|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.999
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.999
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.999
|
Rat Fly |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.999
|
Worm Fly |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.999
|
Worm Fly |
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.998
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.998
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.998
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.998
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.997
|
Fly |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.997
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.997
|
Rat |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.996
|
Rat Fly |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.996
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.996
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.996
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.993
|
Fly |
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.992
|
|
|
|
signal transduction involved in mitotic cell cycle checkpoint
|
GO:0072413 |
13 |
0.990
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.989
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.988
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.986
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.986
|
Fly |
|
|
spindle assembly
|
GO:0051225 |
29 |
0.986
|
Fly |
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.985
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.984
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.984
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.983
|
Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.982
|
|
|
|
neuroblast division
|
GO:0055057 |
1 |
0.981
|
Fly |
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
9 |
0.979
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.978
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.977
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.977
|
|
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.975
|
Rat |
|
|
nuclear division
|
GO:0000280 |
128 |
0.974
|
Fly |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.974
|
Fly |
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.974
|
Fly |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.972
|
Fly |
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.972
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.971
|
Worm |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.970
|
|
|
|
neuronal stem cell division
|
GO:0036445 |
1 |
0.970
|
Fly |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.969
|
Worm |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.966
|
|
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.964
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.963
|
Rat |
|
|
nuclear envelope reassembly
|
GO:0031468 |
3 |
0.961
|
Worm |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.961
|
Worm |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.959
|
Rat |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.953
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.950
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.949
|
Rat |
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.948
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.947
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.941
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.941
|
|
|
|
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process
|
GO:0031145 |
25 |
0.939
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.938
|
|
|
|
mitotic nuclear envelope reassembly
|
GO:0007084 |
3 |
0.934
|
Worm |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.932
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.930
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.928
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.924
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.924
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.919
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.919
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.913
|
Rat |
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.909
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.905
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.895
|
|
|
|
negative regulation of establishment of protein localization to plasma membrane
|
GO:0090005 |
9 |
0.889
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.885
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.884
|
|
|
|
asymmetric stem cell division
|
GO:0098722 |
1 |
0.884
|
Fly |
|
|
apoptotic process involved in morphogenesis
|
GO:0060561 |
3 |
0.881
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.878
|
|
|
|
metaphase anaphase transition of cell cycle
|
GO:0044784 |
21 |
0.876
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.874
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.872
|
Rat |
|
|
protein maturation
|
GO:0051604 |
233 |
0.871
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.871
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.868
|
Fly |
|
|
oogenesis
|
GO:0048477 |
2 |
0.865
|
Fly |
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.856
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.846
|
Rat |
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.838
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.833
|
Rat |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.825
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.823
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.821
|
|
|
|
signal transduction involved in mitotic g1 dna damage checkpoint
|
GO:0072431 |
10 |
0.820
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.818
|
Rat |
|
|
regulation of g1 s transition of mitotic cell cycle
|
GO:2000045 |
40 |
0.815
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.802
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.797
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.795
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.789
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.785
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.783
|
Worm Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.781
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.776
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.768
|
|
|
|
regulation of translation
|
GO:0006417 |
89 |
0.765
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.757
|
|
|
|
mitotic sister chromatid segregation
|
GO:0000070 |
53 |
0.757
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.750
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.750
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.743
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.743
|
Rat |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.725
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.719
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.717
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.716
|
Rat |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.715
|
Rat |
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.705
|
Rat |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.700
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.689
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.685
|
Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.680
|
Rat |
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.672
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.667
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.660
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.659
|
|
|
|
regulation of mitotic sister chromatid separation
|
GO:0010965 |
27 |
0.655
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.650
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.645
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.629
|
Rat |
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.625
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.625
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.622
|
Rat |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.621
|
Fly |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.618
|
Worm Fly |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.604
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.603
|
Worm |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.602
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.601
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.593
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.591
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.590
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.588
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.584
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.583
|
|
|
|
regulation of sister chromatid segregation
|
GO:0033045 |
27 |
0.574
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.570
|
|
|
|
negative regulation of epithelial to mesenchymal transition
|
GO:0010719 |
14 |
0.567
|
|
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
60 |
0.564
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.562
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.559
|
Worm Fly |
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.553
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.551
|
Fly |
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.549
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.547
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.545
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.543
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.537
|
|
|
|
signal transduction involved in mitotic dna integrity checkpoint
|
GO:1902403 |
13 |
0.515
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.515
|
|
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
13 |
0.514
|
|
|
|
spindle organization
|
GO:0007051 |
53 |
0.500
|
Worm Fly |
|
|
aging
|
GO:0007568 |
66 |
0.500
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.497
|
Rat |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.492
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.491
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.486
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.482
|
Rat |
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.477
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.475
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.470
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.466
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.459
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.459
|
Rat |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.456
|
|
|
|
regulation of mitotic metaphase anaphase transition
|
GO:0030071 |
26 |
0.453
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.446
|
Worm Fly |
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.446
|
|
|
|
negative regulation of neural precursor cell proliferation
|
GO:2000178 |
1 |
0.443
|
Fly |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.440
|
Fly |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.440
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.431
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.427
|
Worm Fly |
|
|
negative regulation of mitotic metaphase anaphase transition
|
GO:0045841 |
17 |
0.422
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.419
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.406
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.404
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.403
|
Fly |
|
|
regulation of metaphase anaphase transition of cell cycle
|
GO:1902099 |
26 |
0.395
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.394
|
|
|
|
meiotic nuclear division
|
GO:0007126 |
10 |
0.382
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.381
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.379
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.374
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.370
|
Fly |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.369
|
Rat |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.366
|
Fly |
|
|
regulation of dna replication
|
GO:0006275 |
68 |
0.361
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.359
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.357
|
|
|
|
sperm egg recognition
|
GO:0035036 |
3 |
0.355
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.352
|
Fly |
|
|
single fertilization
|
GO:0007338 |
11 |
0.344
|
Worm |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.338
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.337
|
Rat |
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.334
|
|
|
|
regulation of neuroblast proliferation
|
GO:1902692 |
3 |
0.332
|
Fly |
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.332
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.323
|
Rat |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.322
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.320
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.318
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.316
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.311
|
Rat |
|
|
smoothened signaling pathway
|
GO:0007224 |
14 |
0.310
|
Fly |
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.309
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.308
|
Fly |
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.306
|
|
|
|
positive regulation of dephosphorylation
|
GO:0035306 |
26 |
0.301
|
Rat |
|
|
reproduction
|
GO:0000003 |
63 |
0.293
|
Worm Fly |
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.291
|
|
|
|
mitotic g1 s transition checkpoint
|
GO:0044819 |
17 |
0.287
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.285
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.285
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.285
|
|
|
|
nuclear transcribed mrna catabolic process no go decay
|
GO:0070966 |
2 |
0.283
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.282
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.279
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.279
|
Worm |
|
|
centrosome separation
|
GO:0051299 |
3 |
0.279
|
Worm |
|
|
negative regulation of protein complex assembly
|
GO:0031333 |
43 |
0.277
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.270
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.266
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.265
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.265
|
|
|
|
regulation of chromosome segregation
|
GO:0051983 |
44 |
0.261
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.258
|
Rat |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.256
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.255
|
|
|
|
mitotic dna integrity checkpoint
|
GO:0044774 |
30 |
0.245
|
|
|
|
regulation of cell cycle arrest
|
GO:0071156 |
36 |
0.244
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.242
|
|
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.242
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.241
|
|
|
|
mitotic spindle organization
|
GO:0007052 |
27 |
0.240
|
Worm |
|
|
negative regulation of chromosome segregation
|
GO:0051985 |
18 |
0.239
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.238
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.236
|
Fly |
|
|
negative regulation of cytokinesis
|
GO:0032466 |
3 |
0.235
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.233
|
Rat |
|
|
tor signaling
|
GO:0031929 |
39 |
0.228
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.225
|
|
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.216
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.216
|
Worm Fly |
|
|
establishment of protein localization to mitochondrion
|
GO:0072655 |
22 |
0.214
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.213
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.211
|
|
|
|
development of primary sexual characteristics
|
GO:0045137 |
35 |
0.207
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.200
|
|
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.199
|
Fly |
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.198
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.197
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.196
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
11 |
0.196
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.194
|
Fly |
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.191
|
Rat |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.191
|
|
|
|
negative regulation of protein localization to nucleus
|
GO:1900181 |
34 |
0.191
|
Rat |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.191
|
Rat |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.190
|
|
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
12 |
0.190
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.189
|
Rat |
|
|
nuclear transport
|
GO:0051169 |
179 |
0.187
|
Rat |
|
|
g1 dna damage checkpoint
|
GO:0044783 |
18 |
0.185
|
|
|
|
cell cell recognition
|
GO:0009988 |
4 |
0.180
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.178
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.177
|
Fly |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.177
|
Rat |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.176
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.174
|
Rat |
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.174
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.173
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.172
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.167
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.166
|
Rat |
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.166
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.165
|
Rat |
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.162
|
Fly |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.160
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.158
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.158
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.156
|
Rat |
|
|
tube development
|
GO:0035295 |
125 |
0.155
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.151
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.147
|
Rat |
|
|
dna replication
|
GO:0006260 |
116 |
0.146
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.146
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.143
|
Rat |
|
|
segmentation
|
GO:0035282 |
4 |
0.143
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.142
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.142
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.141
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
15 |
0.139
|
|
|
|
centriole assembly
|
GO:0098534 |
14 |
0.139
|
Fly |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.135
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.134
|
|
|
|
protein localization to mitochondrion
|
GO:0070585 |
25 |
0.133
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.133
|
|
|
|
positive regulation of smoothened signaling pathway
|
GO:0045880 |
4 |
0.131
|
Fly |
|
|
binding of sperm to zona pellucida
|
GO:0007339 |
3 |
0.131
|
|
|
|
meiotic cell cycle
|
GO:0051321 |
13 |
0.130
|
Worm |
|
|
nuclear import
|
GO:0051170 |
106 |
0.129
|
Rat |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.129
|
|
|
|
positive regulation of response to dna damage stimulus
|
GO:2001022 |
43 |
0.128
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.127
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
48 |
0.126
|
|
|
|
response to antibiotic
|
GO:0046677 |
15 |
0.125
|
|
|
|
vesicle localization
|
GO:0051648 |
26 |
0.124
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.122
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.118
|
Fly |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.117
|
|
|
|
regulation of mitotic sister chromatid segregation
|
GO:0033047 |
27 |
0.116
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
17 |
0.115
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001241 |
4 |
0.114
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.113
|
|
|
|
chromosome separation
|
GO:0051304 |
23 |
0.111
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.110
|
Rat |
|
|
negative regulation of cell cycle g1 s phase transition
|
GO:1902807 |
29 |
0.110
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.110
|
|
|
|
signal transduction involved in cell cycle checkpoint
|
GO:0072395 |
16 |
0.109
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.109
|
Fly |
|
|
spindle assembly involved in mitosis
|
GO:0090307 |
12 |
0.107
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.106
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.105
|
|
|
|
positive regulation of translation
|
GO:0045727 |
35 |
0.105
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.103
|
|
|
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.099
|
Fly |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.098
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.098
|
Rat |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.098
|
Rat |
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.097
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.096
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.095
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.095
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.095
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.094
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.094
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.093
|
|
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.092
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.091
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.091
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.091
|
Rat |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.090
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.090
|
Worm |
|
|
hyperosmotic response
|
GO:0006972 |
4 |
0.090
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.090
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.088
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.087
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.086
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.084
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
23 |
0.083
|
|
|
|
spermatogenesis
|
GO:0007283 |
22 |
0.082
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.081
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.081
|
|
|
|
spindle assembly checkpoint
|
GO:0071173 |
17 |
0.080
|
|
|
|
metaphase anaphase transition of mitotic cell cycle
|
GO:0007091 |
21 |
0.080
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.080
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.079
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.078
|
|
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.077
|
Worm |
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
15 |
0.076
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.074
|
|
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.074
|
|
|
|
microtubule anchoring
|
GO:0034453 |
24 |
0.073
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.072
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.070
|
|
|
|
spindle checkpoint
|
GO:0031577 |
26 |
0.070
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.069
|
|
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.069
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.067
|
Fly |
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.067
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.067
|
Fly |
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.066
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.066
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.066
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.064
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.064
|
|
|
|
regulation of oocyte development
|
GO:0060281 |
1 |
0.063
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.063
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.063
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.063
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.062
|
|
|
|
protein import into mitochondrial matrix
|
GO:0030150 |
1 |
0.061
|
|
|
|
posttranscriptional gene silencing by rna
|
GO:0035194 |
25 |
0.060
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.060
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.059
|
Rat |
|
|
response to lipid
|
GO:0033993 |
206 |
0.059
|
Rat |
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.059
|
Fly |
|
|
regulation of histone acetylation
|
GO:0035065 |
19 |
0.059
|
|
|
|
embryonic placenta development
|
GO:0001892 |
1 |
0.059
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.058
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.058
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.058
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.057
|
|
|
|
positive regulation of meiotic cell cycle
|
GO:0051446 |
2 |
0.057
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.056
|
Rat |
|
|
fertilization
|
GO:0009566 |
12 |
0.056
|
Worm |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.056
|
Rat |
|
|
regulation of mitochondrial membrane permeability involved in apoptotic process
|
GO:1902108 |
18 |
0.055
|
|
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.055
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.054
|
Fly |
|
|
regulation of meiosis
|
GO:0040020 |
3 |
0.054
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.054
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.054
|
Rat |
|
|
maintenance of location
|
GO:0051235 |
112 |
0.053
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.052
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.050
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.049
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.049
|
Fly |
|
|
cell death in response to oxidative stress
|
GO:0036473 |
29 |
0.049
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.048
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.047
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.047
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.047
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.047
|
Rat |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.046
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.046
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.046
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.045
|
|
|
|
positive regulation of chromosome organization
|
GO:2001252 |
41 |
0.045
|
|
|
|
translation
|
GO:0006412 |
132 |
0.044
|
|
|
|
negative regulation of stem cell proliferation
|
GO:2000647 |
3 |
0.043
|
Fly |
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.043
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.043
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.042
|
Fly |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.042
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.042
|
|
|
|
growth
|
GO:0040007 |
202 |
0.042
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.042
|
|
|
|
centrosome cycle
|
GO:0007098 |
32 |
0.042
|
Worm Fly |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.042
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.042
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.041
|
Worm |
|
|
sex differentiation
|
GO:0007548 |
45 |
0.041
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.040
|
|
|
|
attachment of spindle microtubules to kinetochore
|
GO:0008608 |
17 |
0.040
|
|
|
|
regulation of membrane permeability
|
GO:0090559 |
25 |
0.039
|
|
|
|
gonad development
|
GO:0008406 |
34 |
0.039
|
|
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.038
|
Rat |
|
|
negative regulation of nucleocytoplasmic transport
|
GO:0046823 |
37 |
0.037
|
Rat |
|
|
regulation of release of cytochrome c from mitochondria
|
GO:0090199 |
29 |
0.037
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.037
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.037
|
Rat |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.036
|
|
|
|
regulation of meiotic cell cycle
|
GO:0051445 |
4 |
0.036
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.034
|
|
|
|
nuclear migration
|
GO:0007097 |
1 |
0.034
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.034
|
Fly |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.034
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.034
|
Rat |
|
|
jun phosphorylation
|
GO:0007258 |
28 |
0.034
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.033
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.033
|
Rat |
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.033
|
|
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.033
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.033
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.033
|
Worm |
|
|
germ cell development
|
GO:0007281 |
8 |
0.032
|
Fly |
|
|
regulation of translational initiation
|
GO:0006446 |
24 |
0.032
|
|
|
|
protein alkylation
|
GO:0008213 |
74 |
0.032
|
|
|
|
gene silencing by rna
|
GO:0031047 |
26 |
0.031
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.031
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.031
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.031
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.030
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.030
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
24 |
0.030
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.030
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.030
|
|
|
|
cytoskeleton dependent cytokinesis
|
GO:0061640 |
22 |
0.030
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.029
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.029
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.029
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.029
|
|
|
|
regulation of neurotrophin trk receptor signaling pathway
|
GO:0051386 |
2 |
0.029
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.029
|
|
|
|
histone h2a s1 phosphorylation
|
GO:0043990 |
1 |
0.029
|
|
|
|
mitochondrial outer membrane permeabilization involved in programmed cell death
|
GO:1902686 |
16 |
0.028
|
|
|
|
regulation of axon regeneration
|
GO:0048679 |
1 |
0.028
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.028
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.028
|
Rat |
|
|
memory
|
GO:0007613 |
3 |
0.028
|
|
