Homo sapiens

0 known processes

PLEKHF2

pleckstrin homology domain containing, family F (with FYVE domain) member 2

(Aliases: PHAFIN2,ZFYVE18,FLJ13187)

PLEKHF2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h3 acetylation GO:0043966 45 0.561
endoplasmic reticulum tubular network organization GO:0071786 8 0.489
histone h4 acetylation GO:0043967 47 0.406
histone acetylation GO:0016573 93 0.328
guanosine containing compound metabolic process GO:1901068 244 0.305
internal protein amino acid acetylation GO:0006475 101 0.278
internal peptidyl lysine acetylation GO:0018393 97 0.273
peptidyl lysine modification GO:0018205 144 0.271
regulation of anatomical structure size GO:0090066 101 0.253
regulation of cell motility GO:2000145 299 0.253
ribose phosphate biosynthetic process GO:0046390 82 0.249
negative regulation of axon extension GO:0030517 2 0.238
carbohydrate derivative biosynthetic process GO:1901137 207 0.212
regulation of cellular component size GO:0032535 82 0.194
cellular macromolecule catabolic process GO:0044265 380 0.175
chromatin organization GO:0006325 351 0.153
negative regulation of phosphorus metabolic process GO:0010563 267 0.148
memory GO:0007613 3 0.138
regulation of locomotion GO:0040012 329 0.125
purine nucleoside triphosphate metabolic process GO:0009144 412 0.112
peptidyl serine modification GO:0018209 106 0.108
purine nucleoside triphosphate catabolic process GO:0009146 392 0.102
anterior posterior axis specification GO:0009948 2 0.097
segmentation GO:0035282 4 0.094
sleep GO:0030431 2 0.089
negative regulation of multicellular organismal process GO:0051241 317 0.089
organophosphate catabolic process GO:0046434 430 0.087
ras protein signal transduction GO:0007265 73 0.086
peptidyl lysine acetylation GO:0018394 101 0.085
tube closure GO:0060606 3 0.084
small gtpase mediated signal transduction GO:0007264 78 0.084
regulation of cellular amino acid metabolic process GO:0006521 6 0.083
circadian sleep wake cycle process GO:0022410 2 0.082
regulation of proteasomal protein catabolic process GO:0061136 87 0.077
ribonucleoside triphosphate catabolic process GO:0009203 391 0.077
peptidyl serine phosphorylation GO:0018105 101 0.073
histone modification GO:0016570 251 0.072
organophosphate biosynthetic process GO:0090407 163 0.071
negative regulation of growth GO:0045926 97 0.070
gtp catabolic process GO:0006184 237 0.070
glycosyl compound catabolic process GO:1901658 413 0.069
regulation of proteolysis GO:0030162 293 0.068
regulation of cellular component biogenesis GO:0044087 281 0.067
positive regulation of apoptotic process GO:0043065 246 0.067
anterograde axon cargo transport GO:0008089 1 0.065
negative regulation of protein metabolic process GO:0051248 391 0.064
nucleoside triphosphate metabolic process GO:0009141 422 0.062
histone h4 k8 acetylation GO:0043982 15 0.059
cilium assembly GO:0042384 63 0.059
negative regulation of axonogenesis GO:0050771 4 0.057
ribonucleotide catabolic process GO:0009261 405 0.056
guanosine containing compound catabolic process GO:1901069 239 0.051
cellular response to external stimulus GO:0071496 111 0.051
oocyte differentiation GO:0009994 2 0.051
post embryonic development GO:0009791 2 0.051
oocyte development GO:0048599 1 0.050
regulation of anatomical structure morphogenesis GO:0022603 286 0.050
protein acetylation GO:0006473 116 0.050
regulation of nucleotide catabolic process GO:0030811 205 0.050
negative regulation of cell growth GO:0030308 83 0.049
regulation of oocyte development GO:0060281 1 0.048
cellular amine metabolic process GO:0044106 41 0.048
chromatin modification GO:0016568 298 0.047
purine ribonucleoside metabolic process GO:0046128 437 0.047
regulation of cellular protein catabolic process GO:1903362 96 0.045
ribonucleoside triphosphate metabolic process GO:0009199 412 0.044
neurotransmitter secretion GO:0007269 4 0.043
regulation of synaptic vesicle exocytosis GO:2000300 2 0.042
regulation of cell migration GO:0030334 289 0.042
cellular response to hormone stimulus GO:0032870 125 0.042
covalent chromatin modification GO:0016569 254 0.041
circadian sleep wake cycle GO:0042745 2 0.041
regulation of cell projection organization GO:0031344 107 0.041
regulation of actin cytoskeleton organization GO:0032956 116 0.040
regulation of growth GO:0040008 165 0.040
optic nerve development GO:0021554 2 0.039
blood vessel morphogenesis GO:0048514 162 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.038
regulation of protein processing GO:0070613 150 0.037
cell development GO:0048468 328 0.037
Fly
regulation of secretion by cell GO:1903530 177 0.036
angiogenesis GO:0001525 147 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.036
positive regulation of cell proliferation GO:0008284 301 0.036
actin filament based process GO:0030029 224 0.035
regulation of cellular component movement GO:0051270 334 0.035
anatomical structure formation involved in morphogenesis GO:0048646 284 0.035
endoplasmic reticulum organization GO:0007029 20 0.034
chemical homeostasis GO:0048878 306 0.034
regulation of natural killer cell activation GO:0032814 9 0.034
negative regulation of cellular amine metabolic process GO:0033239 3 0.034
blood vessel development GO:0001568 172 0.034
negative regulation of cellular protein metabolic process GO:0032269 353 0.034
neural tube formation GO:0001841 3 0.034
purine ribonucleoside catabolic process GO:0046130 398 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
negative regulation of catabolic process GO:0009895 104 0.033
ribonucleotide biosynthetic process GO:0009260 81 0.033
neural tube closure GO:0001843 3 0.032
negative regulation of cell differentiation GO:0045596 171 0.032
cell projection morphogenesis GO:0048858 129 0.031
Fly
primary neural tube formation GO:0014020 3 0.031
glycerolipid metabolic process GO:0046486 107 0.031
regulation of cell differentiation GO:0045595 393 0.031
endosomal transport GO:0016197 129 0.031
Fly
associative learning GO:0008306 1 0.031
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.031
actin cytoskeleton organization GO:0030036 207 0.031
cell morphogenesis GO:0000902 296 0.030
Fly
female gamete generation GO:0007292 2 0.030
proteasomal protein catabolic process GO:0010498 176 0.030
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.030
nervous system development GO:0007399 293 0.030
Fly
epithelial cell differentiation GO:0030855 141 0.030
negative regulation of cell proliferation GO:0008285 228 0.030
mapk cascade GO:0000165 288 0.030
regulation of rho gtpase activity GO:0032319 66 0.029
regulation of protein catabolic process GO:0042176 155 0.029
canonical wnt signaling pathway GO:0060070 116 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.029
endomembrane system organization GO:0010256 196 0.029
Human Fly
neurogenesis GO:0022008 169 0.029
Fly
actin polymerization or depolymerization GO:0008154 56 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.028
vasculature development GO:0001944 181 0.028
regulation of protein kinase activity GO:0045859 289 0.028
actin filament organization GO:0007015 128 0.027
negative regulation of actin filament polymerization GO:0030837 10 0.027
regulation of cell maturation GO:1903429 3 0.027
histone h2a acetylation GO:0043968 12 0.027
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.027
regulation of ras gtpase activity GO:0032318 128 0.027
regulation of circadian sleep wake cycle GO:0042749 2 0.027
cellular response to oxygen containing compound GO:1901701 276 0.026
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.026
long term memory GO:0007616 2 0.026
regulation of cell growth GO:0001558 135 0.026
rho protein signal transduction GO:0007266 26 0.025
protein processing GO:0016485 226 0.025
regulation of establishment of cell polarity GO:2000114 5 0.025
negative regulation of cell projection organization GO:0031345 22 0.025
apoptotic signaling pathway GO:0097190 268 0.025
negative regulation of embryonic development GO:0045992 4 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
cell projection organization GO:0030030 252 0.025
Fly
negative regulation of transferase activity GO:0051348 124 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
cell projection assembly GO:0030031 126 0.024
embryonic epithelial tube formation GO:0001838 4 0.024
regulation of cytoplasmic transport GO:1903649 149 0.024
cranial nerve development GO:0021545 4 0.024
regulation of actin filament length GO:0030832 56 0.024
positive regulation of gtpase activity GO:0043547 166 0.024
amine metabolic process GO:0009308 44 0.024
regulation of establishment of protein localization GO:0070201 242 0.024
circadian sleep wake cycle sleep GO:0050802 2 0.024
cerebral cortex radially oriented cell migration GO:0021799 1 0.024
negative regulation of cell development GO:0010721 48 0.024
neural tube patterning GO:0021532 2 0.024
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
regulation of gtpase activity GO:0043087 180 0.023
positive regulation of gtp catabolic process GO:0033126 166 0.023
regulation of protein localization GO:0032880 296 0.022
cilium organization GO:0044782 68 0.022
signal transduction by phosphorylation GO:0023014 297 0.022
purine nucleoside catabolic process GO:0006152 398 0.022
epithelial cell proliferation GO:0050673 128 0.022
nucleotide biosynthetic process GO:0009165 109 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
regulation of neural precursor cell proliferation GO:2000177 4 0.022
nucleoside triphosphate catabolic process GO:0009143 394 0.022
blastoderm segmentation GO:0007350 2 0.022
histone h4 k12 acetylation GO:0043983 6 0.022
lymphocyte homeostasis GO:0002260 4 0.022
nucleoside catabolic process GO:0009164 408 0.021
positive regulation of adenylate cyclase activity GO:0045762 12 0.021
protein acylation GO:0043543 138 0.021
cell growth GO:0016049 160 0.021
regulation of body fluid levels GO:0050878 99 0.021
antigen processing and presentation GO:0019882 33 0.021
negative regulation of developmental process GO:0051093 247 0.021
negative regulation of protein processing GO:0010955 142 0.021
regulation of ras protein signal transduction GO:0046578 155 0.020
regulation of cell morphogenesis GO:0022604 153 0.020
nuclear division GO:0000280 128 0.020
determination of dorsal ventral asymmetry GO:0048262 4 0.020
stress activated mapk cascade GO:0051403 93 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
membrane organization GO:0061024 292 0.020
Human
cellular protein catabolic process GO:0044257 261 0.020
protein catabolic process GO:0030163 325 0.020
regulation of protein maturation GO:1903317 150 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
regulation of protein polymerization GO:0032271 63 0.020
nucleoside phosphate biosynthetic process GO:1901293 109 0.019
positive regulation of camp biosynthetic process GO:0030819 35 0.019
regulation of protein stability GO:0031647 87 0.019
regulation of epithelial cell proliferation GO:0050678 113 0.019
receptor metabolic process GO:0043112 81 0.019
anterior posterior axis specification embryo GO:0008595 2 0.019
response to oxygen containing compound GO:1901700 369 0.019
negative regulation of neurogenesis GO:0050768 26 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
regulation of jnk cascade GO:0046328 73 0.019
cellular component morphogenesis GO:0032989 314 0.018
Fly
negative regulation of cell death GO:0060548 345 0.018
negative regulation of protein polymerization GO:0032272 16 0.018
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.018
negative regulation of smoothened signaling pathway GO:0045879 3 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
negative regulation of cell cycle GO:0045786 193 0.018
negative regulation of cellular catabolic process GO:0031330 83 0.018
peripheral nervous system development GO:0007422 2 0.018
regulation of cellular response to stress GO:0080135 244 0.018
positive regulation of hydrolase activity GO:0051345 331 0.018
regulation of mapk cascade GO:0043408 262 0.018
negative regulation of phosphorylation GO:0042326 174 0.018
circulatory system development GO:0072359 262 0.018
response to nitrogen compound GO:1901698 184 0.017
tripartite regional subdivision GO:0007351 2 0.017
engulfment of apoptotic cell GO:0043652 2 0.017
response to monosaccharide GO:0034284 20 0.017
cell adhesion GO:0007155 325 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
circadian behavior GO:0048512 2 0.017
positive regulation of secretion GO:0051047 116 0.017
purine containing compound catabolic process GO:0072523 411 0.017
golgi organization GO:0007030 38 0.017
alcohol biosynthetic process GO:0046165 52 0.016
secretion by cell GO:0032940 226 0.016
cytokine production GO:0001816 247 0.016
negative regulation of transport GO:0051051 176 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
glycerolipid biosynthetic process GO:0045017 51 0.016
histone h4 k5 acetylation GO:0043981 15 0.016
small molecule biosynthetic process GO:0044283 157 0.016
negative regulation of cytoskeleton organization GO:0051494 45 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
coagulation GO:0050817 78 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.016
response to axon injury GO:0048678 1 0.016
regulation of transferase activity GO:0051338 355 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.015
microtubule based process GO:0007017 210 0.015
gtp metabolic process GO:0046039 239 0.015
exocytosis GO:0006887 71 0.015
protein localization to plasma membrane GO:0072659 93 0.015
Human
positive regulation of rho gtpase activity GO:0032321 56 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
cell type specific apoptotic process GO:0097285 125 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
regulation of cytokine production GO:0001817 232 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
barbed end actin filament capping GO:0051016 3 0.014
regulation of rho protein signal transduction GO:0035023 79 0.014
regulation of cell projection assembly GO:0060491 47 0.014
protein maturation GO:0051604 233 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
purine containing compound biosynthetic process GO:0072522 88 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
stress activated protein kinase signaling cascade GO:0031098 94 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
actin filament capping GO:0051693 4 0.014
system process GO:0003008 349 0.014
spermatid differentiation GO:0048515 4 0.014
mitochondrion organization GO:0007005 156 0.014
regulation of cyclase activity GO:0031279 19 0.014
positive regulation of epithelial cell proliferation GO:0050679 65 0.014
alcohol metabolic process GO:0006066 114 0.014
cell part morphogenesis GO:0032990 137 0.014
Fly
establishment of vesicle localization GO:0051650 23 0.014
positive regulation of cellular component organization GO:0051130 376 0.014
cerebral cortex cell migration GO:0021795 3 0.014
organic hydroxy compound biosynthetic process GO:1901617 71 0.013
negative regulation of protein catabolic process GO:0042177 59 0.013
neuroblast proliferation GO:0007405 4 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
regulation of intracellular transport GO:0032386 195 0.013
oocyte maturation GO:0001556 1 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
regulation of kinase activity GO:0043549 314 0.013
plasma membrane to endosome transport GO:0048227 6 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
regulation of actin filament polymerization GO:0030833 50 0.013
response to starvation GO:0042594 59 0.013
positive regulation of catabolic process GO:0009896 310 0.013
Human
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
actin filament polymerization GO:0030041 45 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
positive regulation of cell death GO:0010942 263 0.013
t cell homeostasis GO:0043029 3 0.013
plasma membrane organization GO:0007009 115 0.013
Human
intracellular mrna localization GO:0008298 1 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
negative regulation of proteolysis GO:0045861 132 0.012
monosaccharide transport GO:0015749 32 0.012
phospholipid biosynthetic process GO:0008654 44 0.012
regionalization GO:0003002 29 0.012
hemostasis GO:0007599 76 0.012
organ morphogenesis GO:0009887 147 0.012
positive regulation of intracellular protein transport GO:0090316 76 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.012
negative regulation of cell morphogenesis involved in differentiation GO:0010771 24 0.012
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
Human
positive regulation of phosphorylation GO:0042327 394 0.012
regulation of stress activated mapk cascade GO:0032872 84 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.012
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.012
jnk cascade GO:0007254 80 0.012
epithelium migration GO:0090132 119 0.012
cardiovascular system development GO:0072358 262 0.012
biological adhesion GO:0022610 331 0.012
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.012
regulation of cell development GO:0060284 161 0.012
generation of neurons GO:0048699 152 0.012
Fly
protein autophosphorylation GO:0046777 123 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
regulation of leukocyte activation GO:0002694 115 0.012
nucleotide catabolic process GO:0009166 408 0.012
locomotory behavior GO:0007626 1 0.012
regulation of actin polymerization or depolymerization GO:0008064 56 0.012
growth GO:0040007 202 0.012
positive regulation of early endosome to late endosome transport GO:2000643 3 0.011
regulation of camp biosynthetic process GO:0030817 45 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
regulation of establishment or maintenance of cell polarity GO:0032878 7 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
organic acid biosynthetic process GO:0016053 97 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
rhythmic behavior GO:0007622 2 0.011
cell cell signaling GO:0007267 155 0.011
late endosome to vacuole transport GO:0045324 2 0.011
glycoprotein metabolic process GO:0009100 110 0.011
positive regulation of cellular amine metabolic process GO:0033240 7 0.011
response to abiotic stimulus GO:0009628 336 0.011
positive regulation of immune system process GO:0002684 283 0.011
positive regulation of intracellular transport GO:0032388 104 0.011
regulation of neurogenesis GO:0050767 82 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
determination of adult lifespan GO:0008340 2 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
regulation of neurotransmitter secretion GO:0046928 3 0.011
negative regulation of immune system process GO:0002683 136 0.011
regulation of synaptic vesicle transport GO:1902803 3 0.011
mitotic nuclear division GO:0007067 119 0.011
early endosome to late endosome transport GO:0045022 21 0.011
generation of precursor metabolites and energy GO:0006091 68 0.011
oogenesis GO:0048477 2 0.010
positive regulation of stress activated mapk cascade GO:0032874 60 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
response to cytokine GO:0034097 232 0.010
regulation of cell activation GO:0050865 125 0.010
positive regulation of cell migration GO:0030335 172 0.010
camp metabolic process GO:0046058 61 0.010
regulation of secretion GO:0051046 194 0.010
oxidation reduction process GO:0055114 396 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
negative regulation of nervous system development GO:0051961 28 0.010

PLEKHF2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.466
disease of cellular proliferation DOID:14566 174 0.466
organ system cancer DOID:0050686 164 0.277
bone development disease DOID:0080006 55 0.052
bone disease DOID:0080001 88 0.052
musculoskeletal system disease DOID:17 223 0.052
connective tissue disease DOID:65 109 0.052
immune system cancer DOID:0060083 36 0.037
hematologic cancer DOID:2531 36 0.023
myeloid leukemia DOID:8692 18 0.021
acute myeloid leukemia DOID:9119 17 0.021
leukemia DOID:1240 21 0.021
thyroid carcinoma DOID:3963 13 0.018
papillary thyroid carcinoma DOID:3969 6 0.018
endocrine gland cancer DOID:170 26 0.018
thyroid cancer DOID:1781 13 0.018
sensory system disease DOID:0050155 203 0.011
nervous system disease DOID:863 431 0.011