Homo sapiens

35 known processes

POLE3

polymerase (DNA directed), epsilon 3 (p17 subunit)

(Aliases: CHARAC17,YBL1,CHRAC17,p17)

POLE3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication GO:0006260 116 0.993
Yeast
chromatin organization GO:0006325 351 0.960
postreplication repair GO:0006301 12 0.959
Yeast
dna dependent dna replication GO:0006261 44 0.950
Yeast
histone h3 acetylation GO:0043966 45 0.906
translesion synthesis GO:0019985 8 0.895
Yeast
dna strand elongation involved in dna replication GO:0006271 3 0.853
Yeast
dna repair GO:0006281 198 0.828
Yeast
peptidyl lysine modification GO:0018205 144 0.817
cellular response to dna damage stimulus GO:0006974 379 0.799
Yeast Fly
protein acylation GO:0043543 138 0.769
protein dna complex assembly GO:0065004 64 0.723
Fly
histone modification GO:0016570 251 0.707
covalent chromatin modification GO:0016569 254 0.695
heterochromatin organization GO:0070828 6 0.569
Yeast
internal peptidyl lysine acetylation GO:0018393 97 0.558
protein acetylation GO:0006473 116 0.470
protein dna complex subunit organization GO:0071824 80 0.460
Yeast Fly
chromatin modification GO:0016568 298 0.459
histone acetylation GO:0016573 93 0.428
chromatin silencing GO:0006342 12 0.338
Yeast
post embryonic development GO:0009791 2 0.312
Worm
negative regulation of cell cycle phase transition GO:1901988 89 0.244
regulation of gene expression epigenetic GO:0040029 73 0.234
Yeast
leading strand elongation GO:0006272 1 0.229
Yeast
regulation of transcription by chromatin organization GO:0034401 1 0.227
dna biosynthetic process GO:0071897 40 0.202
Yeast
internal protein amino acid acetylation GO:0006475 101 0.192
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.191
nucleosome organization GO:0034728 66 0.188
Yeast Fly
mitotic dna integrity checkpoint GO:0044774 30 0.173
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.164
dna templated transcription initiation GO:0006352 35 0.142
carbohydrate derivative biosynthetic process GO:1901137 207 0.131
mitotic cell cycle checkpoint GO:0007093 68 0.122
purine ribonucleotide biosynthetic process GO:0009152 79 0.120
reproductive process GO:0022414 106 0.117
Worm
mrna processing GO:0006397 133 0.113
chromosome segregation GO:0007059 114 0.097
cellular macromolecular complex assembly GO:0034622 324 0.081
Fly
vesicle mediated transport GO:0016192 371 0.081
nucleobase biosynthetic process GO:0046112 4 0.079
nuclear division GO:0000280 128 0.077
dna integrity checkpoint GO:0031570 71 0.070
protein maturation GO:0051604 233 0.067
dna recombination GO:0006310 77 0.066
purine nucleobase metabolic process GO:0006144 5 0.064
mrna metabolic process GO:0016071 175 0.057
small gtpase mediated signal transduction GO:0007264 78 0.054
mitotic sister chromatid segregation GO:0000070 53 0.052
reproductive structure development GO:0048608 55 0.050
purine nucleobase biosynthetic process GO:0009113 3 0.046
reproductive system development GO:0061458 56 0.045
dna damage checkpoint GO:0000077 68 0.044
sex differentiation GO:0007548 45 0.044
embryo development GO:0009790 123 0.044
Worm
organonitrogen compound biosynthetic process GO:1901566 200 0.041
cell morphogenesis GO:0000902 296 0.041
chromatin remodeling GO:0006338 55 0.040
Yeast Fly
regulation of meiosis GO:0040020 3 0.039
negative regulation of mitotic cell cycle GO:0045930 102 0.036
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.036
pharynx development GO:0060465 1 0.036
peptidyl lysine acetylation GO:0018394 101 0.036
regulation of cell cycle phase transition GO:1901987 126 0.034
endocytosis GO:0006897 159 0.034
cellular component morphogenesis GO:0032989 314 0.033
ribose phosphate biosynthetic process GO:0046390 82 0.032
regulation of cell cycle GO:0051726 393 0.032
dna packaging GO:0006323 77 0.031
Fly
adult locomotory behavior GO:0008344 1 0.030
locomotory behavior GO:0007626 1 0.030
apoptotic signaling pathway GO:0097190 268 0.030
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.030
mitotic cell cycle process GO:1903047 286 0.029
protein ubiquitination GO:0016567 314 0.029
regulation of cell cycle process GO:0010564 266 0.029
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.027
single organism reproductive process GO:0044702 98 0.027
Worm
regulation of mitotic cell cycle GO:0007346 189 0.027
regulation of meiotic cell cycle GO:0051445 4 0.026
cell cycle checkpoint GO:0000075 117 0.025
protein processing GO:0016485 226 0.024
ras protein signal transduction GO:0007265 73 0.024
negative regulation of gene expression epigenetic GO:0045814 19 0.023
Yeast
organelle fission GO:0048285 149 0.023
meiotic chromosome segregation GO:0045132 4 0.022
neuron projection development GO:0031175 106 0.022
cell part morphogenesis GO:0032990 137 0.022
organophosphate biosynthetic process GO:0090407 163 0.022
purine nucleotide biosynthetic process GO:0006164 84 0.020
dna strand elongation GO:0022616 5 0.020
Yeast
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
g1 s transition of mitotic cell cycle GO:0000082 78 0.020
protein modification by small protein conjugation GO:0032446 342 0.019
double strand break repair GO:0006302 101 0.019
gonad development GO:0008406 34 0.019
response to biotic stimulus GO:0009607 276 0.019
regulation of multi organism process GO:0043900 157 0.018
mrna catabolic process GO:0006402 56 0.018
mitotic cell cycle GO:0000278 326 0.018
nuclear transcribed mrna catabolic process GO:0000956 48 0.017
cell morphogenesis involved in differentiation GO:0000904 144 0.017
mitotic dna damage checkpoint GO:0044773 28 0.017
epithelium development GO:0060429 227 0.017
anatomical structure homeostasis GO:0060249 100 0.016
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.016
regulation of protein maturation GO:1903317 150 0.016
mrna splicing via spliceosome GO:0000398 89 0.016
purine ribonucleoside metabolic process GO:0046128 437 0.016
developmental process involved in reproduction GO:0003006 66 0.016
sister chromatid cohesion GO:0007062 24 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
nitrogen compound transport GO:0071705 191 0.015
protein alkylation GO:0008213 74 0.015
cell projection organization GO:0030030 252 0.015
engulfment of apoptotic cell GO:0043652 2 0.015
cell development GO:0048468 328 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
amine metabolic process GO:0009308 44 0.014
cell adhesion GO:0007155 325 0.014
protein modification by small protein removal GO:0070646 92 0.014
determination of adult lifespan GO:0008340 2 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
mitotic sister chromatid cohesion GO:0007064 12 0.013
protein stabilization GO:0050821 64 0.013
cell cycle phase transition GO:0044770 173 0.013
purine containing compound biosynthetic process GO:0072522 88 0.013
positive regulation of immune system process GO:0002684 283 0.013
cytokine production GO:0001816 247 0.013
positive regulation of immune response GO:0050778 159 0.013
multi organism cellular process GO:0044764 156 0.012
regeneration GO:0031099 4 0.012
nucleus organization GO:0006997 28 0.012
regulation of proteolysis GO:0030162 293 0.012
development of primary sexual characteristics GO:0045137 35 0.012
dna templated transcriptional preinitiation complex assembly GO:0070897 5 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.012
regulation of mitotic recombination GO:0000019 1 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
small molecule biosynthetic process GO:0044283 157 0.012
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
positive regulation of multi organism process GO:0043902 56 0.012
regulation of protein processing GO:0070613 150 0.012
mitotic nuclear division GO:0007067 119 0.012
response to ionizing radiation GO:0010212 65 0.012
Fly
lung alveolus development GO:0048286 4 0.012
amine biosynthetic process GO:0009309 4 0.011
nervous system development GO:0007399 293 0.011
negative regulation of cell cycle GO:0045786 193 0.011
nucleoside biosynthetic process GO:0009163 26 0.011
immune system development GO:0002520 195 0.011
macromolecule methylation GO:0043414 97 0.011
reproduction GO:0000003 63 0.011
Worm
cellular response to endogenous stimulus GO:0071495 336 0.011
oxidation reduction process GO:0055114 396 0.011
methylation GO:0032259 106 0.011
nucleoside phosphate biosynthetic process GO:1901293 109 0.011
ribonucleoside monophosphate biosynthetic process GO:0009156 17 0.011
neuron differentiation GO:0030182 138 0.011
response to external biotic stimulus GO:0043207 261 0.011
regulation of cellular component biogenesis GO:0044087 281 0.010
cell projection morphogenesis GO:0048858 129 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010

POLE3 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.076
nervous system disease DOID:863 431 0.076
disease of cellular proliferation DOID:14566 174 0.049
cancer DOID:162 167 0.022
organ system cancer DOID:0050686 164 0.022
auditory system disease DOID:2742 53 0.021
nonsyndromic deafness DOID:0050563 50 0.021
large intestine cancer DOID:5672 29 0.017
gastrointestinal system cancer DOID:3119 52 0.017
intestinal cancer DOID:10155 29 0.017
colorectal cancer DOID:9256 29 0.017
disease of metabolism DOID:0014667 295 0.012
retinal disease DOID:5679 118 0.012
retinal degeneration DOID:8466 89 0.012
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012