Homo sapiens

0 known processes

PRDX4

peroxiredoxin 4

(Aliases: PRX-4,AOE37-2)

PRDX4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein oxidation GO:0018158 5 0.983
Human
cellular response to oxygen radical GO:0071450 6 0.969
Human
cellular response to superoxide GO:0071451 6 0.967
Human
negative regulation of eosinophil migration GO:2000417 2 0.934
regulation of eosinophil extravasation GO:2000419 1 0.908
eosinophil extravasation GO:0072682 1 0.849
response to lipid GO:0033993 206 0.825
cellular response to oxidative stress GO:0034599 85 0.796
Human Worm
negative regulation of eosinophil extravasation GO:2000420 1 0.765
removal of superoxide radicals GO:0019430 6 0.757
Human
response to inorganic substance GO:0010035 127 0.712
Human Worm
cellular response to hydrogen peroxide GO:0070301 37 0.696
Human Worm
negative regulation of cellular extravasation GO:0002692 5 0.692
regulation of mitochondrial membrane potential GO:0051881 23 0.603
Human
regulation of eosinophil migration GO:2000416 2 0.568
hydrogen peroxide metabolic process GO:0042743 20 0.567
Human Worm
response to superoxide GO:0000303 6 0.541
Human
peptidyl cysteine modification GO:0018198 9 0.515
Human
regulation of kinase activity GO:0043549 314 0.511
Human
response to bacterium GO:0009617 144 0.455
response to other organism GO:0051707 261 0.427
cellular amine metabolic process GO:0044106 41 0.415
post embryonic development GO:0009791 2 0.407
response to wounding GO:0009611 168 0.395
response to reactive oxygen species GO:0000302 61 0.374
Human Worm
vesicle mediated transport GO:0016192 371 0.363
cyclic purine nucleotide metabolic process GO:0052652 60 0.357
hydrogen peroxide catabolic process GO:0042744 13 0.305
Human Worm
negative regulation of protein maturation GO:1903318 142 0.285
Human
cellular response to reactive oxygen species GO:0034614 50 0.271
Human Worm
superoxide metabolic process GO:0006801 20 0.268
Human
camp biosynthetic process GO:0006171 47 0.242
response to oxygen radical GO:0000305 6 0.237
Human
response to lipopolysaccharide GO:0032496 70 0.228
oxidation reduction process GO:0055114 396 0.219
Human Mouse Worm
positive regulation of developmental process GO:0051094 314 0.211
Worm
negative regulation of catalytic activity GO:0043086 335 0.207
Human
regulation of response to external stimulus GO:0032101 222 0.197
regulation of response to wounding GO:1903034 101 0.196
positive regulation of cellular amine metabolic process GO:0033240 7 0.195
response to oxygen containing compound GO:1901700 369 0.191
Human Worm
negative regulation of proteolysis GO:0045861 132 0.165
Human
negative regulation of apoptotic process GO:0043066 316 0.164
Human
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.164
Human
response to molecule of bacterial origin GO:0002237 82 0.163
vitamin metabolic process GO:0006766 26 0.157
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.155
Human
cellular modified amino acid metabolic process GO:0006575 64 0.154
Mouse
positive regulation of camp biosynthetic process GO:0030819 35 0.153
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.148
leukocyte migration GO:0050900 107 0.145
peptidyl cysteine oxidation GO:0018171 1 0.139
Human
mitochondrion organization GO:0007005 156 0.139
Human
response to external biotic stimulus GO:0043207 261 0.139
cellular response to oxygen containing compound GO:1901701 276 0.129
Human Worm
carbohydrate metabolic process GO:0005975 207 0.128
protein processing GO:0016485 226 0.125
Human
cellular amino acid metabolic process GO:0006520 116 0.122
Mouse
regulation of membrane potential GO:0042391 95 0.122
Human
endocytosis GO:0006897 159 0.118
regulation of protein maturation GO:1903317 150 0.116
Human
growth GO:0040007 202 0.115
Worm
negative regulation of cellular protein metabolic process GO:0032269 353 0.113
Human
cell type specific apoptotic process GO:0097285 125 0.110
cellular ketone metabolic process GO:0042180 80 0.109
myeloid leukocyte migration GO:0097529 62 0.107
negative regulation of protein metabolic process GO:0051248 391 0.104
Human
blood coagulation GO:0007596 76 0.099
negative regulation of kinase activity GO:0033673 106 0.099
Human
negative regulation of programmed cell death GO:0043069 321 0.095
Human
anatomical structure homeostasis GO:0060249 100 0.092
Human
positive regulation of camp metabolic process GO:0030816 41 0.092
inflammatory response GO:0006954 79 0.091
negative regulation of phosphorus metabolic process GO:0010563 267 0.091
Human
regulation of cell migration GO:0030334 289 0.091
positive regulation of cell proliferation GO:0008284 301 0.090
Human
response to biotic stimulus GO:0009607 276 0.089
peptidyl glutamic acid modification GO:0018200 4 0.087
regulation of nucleotide biosynthetic process GO:0030808 50 0.087
amine metabolic process GO:0009308 44 0.087
negative regulation of immune system process GO:0002683 136 0.086
carbohydrate derivative biosynthetic process GO:1901137 207 0.085
regulation of apoptotic signaling pathway GO:2001233 175 0.082
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.082
Human
regulation of growth GO:0040008 165 0.079
Worm
positive regulation of kinase activity GO:0033674 204 0.075
nucleotide biosynthetic process GO:0009165 109 0.075
regulation of cytoplasmic transport GO:1903649 149 0.075
response to hormone GO:0009725 175 0.075
defense response GO:0006952 315 0.072
organonitrogen compound biosynthetic process GO:1901566 200 0.071
positive regulation of protein phosphorylation GO:0001934 313 0.070
cellular response to lipid GO:0071396 127 0.070
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.070
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 38 0.067
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.067
purine ribonucleoside metabolic process GO:0046128 437 0.066
cyclic nucleotide biosynthetic process GO:0009190 61 0.064
negative regulation of cell motility GO:2000146 104 0.064
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.063
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.061
purine nucleotide biosynthetic process GO:0006164 84 0.060
regulation of purine nucleotide biosynthetic process GO:1900371 50 0.060
regulation of protein processing GO:0070613 150 0.060
Human
negative regulation of integrin activation GO:0033624 2 0.060
hemopoiesis GO:0030097 180 0.059
eosinophil migration GO:0072677 10 0.059
negative regulation of phosphate metabolic process GO:0045936 267 0.059
Human
granulocyte migration GO:0097530 40 0.058
positive regulation of phosphorylation GO:0042327 394 0.058
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.057
reactive oxygen species metabolic process GO:0072593 75 0.055
Human Mouse Worm
response to oxidative stress GO:0006979 121 0.055
Human Worm
positive regulation of smooth muscle contraction GO:0045987 5 0.054
negative regulation of peptidase activity GO:0010466 91 0.054
Human
hindbrain development GO:0030902 3 0.054
camp metabolic process GO:0046058 61 0.053
regulation of camp metabolic process GO:0030814 52 0.053
multicellular organismal homeostasis GO:0048871 67 0.052
Human
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.051
Human
negative regulation of defense response GO:0031348 47 0.049
neuron death GO:0070997 65 0.048
protein glycosylation GO:0006486 62 0.047
positive regulation of programmed cell death GO:0043068 249 0.043
intrinsic apoptotic signaling pathway GO:0097193 127 0.043
small molecule biosynthetic process GO:0044283 157 0.043
sulfur compound metabolic process GO:0006790 101 0.042
protein maturation GO:0051604 233 0.042
Human Mouse
locomotory behavior GO:0007626 1 0.042
regulation of behavior GO:0050795 82 0.041
regulation of defense response GO:0031347 154 0.041
purine containing compound biosynthetic process GO:0072522 88 0.041
regulation of cellular ketone metabolic process GO:0010565 50 0.040
system process GO:0003008 349 0.040
ketone catabolic process GO:0042182 3 0.040
regulation of cellular amino acid metabolic process GO:0006521 6 0.040
determination of adult lifespan GO:0008340 2 0.040
Worm
protein localization to nucleus GO:0034504 136 0.039
regulation of purine nucleotide metabolic process GO:1900542 264 0.038
pigment biosynthetic process GO:0046148 10 0.037
oogenesis GO:0048477 2 0.036
negative regulation of cell death GO:0060548 345 0.035
Human
regulation of cell motility GO:2000145 299 0.035
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.034
regulation of multi organism process GO:0043900 157 0.034
Mouse
response to abiotic stimulus GO:0009628 336 0.034
Worm
vitamin k metabolic process GO:0042373 6 0.033
regulation of cellular amine metabolic process GO:0033238 11 0.033
regulation of response to oxidative stress GO:1902882 26 0.033
dna replication GO:0006260 116 0.033
positive regulation of cell death GO:0010942 263 0.032
positive regulation of multicellular organism growth GO:0040018 6 0.032
Worm
tissue homeostasis GO:0001894 63 0.031
Human
steroid metabolic process GO:0008202 94 0.031
regulation of leukocyte migration GO:0002685 63 0.031
negative regulation of transferase activity GO:0051348 124 0.031
Human
apoptotic signaling pathway GO:0097190 268 0.031
reproduction GO:0000003 63 0.030
Mouse
embryo development GO:0009790 123 0.030
cellular extravasation GO:0045123 21 0.029
regulation of chemotaxis GO:0050920 74 0.029
regulation of reactive oxygen species metabolic process GO:2000377 41 0.029
circulatory system process GO:0003013 113 0.029
alpha amino acid metabolic process GO:1901605 72 0.029
Mouse
glycoprotein metabolic process GO:0009100 110 0.029
extrinsic apoptotic signaling pathway GO:0097191 119 0.029
cellular lipid metabolic process GO:0044255 303 0.029
positive regulation of cytokine production GO:0001819 167 0.029
skin development GO:0043588 76 0.029
response to steroid hormone GO:0048545 80 0.029
reproductive process GO:0022414 106 0.029
Mouse
regulation of transferase activity GO:0051338 355 0.028
Human
carboxylic acid biosynthetic process GO:0046394 97 0.028
single organism reproductive process GO:0044702 98 0.028
Mouse
glial cell migration GO:0008347 4 0.028
organic acid biosynthetic process GO:0016053 97 0.028
heat acclimation GO:0010286 3 0.027
Worm
positive regulation of nucleotide metabolic process GO:0045981 230 0.027
cell activation GO:0001775 213 0.027
integrin activation GO:0033622 8 0.027
negative regulation of leukocyte migration GO:0002686 14 0.027
negative regulation of neuron apoptotic process GO:0043524 23 0.027
cell aging GO:0007569 52 0.026
regulation of camp biosynthetic process GO:0030817 45 0.026
regulation of locomotion GO:0040012 329 0.026
response to mechanical stimulus GO:0009612 51 0.026
cellular component morphogenesis GO:0032989 314 0.025
multicellular organismal response to stress GO:0033555 1 0.025
negative regulation of endopeptidase activity GO:0010951 84 0.025
Human
regulation of cellular extravasation GO:0002691 8 0.025
positive regulation of cyclic nucleotide metabolic process GO:0030801 49 0.025
calcium mediated signaling GO:0019722 44 0.025
regulation of nucleotide metabolic process GO:0006140 269 0.024
signal transduction by phosphorylation GO:0023014 297 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.024
Worm
rna interference GO:0016246 4 0.024
vasoconstriction GO:0042310 11 0.024
fat soluble vitamin metabolic process GO:0006775 19 0.023
lipid metabolic process GO:0006629 381 0.023
immune system development GO:0002520 195 0.023
response to topologically incorrect protein GO:0035966 29 0.023
neutrophil migration GO:1990266 25 0.023
receptor mediated endocytosis GO:0006898 84 0.023
reactive oxygen species biosynthetic process GO:1903409 4 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.022
Mouse
protein targeting to nucleus GO:0044744 104 0.022
response to metal ion GO:0010038 84 0.022
Worm
regulation of peptidase activity GO:0052547 180 0.022
Human
multicellular organismal aging GO:0010259 3 0.022
Worm
positive regulation of cell differentiation GO:0045597 211 0.022
negative regulation of hydrolase activity GO:0051346 182 0.022
Human
lipid catabolic process GO:0016042 84 0.022
purine nucleobase metabolic process GO:0006144 5 0.022
regulation of meiotic cell cycle GO:0051445 4 0.021
cellular response to estrogen stimulus GO:0071391 16 0.021
reproductive system development GO:0061458 56 0.021
Mouse
gtp catabolic process GO:0006184 237 0.021
response to hydrogen peroxide GO:0042542 40 0.021
Human Worm
regulation of map kinase activity GO:0043405 108 0.021
nervous system development GO:0007399 293 0.021
positive regulation of transport GO:0051050 336 0.021
negative regulation of response to wounding GO:1903035 47 0.021
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.020
nucleoside phosphate biosynthetic process GO:1901293 109 0.020
cellular modified amino acid biosynthetic process GO:0042398 15 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
Human
alcohol metabolic process GO:0006066 114 0.020
regulation of inflammatory response GO:0050727 46 0.020
embryo development ending in birth or egg hatching GO:0009792 34 0.020
nuclear transport GO:0051169 179 0.020
cell death in response to hydrogen peroxide GO:0036474 10 0.019
cellular homeostasis GO:0019725 196 0.019
Mouse
regulation of proteolysis GO:0030162 293 0.019
Human
female gamete generation GO:0007292 2 0.019
muscle cell proliferation GO:0033002 35 0.019
negative regulation of catabolic process GO:0009895 104 0.019
positive regulation of growth GO:0045927 58 0.019
Worm
response to toxic substance GO:0009636 37 0.018
glycoprotein biosynthetic process GO:0009101 91 0.018
regulation of cellular component movement GO:0051270 334 0.018
regulation of cytokine production GO:0001817 232 0.018
anion transmembrane transport GO:0098656 76 0.018
immune effector process GO:0002252 159 0.018
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.017
adult locomotory behavior GO:0008344 1 0.017
single organism carbohydrate metabolic process GO:0044723 193 0.017
membrane hyperpolarization GO:0060081 1 0.017
regulation of neuron death GO:1901214 56 0.016
calcium ion transport GO:0006816 147 0.016
purine ribonucleotide biosynthetic process GO:0009152 79 0.016
regulation of neuron apoptotic process GO:0043523 35 0.016
cytokine production GO:0001816 247 0.016
chaperone mediated protein folding GO:0061077 13 0.016
calcium mediated signaling using intracellular calcium source GO:0035584 7 0.016
negative regulation of cellular catabolic process GO:0031330 83 0.016
protein import into nucleus GO:0006606 104 0.016
organic hydroxy compound metabolic process GO:1901615 147 0.016
positive regulation of coagulation GO:0050820 11 0.016
regulation of gene expression epigenetic GO:0040029 73 0.016
negative regulation of protein processing GO:0010955 142 0.016
Human
cellular response to toxic substance GO:0097237 4 0.015
leukocyte activation GO:0045321 164 0.015
regulation of blood circulation GO:1903522 59 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
Human
cell morphogenesis GO:0000902 296 0.015
ribonucleotide biosynthetic process GO:0009260 81 0.015
cell growth GO:0016049 160 0.014
negative regulation of hydrogen peroxide induced cell death GO:1903206 9 0.014
single organism nuclear import GO:1902593 104 0.014
i kappab kinase nf kappab signaling GO:0007249 166 0.014
negative regulation of neuron death GO:1901215 32 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
coagulation GO:0050817 78 0.014
primary alcohol metabolic process GO:0034308 17 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
lymphocyte proliferation GO:0046651 70 0.014
mrna metabolic process GO:0016071 175 0.014
regulation of cell substrate adhesion GO:0010810 68 0.014
endoplasmic reticulum unfolded protein response GO:0030968 16 0.014
female pregnancy GO:0007565 17 0.014
regulation of coagulation GO:0050818 44 0.014
regulation of response to reactive oxygen species GO:1901031 12 0.013
blood circulation GO:0008015 113 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
monocarboxylic acid metabolic process GO:0032787 185 0.013
Mouse
positive regulation of map kinase activity GO:0043406 80 0.013
protein localization to organelle GO:0033365 280 0.013
ribose phosphate biosynthetic process GO:0046390 82 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
cell division GO:0051301 168 0.013
oocyte development GO:0048599 1 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
nuclear import GO:0051170 106 0.013
response to organic cyclic compound GO:0014070 204 0.013
cell chemotaxis GO:0060326 112 0.013
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.013
regulation of intracellular transport GO:0032386 195 0.012
cellular response to oxygen levels GO:0071453 55 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
regulation of camp mediated signaling GO:0043949 13 0.012
wound healing GO:0042060 115 0.012
phospholipid metabolic process GO:0006644 99 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
regulation of low density lipoprotein particle receptor biosynthetic process GO:0045714 4 0.012
regulation of nucleocytoplasmic transport GO:0046822 98 0.012
negative regulation of growth GO:0045926 97 0.012
ion transmembrane transport GO:0034220 338 0.012
regulation of peptidyl serine phosphorylation GO:0033135 50 0.012
negative regulation of intracellular transport GO:0032387 60 0.012
regulation of protein transport GO:0051223 213 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
regulation of tube size GO:0035150 18 0.012
developmental growth GO:0048589 48 0.012
Worm
regulation of body fluid levels GO:0050878 99 0.012
regulation of protein localization to nucleus GO:1900180 85 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
regulation of oxidative stress induced cell death GO:1903201 24 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
fear response GO:0042596 0 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.012
maternal placenta development GO:0001893 5 0.012
regulation of cell growth GO:0001558 135 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
Human
innate immune response GO:0045087 178 0.012
chemical homeostasis GO:0048878 306 0.012
glycerolipid metabolic process GO:0046486 107 0.012
cell death in response to oxidative stress GO:0036473 29 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
Human
response to drug GO:0042493 81 0.011
cytoplasmic transport GO:0016482 379 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
regulation of ion transport GO:0043269 189 0.011
cyclic nucleotide metabolic process GO:0009187 82 0.011
regulation of developmental growth GO:0048638 30 0.011
Worm
actin cytoskeleton organization GO:0030036 207 0.011
cell projection organization GO:0030030 252 0.011
immune response GO:0006955 307 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
regulation of leukocyte differentiation GO:1902105 61 0.011
quinone metabolic process GO:1901661 18 0.011
response to thyroid hormone GO:0097066 9 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.010
cellular response to steroid hormone stimulus GO:0071383 37 0.010
positive regulation of chemotaxis GO:0050921 57 0.010
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.010
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.010
positive regulation of cellular component organization GO:0051130 376 0.010
cellular ion homeostasis GO:0006873 168 0.010
lymphocyte activation GO:0046649 133 0.010
regulation of autophagy GO:0010506 52 0.010
response to nitrogen compound GO:1901698 184 0.010

PRDX4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.601
inherited metabolic disorder DOID:655 242 0.118
central nervous system disease DOID:331 186 0.065
neurodegenerative disease DOID:1289 102 0.065
nervous system disease DOID:863 431 0.065
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
organ system cancer DOID:0050686 164 0.028
immune system disease DOID:2914 155 0.023