379 0.092
regulation of hormone levels GO:0010817 125 0.092
Mouse
negative regulation of cell proliferation GO:0008285 228 0.091
regulation of nucleoside metabolic process GO:0009118 209 0.087
positive regulation of cellular catabolic process GO:0031331 284 0.087
dephosphorylation GO:0016311 209 0.087
cellular homeostasis GO:0019725 196 0.086
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.086
cortisol secretion GO:0043400 4 0.085
reactive oxygen species biosynthetic process GO:1903409 4 0.082
regulation of cell differentiation GO:0045595 393 0.082
protein catabolic process GO:0030163 325 0.078
glycerolipid metabolic process GO:0046486 107 0.078
regulation of cellular component biogenesis GO:0044087 281 0.077
positive regulation of adenylate cyclase activity GO:0045762 12 0.076
negative regulation of cellular component organization GO:0051129 235 0.075
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.075
regulation of secretion by cell GO:1903530 177 0.074
positive regulation of ion transport GO:0043270 87 0.074
nervous system development GO:0007399 293 0.073
purine nucleoside triphosphate metabolic process GO:0009144 412 0.073
cellular ketone metabolic process GO:0042180 80 0.071
cellular amino acid metabolic process GO:0006520 116 0.071
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.070
potassium ion transport GO:0006813 62 0.070
mapk cascade GO:0000165 288 0.070
cation transport GO:0006812 331 0.069
negative regulation of transport GO:0051051 176 0.069
glycerophospholipid metabolic process GO:0006650 84 0.068
divalent inorganic cation homeostasis GO:0072507 136 0.068
purine ribonucleoside metabolic process GO:0046128 437 0.067
negative regulation of lipid catabolic process GO:0050995 9 0.067
regulation of nucleotide metabolic process GO:0006140 269 0.067
negative regulation of secretion GO:0051048 58 0.066
ribonucleoside triphosphate metabolic process GO:0009199 412 0.065
wound healing GO:0042060 115 0.064
lipid catabolic process GO:0016042 84 0.063
lipid biosynthetic process GO:0008610 177 0.062
cellular cation homeostasis GO:0030003 163 0.061
cyclic nucleotide metabolic process GO:0009187 82 0.060
monovalent inorganic cation transport GO:0015672 128 0.060
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.060
response to organonitrogen compound GO:0010243 156 0.060
cell projection organization GO:0030030 252 0.060
negative regulation of catalytic activity GO:0043086 335 0.060
regulation of protein kinase activity GO:0045859 289 0.059
tor signaling GO:0031929 39 0.059
cerebellum development GO:0021549 2 0.058
cellular response to oxygen containing compound GO:1901701 276 0.058
action potential GO:0001508 34 0.057
divalent inorganic cation transport GO:0072511 158 0.057
transmission of nerve impulse GO:0019226 11 0.057
regulation of kinase activity GO:0043549 314 0.057
negative regulation of cell death GO:0060548 345 0.056
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 38 0.056
calcium ion homeostasis GO:0055074 122 0.055
peptidyl serine phosphorylation GO:0018105 101 0.055
neurological system process GO:0050877 163 0.055
regulation of response to wounding GO:1903034 101 0.055
camp biosynthetic process GO:0006171 47 0.054
cell morphogenesis GO:0000902 296 0.053
cellular potassium ion transport GO:0071804 60 0.052
vesicle mediated transport GO:0016192 371 0.052
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 6 0.051
positive regulation of developmental process GO:0051094 314 0.051
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.050
response to nitrogen compound GO:1901698 184 0.049
regulation of metal ion transport GO:0010959 120 0.049
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.049
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.049
positive regulation of protein phosphorylation GO:0001934 313 0.049
positive regulation of nucleotide metabolic process GO:0045981 230 0.048
protein localization to organelle GO:0033365 280 0.048
regulation of hormone secretion GO:0046883 57 0.047
behavioral defense response GO:0002209 0 0.047
negative regulation of nucleotide metabolic process GO:0045980 29 0.046
neuron differentiation GO:0030182 138 0.046
regulation of proteolysis GO:0030162 293 0.046
cellular divalent inorganic cation homeostasis GO:0072503 128 0.046
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.046
ribose phosphate biosynthetic process GO:0046390 82 0.046
response to wounding GO:0009611 168 0.045
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.045
oogenesis GO:0048477 2 0.045
hormone secretion GO:0046879 65 0.045
female gamete generation GO:0007292 2 0.045
adrenergic receptor signaling pathway GO:0071875 9 0.044
regulation of protein catabolic process GO:0042176 155 0.044
positive regulation of camp dependent protein kinase activity GO:2000481 4 0.044
regulation of calcium ion transport into cytosol GO:0010522 33 0.044
actin cytoskeleton organization GO:0030036 207 0.043
intracellular protein transport GO:0006886 270 0.043
regulation of membrane potential GO:0042391 95 0.043
response to hormone GO:0009725 175 0.043
divalent metal ion transport GO:0070838 152 0.043
regulation of cell cycle GO:0051726 393 0.042
i kappab kinase nf kappab signaling GO:0007249 166 0.042
cellular response to glucocorticoid stimulus GO:0071385 4 0.041
membrane organization GO:0061024 292 0.041
peptidyl tyrosine modification GO:0018212 170 0.041
regulation of tor signaling GO:0032006 30 0.041
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.041
regulation of ion transport GO:0043269 189 0.040
positive regulation of cyclase activity GO:0031281 13 0.040
positive regulation of cell proliferation GO:0008284 301 0.040
peptidyl tyrosine phosphorylation GO:0018108 170 0.040
positive regulation of calcium ion transport GO:0051928 51 0.040
adenylate cyclase activating dopamine receptor signaling pathway GO:0007191 3 0.039
positive regulation of camp metabolic process GO:0030816 41 0.039
negative regulation of purine nucleotide metabolic process GO:1900543 28 0.039
calcium ion transport GO:0006816 147 0.039
regulation of nucleotide biosynthetic process GO:0030808 50 0.039
dopamine receptor signaling pathway GO:0007212 10 0.039
negative regulation of phosphate metabolic process GO:0045936 267 0.038
regulation of sequestering of calcium ion GO:0051282 41 0.038
activation of phospholipase c activity GO:0007202 7 0.038
positive regulation of gtpase activity GO:0043547 166 0.038
ribonucleotide biosynthetic process GO:0009260 81 0.037
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.037
regulation of cell cycle process GO:0010564 266 0.037
regulation of lipid metabolic process GO:0019216 96 0.036
regulation of lipid catabolic process GO:0050994 23 0.036
regulation of peptidyl serine phosphorylation GO:0033135 50 0.036
glycerolipid biosynthetic process GO:0045017 51 0.036
protein dephosphorylation GO:0006470 81 0.036
endothelial cell proliferation GO:0001935 65 0.036
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.036
regulation of dendritic cell apoptotic process GO:2000668 4 0.035
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.035
regulation of lyase activity GO:0051339 23 0.035
system process GO:0003008 349 0.035
reactive oxygen species metabolic process GO:0072593 75 0.035
generation of neurons GO:0048699 152 0.035
positive regulation of cytokine production GO:0001819 167 0.034
response to oxygen containing compound GO:1901700 369 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.034
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.034
purine nucleotide biosynthetic process GO:0006164 84 0.034
cellular response to nitrogen compound GO:1901699 144 0.034
peptidyl tyrosine dephosphorylation GO:0035335 36 0.034
vasculature development GO:0001944 181 0.034
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.034
positive regulation of locomotion GO:0040017 186 0.033
positive regulation of release of sequestered calcium ion into cytosol GO:0051281 16 0.033
regulation of cytokine production GO:0001817 232 0.032
regulation of camp biosynthetic process GO:0030817 45 0.032
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.032
nitrogen compound transport GO:0071705 191 0.032
phosphatidylinositol metabolic process GO:0046488 53 0.032
purine ribonucleotide biosynthetic process GO:0009152 79 0.032
cyclic nucleotide mediated signaling GO:0019935 26 0.031
regulation of glucocorticoid secretion GO:2000849 4 0.031
positive regulation of transferase activity GO:0051347 227 0.031
determination of adult lifespan GO:0008340 2 0.031
gtp catabolic process GO:0006184 237 0.031
phospholipid biosynthetic process GO:0008654 44 0.031
lipid localization GO:0010876 106 0.031
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.031
tissue migration GO:0090130 119 0.030
muscle system process GO:0003012 81 0.030
cytokinesis GO:0000910 96 0.030
regulation of nucleotide catabolic process GO:0030811 205 0.030
secretion by cell GO:0032940 226 0.030
regulation of nervous system development GO:0051960 88 0.030
regulation of cell motility GO:2000145 299 0.029
regulation of mitotic cell cycle GO:0007346 189 0.029
positive regulation of secretion GO:0051047 116 0.029
regulation of transporter activity GO:0032409 82 0.029
phospholipid metabolic process GO:0006644 99 0.029
positive regulation of cytoplasmic transport GO:1903651 82 0.029
cyclic purine nucleotide metabolic process GO:0052652 60 0.029
compound eye development GO:0048749 1 0.029
response to lipid GO:0033993 206 0.028
negative regulation of homeostatic process GO:0032845 59 0.028
blood vessel development GO:0001568 172 0.028
maintenance of location GO:0051235 112 0.028
regulation of ras gtpase activity GO:0032318 128 0.027
protein ubiquitination GO:0016567 314 0.027
positive regulation of epithelial cell proliferation GO:0050679 65 0.027
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.027
negative regulation of apoptotic process GO:0043066 316 0.027
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.027
regulation of wound healing GO:0061041 56 0.027
behavioral fear response GO:0001662 0 0.027
neurogenesis GO:0022008 169 0.027
metencephalon development GO:0022037 2 0.027
regulation of potassium ion transmembrane transport GO:1901379 20 0.026
epithelium migration GO:0090132 119 0.026
response to biotic stimulus GO:0009607 276 0.026
positive regulation of phospholipid biosynthetic process GO:0071073 4 0.026
cytosolic calcium ion transport GO:0060401 48 0.026
rho protein signal transduction GO:0007266 26 0.026
regulation of peptide hormone secretion GO:0090276 41 0.026
biological adhesion GO:0022610 331 0.025
Human
immune response regulating signaling pathway GO:0002764 97 0.025
regulation of adenylate cyclase activity GO:0045761 17 0.025
positive regulation of cell differentiation GO:0045597 211 0.025
positive regulation of lipid biosynthetic process GO:0046889 22 0.025
protein maturation GO:0051604 233 0.025
positive regulation of cell death GO:0010942 263 0.025
regulation of reactive oxygen species metabolic process GO:2000377 41 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.024
regulation of cell growth GO:0001558 135 0.024
calcium ion transport into cytosol GO:0060402 48 0.024
multicellular organismal aging GO:0010259 3 0.024
cellular response to dna damage stimulus GO:0006974 379 0.024
regulation of cell division GO:0051302 116 0.024
morphogenesis of embryonic epithelium GO:0016331 4 0.024
lipid transport GO:0006869 90 0.024
peptide hormone secretion GO:0030072 50 0.024
regulation of map kinase activity GO:0043405 108 0.024
establishment of protein localization to organelle GO:0072594 172 0.024
blood circulation GO:0008015 113 0.024
regulation of cortisol secretion GO:0051462 4 0.024
positive regulation of secretion by cell GO:1903532 108 0.024
protein oligomerization GO:0051259 173 0.023
negative regulation of camp mediated signaling GO:0043951 4 0.023
immune response activating signal transduction GO:0002757 90 0.023
neuromuscular junction development GO:0007528 3 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
regulation of system process GO:0044057 101 0.023
apoptotic signaling pathway GO:0097190 268 0.023
regulation of immune response GO:0050776 201 0.023
mitotic cell cycle GO:0000278 326 0.023
calcium mediated signaling GO:0019722 44 0.023
positive regulation of cell cycle GO:0045787 140 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
carbohydrate metabolic process GO:0005975 207 0.022
segmentation GO:0035282 4 0.022
rap protein signal transduction GO:0032486 7 0.022
amide transport GO:0042886 76 0.022
cgmp metabolic process GO:0046068 19 0.022
regulation of locomotion GO:0040012 329 0.022
regulation of tube size GO:0035150 18 0.022
nuclear transport GO:0051169 179 0.022
cell growth GO:0016049 160 0.022
dendritic cell apoptotic process GO:0097048 4 0.021
positive regulation of autophagy GO:0010508 24 0.021
cell junction assembly GO:0034329 67 0.021
positive regulation of camp mediated signaling GO:0043950 10 0.021
phospholipase c activating dopamine receptor signaling pathway GO:0060158 2 0.021
single organism membrane organization GO:0044802 268 0.021
cell junction organization GO:0034330 79 0.021
stem cell division GO:0017145 2 0.021
protein autophosphorylation GO:0046777 123 0.021
response to external biotic stimulus GO:0043207 261 0.021
circulatory system development GO:0072359 262 0.021
positive regulation of oxidoreductase activity GO:0051353 26 0.020
response to other organism GO:0051707 261 0.020
spermatid differentiation GO:0048515 4 0.020
regulation of oxidoreductase activity GO:0051341 43 0.020
negative regulation of protein metabolic process GO:0051248 391 0.020
response to nutrient levels GO:0031667 81 0.020
defense response GO:0006952 315 0.020
single organism carbohydrate metabolic process GO:0044723 193 0.020
regulation of growth GO:0040008 165 0.020
negative regulation of cellular catabolic process GO:0031330 83 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
positive regulation of ion transmembrane transporter activity GO:0032414 29 0.020
phasic smooth muscle contraction GO:0014821 6 0.020
positive regulation of apoptotic process GO:0043065 246 0.019
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.019
mating GO:0007618 1 0.019
regulation of blood vessel size GO:0050880 18 0.019
positive regulation of ion transmembrane transport GO:0034767 40 0.019
cellular response to acid chemical GO:0071229 44 0.019
epithelial cell differentiation GO:0030855 141 0.019
positive regulation of cortisol secretion GO:0051464 4 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.019
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 7 0.019
negative regulation of cell growth GO:0030308 83 0.019
inner ear morphogenesis GO:0042472 4 0.019
regulation of monooxygenase activity GO:0032768 22 0.019
anterior posterior axis specification GO:0009948 2 0.019
cell matrix adhesion GO:0007160 85 0.018
Human
response to organic cyclic compound GO:0014070 204 0.018
negative regulation of sequestering of calcium ion GO:0051283 41 0.018
positive regulation of organelle organization GO:0010638 195 0.018
regulation of calcium ion transport GO:0051924 79 0.018
regulation of peptide transport GO:0090087 62 0.018
associative learning GO:0008306 1 0.018
cellular response to abiotic stimulus GO:0071214 117 0.018
peripheral nervous system development GO:0007422 2 0.018
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.018
oxidation reduction process GO:0055114 396 0.018
negative regulation of cellular amine metabolic process GO:0033239 3 0.018
neuron projection regeneration GO:0031102 1 0.018
immune response GO:0006955 307 0.018
positive regulation of gliogenesis GO:0014015 4 0.018
negative regulation of programmed cell death GO:0043069 321 0.018
enzyme linked receptor protein signaling pathway GO:0007167 303 0.018
Mouse
positive regulation of transporter activity GO:0032411 32 0.018
activation of immune response GO:0002253 114 0.018
negative regulation of protein modification process GO:0031400 200 0.018
activation of mapk activity by adrenergic receptor signaling pathway GO:0071883 3 0.017
regeneration GO:0031099 4 0.017
positive regulation of wound healing GO:0090303 20 0.017
memory GO:0007613 3 0.017
salivary gland morphogenesis GO:0007435 4 0.017
protein targeting GO:0006605 187 0.017
positive regulation of phospholipase activity GO:0010518 22 0.017
response to virus GO:0009615 126 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
negative regulation of protein binding GO:0032091 35 0.017
regulation of binding GO:0051098 111 0.017
innate immune response GO:0045087 178 0.017
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.017
protein kinase c signaling GO:0070528 17 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
regulation of anatomical structure size GO:0090066 101 0.017
protein import into nucleus GO:0006606 104 0.017
growth GO:0040007 202 0.016
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
negative regulation of nucleotide catabolic process GO:0030812 16 0.016
cellular response to drug GO:0035690 27 0.016
regulation of synaptic plasticity GO:0048167 3 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
nerve development GO:0021675 4 0.016
regulation of protein localization GO:0032880 296 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.016
negative regulation of catabolic process GO:0009895 104 0.016
blastoderm segmentation GO:0007350 2 0.016
cellular response to reactive oxygen species GO:0034614 50 0.016
protein processing GO:0016485 226 0.016
positive regulation of phospholipase c activity GO:0010863 13 0.016
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
spermatid development GO:0007286 4 0.016
cation transmembrane transport GO:0098655 238 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
regulation of cellular response to stress GO:0080135 244 0.016
regulation of actin cytoskeleton organization GO:0032956 116 0.016
nucleocytoplasmic transport GO:0006913 176 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
rna interference GO:0016246 4 0.015
negative regulation of protein maturation GO:1903318 142 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
atp metabolic process GO:0046034 176 0.015
negative adaptation of signaling pathway GO:0022401 7 0.015
response to inorganic substance GO:0010035 127 0.015
negative regulation of cell development GO:0010721 48 0.015
cellular protein catabolic process GO:0044257 261 0.015
cellular response to decreased oxygen levels GO:0036294 51 0.015
positive regulation of transport GO:0051050 336 0.015
establishment of protein localization to membrane GO:0090150 121 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
erbb signaling pathway GO:0038127 44 0.015
cell cell junction organization GO:0045216 69 0.015
endomembrane system organization GO:0010256 196 0.015
positive regulation of cell division GO:0051781 59 0.015
positive regulation of corticosteroid hormone secretion GO:2000848 5 0.014
organ formation GO:0048645 3 0.014
ion homeostasis GO:0050801 230 0.014
protein localization to membrane GO:0072657 160 0.014
positive regulation of neurogenesis GO:0050769 49 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
oocyte development GO:0048599 1 0.014
regulation of peptide secretion GO:0002791 42 0.014
negative regulation of protein transport GO:0051224 75 0.014
negative regulation of g protein coupled receptor protein signaling pathway GO:0045744 18 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
regulation of response to external stimulus GO:0032101 222 0.014
response to oxygen levels GO:0070482 100 0.014
wnt protein secretion GO:0061355 1 0.014
positive regulation of membrane protein ectodomain proteolysis GO:0051044 13 0.014
adult locomotory behavior GO:0008344 1 0.014
endocrine hormone secretion GO:0060986 13 0.014
response to catecholamine GO:0071869 7 0.014
regulation of receptor activity GO:0010469 47 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
regulation of release of sequestered calcium ion into cytosol GO:0051279 27 0.014
organelle assembly GO:0070925 176 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
regulation of lipid transport GO:0032368 44 0.014
nitric oxide biosynthetic process GO:0006809 20 0.014
ameboidal type cell migration GO:0001667 135 0.014
regulation of erbb signaling pathway GO:1901184 27 0.014
regulation of cell matrix adhesion GO:0001952 42 0.013
Human
sensory perception GO:0007600 103 0.013
hindbrain development GO:0030902 3 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
regulation of protein maturation GO:1903317 150 0.013
cell fate determination GO:0001709 3 0.013
negative regulation of synaptic transmission GO:0050805 2 0.013
nucleoside monophosphate catabolic process GO:0009125 159 0.013
cation homeostasis GO:0055080 189 0.013
positive regulation of cell adhesion GO:0045785 84 0.013
Human
regulation of epidermal growth factor activated receptor activity GO:0007176 14 0.013
behavior GO:0007610 112 0.013
cellular component morphogenesis GO:0032989 314 0.013
negative regulation of camp metabolic process GO:0030815 9 0.013
sleep GO:0030431 2 0.013

PLEKHA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.206
nervous system disease DOID:863 431 0.206
brain disease DOID:936 73 0.131
cerebral degeneration DOID:1443 16 0.060
musculoskeletal system disease DOID:17 223 0.027
disease of metabolism DOID:0014667 295 0.025
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
organ system cancer DOID:0050686 164 0.019
inherited metabolic disorder DOID:655 242 0.018
muscular disease DOID:0080000 114 0.017
muscle tissue disease DOID:66 113 0.017
connective tissue disease DOID:65 109 0.016
myopathy DOID:423 104 0.014
sensory system disease DOID:0050155 203 0.014